Abstract
The decline in cognitive functions in aged humans and in other species, or their loss in senile dementia of the Alzheimer’s type (SDAT), is attributed mainly to an impairment of cholinergic activity in the brain cortex and hippocampus.
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References
Angelucci L, Ramacci MT, Taglialatela G, Huselbosch C, Morgan B, Werrbach-Perez K and Perez-Polo JR (1988): Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine. J. Neurosci Res 20:491–496.
Angelucci L, Imperato A, Ramacci MT, Taglialatela G and Perez-Polo JR (1990): Neurotransmission and neurotrophism in the aging brain. In: Regulation of gene expression in the nervous system, Giuffrida-Stella AM, De Vellis J and Perez-Polo JR, eds. New York: Wiley-Liss, pp. 319–332.
Curti D, Dagani G, Galmozzi MR and Marzatico F (1989): Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. Mech of Aging and Dev 47:39–45.
De Boer P, Westerink BHC, Rollema H, Zaagsma J and Horn AS (1990): An M3-like muscarinic autoreceptor regulates the in vivo release of acetylcholine in rat striatum. Eur J Pharmacol 179:167–172.
Doležal V and Tuček S (1981): Utilization of citrate, acetyl-carnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 36:1323–1330.
Gibson GE and Shimada M (1980): Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis. Biochem Pharmac 29:167–174.
Imperato A, Ramacci MT and Angelucci L (1989): Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci Lett 107:251–255.
Sterri SH and Fonnum F (1980): Acetyl-CoA synthesizing enzymes in cholinergic nerve terminals. J Neurochem 35:249–254.
Taglialatela G, Angelucci L, Ramacci MT, Werrbach-Perez K, Jackson GR and Perez-Polo JR (1990): Acetyl-L-carnitine potentiates nerve growth factor effects in rat pheochromocytoma (PC12) cells. Int J Devl Neurosci 8:81–90.
White HL and Scates PW (1990): Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res 15:597–601.
Wu CF, Bertorelli R, Sacconi M, Pepeu G and Consolo S (1988): Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis. Neurobiol Aging 9:357–361.
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© 1991 Springer Science+Business Media New York
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Angelucci, L., Alemà, G.S., Imperato, A., Castorina, M., Ramacci, M.T., Scrocco, M.G. (1991). Aging of the Cholinergic Synapse in the Rat’s Hippocampus: Effect of Acetyl-L-Carnitine. In: Becker, R., Giacobini, E. (eds) Cholinergic Basis for Alzheimer Therapy. Advances in Alzheimer Disease Therapy. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6738-1_16
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DOI: https://doi.org/10.1007/978-1-4899-6738-1_16
Publisher Name: Birkhäuser, Boston, MA
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