Relationship of the Amygdala to the Mechanism of Action of Two Types of Antidepressants (Thiazenone and Imipramine)

  • Zola P. Horovitz


Cole’s recent review of the efficacy of antidepressant drugs [1] suggests that we do not yet know whether the newer types of imipramine-like antidepressants are useful therapeutic agents. He also found little evidence in the literature for utility of the monoamine oxidase (MAO) inhibitors, and the inherent toxicity of this group of compounds [2] limits their usefulness. Studies by Wittenborn [3,4] indicate that the MAO inhibitors have a specific psychomotor stimulant effect not apparent after imipramine. This suggests that these two classes of compounds have different mechanisms of action.


Lateral Hypothalamus Septal Lesion Basolateral Amygdala Median Effective Dose Basolateral Nucleus 
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© Springer Science+Business Media New York 1966

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  • Zola P. Horovitz

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