Summary
Twenty-two of 3033 patients with Hodgkin’s disease (HD) randomised into the clinical trials of the BNLI have developed non-Hodgkin’s lymphomas (NHLs) at periods up to 16 years after presentation (1 simultaneous and 1 composite), giving an incidence of 0.7%. The frequency of NHL varied from 3.8% in lymphocyte-predominant HD to 0.3% in nodular sclerosing HD. In this series, 16 patients developed high-grade NHL (12 B cell; 4 peripheral T cell) and 6 developed low-grade NHL (all B cell). The histological subtype of NHL did not appear to be related to initial histological subtype of HD or the treatment received. In histological subtypes other than lymphocyte predominant, there was commonly evidence of immunosuppression in the form of low presentation lymphocyte counts, advanced stage and systemic (B) symptoms. The results suggest that these patients have a propensity for lymphoproliferative disorders, possibly associated with some immune deficiency and the subsequent development of NHL is not treatment related. The findings also emphasise how important it is to biopsy recurrent disease.
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References
Krikorian JG, Burke JS, Rosenberg SA, Kaplan HS. Occurrence of non-Hodgkin’s lymphoma after therapy for Hodgkin’s disease. N Engl J Med 1979; 300: 452–8.
Armitage JO, Dick FR, Goeken JA, Foucar K, Gingrich RD. Second lymphoid malignant neoplasms occurring in patients treated for Hodgkin’s disease. Arch Internal Med 1983; 143: 445–50.
Jacquillat C, Khayat D, Desprey-Curely JP et al. Non-Hodgkin’s lymphoma occurring after Hodgkin’s disease. Cancer 1984; 53: 459–62.
Miettinen M, Franssila KO, Saxen E. Hodgkin’s disease, lymphocytic predominance nodular increased risk for subsequent non-Hodgkin’s lymphoma.Cancer 1983; 51: 2293–300.
Zarrabi MH, Rosner E Second neoplasms in Hodgkin’s disease: Current controversies. Haematol./Oncol. Clinics of North America 1989; 3: 303–18.
Hansmann M-L, Stein H, Fellbaum C et al. Nodular para-granuloma can transform into high-grade malignant lymphoma of B type. Hum Pathol 1989; 20: 1169–75.
Karp SJ, Bennett MH. Non-Hodgkin’s lymphoma following radiotherapy for Hodgkin’s disease. Clinical Radiology 1986; 37: 479–481.
Kim H, Hendrickson MR, Dorfman RE Composite Lymphoma. Cancer 1977; 40: 959–76.
Sundeen JT, Cossman J, Jaffe ES. Lymphocyte predominant Hodgkin’s disease with coexistent `large cell lymphoma’: Histological progression or composite malignancy? Am J Surg Pathol 1988; 12: 599–606.
Hansmann ML, Fellbaum CM, Hui PK, Lennert K. Morphological and immunohistochemical investigation of non-Hodgkin’s lymphoma combined with Hodgkin’s disease. Histopathology 1989; 15: 35–48.
Lowenthal RM, Harlow RWH, Mead AE, Tuck D, Challis DR. T-cell non-Hodgkin’s lymphoma after radiotherapy and chemotherapy for Hodgkin’s disease. Cancer 1981; 48: 1586–9.
Bouchiex C, Zittoun R, Reynes M, Diebold J, Bernadou A, Bilski-Pasquier G. A typical T-cell leukaemia terminating Hodgkin’s disease. Cancer 1979; 44: 1403–7.
Kim H, Zelman RJ, Fox MA et al. Pathology panel for lymphoma clinical studies: A comprehensive analysis of cases accumulated since its inception. JNCI 1982; 68: 43–67.
Caya JG, Choi H, Tieu TM, Wollenberg NJ, Almagro UA. Hodgkin’s disease followed by mycosis fungoides in the same patient. Cancer 1984; 53: 463–7.
Jelliffe AM, Vaughan Hudson G. The evolution of the British National Lymphoma Investigation. Clinical Radiology 1981; 32: 483–90.
Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981; 29: 577–80.
Ishii Y, Takami T, Yuasa H, Takei T, Kikuchi K. Two distinct antigen systems in human B lymphocytes: identification of cell surface and intracellular antigens using monoclonal antibodies. Clin Exp Immunol 1984; 58: 183–92.
Norton AJ, Ramsay AD, Smith SH, Beverly PCL, Isaacson PG. Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues. J Clin Path 1986; 39: 399–405.
Hall PA, D’Ardenne AJ. Value of CD 15 immunostaining in diagnosing Hodgkin’s disease: a review of published literature. J Clin Pathol 1987; 40: 1298–304.
Ramsey AD, Smith WJ, Isaacson PG. T-cell-rich-Bcell lymphoma. Am J Surg Pathol 1988; 12: 433–43.
Ng CS, Chan JKC, Hui PK, Lau WH. Large B-cell lymphomas with a high content of reactive T cells. Hum Pathol 1989; 20: 1145–54.
Henry-Amar M Second Malignancies in Hodgkin’s disease. In: Treatment strategy in Hodgkin’s disease, EORTC symposium. Sommers R, Henry-Amar M, Meerwaldt JH, Carde P (eds), 1990; John Libbey, London, Paris.
Colman M, Selby P. Second malignancies and Hodgkin’s disease. In: Hodgkin’s Disease. Selby P, Mcelwain TJ 1987; Blackwell Scientific Publications, Oxford. Chapter 14: 361–77.
Tiemens W, Visser L, Poppema S (1986): Nodular lymphocyte predominance type of Hodgkin’s disease is a germinal centre lymphoma. Lab Invest 1989; 54: 457–61.
Banks PM, Lust JA, Thibodeau SN. Nodular lymphocyte predominance Hodgkin’s disease (NLPHD) and its transition to large cell lymphoma (LCL)• Immunophenotypic and genetic probe analysis. Lab Invest 1989; 60: 5A (28).
Riggs S, Hagemeister FB. Immunodeficiency states: A predisposition to lymphoma. In Hodgkin’s disease and Non-Hodgkin’s lymphoma in adults and children. LM Fuller et al. (eds); Raven Press, New York, pp 451–78.
Vaughan Hudson B, MacLennan KA, Bennett MH, Easterling MJ, Vaughan Hudson G, Jelliffe AM. Systemic disturbance in Hodgkin’s disease and its relation to histopathology and prognosis. Clinical Radiology 1987; 38: 257–261.
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Bennett, M.H., MacLennan, K.A., Hudson, G.V., Hudson, B.V., British National Lymphoma Investigation. (1991). Non-Hodgkin’s lymphoma arising in patients treated for Hodgkin’s disease in the BNLI: A 20-year experience. In: Ultmann, J.E., Samuels, B.L. (eds) Annals of Oncology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7305-4_14
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