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The Effect of Intestinal Flora on Toxicity of Nitrogen Mustard

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Germ-Free Biology Experimental and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

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Abstract

The clinical use of germ-free isolators in cancer medicine is based on numerous investigations which have demonstrated reduced toxicity from chemotherapeutic agents or radiation in axenic animals (1–3). Earlier workers have attempted to show a similar decrease in toxicity in antibiotic-sterilized animals (1, 4). The clinical approach tacitly assumes that results of experiments with axenic animals can be approximated by results in antibiotic-sterilized man. Our experiments with mice were designed to test the validity of this assumption by comparing nitrogen mustard (HN2) toxicity in axenic, conventional and antibiotic-sterilized animals.

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References

  1. White, L.P., and Claflin, E.F. “Nitrogen Mustard: Diminution of Toxicity in Axenic Mice.” Science 140, 1400–1401, June 28, (1963).

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  2. McLaughlin, M.M., Dacquisto, M.P., Jacobus, D.P., and Horowitz, R.E. “Effects of the Germ-free State on Responses of Mice to Whole-Body Irradiation.” Radiation Research, 23, 333–349, (1964).

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  3. Wilson, B.R. “Survival Studies of Whole-Body X-Irradiated Germ-free (axenic) Mice.” Radiation Research, 20, 477–483, (1963).

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  4. Rosoff, C.B. “The Role of Intestinal Bacteria in the Recovery from Whole Body Radiation.” J. Exp. Med., 118. 935–943, Dec., (1963).

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  5. Schneirson, S. “Production of Discrete, Nonswarming Colonies by Proteus on Medium Deficient in Sodium Chloride and other Salts. J. Bact., 82, 621–622, (1961).

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Author information

Authors and Affiliations

  1. Roswell Park Memorial Institute, Buffalo, New York, USA

    Judith A. O’Malley, Joyce Jividen, Edwin A. Mirand & James F. Holland

Authors
  1. Judith A. O’Malley
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  2. Joyce Jividen
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  3. Edwin A. Mirand
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  4. James F. Holland
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1969 Springer Science+Business Media New York

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O’Malley, J.A., Jividen, J., Mirand, E.A., Holland, J.F. (1969). The Effect of Intestinal Flora on Toxicity of Nitrogen Mustard. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_26

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  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_26

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

  • eBook Packages: Springer Book Archive

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