Skip to main content

SDAT Models and Their Dynamics

  • Chapter
Cholinergic Basis for Alzheimer Therapy

Part of the book series: Advances in Alzheimer Disease Therapy ((AADT))

Abstract

It is a foregone conclusion that the major part of the battle for the cure of a human disease is won when an appropriate and specifically pertinent animal-model becomes available.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agnati LF, Zoli M, Pich EM, Toffano G, Guggei M and Fuxe K (1990): Morphofunctional studies on the aging brain. In: Aging Brain and Dementia, Battistin L and Gerstenbrand F, eds. New York: Wiley-Liss, pp. 133–152.

    Google Scholar 

  • Aureli T, Miccheli A, Ricciolini R, Di Cocco ME, Ramacci MT, Angelucci L, Ghirardi O and Conti P (1990): Aging brain: effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy. Brain Res. 526:108–112.

    Article  Google Scholar 

  • Blass JP and Zemcov I (1984): Alzheimer disease — A metabolic system degeneration? Neurochem Path 2:103.

    Article  Google Scholar 

  • Brocklehurst KW, Cotman CW, Cummings BJ, Kosik KS, Mattson MP and Ziff EB (1991): Pathology of Alzheimer’s disease. Neuroscience Facts, Fidia. Res Found 2:1–2.

    Google Scholar 

  • Butcher LL and Woolf NJ (1989): Neurotrophic agents may exacerbate the pathologic cascade of Alzheimer’s disease. Neurdbiol of Aging 10:55–570.

    Article  Google Scholar 

  • Clement JG and Colhoun EH (1975): Presynaptic effect of the aziridinium ion of acetylcholine mustard (metyl-beta-acetoxyethyl-2′-chloroethylamine) in the phrenic nerve-rat diaphragm preparation. Can J Physiol Pharmacol 53:264–272.

    Article  Google Scholar 

  • Collins MA (1988): Acetaldehyde and its condensation products as markers of alcoholism. In: Recent Developments in Alcoholism, Galanter M, ed. New York: Plenum Press, pp. 387–403.

    Chapter  Google Scholar 

  • Cotman CW, Geddes JW and Kahle JS (1990): Axon sprouting in Alzheimer’s disease brain: a reactivation of developmental mechanisms? Prog Brain Res 83:427–434.

    Article  Google Scholar 

  • El Tamer A, Corey J, Wulfert E and Hanin I (1991): Dose and time dependent cholinergic changes induced by AF64A in rat hippocampus and septum reversible inhibition at low doses and possible septal compensatory effect. J Neuropharmacol (Submitted).

    Google Scholar 

  • Gage FH and Bjorklund A (1981): Compensatory collateral sprouting of aminergic systems in the hippocampal formation following partial deafferentation. In: The Hippocampus, Vol. 3, Isaacson RL and Pribram KH, eds. New York: Plenum Press, pp. 33–63.

    Google Scholar 

  • Graves AB, White E, Koepsell TD, Reifler BV, Van Belle G, Larson EB and Raskind M (1990): The association between head trauma and Alzheimer’s disease. Amer J Epidemiol 131:491–501.

    Google Scholar 

  • Greenmayre JT and Young AB (1989): Excitatory aminoacids and Alzheimer’s disease. Neurobiol Aging 10:593–602.

    Article  Google Scholar 

  • Halliwell B (1989): Oxidants and the central nervous system: some fundamental questions. Acta Neurol Scand 126:23–33.

    Article  Google Scholar 

  • Hanin I, Fisher A, Hortnagl H, Leventer SM, Potter PE and Walsh TJ (1987): Ethylcholine aziridinium (AF64A;ECMA) and other potential cholinergic neuron-specific neurotoxins. In: Psychopharmacology: The Third Generation of Progress, Meltzer HY, ed. New York: Raven Press, pp. 341–349.

    Google Scholar 

  • Haroutunian V, Santucci A and Davis KL (1990): Implications of multitransmitter system lesions for cholinomimetic therapy in Alzheimer’s disease. In: Cholinergic Neurotransmission: Functional and Clinical Aspects, Aquilonius S-M and Gillberg P-G, eds. Amsterdam: Elsevier Science Publs., pp. 333–345.

    Chapter  Google Scholar 

  • Hetnarski B, Wisniewski HM, Iqbal K and Lajtha A (1980): Central cholinergic activity in aluminum-induced neurofibrillary degeneration. Ann Neurol 7:489–490.

    Article  Google Scholar 

  • Iqbal K, Grndke-Iqbal I, Smith AJ, George L, Tung Y-C and Zaidi T (1989): Identification and localization of a tau peptide to paired helical filaments of Alzheimer’s disease. Proc Natl Acad. Sci USA 86:5646–5650.

    Article  Google Scholar 

  • Jenden DJ, RĂĽssel RW, Booth RA, Knusel BJ, Lauretz SD, Rice KM and Roch M (1989): Effects of chronic in vivo replacement of choline with a false cholinergic precursor. In: Central Cholinergic Synaptic Transmission, Frotscher M and Misgeld U, eds. Basel: Birkhauser Verlag, pp. 229–235.

    Chapter  Google Scholar 

  • Johnson MK (1980): Delayed neurotoxicity induced by organophosphorus compounds: area of misunderstanding and ignorance. Dev Toxicol Environ Sci 8:27–38.

    Google Scholar 

  • Karczmar AG (1984): Acute and long lasting central actions of organophosphorus agents. Fund Appl Toxicol 4:S1–S17.

    Article  Google Scholar 

  • Karczmar AG (1981): Multifactorial and multitranmsitter basis of behaviors and their cholinergic concommitants. Psychopharmacol Bull 17:68–70.

    Google Scholar 

  • Kosik KS, Orecchio LD, Binder LI, Trojanowski J, Lee V and Lee G (1988): Epitopes that span the tau molecule are shared with paired helical filaments. Neuron 1:817–825.

    Article  Google Scholar 

  • Luria AR (1973): The Working Brain. New York: Basic Books Inc.

    Google Scholar 

  • Mattson MP (1990): Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca++ influx in cultured hippocampal neurons. Neuron 2:105–117.

    Article  Google Scholar 

  • Maysinger D, Garofalo I, Jalsenyak I and Cuello AC (1989): Effects of microencapsulated monoganglioside GM1 on cholinergic neurons. Brain Res 496:165–172.

    Article  Google Scholar 

  • Millard WJ, Arendash GW, Dunn AJ and Meyer EM (1990): Effects of nucleus basalis lesions on cerebral cortices concentrations of corticotropin-releasing hormone (CRH)-like reactivity in the rat. Neurosci Lett 113:233–239.

    Article  Google Scholar 

  • Price DL, Whitehbure PJ, Struble RG, Coyle JT, Clark AW, DeLong MR, Cork LC, and Hedreen JC (1982): Alzheimer’s disease and Down’s syndrome. Ann New YorkAcad Sci 396:145–164.

    Article  Google Scholar 

  • Represa A and Ben-Ari Y (1989): Effects of colchicine treatment on the cholinergic septohippocampal system. In: Central Cholinergic Synaptic Transmission, Frotscher M and Misgeld U, eds. Basel: Birkhauser Verlag, pp. 288–294.

    Chapter  Google Scholar 

  • Saito M, Kindel G, Karczmar AG and Rosenberg A (1986): Metabolism of choline in brain of the aged CBF-1 mouse. J Neurosci Res 15:197–04.

    Article  Google Scholar 

  • Siman R, Card JP and Davis LG (1990): Presynaptic processing of betaamyloid precursor by calpain I. J Neurosci 10:2400–2411.

    Google Scholar 

  • Ueda K, Masliah E, Saitoh T, Bakalis SL, Scobie H and Kosik KL (1990): Alz-50 recognizes a phosphorylated epitope of tau protein. J Neurosci 10:3295–3304.

    Google Scholar 

  • Wallace WC, Bragin V, Robakis NK, Sambamurti K, Vanderputten D. Merril RC, Davis KL, Santucci AC and Haroutunian V (1991): Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Molec Brain Res (In Press).

    Google Scholar 

  • Wurtman RJ (1987): Use of choline in cholinergic neurons to form acetylcholine and membrane phospholipids: Possible implications for lzheimer’s disease. In: Advancing Frontiers in Alzheimer’s Disease Research, Glenner GG and Wurtman RJ, eds. Austin: University of Texas Press, pp. 1–10.

    Google Scholar 

  • Zubenko GS and Hanin I (1989): Cholinergic and adrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus. Brain Res 498:381–384.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Karczmar, A.G. (1991). SDAT Models and Their Dynamics. In: Becker, R., Giacobini, E. (eds) Cholinergic Basis for Alzheimer Therapy. Advances in Alzheimer Disease Therapy. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6738-1_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-6738-1_17

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4899-6740-4

  • Online ISBN: 978-1-4899-6738-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics