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Management of Blistering Diseases pp 63–82Cite as

Bullous pemphigoid

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Abstract

Bullous pemphigoid (BP) is an acquired blistering disease of the elderly with a substantially lower mortality than pemphigus vulgaris (PV). It is characterized histologically by subepidermal bullae and immunopathologically by in vivo deposition of autoantibodies and complement components along the epidermal basement membrane zone (BMZ). The majority of these patients also have circulating autoantibodies directed against the BMZ of stratified squamous epithelium. Because of these characteristics, BP is felt to be an autoimmune disease in which the cutaneous lesions may result as a consequence of these anti-BMZ antibodies.

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Authors
  1. Lynne H. Morrison
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  2. Luis A. Diaz
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  3. Grant J. Anhalt
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Editor information

Editors and Affiliations

  1. The Slade Hospital, Oxford, UK

    Fenella Wojnarowska

  2. University of North Carolina School of Medicine, Chapel Hill, USA

    Robert A. Briggaman

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Morrison, L.H., Diaz, L.A., Anhalt, G.J. (1990). Bullous pemphigoid. In: Wojnarowska, F., Briggaman, R.A. (eds) Management of Blistering Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7190-6_5

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  • DOI: https://doi.org/10.1007/978-1-4899-7190-6_5

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