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Relationship of the Amygdala to the Mechanism of Action of Two Types of Antidepressants (Thiazenone and Imipramine)

  • Zola P. Horovitz

Abstract

Cole’s recent review of the efficacy of antidepressant drugs [1] suggests that we do not yet know whether the newer types of imipramine-like antidepressants are useful therapeutic agents. He also found little evidence in the literature for utility of the monoamine oxidase (MAO) inhibitors, and the inherent toxicity of this group of compounds [2] limits their usefulness. Studies by Wittenborn [3,4] indicate that the MAO inhibitors have a specific psychomotor stimulant effect not apparent after imipramine. This suggests that these two classes of compounds have different mechanisms of action.

Keywords

Lateral Hypothalamus Septal Lesion Basolateral Amygdala Median Effective Dose Basolateral Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cole, J. O.: Therapeutic Efficacy of Antidepressant Drugs, J.A.M.A. 190: 448 (1964).PubMedCrossRefGoogle Scholar
  2. 2.
    Goldberg, L. I.: Monoamine Oxidase Inhibitors, J.A.M.A. 190: 456 (1964).PubMedCrossRefGoogle Scholar
  3. 3.
    Wittenborn, J. R., Plante, M., Burgess, F., and Maurer, H.: Comparison of Imipramine, Electroconvulsive Therapy, and Placebo in Treatment of Depressions, J. Nervous Mental Disease 135: 131 (1962).CrossRefGoogle Scholar
  4. 4.
    Wittenborn, J. R., Plante, M., Burgess, F., and Livermore, N.: Efficacy of Electroconvulsive Therapy, Iproniazad, and Placebo in Treatment of Young Depressed Women, J. Nervous Mental Disease 133: 332 (1961).Google Scholar
  5. 5.
    Penaloza-Rojas, J. H., Bach-y-Rita, G., Rubio-Chevannier, H. F., and Hernandez-Peon, R.: Effects of Imipramine upon Hypothalamic and Amygdaloid Excitability, Exper. Neurol. 4: 205 (1961).Google Scholar
  6. 6.
    Horovitz, Z. P., Chow, M., and Carlton, P. L.: Self-Stimulation of the Brain of Cats: Effects of Imipramine, Amphetamine, and Chlorpromazine, Psychopharmacologia (Berlin) 3: 455 (1962).CrossRefGoogle Scholar
  7. 7.
    Himwich, H. E., Morillo, A., and Steiner, W. G.: Drugs Affecting Rhinencephalic Structures, J. Neuropsychiat. 3 (Suppl. 1): S15 (1962).Google Scholar
  8. 8.
    Schallek, W., and Kuehn, A.: Effects of Psychotropic Drugs on Limbic System of Cat, Proc. Soc, Exper. Biol. Med. 105: 115 (1960).CrossRefGoogle Scholar
  9. 9.
    MacLean, P. D.: Contrasting Functions of Limbic and Neocortical Systems of the Brain and Their Relevance to Psychophysiological Aspects of Medicine, Am. J. Med. 25: 611 (1958).PubMedCrossRefGoogle Scholar
  10. 10.
    Horovitz, Z. P., Furgiuele, A. R., Brannick, L. J., Burke, J. C., and Craver, B. N.: A New Chemical Structure with Specific Depressant Effects on the Amygdala and on the Hyperirritability of the “Septal” Rat, Nature 200: 369 (1963).PubMedCrossRefGoogle Scholar
  11. 11.
    Barratt, E. S., and Pray, S. L.: The Effect of a Chemically Depressed (SQ 10,496) Amygdala on the Behavioral Manifestations of LSD-25 in Cats, Exper, Neurol. 12: 173 (1965).CrossRefGoogle Scholar
  12. 12.
    Gorby, C. K.: Personal communication from Squibb Institute for Medical Research, Clinical Pharmacology Section.Google Scholar
  13. 13.
    Schallek, W., Kuehn, A., and Jew, N.: Effects of Chlordiazepoxide (Librium) and Other Psychotropic Agents on the Limbic System of the Brain, Ann. N. Y. Acad. Sci. 96: 303 (1962).PubMedCrossRefGoogle Scholar
  14. 14.
    Kinnard, W. J., Jr., and Carr, C. J.: A Preliminary Procedure for the Evaluation of Central Nervous System Depressants, J. Pharmacol. Exper. Therap. 121: 354 (1957).Google Scholar
  15. 15.
    Furgiuele, A.R., Aumente, M. H., and Horovitz, Z. P.: Acute and Chronic Effects of Imipramine and Desipramine in Normal Rats and in Rats with Lesioned Amygdalae, Arch Intern. Pharmacodyn. 151: 170 (1964).Google Scholar
  16. 16.
    Furgiuele, A. R., High, J. P., and Horovitz, Z. P.: Some Central Effects of SQ 10,643, a Potent Serotonin Antagonist, Arch. Intern. Pharmacodyn. 155: 225 (1965).Google Scholar
  17. 17.
    Miller, C. L., and Tainter, M. L.: Estimation of the ED50 and Its Error by Means of LogarithmicProbit Graph Paper, Proc. Soc. Exper. Biol. Med. 57: 261 (1944).CrossRefGoogle Scholar
  18. 18.
    Karli, P.: The Norway Rat’s Killing Response to the White Mouse. An Experimental Analysis, Behavior (Leiden) 10: 81 (1956).Google Scholar
  19. 19.
    Horovitz, Z. P., Mulroy, M. I., Waldron, T. L., and Leaf, R. C.: Behavioral and Electroencephalographic Effects of LSD, J. Pharm. Sci. 54: 108 (1965).PubMedCrossRefGoogle Scholar
  20. 20.
    Horovitz, Z. P., Chow, M., and Carlton, P. L.: Self-Stimulation of the Brain of Cats: Techniques and Preliminary Drug Effects, Psychopharmacologia (Berlin) 3: 449 (1962).CrossRefGoogle Scholar
  21. 21.
    Horovitz, Z. P., and Chow, M.: Technique of Implanting Permanent Electrodes in Cats for Chronic Stimulation and Observation of EEG and Behavioral Effects, J. Pharm. Sci. 52: 198 (1963).PubMedCrossRefGoogle Scholar
  22. 22.
    Brannick, L. J.: Pharmacophysiologic Monitoring for Drug Evaluation, Trans. N.Y. Acad. Sci. (in press).Google Scholar
  23. 23.
    Brady, J. V., and Nauta, W. J. H.: Subcortical Mechanisms in Emotional Behavior: The Duration of Affective Changes Following Septal and Habenular Lesions in the Albino Rat, J. Comp. Physiol. Psychol. 46: 339 (1953).PubMedCrossRefGoogle Scholar
  24. 24.
    King, F. A., and Meyer, P. M.: Effects of Amygdaloid Lesions upon Septal Hyperemotionality in the Rat, Science 128: 655 (1958).PubMedCrossRefGoogle Scholar
  25. 25.
    Myer, J. S.: Stimulus Control of Mouse-Killing Rats, J. Comp. Physiol. Psychol. 58: 112 (1964).PubMedCrossRefGoogle Scholar
  26. 26.
    Gloor, P.: Amygdala, in Field, J., Magoun, H.W., and Hall, V.E. (editors): Handbook of Physiology, Vol. 1, Section 1: Neurophysiology, Williams and Wilkins, Baltimore, Maryland, 1960, pp. 1395–1420.Google Scholar
  27. 27.
    Karli, P.: Aggressivity and Tranquillizers, Rev. Intern. Serv. 34: 19 (1961).Google Scholar
  28. 28.
    Karli, P.: Recherches pharmacologique sur le comportement d’agression rat-souris, J. Physiol. (Paris) 51: 497 (1959).Google Scholar
  29. 29.
    Janssen, P. A. J., Niemegeers, C. J. E., and Verbrug, F. J.: A propos d’une methode d’investigation de substances susceptibles de modifier le comportment agressif inné du rat blanc vis-â-vis de la souris blance, Psychopharmacologia (Berlin) 3: 114 (1962).CrossRefGoogle Scholar
  30. 30.
    Wood, C. D.: Selective Brain Damage on the Response to Lysergic Acid Diethylamide, Neurology (submitted).Google Scholar
  31. 31.
    Heath, R. G., Leach, B. E., and Cohen, M.: in Gibbs, F. A. (editor): Molecules and Mental Health, J. B. Lippincott Co., Philadelphia, 1959, p. 477.Google Scholar
  32. 32.
    Wood, C. D., and Frost, L. L.: Electrical and Drug Studies of the Primate Anterior Commissure, Personal communication, 1965.Google Scholar
  33. 33.
    Karli, P.: Effets de lesions experimentales du septum sur l’agressivite interspecifique rat-souris, Compt. Rend. Soc. Biol. (Paris) 154: 1079 (1960).Google Scholar
  34. 34.
    Lapin, I. P.: Qualitative and Quantitative Relationships Between the Effects of Imipramine and Chlorpromazine on Amphetamine Group Toxicity, Psychopharmacologia (Berlin) 3: 413 (1962).CrossRefGoogle Scholar
  35. 35.
    Horovitz, Z. P., Mulroy, M. I., and Waldron, T. L.: Effects of Phenothiazines and Imipramine on Inhibitory and Arousal Systems of the Brain, Pharmacologist 5: 239 (1963).Google Scholar
  36. 36.
    Kaada, B. R., Andersen, P., and Jansen, J., Jr.: Stimulation of the Amygdaloid Nuclear Complex in Unanesthetized Cats, Neurology 4: 48 (1954).PubMedCrossRefGoogle Scholar
  37. 37.
    Sigg, E. B.: Pharmacological Studies with Tofranil, Canad. Psychiat. Assoc. J. 4: 575 (1959).Google Scholar
  38. 38.
    Garattini, S., Giochetti, A., Joni, A., Pieri, L., and Valzelli, L.: Effect of Imipramine, Amitryptyline, and Their Monomethyl Derivative on Reserpine Activity, J. Pharm. Pharmacol. 14: 509 (1962).PubMedCrossRefGoogle Scholar
  39. 39.
    Horovitz, Z. P., Furgiuele, A. R., Uczen, E., and Ragozzino, P. W.: The Pharmacologic Actions of Two Potential Antidepressant Drugs (SQ 10,496) and (SQ 10,777) with Specific Actions on the Limbic System, Fed. Proc. 24: 134 (1965).Google Scholar

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© Springer Science+Business Media New York 1966

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  • Zola P. Horovitz

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