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Germ-Free Biology Experimental and Clinical Aspects pp 117–124Cite as

Viral Status of Germfree Rodents; Present and Future

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

Abstract

The materials used in experimentation must be clearly defined as to their purity. Experimental animals are standardized by specifying species, strain, sex, age, diet, housing and microflora; for these factors are important for obtaining clear results and for correct interpretations of the results obtained. Considerable efforts have been directed toward producing and controlling animals as pure materials for experimentation. Germfree (GF) rodents that are caesarean-derived into a sterile isolator, fed a sterilized diet and maintained aseptically, are desirable subjects for some types of experimentation because they have proven to be free from bacteria, protozoa, fungi and mycoplasma (1, 2, 3, 4). In the field of virology, possibly other fields (such as oncology, serology, and pathology) it is important to obtain “Virus-defined” or “virus-free” animals as reliable experimental tools.

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Author information

Authors and Affiliations

  1. Lobund Laboratory, Department of Microbiology, University of Notre Dame, Notre Dame, Indiana, USA

    Masahiro Kajima

Authors
  1. Masahiro Kajima
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1969 Springer Science+Business Media New York

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Kajima, M. (1969). Viral Status of Germfree Rodents; Present and Future. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_14

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  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_14

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

  • eBook Packages: Springer Book Archive

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