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Lysosomes

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Handbook of Neurochemistry

Abstract

In the nervous system, as elsewhere, hydrolytic enzymes with acid pH optima are sequestered in a latent state within a special cytoplasmic granule, the lysosome. This organelle has been implicated in a number of physiological and pathological processes and has attracted considerable attention because of the destructive potential of its enzymes. In this chapter we shall briefly survey the current status of lysosomes with particular reference to the nervous system. For a general review of this subject, the reader is referred to several comprehensive articles.(1–4)

The studies in which the author participated were supported in part by grants from the following: National Institutes of Health, U.S. Public Health Service (Nos. NB05509 and NB06838); National Multiple Sclerosis Society (Nos. MS-304 and MS-372); and Atomic Energy Commission [Contract No. AT(11-1)1180].

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Authors and Affiliations

  1. Neurology Service V.A. Research Hospital and Department of Neurology and Psychiatry, Northwestern University Medical School, Chicago, Illinois, USA

    Harold Koenig

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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’s Island, New York, New York, USA

    Abel Lajtha

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Koenig, H. (1969). Lysosomes. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7321-4_12

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