Skip to main content

Long-term toxicity of early stages of Hodgkin’s disease therapy: The EORTC experience

  • Chapter
Annals of Oncology

Abstract

The ultimate goal of Hodgkin’s disease (HD) therapy is no longer merely to achieve the cure of the patients, but to reach the Holy Grail of ‘uncomplicated cure.’ Actually, a cure associated with a low risk of benign complications might be acceptable in most cases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tubiana M, Henry-Amar M, Carde P et al. Towards comprehensive management tailored to prognostic factors of patients with clinical stage I and II in Hodgkin’s disease. The EORTC lymphoma group controlled clinical trials 1964–1987. Blood 1989; 73: 47–56.

    PubMed  CAS  Google Scholar 

  2. Hohl RJ, Schlilsky RL. Non malignant complications of therapy for Hodgkin’s disease. Hematology/Oncology Clinics of North America 1989; 3: 331–43.

    PubMed  CAS  Google Scholar 

  3. Cosset JM, Henry-Amar M, Burgers JMV et al. Late radiation injuries of the gastro-intestinal tract in the H2 and H5 EORTC Hodgkin’s disease trials: Emphasis on the role of exploratory laparotomy and fractionation. Radiother Oncol 1988; 13: 618.

    Google Scholar 

  4. Gallez-Marchal D, Fayolle M, Henry-Amar M et al. Radiation injuries of the gastro-intestinal tract in Hodgkin’s disease: The role of exploratory laparotomy and fractionation. Radiother Oncol 1984; 2: 93–9.

    Article  PubMed  CAS  Google Scholar 

  5. Thames HD, Hendry JH. Fractionation in radiotherapy. London: Taylor and Francis, 1987.

    Google Scholar 

  6. Cosset JM, Henry-Amar M, Girinsky T et al. Late toxicity of radiotherapy in Hodgkin’s disease: The role of fraction size. Acta Oncologica 1988; 27: 113–29.

    Article  Google Scholar 

  7. Host H, Vale JR. Lung function after mantle field irradiation in Hodgkin’s disease. Cancer 1973; 32: 328–32.

    Article  PubMed  CAS  Google Scholar 

  8. Evans RF, Sagerman RH, Ringrose TL et al. Pulmonary function following mantle field irradiation for Hodgkin’s disease. Radiology 1974; 111: 729–31.

    PubMed  CAS  Google Scholar 

  9. Watchie J, Coleman CN, Raffin TA et al. Minimal long term cardiopulmonary dysfunction following treatment for Hodgkin’s disease. Int J Radiat Oncol Biol Phys 1989; 16: 79–84.

    Article  Google Scholar 

  10. Smith LM, Mendenhall NP, Cicale MJ et al. Results of a prospective study evaluating the effects of mantle irradition on pulmonary function. Int J Radiat Oncol Biol Phys 1989; 16: 7984.

    Google Scholar 

  11. Cosset JM, Henry-Amar M, Thomas J et al. Increased pulmonary toxicity in the ABVD arm of the EORTC H6-U trial. Proc Am Soc Clin Oncol 1989; 8: 253.

    Google Scholar 

  12. Zucali R, Pagnoni AM, Zanini M et al. Radiobiological and spirometric evaluation of mediastinal and pulmonary late effects after radiotherapy and chemotherapy for Hodgkin’s disease. J Eur Radiother 1981; 2: 169–76.

    Google Scholar 

  13. Boivin JF, Hutchison GB. Coronary heart disease mortality after irradiation of Hodgkin’s disease. Cancer 1982; 49: 24705.

    Article  Google Scholar 

  14. Pohjola-Sintonen S, Totterman KJ, Salmo M et al. Late cardiac effects of mediastinal radiotherapy in patients with Hodgkin’s disease. Cancer 1987; 60: 31–7.

    Article  PubMed  CAS  Google Scholar 

  15. Hancock SL, Hoppe RT, Horning SJ et al. Intercurrent death after Hodgkin’s disease therapy in radiotherapy and adjuvant MOPP trials. Ann Int Med 1988; 109: 183–9.

    Article  PubMed  CAS  Google Scholar 

  16. Rijswijk REN, Verbeek J, Haanen C et al. Major complications and causes of death in patients treated for Hodgkin’s disease. J Clin Oncol 1987; 5: 1624–33.

    PubMed  Google Scholar 

  17. Cosset JM, Henry-Amar M, Pellae Cosset B et al. Pericarditis and myocardial infarctions after Hodgkin’s disease therapy at the Institut Gustave-Roussy. Int J Radiat Oncol Biol Phys 1990 (in press).

    Google Scholar 

  18. Corn BW, Trock BJ, Goodman RL. Irradiation-related ischaemic heart disease. J Clin Oncol 1990; 8: 741–50.

    PubMed  CAS  Google Scholar 

  19. Henry-Amar M, Somers R. Long-term survival in early stages Hodgkin’s disease: The EORTC experience. In: Treatment Strategy in Hodgkin’s disease, Somers R, Henry-Amar M, Meerwaldt JH, Carde P (eds). Colloque INSERM no 196. London, Paris: INSERM/John Libbey Eurotext, 1990; 151–66.

    Google Scholar 

  20. Henry-Amar M. Risk of second cancer after therapy for early stage Hodgkin’s disease: The EORTC experience. Int J Radiat Oncol Biol Phys 1990 (in press).

    Google Scholar 

  21. Henry-Amar M, Pellae-Cosset B, Bayle-Weisgerber C et al. Risk of secondary acute leukemia and preleukemia after Hodgkin’s disease. The Institut Gustave-Roussy experience. In: New aspects in the diagnosis and treatment of Hodgkin’s disease. Diehl V, Pfreundschuh M, Diehl V, 1989; 117: 270–83.

    Google Scholar 

  22. Pedersen-Bjergaard J, Specht L, Larsen SO et al. Risk of therapy-related leukemia and preleukemia after Hodgkin’s disease. Relation to age, cumulative dose of alkylating agents, and time from chemotherapy. Lancet 1987; ii: 83–88.

    Google Scholar 

  23. Kaldor JM, Day NE, Clarke EA et al. Leukemia following Hodgkin’s disease. N Engl J Med 1990; 322: 7–13.

    Article  PubMed  CAS  Google Scholar 

  24. Van Leeuwen FE, Somers R, Hart AAM. Splenectomy in Hodgkin’s disease and second leukemia. Lancet 1987; 2: 2101.

    Google Scholar 

  25. Leeuwen FE, Somers R, Tall BG et al. Increased risk of lung cancer, non-Hodgkin’s lymphoma, and leukemia following Hodgkin’s disease. J Clin Oncol 1989; 7: 1046–58.

    PubMed  Google Scholar 

  26. Velden JW, Putten WL, Gurnee VF et al. Subsequent development of acute non-lymphocytic leukemias in patients treated for Hodgkin’s disease. Int J Cancer 1988; 42: 252–5.

    Article  PubMed  Google Scholar 

  27. Henry-Amar M, Somers R. Survival outcome after Hodgkin disease. A report from the International Database on Hodgkin disease (IDHD) Seminars in Oncology 1990 (in press).

    Google Scholar 

  28. Somers R, Henry-Amar M, Meerwaldt JH, Carde P (eds). Treatment Strategy in Hodgkin’s disease. Statistical report, part X. Colloque INSERM no 196. London, Paris: INSERM/John Libbey Eurotext, 1990; 381–418.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Consortia

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Cosset, J.M., Henry-Amar, M., Meerwaldt, J.H., EORTC Lymphoma Cooperative Group. (1991). Long-term toxicity of early stages of Hodgkin’s disease therapy: The EORTC experience. In: Ultmann, J.E., Samuels, B.L. (eds) Annals of Oncology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7305-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-7305-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-7294-1

  • Online ISBN: 978-1-4899-7305-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics