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Kinin-Forming Activity in Cecal Contents of Germ-Free and Conventional Mice

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Germ-Free Biology Experimental and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

Abstract

Recently, a substance was isolated from the cecal contents of both germ-free and conventional rodents that stimulated the smooth muscle of the perfused rat uterus.1 Further studies identified this substance as cecal kallikrein possessing musculotropic activity both by direct and indirect kinin-forming action.2

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Bibliography

  1. Wiseman, R.F., Gordon, H.A.: A bioactive substance with caecum of germ-free animals. Nature, 205: 571, 1965.

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  2. Gordon, H.A.: A substance acting on smooth muscle in intestinal contents of germ-free animals. Ann. N.Y. Acad. Sci. 147: 83, 1967.

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  3. Armstrong, D., Jepson, J.B., Keele, C.A., Stewart, J.W.: Pain-producing substance in human inflammatory exudates and plasma. J. Physiol. London, 135: 350, 1957.

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  4. Back, N., Guth, P.S., Munson, A.E.: On the relationship between plasmin and kinin. Ann. N.Y. Acad. Sci. 104: 53, 1963.

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  5. Margolis, J.: Activation of plasma by contact with glass: evidence for a common reaction which releases plasma kinin and initiates coagulation. J. Physiol. London 144: 1, 1958.

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  6. Back, N., Steger, R.: Effect of inhibitors on kinin-releasing activity of proteases. Fed. Proc. 27: 96, 1968.

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  7. Back, N., Wilkens, H., Steger, R.: Fibrinolysis and vasoactive peptides in anaphylaxis. In Hypotensive Peptides. Eds. E.G. Erdos, N. Back, and F. Sicuteri, Springer-Verlag, pg. 485, 1966.

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Author information

Authors and Affiliations

  1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, USA

    N. Back, R. Steger & E. A. Mirand

  2. Roswell Park Memorial Institute, Buffalo, New York, USA

    N. Back, R. Steger & E. A. Mirand

Authors
  1. N. Back
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  2. R. Steger
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  3. E. A. Mirand
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1969 Springer Science+Business Media New York

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Back, N., Steger, R., Mirand, E.A. (1969). Kinin-Forming Activity in Cecal Contents of Germ-Free and Conventional Mice. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_23

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  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_23

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

  • eBook Packages: Springer Book Archive

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