Abstract
Cole’s recent review of the efficacy of antidepressant drugs [1] suggests that we do not yet know whether the newer types of imipramine-like antidepressants are useful therapeutic agents. He also found little evidence in the literature for utility of the monoamine oxidase (MAO) inhibitors, and the inherent toxicity of this group of compounds [2] limits their usefulness. Studies by Wittenborn [3,4] indicate that the MAO inhibitors have a specific psychomotor stimulant effect not apparent after imipramine. This suggests that these two classes of compounds have different mechanisms of action.
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References
Cole, J. O.: Therapeutic Efficacy of Antidepressant Drugs, J.A.M.A. 190: 448 (1964).
Goldberg, L. I.: Monoamine Oxidase Inhibitors, J.A.M.A. 190: 456 (1964).
Wittenborn, J. R., Plante, M., Burgess, F., and Maurer, H.: Comparison of Imipramine, Electroconvulsive Therapy, and Placebo in Treatment of Depressions, J. Nervous Mental Disease 135: 131 (1962).
Wittenborn, J. R., Plante, M., Burgess, F., and Livermore, N.: Efficacy of Electroconvulsive Therapy, Iproniazad, and Placebo in Treatment of Young Depressed Women, J. Nervous Mental Disease 133: 332 (1961).
Penaloza-Rojas, J. H., Bach-y-Rita, G., Rubio-Chevannier, H. F., and Hernandez-Peon, R.: Effects of Imipramine upon Hypothalamic and Amygdaloid Excitability, Exper. Neurol. 4: 205 (1961).
Horovitz, Z. P., Chow, M., and Carlton, P. L.: Self-Stimulation of the Brain of Cats: Effects of Imipramine, Amphetamine, and Chlorpromazine, Psychopharmacologia (Berlin) 3: 455 (1962).
Himwich, H. E., Morillo, A., and Steiner, W. G.: Drugs Affecting Rhinencephalic Structures, J. Neuropsychiat. 3 (Suppl. 1): S15 (1962).
Schallek, W., and Kuehn, A.: Effects of Psychotropic Drugs on Limbic System of Cat, Proc. Soc, Exper. Biol. Med. 105: 115 (1960).
MacLean, P. D.: Contrasting Functions of Limbic and Neocortical Systems of the Brain and Their Relevance to Psychophysiological Aspects of Medicine, Am. J. Med. 25: 611 (1958).
Horovitz, Z. P., Furgiuele, A. R., Brannick, L. J., Burke, J. C., and Craver, B. N.: A New Chemical Structure with Specific Depressant Effects on the Amygdala and on the Hyperirritability of the “Septal” Rat, Nature 200: 369 (1963).
Barratt, E. S., and Pray, S. L.: The Effect of a Chemically Depressed (SQ 10,496) Amygdala on the Behavioral Manifestations of LSD-25 in Cats, Exper, Neurol. 12: 173 (1965).
Gorby, C. K.: Personal communication from Squibb Institute for Medical Research, Clinical Pharmacology Section.
Schallek, W., Kuehn, A., and Jew, N.: Effects of Chlordiazepoxide (Librium) and Other Psychotropic Agents on the Limbic System of the Brain, Ann. N. Y. Acad. Sci. 96: 303 (1962).
Kinnard, W. J., Jr., and Carr, C. J.: A Preliminary Procedure for the Evaluation of Central Nervous System Depressants, J. Pharmacol. Exper. Therap. 121: 354 (1957).
Furgiuele, A.R., Aumente, M. H., and Horovitz, Z. P.: Acute and Chronic Effects of Imipramine and Desipramine in Normal Rats and in Rats with Lesioned Amygdalae, Arch Intern. Pharmacodyn. 151: 170 (1964).
Furgiuele, A. R., High, J. P., and Horovitz, Z. P.: Some Central Effects of SQ 10,643, a Potent Serotonin Antagonist, Arch. Intern. Pharmacodyn. 155: 225 (1965).
Miller, C. L., and Tainter, M. L.: Estimation of the ED50 and Its Error by Means of LogarithmicProbit Graph Paper, Proc. Soc. Exper. Biol. Med. 57: 261 (1944).
Karli, P.: The Norway Rat’s Killing Response to the White Mouse. An Experimental Analysis, Behavior (Leiden) 10: 81 (1956).
Horovitz, Z. P., Mulroy, M. I., Waldron, T. L., and Leaf, R. C.: Behavioral and Electroencephalographic Effects of LSD, J. Pharm. Sci. 54: 108 (1965).
Horovitz, Z. P., Chow, M., and Carlton, P. L.: Self-Stimulation of the Brain of Cats: Techniques and Preliminary Drug Effects, Psychopharmacologia (Berlin) 3: 449 (1962).
Horovitz, Z. P., and Chow, M.: Technique of Implanting Permanent Electrodes in Cats for Chronic Stimulation and Observation of EEG and Behavioral Effects, J. Pharm. Sci. 52: 198 (1963).
Brannick, L. J.: Pharmacophysiologic Monitoring for Drug Evaluation, Trans. N.Y. Acad. Sci. (in press).
Brady, J. V., and Nauta, W. J. H.: Subcortical Mechanisms in Emotional Behavior: The Duration of Affective Changes Following Septal and Habenular Lesions in the Albino Rat, J. Comp. Physiol. Psychol. 46: 339 (1953).
King, F. A., and Meyer, P. M.: Effects of Amygdaloid Lesions upon Septal Hyperemotionality in the Rat, Science 128: 655 (1958).
Myer, J. S.: Stimulus Control of Mouse-Killing Rats, J. Comp. Physiol. Psychol. 58: 112 (1964).
Gloor, P.: Amygdala, in Field, J., Magoun, H.W., and Hall, V.E. (editors): Handbook of Physiology, Vol. 1, Section 1: Neurophysiology, Williams and Wilkins, Baltimore, Maryland, 1960, pp. 1395–1420.
Karli, P.: Aggressivity and Tranquillizers, Rev. Intern. Serv. 34: 19 (1961).
Karli, P.: Recherches pharmacologique sur le comportement d’agression rat-souris, J. Physiol. (Paris) 51: 497 (1959).
Janssen, P. A. J., Niemegeers, C. J. E., and Verbrug, F. J.: A propos d’une methode d’investigation de substances susceptibles de modifier le comportment agressif inné du rat blanc vis-â-vis de la souris blance, Psychopharmacologia (Berlin) 3: 114 (1962).
Wood, C. D.: Selective Brain Damage on the Response to Lysergic Acid Diethylamide, Neurology (submitted).
Heath, R. G., Leach, B. E., and Cohen, M.: in Gibbs, F. A. (editor): Molecules and Mental Health, J. B. Lippincott Co., Philadelphia, 1959, p. 477.
Wood, C. D., and Frost, L. L.: Electrical and Drug Studies of the Primate Anterior Commissure, Personal communication, 1965.
Karli, P.: Effets de lesions experimentales du septum sur l’agressivite interspecifique rat-souris, Compt. Rend. Soc. Biol. (Paris) 154: 1079 (1960).
Lapin, I. P.: Qualitative and Quantitative Relationships Between the Effects of Imipramine and Chlorpromazine on Amphetamine Group Toxicity, Psychopharmacologia (Berlin) 3: 413 (1962).
Horovitz, Z. P., Mulroy, M. I., and Waldron, T. L.: Effects of Phenothiazines and Imipramine on Inhibitory and Arousal Systems of the Brain, Pharmacologist 5: 239 (1963).
Kaada, B. R., Andersen, P., and Jansen, J., Jr.: Stimulation of the Amygdaloid Nuclear Complex in Unanesthetized Cats, Neurology 4: 48 (1954).
Sigg, E. B.: Pharmacological Studies with Tofranil, Canad. Psychiat. Assoc. J. 4: 575 (1959).
Garattini, S., Giochetti, A., Joni, A., Pieri, L., and Valzelli, L.: Effect of Imipramine, Amitryptyline, and Their Monomethyl Derivative on Reserpine Activity, J. Pharm. Pharmacol. 14: 509 (1962).
Horovitz, Z. P., Furgiuele, A. R., Uczen, E., and Ragozzino, P. W.: The Pharmacologic Actions of Two Potential Antidepressant Drugs (SQ 10,496) and (SQ 10,777) with Specific Actions on the Limbic System, Fed. Proc. 24: 134 (1965).
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Horovitz, Z.P. (1966). Relationship of the Amygdala to the Mechanism of Action of Two Types of Antidepressants (Thiazenone and Imipramine). In: Wortis, J. (eds) Recent Advances in Biological Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7313-9_3
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