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Presynaptic Cholinergic Mechanisms in Human Cerebral Cortex of Adult and Aged Patients

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Cholinergic Basis for Alzheimer Therapy

Abstract

It is now well accepted that cholinergic nerve terminals possess muscarinic autoreceptors which mediates the inhibition of acetylcholine (ACh) release in rat brain (Molenaar and Polak, 1970; Marchi et al., 1981). A muscarinic receptor mediated mechanism similar to that present in the rodent was proposed to exist, on the basis of indirect evidence, also in human brain (Marek et al., 1982; Nordstrom et al., 1982; Nilsson et al., 1987).

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Marchi, M. et al. (1991). Presynaptic Cholinergic Mechanisms in Human Cerebral Cortex of Adult and Aged Patients. In: Becker, R., Giacobini, E. (eds) Cholinergic Basis for Alzheimer Therapy. Advances in Alzheimer Disease Therapy. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6738-1_11

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  • DOI: https://doi.org/10.1007/978-1-4899-6738-1_11

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4899-6740-4

  • Online ISBN: 978-1-4899-6738-1

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