Abstract
Atropine and JB-329 have been observed to produce a depression of thresholds for production of caudate spindles and the elevation of thresholds for inhibition of these spindles by reticular stimulation. The spontaneous activity of the hippocampus was also altered by the two drugs [1]. Since these observations indicated that there might be some relationship between the reticular “depression” and hippocampal activity, it seemed desirable to attempt to determine whether any such relationship existed. This could be readily done by use of a preparation with mesencephalic reticular lesions. Concomitantly, these animals were also used to investigate the effect of the two drugs on the nonspecific projection system and the visual evoked response.
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References
Spradlin, W. W., Sternbergh, W. C.A., Wilson, W. P., and Hughes, J. L.: Anticholinergic Hallucinosis. I. Effect of Atropine and JB-329 on ‘Caudate Spindle“ Phenomena and Electrical Activity of the Hippocampus in Cats, in Wortis, J. (editor): Recent Advances in Biological Psychiatry, Vol. 8, Plenum Press, New York, 1965, p. 175.
Jasper, H., and Ajmone-Marsan, C.: A Stereotaxic Atlas of the Diencephalon of the Cat, National Research Council of Canada.
Chang, H. T., and Kaada, B.: An Analysis of Primary Response of Visual Cortex to Optic Nerve Stimulation in Cats, J. Neurophysiol. 13: 305, 1960
Jasper, H., Naquet, R., and King, E. E.: Thalamocortical Recruiting Responses in Sensory Receiving Areas in the Cat, Electroencephalog. Clin. Neurophysiol. 7: 99, 1955.
Bishop, P.O., Field, G., Hennessey, B. L., and Smith, J. R.: Action of D-Lysergic Acid Diethyl-amide on Lateral Geniculate Synapses, J. Neurophysiol. 21: 529, 1958.
Rinaldi, F., and Himwich, H.: Alerting Responses and Actions of Atropine and Cholinergic Drugs, Arch. Neurol. Psychiat. 73: 387, 1955.
Rinaldi, F., and Himwich, H.: Drugs Affecting Psychotic Behavior and Function of the Mesodiencephalic Activating System, Dis. Nervous System 16: 133, 1955.
Ogawa, T.: Midbrain Reticular Influences upon Single Neurons in Lateral Geniculate Nucleus, Science 139: 343, 1963.
Taira, N., and Okuda, J.: Sensory Transmission in Visual Pathways in Various Arousal States of Cats, Tohoku J. Exper. Med. 78: 76, 1962.
Dumont, S., and Dell, P.: Facilitation réticulaire des mechanismes visuals corticaus, Electroencephalog. Clin. Neurophysiol. 12: 796, 1960.
Fuster, J. M., and Docter, R. F.: Variations of Optic Evoked Potentials as a Function of Reticular Activity in Rabbits with Chronically Implanted Electrodes, J. Neurophysiol. 25: 324, 1962.
Long, R. G.: Modification of Sensory Mechanisms by Subcortical Structures, J. Neurophysiol. 22: 412, 1959.
Bradley, P. B., and Elkes, J.: The Effects of Some Drugs on the Electrical Activity of the Brain, Brain 80: 77, 1957.
Bradley, P. B., and Key, B. J.: A Comparative Study of the Effects of Drugs on the Arousal System of the Brain, Brit. J. Pharmacol. 14: 340, 1959.
Bradley, P. B., and Nicholson, A. N.: The Effect of Some Drugs on Hippocampal Arousals, Electroencephalog. Clin. Neurophysiol. 14: 824, 1962.
Hance, A. J., Winters, W. D., Bach-y-Rita, P., and Killam, K. F.: A Neuropharmacological Study of Gamma-Aminoluityryl-Choline, Gamma-Aminoluityric Acid, Physostigmine, and Atropine, J. Pharmacol. Exper. Therap. 140: 385, 1963.
Horovitz, Z. P., and Chow, M. I.: Effects of Centrally Acting Drugs on the Correlation of Electrocortical Activity and Wakefulness in Cats, J. Pharmacol. Exper. Therap. 137: 127, 1962.
Wilson, W. P.: Observations on the Effect of Toxic Doses of Atropine on the Electroencephalogram of Man, J. Neuropsychiat. 2: 186, 1961.
Bach-y-Rita, P., Hance, A. J., and Winters, W. D.: Some Effects of Atropine and Eserine on Thalamocortical Pathways in the Cat., Proc. West. Pharmacol. Soc. 3: 69, 1960.
Bell, C., Gershon, S„ Carroll, B., and Holand, G.: Behavioral Antagonism to a New Psychotomimetic: JB-329, Arch. Intern. Pharmacodyn. 147: 9, 1964.
Wilson, W. P.: Unpublished observations.
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Sternbergh, W.C.A., Wilson, W.P. (1966). Anticholinergic Hallucinosis. II. Effects of Atropine and JB-329 on Activity of the Visual System, Nonspecific Projection System, and Hippocampus in Animals with and without Reticular System Lesions. In: Wortis, J. (eds) Recent Advances in Biological Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7313-9_23
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DOI: https://doi.org/10.1007/978-1-4899-7313-9_23
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