Skip to main content

Neuropsychological Effects of Stimulant Medication on Children’s Learning and Behavior

  • Chapter
Handbook of Clinical Child Neuropsychology

Part of the book series: Critical Issues in Neuropsychology ((CINP))

Abstract

Bradley’s (1937) seminal publication of the ameliorative effects of Benzedrine on behavior-disordered children had significant impact on pediatric psychopharmacology and to a large extent altered child psychiatric and neurological services in this country. According to Bradley and his colleagues, the main clinical effects of stimulant drugs were reduced hyperactivity, distractibility, and impulsivity in children who had not responded to traditional psychotherapy. Ironically, Bradley’s earlier clinical observations, which were based on insufficient investigation and inadequate methodology, are generally consistent with contemporary research findings, which generally support the efficacy of stimulants in improving performance on a wide array of cognitive tasks and decreasing disruptive behaviors (Gittelman, 1983).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abikoff, H., and Gittelman, R. (1985). Hyperactive children treated with stimulants: Is cognitive training a useful adjunct? Archives of General Psychiatry, 42, 953–961.

    PubMed  CAS  Google Scholar 

  • Abikoff, H., Gittelman-Klein, R., and Klein, D. F. (1977). Validation of a classroom observation code for hyperactive children. Journal of Consulting and Clinical Psychology, 45, 77 2783.

    Google Scholar 

  • Adams, W. (1982). Effect of methylphenidate on thought processing time in children. Developmental and Behavioral Pediatrics. 3, 133–135.

    Google Scholar 

  • Allen, R. P., and Safer, D. (1979). Long-term effects of stimulant therapy for HA children: Risk benefits analysis. In M. J. Cohen (Ed.), Drugs and the special child (pp. 189–202 ). New York: Gardner.

    Google Scholar 

  • Aman, M. G. (1982a). Psychotropic drugs in the treatment of reading disorders. In R. N. Malatesha and P. G. Aaron (Eds.), Reading disorders: Varieties and treatments (pp. 453–471 ). New York: Academic Press.

    Google Scholar 

  • Aman, M. G. (1982b). Stimulant drug effects in developmental disorders and hyperactivity-Toward a resolution of disparate findings. Journal of Austism and Developmental Disorders, 12, 385–398.

    CAS  Google Scholar 

  • Aman, M. G., and Sprague, R. L. (1974). The state-dependent effects of methylphenidate and dextroamphetamine. Journal of Nervous and Mental Disease, /58, 268–279.

    Google Scholar 

  • Aman, M. G., and Werry, J. S. (1982). Methylphenidate and diazepam in severe reading retardation. Journal of the American Academy of Child Psychiatry, 1, 31–37.

    Google Scholar 

  • American Academy of Pediatrics, Council on Child Health. (1975). Medication for hyperkinetic children. Pediatrics, 55, 560–561.

    Google Scholar 

  • American Psychiatric Association. (1980). Diagnostic and statistical manual of mental disorders ( 3rd ed. ). Washington, DC: Author.

    Google Scholar 

  • Arnold, L. E., Christopher, J., and Huestis, R. (1978). Methylphenidate vs. dextroamphetamine vs. caffeine in minimal brain dysfunction. Archives of General Psychiatry, 35, 463–473.

    PubMed  CAS  Google Scholar 

  • Bandura, A., Jeffrey, R. W., and Gajdos, E. (1975). Generalizing change through participant modeling with self-directed mastery. Behavior Research and Therapy, 13, 141–152.

    CAS  Google Scholar 

  • Barcai, A. (1971). Predicting the response of children with learning disabilities and behavior problems to dextroamphetamine sulfate. Pediatrics, 47, 73–80.

    Google Scholar 

  • Barkley, R. A. (1976). Predicting the response of hyperkinetic children to stimulant drugs: A review. Journal of Abnormal Child Psychology, 4, 327–348.

    PubMed  CAS  Google Scholar 

  • Barkley, R. A. (1977). The effects of methylphenidate on various measures of activity level and attention in hyperkinetic children. Journal of Abnormal Child Psychology, 5, 351–369.

    PubMed  CAS  Google Scholar 

  • Barkley, R. A. (1981). Hyperactive children: A handbook for diagnosis and treatment. New York: Guilford Press.

    Google Scholar 

  • Barkley, R. A., Karlsson, J., Pollard, S., and Murphy, J. V. (1985). Developmental changes in the mother-child interactions of hyperactive boys: Effects of two dose levels of Ritalin. Journal of Child Psychology and Psychiatry, 24, 705–715.

    Google Scholar 

  • Blouin, A. G. A., Bornstein, R. A., and Trites, R. L. (1978). Teenage alcohol use among hyperactive children: A five-year follow-up study. Journal of Pediatric Psychology, 3, 188194.

    Google Scholar 

  • Blunden, D., Spring, C., and Greenberg, L. (1974). Validation of the classroom behavior inventory. Journal of Consulting and Clinical Psychology, 42, 84–88.

    PubMed  CAS  Google Scholar 

  • Boileau, R. A., Ballard, J. E., Sprague, R. L., Sleator, E. K., and Massey, B. H. (1976). Effect of methylphenidate on cardiorespiratory responses in hyperactive children. Research Quarterly, 47, 590–596.

    PubMed  CAS  Google Scholar 

  • Borden, K. A. (1986). Attributional outcomes: The subtle messages of treatments for attention deficit disorder. Un-published doctoral dissertation, University of Illinois, Urbana-Champaign.

    Google Scholar 

  • Bosco, J. J., and Robin, S. S. (1980). Hyperkinesis: Prevalence and treatment. In C. K. Whalen and B. Henker (Eds.), Hyperactive children (pp. 173–187 ). New York: Academic Press.

    Google Scholar 

  • Bradley, C. (1937). The behavior of children receiving Ben- zedrine. American Journal of Psychiatry, 94, 577–585.

    Google Scholar 

  • Brown, R. T., Borden, K. A., and Clingerman, S. R. (1985). Adherence to methylphenidate therapy in a pediatric population: A preliminary investigation. Psychopharmacology Bulletin, 21, 28–36.

    PubMed  CAS  Google Scholar 

  • Brown, R. T., Borden, K. A., Spunt, A. L., and Medenis, R. (1985). Depression following pemoline withdrawal in a hy- peractive child [letter]. Clinical Pediatrics, 24, 174–175.

    PubMed  CAS  Google Scholar 

  • Brown, R. T., Borden, K. A., Wynne, M. E., Clingerman, S. R., and Spunt, A. (1987). An examination of compliance with pharmacological and cognitive treatments for attention deficit disorder. American Academy of Child and Adolescent Psychiatry, 26, 521–526.

    CAS  Google Scholar 

  • Brown, R. T., Borden, K. A., Wynne, M. A., Schiesser, R., and Clingerman, S. R. (1986). Methylphenidate and cognitive therapy with ADD children: A methodological reconsideration. Journal of Abnormal Child Psychology, 4, 481–497.

    Google Scholar 

  • Brown, R. T., and Sexson, S. B. ( 1986, August). Methylphenidate in the treatment of ADD adolescents. Paper presented at the annual meeting of the American Psychological Association. Washington, DC.

    Google Scholar 

  • Brown, R. T., and Sleator, E. K. (1979). Methylphenidate in hyper-kinetic children: Differences in dose effects on impulsive behavior. Pediatrics, 64, 408–411.

    PubMed  CAS  Google Scholar 

  • Brown, R. T., Slimmer, L., and Wynne, M. E. (1984). How much stimulant medication is appropriate for hyperactive school children? Journal of School Health, 54, 128–130.

    PubMed  CAS  Google Scholar 

  • Brown, R. T., Wynne, M. E., and Medenis, R. (1985). Methylphenidate and cognitive therapy: A comparison of treatment approaches with hyperactive boys. Journal ofAbnormal Child Psychology, 13, 69–87.

    CAS  Google Scholar 

  • Bryan, T. H., and Bryan, J. H. (1978). Understanding learning disabilities. Palo Alto, CA: Alfred.

    Google Scholar 

  • Bugenthal, D. B., Whalen, C. K., and Henker, B. (1977). Causal attributions of hyperactive children and motivational assumptions of two behavior change approaches: Evidence for an interactionist position. Child Development, 48, 874–884.

    Google Scholar 

  • Campbell, S. B., Endman, M. W., and Bernfeld, G. (1977). A three-year follow-up of hyperactive preschoolers into elementary school. Journal of Child Psychology and Psychiatry, 18, 239–249.

    PubMed  CAS  Google Scholar 

  • Cantwell, D. P. (1979). Use of stimulant medication with psychiatrically disordered adolescents. Adolescent Psychiatry, 7, 375–388.

    Google Scholar 

  • Cantwell, D. P. (1985). Pharmacotherapy of ADD in adolescence: What do we know, where should we go, how should we do it?

    Google Scholar 

  • Psychopharmacology Bulletin, 21, 251–257.

    Google Scholar 

  • Cantwell, D. P., and Carlson, G. A. (1978). Stimulants. In J. S.

    Google Scholar 

  • Werry (Ed.), Pediatric psychopharmacology: The use of behavior-modifying drugs in children (pp. 171–207). New York: Brunner/Mazel.

    Google Scholar 

  • Chamberlin, R. W. (1974). Convulsions and Ritalin? [Letter]. Pediatrics, 54, 658–659.

    Google Scholar 

  • Chan, Y.-P. M., Swanson, J. M., Soldin, S. S., Thiessen, J. J., MacLeod, S. M., and Logan, W. (1983). Methylphenidate hydrochloride given with or before breakfast. Il. Effects on plasma concentration of methylphenidate and ritalinic acid. Pediatrics, 72, 56–59.

    PubMed  CAS  Google Scholar 

  • Charles, L., Schain, R., and Zelniker, T. (1981). Optimal dosages of methylphenidate for improving the learning and behavior of hyperactive children. Developmental and Behavioral Pediatrics, 2, 78–81.

    CAS  Google Scholar 

  • Clampit, M. K., and Pirkle, J. B. (1983). Stimulant medication and the hyperactive adolescent: Myths and facts. Adolescence, 18, 811–822.

    CAS  Google Scholar 

  • Close, J. (1973). Scored neurological examination. Psychopharmacology Bulletin, 9, 142–148.

    Google Scholar 

  • Conners, C. K. (1969). A teacher rating scale for use in drug studies with children. American Journal of Psychiatry, 126, 152–156.

    Google Scholar 

  • Conners, C. K. (1971). Recent drug studies with hyperkinetic children. Journal of Learning Disabilities, 4, 476–483.

    Google Scholar 

  • Conners, C. K. (1972). Psychological effects of stimulant drugs in children with minimal brain dysfunction. Pediatrics, 49, 702–708.

    PubMed  CAS  Google Scholar 

  • Conners, C. K. (1973, September). A Clinical comparison of methylphenidate and placebo in the treatment of children with minimal brain dysfunction. Paper presented at the annual meeting of the American Psychological Association, Montreal, Canada.

    Google Scholar 

  • Conners, C. K., and Eisenberg, L. (1963). The effects of methylphenidate on symptomatology and learning in disturbed children. American Journal of Psychiatry, 120, 458–464.

    PubMed  CAS  Google Scholar 

  • Conners, C. K., and Taylor, E. (1980). Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction. Archives of General Psychiatry, 37, 922–930.

    PubMed  CAS  Google Scholar 

  • Coons, H. W., Klorman, R., and Borgstedt, A. D. (1987). Enhancing effects of methylphenidate on sustained attention and event-related potentials of adolescent patients with attention deficit disorders. Psychophysiology, 24, 572–573.

    Google Scholar 

  • Coons, H. W., Peloquin, L., and Klorman, R. (1981). Effect of methylphenidate on young adults’ vigilance and event related potentials. Electroencephalography and Clinical Neurophysiology, 51, 373–387.

    PubMed  CAS  Google Scholar 

  • Cutler, M., Little, J. W., and Strauss, A. A. (1940). The effect of Benzedrine on mentally deficient children. American Journal of Mental Deficiency, 45, 49–65.

    Google Scholar 

  • Donchin, E., Ritter, W., and McCallum, W. C. (1978). Cognitive psychophysiology: The endogenous components of the ERP. In E. Callaway, P. Tueting, and S. H. Koslow (Eds.), Event-related potentials in man (pp. 349–411 ). New York: Academic Press.

    Google Scholar 

  • Donnelly, M., and Rapoport, J. L. (1985). Attention deficit disorders. In J. M. Wiener (Ed.), Diagnosis and psychopharmacology of childhood and adolescent disorders (pp. 179–197 ). New York: Wiley.

    Google Scholar 

  • Douglas, V. I. (1980). Treatment and training approaches to hyperactivity: Establishing internal or external control. In C. K. Whalen and B. Henker (Eds.), Hyperactive children: The social ecology of identification and treatment (pp. 283–317 ). New York: Academic Press.

    Google Scholar 

  • Douglas, V. I., Barr, R. G., O’Neill, M. E., and Britton, B. G. (1986). Short-term effects of methylphenidate on the cognitive, learning and academic performance of children with attention deficit disorder in the laboratory and classroom. Journal of Child Psychology and Psychiatry, 27, 191–211.

    Google Scholar 

  • Douglas, V. I., and Peters, K. G. (1979). Toward a clearer defini-tion of the attentional deficit of hyperactive children. In G. A. Hale and M. Lewis (Eds.), Attention and the development of cognitive skills (pp. 173–247 ). New York: Plenum Press.

    Google Scholar 

  • Dulcan, M. K. (1985). Attention deficit disorder: Evaluation and treatment. Pediatric Annals, 14, 383–398.

    PubMed  CAS  Google Scholar 

  • Dulcan, M. K. (1986). Comprehensive treatment of children and adolescents with attention deficit disorders: The state of the art. Clinical Psychology Review, 6, 539–569.

    Google Scholar 

  • Dykman, R., Ackerman, P. T., and Oglesby, C. (1979). Selective and sustained attention in hyperactive, learning-disabled, and normal boys. Journal of Nervous and Mental Disease, 167, 288–297.

    CAS  Google Scholar 

  • Edelbrock, C., and Rancurello, M. (1985). Assessment of childhood hyperactivity: Rating scales and their applications. Clinical Psychology Review, 5, 429–445.

    Google Scholar 

  • Eisenberg, L. (1972). The hyperkinetic child and stimulant drugs. New England Journal of Medicine, 287, 249–250.

    Google Scholar 

  • Eisenberg, L., Lachman, R., Moiling, P. A., Lockner, A., Mizelle, J. D., and Conners, C. K. (1963). A psychopharmacological experiment in a training school for delinquent boys: Methods, problems, findings. American Journal of Orthopsychiatry, 33, 431–447.

    Google Scholar 

  • Firestone, P. (1982). Factors associated with children’s adherence to stimulant medication. American Journal of Orthopsychiatry, 52, 447–457.

    CAS  Google Scholar 

  • Fish, B. (1971). The “one child, one drug” myth of stimulants in hyperkinesis. Archives of General Psychiatry, 25, 193–203. Fisher, K. C., and Wilson, W. P. (1971). Methylphenidate and the hyperkinetic. Diseases of the Nervous System, 32, 695–698.

    Google Scholar 

  • Gadow, K. D. (1981). Drug therapy for hyperactivity: Treatment procedures in natural settings. In K. D. Gadow and J. Loney (Eds.), Psychosocial aspects of drug treatment for hyperactivity (pp. 325–378 ). Boulder, CO: Westview.

    Google Scholar 

  • Gadow, K. D. (1983). Pharmacotherapy for behavior disorders: Typical treatment practices. Clinical Pediatrics, 22, 48–53.

    PubMed  CAS  Google Scholar 

  • Gadow, K. D. (1985a). Prevalence and efficacy of stimulant drug use with mentally retarded children and youth. Psychopharmacology Bulletin, 21, 291–303.

    PubMed  CAS  Google Scholar 

  • Gadow, K. D. (19856). Relative efficacy of pharmacological, behavioral, and combination treatments for enhancing academic performance. Clinical Psychology Review, 5,513533.

    Google Scholar 

  • Gadow, K., and Sprague, R. L. ( 1980, September). An anterospecrive follow-up of hyperactive children into adolescence: Licit and illicit drug use. Paper presented at the annual meeting of the American Psychological Association, Montreal, Canada.

    Google Scholar 

  • Gadow, K. D., and Swanson, H. L. (1985). Assessing drug effects on academic performance. Psychopharmacology Bulletin, 21, 877–886.

    PubMed  CAS  Google Scholar 

  • Gadow, K. D., Torgesen, J., Greenstein, J., and Schell, R. (1986). Learning disabilities. In M. Hersen and S. E. Breuning (Eds.), Pharmacological and behavioral treatment: An integrated approach (pp. 149–196 ). New York: Wiley.

    Google Scholar 

  • Gan, J., and Cantwell, D. (1982). Dosage effects of methylphenidate on paired associate learning: Positive/negative placebo responders. Journal of the American Academy of Child Psychiatry, 21. 237–242.

    PubMed  CAS  Google Scholar 

  • Garfinkel, B. D. (1986). Recent developments in attention deficit disorder. Psychiatric Annals. 16. 11–15.

    Google Scholar 

  • Garfinkel, B. D., Brown, W. A., Klee, S. H., Braden, W., Beauchesne, H., and Shapiro, S. K. (in press). Neuroendocrine and cognitive responses to amphetamine in adolescents with a history of ADD. Journal of Clinical Pharmacology.

    Google Scholar 

  • Gilman, A. G., Goodman, L. S., andGilman, A. (1980). Goodman and Gilman’s the pharmacologic basis of therapeutics ( 6th ed. ). New York: Macmillan Co.

    Google Scholar 

  • Gittelman, R. (1980). Indications for the use of stimulant treatment in learning disorders. Journal of the American Academy of Child Psychiatry, 19, 623–636.

    PubMed  CAS  Google Scholar 

  • Gittelman, R. (1982). Controlled study of methylphenidate in combination with academic instruction. Psychopharmacology Bulletin, 18, 112–113.

    Google Scholar 

  • Gittelman, R. (1983). Hyperkinetic syndrome: Treatment issues and principles. In M. Rutter (Ed.), Developmental neuro-psychiatry (pp. 437–449 ). New York: Guilford Press.

    Google Scholar 

  • Gittelman, R., Klein, D. F., and Feingold, I. (1983). Children with reading disorders. II. Effects of methylphenidate in combination with reading remediation. Journal of Child Psychology and Psychiatry, 24, 193–212.

    Google Scholar 

  • Gittelman-Klein, R., and Klein, D. F. (1975). Are behavioral and psychometric changes related in methylphenidate-treated, hyperactive children? International Journal of Mental Health, 4, 182–198.

    Google Scholar 

  • Gittelman-Klein, R., and Klein, D. F. (1976). Methylphenidate effects in learning disabilities: Psychometric changes. Archives of General Psychiatry 33655–664.

    Google Scholar 

  • Gittelman-Klein, R., Klein, D., Katz, S., Saraf, K., and Pollack, E. (1976). Comparative effects of methylphenidate and thioridazine in hyperkinetic children. Archives of General Psychiatry, 33, 1217–1231.

    PubMed  CAS  Google Scholar 

  • Grimm, L. G. (1980). The maintenance of self-and drug-attributed behavior change: A critique. Journal of Abnormal Psychology, 89, 282–285.

    PubMed  CAS  Google Scholar 

  • Gross, M. D., and Wilson, N. C. (1974). Minimal brain dysfunction. New York: Brunner/Mazel.

    Google Scholar 

  • Halliday, R. A., Rosenthal, J. H., Naylor, H., and Callaway, E. (1976). Average evoked potential predictors of clinical improvement in hyperactive children treated with methylphenidate: An initial study and replication. Psychophysiology, 13. 429–440.

    PubMed  CAS  Google Scholar 

  • Henker, B., and Whalen, C. K. (1980). The changing faces of hyperactivity: Retrospect and prospect. In C. K. Whalen and B. Henker (Eds.), Hyperactive children (pp. 321–363 ). New York: Academic Press.

    Google Scholar 

  • Henker, B., Whalen, C. K., Bugenthal, D. B., and Barker, C. (1981). Licit and illicit drug patterns in stimulant treated children and their peers. In K. D. Gadow and J. Loney (Eds.), Psychosocial aspects of drug treatment for hyperactivity (pp. 443–462 ). Boulder, CO: Westview.

    Google Scholar 

  • Hinshaw, S. P., Henker, B., and Whalen, C. K. (1984). Self-control in hyperactive boys in anger-inducing situations: Effects of cognitive-behavioral training and methylphenidate. Journal of Abnormal Child Psychology, 52, 739–749.

    CAS  Google Scholar 

  • Hoy, E., Weiss, G., Minde, K., and Cohen, N. (1978). The hyperactive child at adolescence: Cognitive, emotional, and social functioning. Journal of Abnormal Child Psychology, 6, 31 1324.

    Google Scholar 

  • Huddleston, W., Staiger, R. C., Frye, R., Musgrave, R. S., and Stritch, T. (1961). Deanol as aid in overcoming reading retardation. Clinical Medicine. 8, 1340–1342.

    PubMed  CAS  Google Scholar 

  • Huessey, H. R., Cohen, S. M., Blair, C. L., and Wood, P. (1979). Clinical explorations in adult minimal brain dysfunction. In L. Bellak (Ed.), Psychiatric aspects of minimal brain dysfunction (pp. 19–36 ). New York: Grune and Stratton.

    Google Scholar 

  • Huey, L. Y. (1985). Attention deficit disorders. In R. Michaels, J. O. Cavenar, K. H. Brodie, A. M. Cooper, S. B. Guze, L. L. Judd, G. L. Klerman, and A. J. Solnit (Eds.), Psychiatry (Vol. 3, pp. 1–31 ). Philadelphia: Lippincott.

    Google Scholar 

  • Kagan, J. (1965). Reflection-impulsivity and reading ability in primary grade children. Child Development, 36, 609–628.

    Google Scholar 

  • Kalachnik, J. E., Sprague, R. L., Sleator, E. K., Cohen, M. N., and Ullmann, R. K. (1981). Use of the RWT stature prediction formula in monitoring growth suppression effects in methylphenidate. Unpublished manuscript, University of Illinois.

    Google Scholar 

  • Kaufman, A. S. (1979). Intelligence testing with the WISC-R. New York: Wiley.

    Google Scholar 

  • Kavale, K. (1982). The efficacy of stimulant drug treatment for hyperactivity: A meta-analysis. Journal of Learning Disabilities, 15, 280–289.

    PubMed  CAS  Google Scholar 

  • Kinsboume, M. (1973). Minimal brain dysfunction as a neurodevelopmental lag. Annals of the New York Academy of Sciences, 205, 263–273.

    Google Scholar 

  • Kinsboume, M., and Swanson, J. M. (1980). Evaluation of symptomatic treatment of hyperactive behavior by stimulant drugs. In R. Knights and D. Bakker (Eds.), Treatment of hyperactive and learning disordered children (pp. 207–217 ). Baltimore: University Park Press.

    Google Scholar 

  • Klee, S. H. (1986). The clinical psychological evaluation of atten- tion deficit disorder. Psychiatric Annals, 16, 43–46.

    Google Scholar 

  • Klein, D. F., Gittelman, R., Quitkin, F., and Rifkin, A. (1980). Diagnosis and drug treatment of psychiatric disorders: Adults and children. Baltimore: Williams and Wilkins.

    Google Scholar 

  • Klorman, R. (1986). Attention-deficit disorder in adolescents. In R. A. Feldman and A. R. Stiffman (Eds.), Advances in adolescent mental health. Greenwich, CT: JAI Press.

    Google Scholar 

  • Korey, S. R. (1949). The effects of Benzedrine sulfate on the behavior of psychopathic and neurotic juvenile delinquents. Psychiatric Quarterly, 18, 127–137.

    Google Scholar 

  • Laufer, M. W., Denhoff, E., and Solomon, G. (1957). Hyper-kinetic impulse disorder in children’s behavior problems. Psychosomatic Medicine, 19, 38–49.

    PubMed  Google Scholar 

  • Lerer, R. J., and Lerer, P. (1977). Response of adolescents with minimal brain dysfunction to methylphenidate. Journal of Learning Disabilities, 10, 35–40.

    Google Scholar 

  • Lezak, M. D. (1983). Neuropsychological assessment. New York: Oxford University Press.

    Google Scholar 

  • Loiselle, D., Stamm, J. S., Maitinsky, S., and Whipple, S. C. (1980). Evoked potential and behavioral signs of attention dysfunctions in hyperactive boys. Psychophysiology, 17, 193–201.

    PubMed  CAS  Google Scholar 

  • Loney, J. (1986). Predicting stimulant drug response among hyperactive children. Psychiatric Annals, 16, 16–19.

    Google Scholar 

  • Loney, J., Kramer, J., and Milich, R. S. (1981). The hyperactive child grows up: Predictors of symptoms, delinquency and achievement at follow-up. In K. D. Gadow and J. Loney (Eds.), Psychosocial aspects of drug treatment for hyperactivity (pp. 381–415 ). Boulder, CO: Westview.

    Google Scholar 

  • Loney, J., Whaley-Klahn, M. A., Porto, L. B., and Adney, K. (1981). Predictors of adolescent height and weight in hyper-kinetic boys treated with methylphenidate. Psychopharmacology Bulletin, 17. 132–134.

    PubMed  CAS  Google Scholar 

  • Lucas, A. R., and Weiss, M. (1971). Methylphenidate hallucinosis. Journal of the American Medical Association, 217, 1079 1081.

    Google Scholar 

  • MacKay, M. C., Beck, L., and Taylor, R. (1973). Methylphenidate for adolescents with minimal brain dysfunction. New York State Journal of Medicine, 73, 550–554.

    PubMed  CAS  Google Scholar 

  • Maletzky, B. M. (1974). o-Amphetamine and delinquency: Hyperkinesis persisting? Diseases of the Nervous System, 35, 543–547.

    Google Scholar 

  • Michael, R. L., Klorman, R., and Salzman, L. F. (1981). Normalizing effects of methylphenidate on hyperactive children’s vigilance performance and evoked potentials. Psychophysiology, 17, 193–201.

    Google Scholar 

  • Mirsky, A. F., and Rosvold, H. E. (1963). Behavioral and physiological studies in impaired attention. In Z. Votava, M. Horvath, and O. Vinar (Eds.), Psychopharmacological methods: Proceedings of a symposium on the effects of psychotropic drugs on higher nervous activity (pp. 302–315). Elmsford, NY: Pergamon Press.

    Google Scholar 

  • Molitch, M. J., and Sullivan, J. P. (1937). The effect of Benzedrine sulfate on children taking the new Stanford Achievement Test. American Journal of Orthopsychiatry, 7, 519–522.

    CAS  Google Scholar 

  • Newell, G. R., and Henderson, B. E. (1973). Case-control study of Hodgkin’s disease. I. Results of the interview questionnaire. Journal of the National Cancer Institute, 51, 1437–1441.

    PubMed  CAS  Google Scholar 

  • O’Irary, K. D., Romanczyk, R. G., Kass, R. E., Dietz, A., and Santagrossi, D. (1971). Procedures for classroom observation of teachers and children. Unpublished manuscript, State University of New York, Stony Brook.

    Google Scholar 

  • Page, J. G., Bernstein, J. E., Janicki, R. S., and Michelli, P. A. (1974). A multi-clinic trial of pemoline in childhood hyperkinesis. In C. K. Conners (Ed.), Clinical uses of stimulant drugs in children (pp. 98–129 ). Amsterdam: Excerpta Medica.

    Google Scholar 

  • Pelham, W. E. (1980, September). Peer relationships in hyperactive children: Description and treatment effects. In R. Milich (Chair), Peer relationships among hyperactive children. Symposium conducted at the annual meeting of the American Psychological Association, Montreal, Canada.

    Google Scholar 

  • Pelham, W. E., Bender, M. E., Caddell, J., Booth, S., and Moorer, S. H. (1985). Methylphenidate and children with attention deficit disorder: Dose effects on classroom academic and social behavior. Archives of General Psychiatry, 42, 948–952.

    PubMed  CAS  Google Scholar 

  • Pelham, W. E., and Murphy, H. A. (1986). Behavioral and pharmacological treatment of attention deficit and conduct disorders. In M. Hersen and S. E. Breuning (Eds.), Pharmacological and behavioral treatment: An integrative approach. New York: Wiley.

    Google Scholar 

  • Poling, A., and Breuning, S. E. (1983). Effects of methylphenidate on the fixed-ration performance of mentally retarded children. Pharmacology, Biochemistry, and Behavior, 18, 53 1544.

    Google Scholar 

  • Porrino, L. J., Rapoport, J. L., Behar, D., Ismond, D., and Bunney, W. E. (1983). A naturalistic assessment of the motor activity of hyperactive boys. Il. Stimulant drug effects. Archives of General Psychiatry, 40, 688–693.

    Google Scholar 

  • Rapoport, J. L. (1983). The use of drugs: Trends in research. In M. Rutter (Ed.), Developmental neuropsychiatre (pp. 385403 ). New York: Guilford Press.

    Google Scholar 

  • Rapoport, J., Quinn, P., Bradbard, G., Riddle, D., and Brooks, E. (1974). Imipramine and methylphenidate treatments of hyperactive boys. Archives of General Psychiatry, 30, 789793.

    Google Scholar 

  • Rapport, M. D., DuPaul, G. J., Stoner, G., Birmingham, B. K., and Masse, G. (1985b). Attention deficit disorder with hyperactivity: Differential effects of methylphenidate on impulsivity. Pediatrics, 76, 938–943.

    PubMed  CAS  Google Scholar 

  • Rapport, M. D., Stoner, G., DuPaul, G. J., Birmingham, B. K., and Tucker, S. (1985). Methylphenidate in hyperactive children: Differential effects of dose on academic, learning, and social behavior. Journal of Abnormal Child Psychology, 13, 227–244.

    PubMed  CAS  Google Scholar 

  • Roche, A. F., Lipman, R. S., Overall, J. E., and Hung, W. (1979). The effects of stimulant medication on the growth of hyperactive children. Pediatrics, 63, 847–850.

    Google Scholar 

  • Rosen. L. A., O’Leary, S. G., and Conway, G. (1985). The withdrawal of stimulant medication for hyperactivity: Overcoming detrimental attributions. Behavior Therapy, 16, 538544.

    Google Scholar 

  • Rosenhan, D. L. (1973). On being sane in insane places. Science. 179, 250–258.

    PubMed  CAS  Google Scholar 

  • Rosenthal, R. H., and Allen, T. W. (1978). An examination of attention, arousal, and learning dysfunctions of hyperkinetic children. Psychological Bulletin, 85, 689–715.

    PubMed  CAS  Google Scholar 

  • Ross, D. M., and Ross, S. A. (1982). Hyperactivity. New York: Wiley.

    Google Scholar 

  • Safer, D. J., and Allen, R. P. (1973). Factors influencing the suppressant effects of two stimulant drugs on the growth of hyperactive children. Pediatrics, 51, 660–667.

    PubMed  CAS  Google Scholar 

  • Safer, D. J., and Allen, R. P. (1975a). Side effects from long-term use of stimulants in children. In R. Gittelman-Klein (Ed.), Recent advances in child psychopharmacology (pp. 109122 ). New York: International Arts and Science Press.

    Google Scholar 

  • Safer, D. J., and Allen, R. P. (1975b). Stimulant treatment of hyperactive adolescents. Diseases of the Nervous System, 36, 454457.

    Google Scholar 

  • Safer, D., Allen, R., and Barr, E. (1972). Depression of growth in hyperactive children on stimulant drugs. New England Journal of Medicine, 287, 217–220.

    PubMed  CAS  Google Scholar 

  • Safer, D. J., Allen, R. P., and Barr, E. (1975). Growth rebound after termination of stimulant drugs. Journal of Pediatrics, 86, 113–116.

    PubMed  CAS  Google Scholar 

  • Safer, D. J., and Krager, J. M. (1985). Prevalence of medication treatment for hyperactive adolescents. Psychopharmacology Bulletin, 21, 212–221.

    PubMed  CAS  Google Scholar 

  • Sallee, F., Stiller, R., Perel, J., and Bates, T. (1985). Oral pemoline kinetics in hyperactive children. Clinical Pharmacology and Therapeutics, 37, 606–609.

    PubMed  CAS  Google Scholar 

  • Sandoval, J. (1977). Measurement of the hyperactive syndrome in children. Review of Educational Research, 47, 293–318.

    Google Scholar 

  • Satterfield, J. H., Cantwell, D. P., and Satterfield, B. T. (1974). Pathophysiology of the hyperactive child syndrome. Archives of Genera! Psychiatry, 31, 839–844.

    CAS  Google Scholar 

  • Satterfield, J. H., and Dawson, M. E. (1971). Electrodermal correlates of hyperactivity in children. Psychophysiology, 8, 19 1197.

    Google Scholar 

  • Schleifer, M., Weiss, G., Cohen, N., Elman, M., Cvejic, H., and Kruger, E. (1975). Hyperactivity in preschoolers and the effect of methylphenidate. American Journal of Orthopsychiatry, 45, 38–50.

    PubMed  CAS  Google Scholar 

  • Shekim, W. O., Dekirmenjlan, H., and Chapel, J. L. (1979). Urinary MHPH excretion in minimal brain dysfunction in older children. American Journal of Psychiatry, 136, 667–671.

    PubMed  CAS  Google Scholar 

  • Sleator, E. K. (1980). Deleterious effects of drugs used for hyperactivity on patients with Gilles de la Tourette’s syndrome. Clinical Pediatrics, 19, 453–454.

    PubMed  CAS  Google Scholar 

  • Sleator, E. K. (1985). Measurement of compliance. Psychopharmacology Bulletin, 21, 1089–1093.

    PubMed  CAS  Google Scholar 

  • Sleator, E. K., Ullmann, R. K., and von Neumann, A. (1982). How do hyperactive children feel about taking stimulants and will they tell the doctor? Clinical Pediatrics, 21, 474–479.

    PubMed  CAS  Google Scholar 

  • Sleator, E. K., von Neumann, A., and Sprague, R. L. (1974). Hyperactive children: A continuous long-term placebo-controlled follow-up. Journal of the American Medical Association, 227, 316–327.

    Google Scholar 

  • Solanto, M. V. (1984). Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: A review and synthesis. Psychological Bulletin, 95, 387–409.

    PubMed  CAS  Google Scholar 

  • Solomons, G. (1973). Drug therapy: Initiation and follow-up. Annals of the New York Academy of Sciences, 205, 335–344.

    PubMed  CAS  Google Scholar 

  • Sprague, R. L. (1977). Psychopharmacotherapy in children. In M. F. MacMillan and S. Henao (Eds.), Child psychiatry: Treatment and research. New York: Brunner/Mazel.

    Google Scholar 

  • Sprague, R. L. (1983). Behavior modification and educational techniques. In M. Rutter (Ed.), Developmental neuro-psychiatry (pp. 404–421 ). New York: Guilford Press.

    Google Scholar 

  • Sprague, R. L., and Berger, B. D. (1980)? Drug effects on learning performance: Relevance of animal research to pediatric psychopharmacology. In R. M. Knights and D. J. Bakker (Eds.), Rehabilitation, treatment and management of learning disorders (pp. 167–183). Baltimore: University Park Press.

    Google Scholar 

  • Sprague, R. L., and Sleator, E. K. (1977). Methylphenidate in hyperkinetic children: Differences in dose effects on learning and social behavior. Science, 198, 1274–1276.

    PubMed  CAS  Google Scholar 

  • Stephens, R. S., Pelham, W. E., and Skinner, R. (1984). State-dependent and main effects of methylphenidate and pemoline on paired-associate learning and spelling in hyperactive chil- dren. Journal of Consulting and Clinical Psychology, 52, 104–113.

    PubMed  CAS  Google Scholar 

  • Surwillo, W. W. (1980). Changes in the electroencephalogram accompanying the use of stimulant drugs (methylphenidate and dextroamphetamine) in hyperactive children. Biological Psychiatry, 12, 787–799.

    Google Scholar 

  • Swanson, J. M., and Kinsboume, M. (1976). Stimulant-related state-dependent learning in hyperactive children. Science, 192, 1354–1357.

    PubMed  CAS  Google Scholar 

  • Swanson, J. M., and Kinsboume, M. (1979). The cognitive effects of stimulant drugs on hyperactive (inattentive) children. In G. Hales and M. Lewis (Eds.), Attention and the development of cognitive skills (pp. 249–274 ). New York: Plenum Press.

    Google Scholar 

  • Swanson, J., Kinsboume, M., Roberts, W., and Zucker, K. (1978). Dose response analysis of the effect of stimulant medication on the learning ability of children referred for hyperactivity. Pediatrics, 61, 21–29.

    PubMed  CAS  Google Scholar 

  • Swanson, J., Sandman, C., Deutsch, C., and Baren, M. (1983). Methylphenidate hydrochloride given with or before break- fast. I. Behavioral, cognitive and electrophysiologic effects. Pediatrics, 72, 49–55.

    PubMed  CAS  Google Scholar 

  • Thorley, G. (1984). Review of follow-up and follow-back studies of childhood hyperactivity. Psychological Bulletin, 96, 116132.

    Google Scholar 

  • Ullmann, R. K., and Sleator, E. K. (1985). Attention deficit disordered children with or without hyperactivity: Which behaviors are helped by stimulants? Clinical Pediatrics, 24, 547552.

    Google Scholar 

  • Varley, C. K. (1983). Effects of methylphenidate in adolescents with attention deficit disorder. Journal of the American Academy of Child Psychiatry, 22, 351–354.

    PubMed  CAS  Google Scholar 

  • Varley, C. K. (1985). A review of studies of drug treatment efficacy for attention deficit disorder with hyperactivity in adolescents. Psychopharmacology Bulletin, 21, 216–221.

    PubMed  CAS  Google Scholar 

  • Varley, C. K., and Trupin, E. W. (1982). Double-blind administration of methylphenidate to mentally retarded children with attention deficit disorder: A preliminary study. American Journal of Mental Deficiency, 86, 560–566.

    PubMed  CAS  Google Scholar 

  • Volkmar, F. R., Hoder, E. L., and Cohen, D. J. (1985). Inappropriate uses of stimulant medication. Clinical Pediatrics, 24, 127–130.

    PubMed  CAS  Google Scholar 

  • Weingartner, H., Ebert, M. H., Mikkelsen, E. J., Rapoport, J. L., Buchsbaum, M. S., Bunney, W. E., and Caine, E. D. (1980). Cognitive processes in normal and hyperactive children and their response to amphetamine treatment. Journal of Abnormal Psychology, 89, 25–37.

    PubMed  CAS  Google Scholar 

  • Weiss, G. (1983). Long-term outcome: Findings, concepts, and practical implications. In M. Rutter (Ed.), Developmental neuropsychiatry (pp. 422–449 ). New York: Guilford Press.

    Google Scholar 

  • Weiss, G., and Hechtman, L. T. (1979). The hyperactive child syndrome. Science, 205, 1348–1354.

    PubMed  CAS  Google Scholar 

  • Weiss, G., Hechtman, L., Hopkins, J., Perlman, T., and Wenar, A. (1979). Hyperactives as young adults: A controlled-perspective ten-year follow-up of 75 children. Archives of General Psychiatry, 36, 675–681.

    PubMed  CAS  Google Scholar 

  • Weiss, G., Kruger, E., Danielson, V., and Elman, J. (1975). Effects of long-term treatment of hyperactive children with methylphenidate. Canadian Medical Association Journal, 112, 159–165.

    PubMed  CAS  Google Scholar 

  • Weiss, G., Minde, K., Douglas, V., Werry, J., and Sykes, D. (1971). Comparison of the effect of chloropromazine, dextroamphetamine, and methylphenidate on the behavior and intellectual functioning of hyperactive children. Canadian Medical Association Journal, 104, 20–25.

    PubMed  CAS  Google Scholar 

  • Wender, P. H. (1971). Minimal brain dysfunction in children. New York: Wiley.

    Google Scholar 

  • Wender, P. H., Reimherr, F. W., and Wood, M. D. (1981). Diagnosis and drug treatment of attention deficit disorder (minimal brain dysfunction) in adults: A replication. Archives of General Psychiatry, 38, 449–456.

    PubMed  CAS  Google Scholar 

  • Whalen, C. K., Collins, B. E., Henker, B., Alkus, S. R., Adams, D., and Stapp, J. (1978). Behavior observations of hyperactive children and methylphenidate (Ritalin) effects in systematically structured classroom environments: Now you see them; now you don’t. Journal of Pediatric Psychology, 3, 177–187.

    Google Scholar 

  • Whalen, C. K., Henker, B., and Dotemoto, S. (1981). Teacher response to the methylphenidate (Ritalin) versus placebo status of hyperactive boys in the classroom. Child Development, 52, 1005–1014.

    PubMed  CAS  Google Scholar 

  • Whalen, C. K., Henker, B., and Finch, D. (1981). Medication effects in the classroom: Three naturalistic indicators. Journal of Abnormal Child Psychology, 9, 419–433.

    PubMed  CAS  Google Scholar 

  • Whalen, C. K., Henker, B., and Hinshaw, S. P. (1985). Cognitive–behavioral therapies for hyperactive children: Premises, problems, and prospects. Journal of Abnormal Child Psychology, 13, 391–410.

    PubMed  CAS  Google Scholar 

  • Whalen, C. K., and Henker, B. (1980). The social ecology of psychostimulant treatment: A model for conceptual and empirical analysis. In C. K. Whalen and B. Henker (Eds.), Hyperactive children: The social ecology of identification and treatment (pp. 3–51 ). New York: Academic Press.

    Google Scholar 

  • Whalen, C. K., and Henker, B. (1984). Hyperactivity and the attention deficit disorders: Expanding frontiers. Pediatric Clinics of North America, 31, 399–427.

    Google Scholar 

  • Whitehouse, D., Shah, U., and Palmer, F. B. (1980). Comparison of sustained-release and standard methylphenidate in the treatment of minimal brain dysfunction. Journal of Clinical Psychiatry, 41, 282–285.

    PubMed  CAS  Google Scholar 

  • Woods, D. (1986). The diagnosis and treatment of attention deficit disorder—residual type. Psychiatric Annals, 16, 23–28.

    Google Scholar 

  • Yellin, A. M. (1986). Psychophysiological correlates of attention deficit disorder. Psychiatric Annals, 16. 29–34.

    Google Scholar 

  • Zahn, T. P., Rapoport, J. L., and Thompson, C. L. (1980). Autonomic and behavioral effects of dextroamphetamine and placebo in normal and hyperactive prepubertal boys. Journal of Abnormal Child Psychology, 8, 145–160.

    PubMed  CAS  Google Scholar 

  • Zara, M. M. (1973). Effects of medication on learning in hyperactive four-year-old children. Dissertation Abstracts International, 34, 2407A.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this chapter

Cite this chapter

Brown, R.T., Borden, K.A. (1989). Neuropsychological Effects of Stimulant Medication on Children’s Learning and Behavior. In: Reynolds, C.R., Fletcher-Janzen, E. (eds) Handbook of Clinical Child Neuropsychology. Critical Issues in Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6807-4_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-6807-4_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-6809-8

  • Online ISBN: 978-1-4899-6807-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics