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Expression of myelomonocytic antigens is associated with unfavourable clinicoprognostic factors in B-cell chronic lymphocytic leukaemia

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Annals of Oncology

Summary

The cross-lineage expression of five myelomonocytic antigens (CD11b, CD11c, CD13, CD14, and CD15) was analysed in neoplastic lymphocytes from 100 consecutive B-cell chronic lymphocytic leukaemia (B-CLL) patients. CD14 antigen was detected on lymphocytes from more than 50% of patients whilst smaller percentages of samples were positive for CD11b (21%), CD11c (26%), CD13 (22%), and CD15 (7%). The presence of the CD13 antigen on neoplastic lymphocytes showed a statistically significant association with the two most important unfavourable clinicoprognostic factors in B-CLL: advanced clinical stage (CD13, P < 0.01 by the Rai staging system; P < 0.05 by the Binet staging system) and the diffuse pattern of bone marrow infiltration (CD13, P < 0.001). A multiple logistic regression analysis showed that the increased risk for CD13-positive patients (13.7-fold higher than CD13-negative cases; P = 0.001) of presenting a diffuse pattern of bone marrow infiltration is independent of all other prognostic factors analysed including sex, age, lymphocyte counts, and clinical stage. A statistically significant association of CD11c (P = 0.002) and CD11b (P = 0.032) expression with the pattern of bone marrow infiltration was also found.

Our results indicate for the first time a statistically significant association of CD13, CD11c, and CD11b antigens with unfavourable prognostic factors in B-CLL. They suggest that the cross-lineage expression of myeloid-associated surface peptidase (CD13-aminopeptidase N) and/or cell adhesion molecules (CD11c-LeuCAMc, CD11b-LeuCAMb) may influence the biological and clinical behaviour of chronic lymphoproliferative disorders of B cells.

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References

  1. Catovsky D.: Chronic lymphocytic, prolymphocytic and hairy cell leukaemias. In: Goldman JM and Preisler HD (eds). Haematology I. Leukaemias 1984; 266–98.

    Google Scholar 

  2. Freedman AS.: Immunobiology of chronic lymphocytic leukemia. Hematology/Oncology Clinics of North America 1990; 4: 405–29.

    PubMed  CAS  Google Scholar 

  3. Freedman AS, Boyd AW, Bieber FR et al.: Normal cellular counterparts of B cell chronic lymphocytic leukemia. Blood 1987; 70: 418–27.

    PubMed  CAS  Google Scholar 

  4. Caligaris-Cappio F, Gobbi M, Bofill M et al.: Infrequent normal B lymphocytes express features of B chronic lymphocytic leukemia. J Exp Med 1982; 155: 623–8.

    Article  PubMed  CAS  Google Scholar 

  5. Gale RP, Foon KA.: Biology of chronic lymphocytic leukaemia. Sem Hematol 1987; 24: 209–14.

    CAS  Google Scholar 

  6. Rai KR, Montserrat E.: Prognostic factors in chronic lymphocytic leukemia. Sem Hematol 1987; 4: 252–5.

    Google Scholar 

  7. Hamblin TJ.: Chronic lymphocytic leukaemia. Bailliere’s Clinical Haematology 1987; 1: 449–91.

    Article  CAS  Google Scholar 

  8. Rai KR, Sawitsky A, Cronkite EP et al.: Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46: 219–34.

    PubMed  CAS  Google Scholar 

  9. Binet JL, Catovsky D, Chandra P et al.: Chronic lymphocytic leukemia: proposals for a revised prognostic staging system. Br J Haematol 1981; 48: 365–7.

    Article  Google Scholar 

  10. Foon KA, Todd RF III.: Immunologic classification of leukemia and lymphoma. Blood 1986; 68: 1–31.

    PubMed  CAS  Google Scholar 

  11. Maitreyan V, Gale RP.: What is hybrid acute leukemia. Leukemia Res 1989; 13: 725–8.

    Article  CAS  Google Scholar 

  12. Altman AJ.: Clinical features and biological implications of acute mixed lineage (Hybrid) leukemias. Am J Pediatr Hematol Oncol 1990; 12: 123–33.

    Article  PubMed  CAS  Google Scholar 

  13. Sobol RE, Mick R, Royston I et al.: Clinical importance of myeloid antigen expression in adult acute lymphoblastic leukemia. New Engl J Med 1987; 316: 1111–7.

    Article  PubMed  CAS  Google Scholar 

  14. Mirro J, Zipft TF, Pui CH et al.: Acute mixed lineage leukemia: clinicopathologic correlations and prognostic significance. Blood 1985; 66: 1115–23.

    PubMed  CAS  Google Scholar 

  15. Grogan TM, Durie BGM, Spier CM et al.: Myelomonocytic antigen positive multiple myeloma. Blood 1989; 73: 763–9.

    PubMed  CAS  Google Scholar 

  16. Epstein J, Xiao H, He X-Y.: Markers of multiple hematopoieticcell lineages in multiple myeloma. N Engl J Med 1990; 322: 664–8.

    Article  PubMed  CAS  Google Scholar 

  17. Pinto A, Colletta G, Del Vecchio L et al.: C-fos expression in human hemopoietic malignancies is restricted to acute leukemias with monocytic phenotype and to subsets of B cell leukemias. Blood 1987; 70: 1450–7.

    PubMed  CAS  Google Scholar 

  18. Morabito F, Prasthofer EF, Dunlap NE et al.: Expression of myelomonocytic antigens on chronic lymphocytic leukemia B cells correlates with their ability to produce Interleukin 1. Blood 1987; 70: 1750–7.

    PubMed  CAS  Google Scholar 

  19. Del Vecchio L, Pinto A, Lo Pardo C et al.: Myeloid aspects of B cell differentiation: immunophenotypic analysis of B-leukemic cells exposed in vitro to maturation inducers. In: McMichael AJ (ed). `Leucocyte Typing IIE. Oxford University Press 1987; 650.

    Google Scholar 

  20. Cheson BD, Bennett JM, Rai KR et al.: Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group. Am J Hematol 1988; 29: 152–63.

    Article  PubMed  CAS  Google Scholar 

  21. Knapp W (ed.). Leucocyte typing IV. Oxford: Oxford University Press, 1989.

    Google Scholar 

  22. Carbone A, Gloghini A, Pinto A et al.: Monocytoid B-cell lymphoma with bone marrow and peripheral blood involvement at presentation. Am J Clin Pathol 1989; 92: 228–36.

    PubMed  CAS  Google Scholar 

  23. Carbone A, Manconi R, Sulfaro S et al.: Practical importance of routine paraffin-embedded bone marrow biopsy in multiple myeloma. Tumori 1987; 73: 315–9.

    PubMed  CAS  Google Scholar 

  24. Rozman C, Montserrat E, Rodriguez-Fernandez JM et al.: Bone marrow histological pattern. The best single prognostic parameter in chronic lymphocytic leukemia. A multivariate survival analysis of 329 cases. Blood 1984; 64: 642–8.

    PubMed  CAS  Google Scholar 

  25. Han T, Bancos M, Emrich L et al.: Bone marrow infiltration patterns and their prognostic significance in chronic lymphocytic leukemia: correlations with clinical, immunologic, phenotypic, and cytogenetic data. J Clin Oncol 1984; 2: 562–70.

    PubMed  CAS  Google Scholar 

  26. Carbone A, Santoro A, Pilotti S et al.: Bone marrow patterns and clinical staging in chronic lymphocytic leukaemia. Lancet 1978; i: 606.

    Google Scholar 

  27. Catowsky D, Fooks J, Richards S.: Prognostic factors in chronic lymphocytic leukaemia: the importance of age, sex and response to treatment. Br J Haematol 1989; 72: 141–9.

    Article  Google Scholar 

  28. Armitage P, Berry G.: Statistical methods in medical research. Blackwell Scientific Publications, second edition, London 1987; 125–32.

    Google Scholar 

  29. Breslow NE, Day NE.: Statistical methods in cancer research IARC Scientific Publication 1980; 32: 192–246.

    Google Scholar 

  30. Patarroyo M, Makgoba MW.: Leucocyte adhesion to cells in immune and inflammatory responses. Lancet 1989; 11: 1139–41.

    Article  Google Scholar 

  31. Look AT, Ashmur RA, Shapiro LH, Peiper SC.: Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J Clin Invest 1989; 83: 1299–307.

    Article  CAS  Google Scholar 

  32. Kenny AJ, O’Hare MJ, Gusterson BA.: Cell surface peptidase as modulators of growth and differentiation. Lancet 1989; 11: 785–7.

    Article  Google Scholar 

  33. Peiper C, Leboeuf RD, Hughes CB et al.: Report on the CD33 cluster Workshop: biochemical and genetic characterization of gp67. In: Knapp W (ed.) Leucocyte typing IV. Oxford: Oxford University Press 1989; 814–6.

    Google Scholar 

  34. Pinto A, Zagonel V, Carbone A et al.: The expression of myelomonocytic antigens on chronic lymphocytic leukaemia B-cells identifies a subset of patients with a `variant’ CLL phenotype and different biological and clinicopathological features. In: Knapp W (ed.) Leucocyte typing IV. Oxford: Oxford University Press 1989; 929–30.

    Google Scholar 

  35. Geisler C, Ralfkajer E, Hansen MM et al.: The bone marrow histological pattern has independent prognostic value in early stage chronic lymphocytic leukaemia. Br J Haematol 1986; 24: 47–54.

    Article  Google Scholar 

  36. Korshkind K.: Hemopoietic stem cells and B-lymphocyte differentiation. Immunol Today 1989; 10: 399–401.

    Article  Google Scholar 

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Authors and Affiliations

  1. The Leukaemia Unit, Centro di Riferimento Oncologico, Aviano, I-33081, Italy

    Antonio Pinto M.D., A. Carbone, S. Monfardini, A. Colombatti & V. Zagonel

  2. Divisions of Experimental Oncology 2, Centro di Riferimento Oncologico, Aviano, I-33081, Italy

    Antonio Pinto M.D. & A. Colombatti

  3. Blood Transfusion Service, Cardarelli General Hospital, Naples, Italy

    L. Del Vecchio

  4. Divisions of Pathology, Centro di Riferimento Oncologico, Aviano, I-33081, Italy

    A. Carbone & R. Volpe

  5. Divisions of Radiotherapy, Centro di Riferimento Oncologico, Aviano, I-33081, Italy

    M. Roncadin

  6. Divisions of Epidemiology, Centro di Riferimento Oncologico, Aviano, I-33081, Italy

    D. Serraino

  7. Medical Oncology, Centro di Riferimento Oncologico, Aviano, I-33081, Italy

    S. Monfardini & V. Zagonel

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  1. Antonio Pinto M.D.
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  2. L. Del Vecchio
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  7. S. Monfardini
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Editors and Affiliations

  1. Section of Hematology/Oncology, Department of Medicine, The University of Chicago Cancer Research Center, Chicago, Illinois, USA

    John E. Ultmann  & Brian L. Samuels  & 

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© 1991 Springer Science+Business Media Dordrecht

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Pinto, A. et al. (1991). Expression of myelomonocytic antigens is associated with unfavourable clinicoprognostic factors in B-cell chronic lymphocytic leukaemia. In: Ultmann, J.E., Samuels, B.L. (eds) Annals of Oncology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7305-4_17

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  • DOI: https://doi.org/10.1007/978-1-4899-7305-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-7294-1

  • Online ISBN: 978-1-4899-7305-4

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