Skip to main content

The S. Kuffler Lecture

The Rise of Experimental Neuroembryology: A Personal Reassessment

  • Chapter
Neuroembryology
  • 161 Accesses

Abstract

The Germans have a penchant for condensing their collective wisdom in proverbs: “All is well that ends well,” “Pride comes before the downfall,” and “that which wants to become a hook, bends early.” At age 14 I was exploring the countryside around the small German town in which I grew up. I collected plants, animals, fossils, and brought home salamander and frog eggs and watched them develop and metamorphose. There was never any doubt in my mind that I would become a naturalist. Years later, I made the conscious choice to study Zoology. I felt that the Natural Sciences brought me closer to their subject matter than the Cultural Sciences, as the Humanities were then called. Animals and plants could be ordered in a rational taxonomic system, and frog embryos displayed a reassuring regularity. There was hope to understand some of the rules that govern these phenomena. Surely, others would find history more dramatic. No doubt, the lives of Caesar, Napoleon, or George Washington could be more fascinating than those of my tadpoles. But to unravel the mysteries of their genius seemed to me beyond my ken.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Attardi D, Sperry RW: Preferential selection of central pathways by regenerating optic fibers. Exp. Neurol. 1963; 7: 46.

    Article  Google Scholar 

  • Brunso-Bechtold J, Hamburger V: Retrograde transport of nerve growth factor in chick embryo. Proc. Natl. Acad. Sci. (USA). 1979; 76: 1494.

    Article  Google Scholar 

  • Coghill GE: Anatomy and the Problem of Behaviour. Cambridge: Cambridge University Press, 1929.

    Google Scholar 

  • Detwiler SR: On the hyperplasia of nerve centers resulting from excessive peripheral loading. Proc. Natl. Acad. Sci. 1920; 6: 96.

    Article  Google Scholar 

  • Detwiler SR: Neuroembryology. New York: The Macmillan Company, 1936.

    Google Scholar 

  • Gaze RM, Keating MJ: The visual system and “neuronal specificity.” Nature. 1972; 237: 375.

    Article  Google Scholar 

  • Hamburger V: Entwicklungsphysiologische Beziehungen zwischen den Extremitaeten der Amphibien und ihrer Innervation. Naturwiss. 1927; 15: 657, 677.

    Article  Google Scholar 

  • Hamburger V: Die Entwicklung experimentell erzeugter nervenloser und schwach innervierter Extremitaeten von Anuren. Roux’. Arch. f. Entw. mech. 1928; 114: 272.

    Article  Google Scholar 

  • Hamburger V: The effects of wing bud extirpation on the development of the central nervous system in chick embryos. J. exp. Zool. 1934; 68: 449.

    Article  Google Scholar 

  • Hamburger V: Motor and sensory hyperplasia following limb bud transplantations in chick embryos. Physiol. Zool. 1939; 12: 268.

    Google Scholar 

  • Hamburger V: The mitotic patterns in the spinal cord of the chick embryo and their relation to histogenetic processes. J. Comp. Neur. 1948; 88: 221.

    Article  Google Scholar 

  • Hamburger V: Some aspects of the embryology of behavior. Quart. Rev. Biol. 1963; 38: 342.

    Article  Google Scholar 

  • Hamburger V: Development of embryonic motility. The Neurosciences Second Study Program (F.O. Schmitt, ed.). New York: Rockefeller Univ. Press, 1970.

    Google Scholar 

  • Hamburger V, Brunso-Bechtold JK, Yip J: Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor. J. Neurosci. 1981; 1: 60–71.

    Google Scholar 

  • Hamburger V, Levi-Montalcini R: Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. J. exp. Zool. 1949; 111: 451.

    Article  Google Scholar 

  • Hamburger V, Oppenheim R: Prehatching motility and hatching behavior in the chick. J. exp. Zool. 1967; 166: 171.

    Article  Google Scholar 

  • Hamburger V, Wenger E, Oppenheim R: Motility in the chick embryo in the absence of sensory input. J. exp. Zool. 162: 133-160.

    Google Scholar 

  • Hamburger V, Yip J: Reduction of experimentally induced neuronal death in spinal ganglia of the chick embryo by nerve growth factor. J. Neurosci. 1984; 4: 767.

    Google Scholar 

  • Harrison RG: Observations on the living developing nerve fiber. Anat. Rec. 1907a; 1: 116.

    Article  Google Scholar 

  • Harrison RG: Experiments in transplanting limbs and their bearing on the problem of the development of nerves. J. exp. Zool. 1907b; 4: 239.

    Article  Google Scholar 

  • Harrison RG: The outgrowth of the nerve fiber as a mode of protoplasmic movement. J. exp. Zool. 1910; 9: 787.

    Article  Google Scholar 

  • Hughes AFW: Aspects of Neural Ontogeny. London: Logos Press, Academic Press, 1968.

    Google Scholar 

  • Levi-Montalcini R, Hamburger V: Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J. exp. Zool. 1951; 116: 321.

    Article  Google Scholar 

  • Levi-Montalcini R, Hamburger V: A diffusible agent of mouse sarcoma, producing hyperneurotization of viscera in the chick embryo. J. exp. Zool. 1953; 123: 233.

    Article  Google Scholar 

  • Levi-Montalcini R, Levi G: Récherches quantitatives sur la marche du processus de diffèrentiation des neurones dans les ganglions spinaux de l’embryon du poulet. Arch. de. Biol. 1943; 54: 189.

    Google Scholar 

  • Levi-Montalcini R, Sacerdote E: Ricerche quantitative sul sistema nervoso di mus musculus. Monitore Zool. Ital. 1934; 45: 162.

    Google Scholar 

  • Lillie, FR: The Development of the Chick. New York: Henry Holt, 1909.

    Google Scholar 

  • Preyer W: Die Specielle Physiologie des Embryo. Leipzig: Grieben’s Verlag, 1883.

    Google Scholar 

  • Shorey M: The effect of the destruction of peripheral areas on the differentiation of the neuroblasts. J. exp. Zool. 1909; 7: 25.

    Article  Google Scholar 

  • Spemann H: Entwicklungsphysiologische Studien am Tritonei I. Roux’. Arch. f. Entw. mech. 1901; 15: 448.

    Google Scholar 

  • Spemann H: Die Erzeugung tierischer Chimaeren durch heteroplastische Transplantation zwischen Triton cristatus und taeniatus. Roux’. Arch. f. Entw. mech. 1921; 48: 533–570.

    Google Scholar 

  • Spemann H: Forschung und Leben. Stuttgart: J. Engelhorn, 1943.

    Google Scholar 

  • Spemann H, Mangold H: Ueber Induktion von Embryonalanlangen durch Implantation artfremder Organisatoren. Roux’, arch. f. Entw. mech. 1924; 100: 599.

    Google Scholar 

  • Sperry WR: Optic nerve regeneration with return of vision. J. Neurophysiol. 1944; 7: 57.

    Google Scholar 

  • Sperry WR: Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc. Natl. Acad. Sci. 1963; 50: 703.

    Article  Google Scholar 

  • Sperry WR: Embryogenesis of behavioral nets, in: Organogenesis (ed. DeHaan and Ursprung), 161, 1965.

    Google Scholar 

  • Weiss, P: In vitro experiments on the factors determining the course of the outgrowing nerve fiber. J. exp. Zool. 1934; 68: 393.

    Article  Google Scholar 

  • Weiss, P: Selectivity controlling the central-peripheral relations in the nervous system. Biol. Rev. 1936; 11: 494.

    Article  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Basel AG

About this chapter

Cite this chapter

Hamburger, V. (1990). The S. Kuffler Lecture. In: Neuroembryology. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6743-5_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-6743-5_26

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4899-6745-9

  • Online ISBN: 978-1-4899-6743-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics