Abstract
I have been asked to discuss recent developments in medical genetics in relation to conception, pregnancy and birth and this is a tall order to fulfil in twenty-five minutes. Fortunately Professor Polani has already described one big aspect, namely the way in which chromosomal abnormalities affect this interesting period in our lives, and it seems to me that a second big field in which there have been exciting advances is immunology. For example, the reasons why a tissue is rejected are being increasingly understood, and successful organ transplantation seems just round the corner—though on the other hand, why the foetus is not rejected is still something of a mystery. Then there are the disorders resulting from blood group incompatibility, of which the Rhesus situation is much the most important, and one which seemed to me to be highly relevant to the general subject of this symposium. Furthermore, I have a particular interest in it, and I am going to stick to this one point and tell you how I think Rh haemolytic disease may be prevented.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Clarke, C. A.et al. 1966. Prevention of Rh-haemolytic disease: results of the clinical trial. A combined study from centres in England and Baltimore. Brit. med. J. ii, 907.
Cohen, F. and Zuelzer, W. W. 1964. Identification of blood group antigens by immunofluorescence, and its application to the detection of the transplacental passage of erythrocytes in mother and child. Vox Sang. (Basel)9, 75.
Freda, V. J., Gorman, J. G. and Pollack, W. 1966. Rh factor: prevention of isoimmunization and clinical trial on mothers. Science151, 828.
Gorman, J. G., Freda, V. J. and Pollack, W. 1963. Intramuscular injection of a new experimental gamma2 globulin preparation containing high levels of anti-Rh antibody, as a means of preventing sensitization to Rh. In Proc. Cong. Int. Soc. Haematol., 9th Sept. 1962. New York, Grune and Stratton.
Kleihauer, E., Braun, H. and Betke, K. 1957. Demonstration von fetalem Hämoglobin in den Erythrocyten eines Blutausstrich. Klin. Wschr.35, 637.
Levine, P. 1943. Serological factors as possible causes in spontaneous abortions. J. Hered.34, 71.
Pollack, W., Gorman, J. G., Freda, V.J., Jennings, E. R., Sullivan, J. F. and Hill, G. H. 1966. Clinical evaluation of Rh immunoglobin in the prophylaxis of immunization to the Rh factor. Proc. Int. Soc. Blood Transfusion. [In Press.]
Preisler, O. and Schneider, J. 1966. Die Prophylaxie der Sensibilisierung der Rhesus-negativen Frau mit Anti-D-Seren und Anti-D-Globulinen. Bibl. gynaec. fasc. 38., 1. S. Karger (Basel).
Zipursky, A., Hull, A., White, F. D. and Israels, L. G. 1959. Foetal erythrocytes in the maternal circulation. Lancet i, 451.
Zipursky, A., Pollock, J., Ghown, B. and Israels, L. G. 1965. Transplacental isoimmunization by foetal red blood cells. Birth Defects Original Articles Series, 1, 1.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer Science+Business Media New York
About this chapter
Cite this chapter
Clarke, C.A. (1967). Recent Developments in Medical Genetics. In: Platt, T.L., Parkes, A.S. (eds) Social and Genetic Influences on Life and Death. Eugenics Society Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6365-9_2
Download citation
DOI: https://doi.org/10.1007/978-1-4899-6365-9_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-6182-2
Online ISBN: 978-1-4899-6365-9
eBook Packages: Springer Book Archive