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Rotaviruses

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Viral Infections of Humans

Abstract

Before the use of rotavirus vaccines, rotaviruses were recognized as the single most important cause of severe infantile gastroenteritis worldwide and were estimated to be responsible for >600,000 deaths annually. Today, rotavirus disease is much less common where the vaccines are available, but rotaviruses continue to cause disease and death in the most impoverished nations where vaccine is not yet available to most. Transmission of rotaviruses occurs primarily by the fecal-oral route, providing a highly efficient mechanism for universal exposure that circumvents differences in cultural practices and public health standards. Nearly all children less than 5 years of age have experienced at least one rotavirus infection.

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Authors and Affiliations

  1. Laboratory of Specialized Clinical Studies, Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave. ML 6014, Cincinnati, OH, 45229, USA

    Monica Malone McNeal MS

  2. Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave. ML 6014, Cincinnati, OH, 45229, USA

    David I. Bernstein MD, MA

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  1. Monica Malone McNeal MS
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Correspondence to David I. Bernstein MD, MA .

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  1. Department of Epidemiology, University of Alabama, Birmingham School of Public Health, Birmingham, Alabama, USA

    Richard A. Kaslow

  2. Departmant of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA

    Lawrence R. Stanberry

  3. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

    James W. Le Duc

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McNeal, M.M., Bernstein, D.I. (2014). Rotaviruses. In: Kaslow, R., Stanberry, L., Le Duc, J. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7448-8_30

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