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Prader — Willi Syndrome

  • J. Waters

Abstract

Prader—Willi Syndrome (PWS) was first described in 1956 by Swiss doctors, Andrea Prader, Heinrich Willi and Alexis Labhart, as a result of their observations of five male and four female patients, who ranged in age from 5 to 23 years old. They described the syndrome as a ‘not infrequent, clearly defined, unique clinical syndrome’ (Prader, Labhart and Willi, 1956). PWS was independently first described in England by Dr B.M. Laurance (1961, 1967), and later by Professor V. Dubowitz (1969). The main features of the syndrome are:
  1. 1.

    Hypotonia (lack of muscle tone, and floppiness at birth).

     
  2. 2.

    Hypogonadism (incomplete development of sexual organs and sexual characteristics).

     
  3. 3.

    Obesity (caused by excessive overeating, i.e. hyperphagia, and a decreased calorific requirement).

     
  4. 4.

    Central nervous dysfunction (causing varying degrees of mental retardation).

     

Keywords

Temper Tantrum Calorific Requirement Willi Syndrome Mental Retar High Pain Threshold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1987

Authors and Affiliations

  • J. Waters

There are no affiliations available

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