Abstract
Candida inhabits the human gastrointestinal tract, and fungi such as Aspergillus and Cryptococcus are abundant in the environment. Despite the ubiquity of these organisms, they do not normally cause infections because the host immune system protects against them. However, the number of patients who are severely immunocompromised by acquired immunodeficiency syndrome (AIDS), organ and bone marrow transplantations, and cancer chemotherapy has rapidly increased recently, and they are vulnerable to bacterial and fungal infections. Recent studies of the new triazoles (fluconazole and itraconazole) (Perfect et al., 1986; Saag and Dismukes, 1988) and the liposomal formulation of amphotericin B (Mehta et al., 1984) appear promising for the treatment of local and systemic fungal infections. Despite such progress, however, a recurrent theme in the study of antifungal agents is reducing their toxicity and efforts to ameliorate their side effects. There is, therefore, a need for a safe and fungal-selective agent for the treatment of life-threatening infections, which we anticipate would even be greater in the future.
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Oki, T. (1992). Pradimicin, A Novel Antifungal Agent. In: Fernandes, P.B. (eds) New Approaches for Antifungal Drugs. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6729-9_5
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DOI: https://doi.org/10.1007/978-1-4899-6729-9_5
Publisher Name: Birkhäuser, Boston, MA
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