Skip to main content
SpringerLink
Log in

Ethylene-Oxide Sterilization of Plastic-Film Isolators: A Six-Year Study of Operational Efficiency

  • Conference paper
  • First Online:
Germ-Free Biology Experimental and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

  • 77 Accesses

Abstract

Ethylene oxide (ETO), an alkylene oxide, has been used for many years to kill microorganisms and insects (1,2). The principle use in the past has been the fumigation of foodstuffs and spices; ethylene oxide is still used extensively in agricultural industries for this purpose (3). During the last 20 years the effect of time, temperature, relative humidity, and concentration of ETO on sterility has been repeatedly discussed (4,5,6,7,8).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cotton, R. T., and Roark, R. C.: Indust. and Engin. Chem. 20: 805 (1928).

    CAS  Google Scholar 

  2. “Fumigating with ‘Carboxide Gas’, pamphlet, Carbide and Carbon Chemicals Division, Union Carbide and Carbon Corp.

    Google Scholar 

  3. Yesair, J., and Williams, O. B.: Spice contamination and its control. Food Res. 7: ll8 (1942).

    Article  Google Scholar 

  4. Phillips, C. R., and Kaye, S.: Am. J. Hyg. 50: 280 (1949).

    CAS  PubMed  Google Scholar 

  5. Perkins, J. J.: “Principles and Methods of Sterilization.” Charles C. Thomas, Springfield, Ill. 1956.

    Google Scholar 

  6. Gilbert, G. L., Gambill, V. M., Spiner, D. R., Hoffman, R. K., and Phillips, C. R. Appl. Microbiology 12: 496.(1964).

    CAS  Google Scholar 

  7. Ernst, R. R., and Shull, J. J.: Appl. Microbiology 10: 337, (1962).

    CAS  Google Scholar 

  8. Ernst, R. R., and Shull, J. J.: Appl. Microbiology 10: 342 (1962).

    CAS  Google Scholar 

  9. Haenni, E. O., Affens, W. A., Lento, H. G., Yeomans, A. M., and Fulton, R. A.: Ind. Eng. Chem. 51: 685 (1959).

    Article  CAS  Google Scholar 

  10. Kaye, S.: J. Lab. and Clin. Med. 35: 823 (1950).

    CAS  Google Scholar 

  11. Znamirowski, R., McDonald, S., and Roy, T.: Canad. M. A. J. 83: 1004 (1960).

    CAS  Google Scholar 

  12. Snow, J. C., and Anderson, M. L.: Mod. Hospital 105: 128 (1965).

    CAS  Google Scholar 

  13. Phillips, C. R., and Hoffman, R. K.: Science 132: 991 (1960).

    Article  CAS  Google Scholar 

  14. Reed, L. L., Gidner, R. S., and Dinger, H. S.: Apparatus for Sterilizing Components of Interplanetary Craft. American Sterilizer Co., Erie, Penna. (1962).

    Google Scholar 

  15. Trexler, P. C. and Reynolds, L. I.: Appl. Microbiology 5: 406 (1957).

    CAS  Google Scholar 

  16. Royce, A., and Moore, W. K.: Brit. J. Ind. Med. 12: 169 (1955).

    CAS  Google Scholar 

  17. Barrett, J. P., Jr.: Proc. Animal Care Panel 9: 127 (1959).

    Google Scholar 

  18. Wescott, R. B., and Gardner, J. A.: “Apparatus and Method for the Steam Sterilization of Food for Germfree Laboratory Animals.” U. S. Army Chemical Corps Biological Laboratories, Fort Detrick, Maryland. April 1962.

    Google Scholar 

  19. Personal communication, American Sterilizer Company, Erie, Penna. (1961).

    Google Scholar 

  20. Lloyd, R. S., and Krahe, J. B.: “Gaseous Sterilization with Ethylene Oxide (A supplement to Chapter XXI), “Principles and Methods of Sterilization” by Perkins, J. J. American Sterilizer Co., Erie, Penna. (1958).

    Google Scholar 

  21. Claghorn, A.: J. Am. Assn. for Inhalation 11: 76 (1966).

    Google Scholar 

  22. Phillips, C. R.: “The Sterilizing Properties of Ethylene Oxide.” Paper read at Symposium on “Recent Developments in the Sterilization of Surgical Materials,” organized by the Pharmaceutical Society of Great Britain and Smith and Nephew Research Ltd. and held at the School of Pharmacy, University of London on April 11–13, 1961, printed in England by Eyre and Spottiswoode Limited, Her Magesty’s Printers at the Thanet Press, Margate.

    Google Scholar 

  23. Perkins, J. J., and Lloyd, R. S.: “Applications and Equipment for Ethylene Oxide Sterilization.” Paper read at above symposium (Ref. 22).

    Google Scholar 

  24. Stierli, H., Reed, L. L., and Billick, I. H.: Public Health Monograph 68 pages 1–15, (1962).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Donald M. Robie & Harry E. Walburg Jr.

Authors
  1. Donald M. Robie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harry E. Walburg Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer Science+Business Media New York

About this paper

Cite this paper

Robie, D.M., Walburg, H.E. (1969). Ethylene-Oxide Sterilization of Plastic-Film Isolators: A Six-Year Study of Operational Efficiency. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_45

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_45

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation