Skip to main content
SpringerLink
Log in

Problems of Genetic Expression in the Nervous System

  • Chapter
The Future of the Brain Sciences

Abstract

Our views on the future in neuroscience are a result of an association of our knowledge, hypotheses and sometimes of utopias. Our interest in neuroscience is in some aspects a result of our curiosity: to know how the most sophisticated human organ is functioning and our desire to influence central nervous system activity and to improve the life of people developing mental diseases. The questions which arise are extremely complicated. When we attempt to answer these questions, the direct way, which seems the shortest, is not always the best. During the last twenty years we have learnt that in biology, success depends on the choice of models and projects as simple as possible. The mechanisms of neural activity, of our behavior and memory and of mental diseases are a result of high specialization of nerve cells, their functional pathways and their connections.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Himwich, W.A. and Himwich, H.E., The developing brain, Progress in Brain Research, Elsevier Publishing Co., Amsterdam, Vol. 9, 267, 1964.

    Google Scholar 

  2. Purpura, D.P. and Schade, J.P., Growth and maturation of the brain, Progress in Brain Research, Elsevier Publishing Co., Amsterdam, Vol. 4, 289, 1964.

    Google Scholar 

  3. Perry, R.P., In: Progress in Nucleic Acid Research and Molecular Biology, J.N. Davidson and W.E. Cohn (Eds.), Academic Press, New York and London, Vol. 6, 220, 1967.

    Google Scholar 

  4. Sensenbrenner, M. and Mandel, P., Z. Zellforsch 82, 65, 1967.

    Article  PubMed  CAS  Google Scholar 

  5. Jacob, F. and Monod, J., J. Mol. Biol., 3, 318, 1961.

    Article  PubMed  CAS  Google Scholar 

  6. Siebert, G., Advances in Enzymology, 27, 239, 1965.

    Google Scholar 

  7. MacEwen, B.S., Allfrey, V.G. and Mirsky, A.E., J. Biol. Chem., 238, 758, 1963.

    Google Scholar 

  8. Pennial, R., Shiu M., and Saunders, J.P., Biochim. Biophys. Acta, 76, 170, 1966.

    Article  Google Scholar 

  9. Karjalainen, E., Acta Chem. Scand., 20, 586, 1966.

    Article  PubMed  CAS  Google Scholar 

  10. Simler, S., Popovic, D. and Mandel, P., Bull. Soc. Chim. Biol., 49, 1509, 1967.

    PubMed  CAS  Google Scholar 

  11. Jacob, M. and Mandel, P., In: Protides of the Biological Fluids, H. Peeters (Ed.), Elsevier Publishing Co., Amsterdam, 63, 1965.

    Google Scholar 

  12. Pete, N., Chambon, P. and Mandel, P., In: Variations in Chemical Composition of the Nervous System, G.B. Ansell (Ed.), Pergamon Press, London, 88, 1965.

    Google Scholar 

  13. Mandel, P., Pete, N. and Dravid, A., J. Physiol., 59, 261, 1967.

    Google Scholar 

  14. Mandel, P., Bull. Soc. Chim. Biol., 49, 1491, 1967.

    PubMed  CAS  Google Scholar 

  15. Edmonds, M. and Abrams, R., J. Biol. Chem., 238, 1186, 1963.

    CAS  Google Scholar 

  16. Doly, J. and Mandel, P., Comptes Rendus (Paris), 264, Serie D, 2687, 1967.

    CAS  Google Scholar 

  17. Chambon, P., Weill, J.D., Doly, J., Strosser, M.T. and Mandel, P., Biochem.Biophys. Res. Commun., 25, 638, 1966.

    Article  CAS  Google Scholar 

  18. Eisenstadt, J.M. and Brawerman, G., Proc. Natl. Acad. Sci. U.S., 58, 1560, 1968.

    Article  Google Scholar 

  19. Revel, M. and Mandel, P., Cancer Res., 22, 456, 1962.

    PubMed  CAS  Google Scholar 

  20. Revel, M., Mandel, L., Wintzerith, M., Klein, N. and Mandel, P., Bull. Soc. Chim. Biol., 43, 91, 1961.

    PubMed  CAS  Google Scholar 

  21. Thorn, W., Pfleiderer, G., Frowein, R.A., and Ross, I.R., Arch. Ges. Physiol., 261, 334, 1958.

    Article  Google Scholar 

  22. Gerlach, E., Doring, H.J. and Fleckenstein, A., Arch. Ges. Physiol., 266, 266, 1958.

    Article  CAS  Google Scholar 

  23. Mandel, P., Harth, S. and Rebel, G., In: Chemical Pathology of the Nervous System, J. Folch-Pi, (Ed.), Pergamon Press, London, 551, 1958.

    Google Scholar 

  24. Palladine, A.., Wiener Klin. Wochenschr., 473, 1954.

    Google Scholar 

  25. Edel, S., J. Physiol., 59, 234, 1967.

    CAS  Google Scholar 

  26. Weiss, B.S., Proc. Natl. Acad. Sci., U.S., 46, 1020, 1960.

    Article  CAS  Google Scholar 

  27. Barondes, S.H., J. Neurochem., 11, 663, 1964.

    Article  PubMed  CAS  Google Scholar 

  28. Bondy, S.C. and Waelsch, H., Life Sciences, 3, 633, 1964.

    Article  PubMed  CAS  Google Scholar 

  29. Pete, N., Wintzerith, M., Mandel, L. and Mandel, P., Comptes Rendus (Paris, 258, 5283, 1964.

    CAS  Google Scholar 

  30. Ramuz, M., Doly, J., Mandel, P. and Chambon, P., Biochem. Biophys. Res. Commun., 19, 114, 1965.

    Article  CAS  Google Scholar 

  31. Munoz, D. and Mandel, P., C.R. Soc. Biol., 1968, in press.

    Google Scholar 

  32. Chambon, P., Ramuz, M., Mandel, P. and Doly, J., Biochim. Biophys. Acta, 157, 504, 1968.

    Article  CAS  Google Scholar 

  33. Scherrer, K., Latham, H. and Darnell, J.E., Proc. Natl. Acad. Sci., U.S., 49, 240, 1963.

    Article  CAS  Google Scholar 

  34. Perry, R.P., Proc. Natl. Acad. Sci., U.S., 48, 2179, 1962.

    Article  CAS  Google Scholar 

  35. Jacob, M., Stevenin, J., Jund, R., Judes, C. and Mandel, P., J. Neurochem., 13, 619, 1966.

    Article  PubMed  CAS  Google Scholar 

  36. Schapira, G., Dreyfus, J.C. and Maleknia, N., Biochem. Biophys. Res. Commun., 32, 558, 1968.

    Article  PubMed  CAS  Google Scholar 

  37. Kempf, J. and Mandel, P., Bull. Soc. Chim. Biol., 50, 773, 1968.

    PubMed  CAS  Google Scholar 

  38. Hall, B.D. and Spiegelman, S., Proc. Natl. Acad. Sci., U.S., 47, 137, 1961.

    Article  CAS  Google Scholar 

  39. Stenenin, J., Samec, J., Jacob, M. and Mandel, P., J. Mol. Biol., 33, 777, 1968.

    Article  Google Scholar 

  40. Schearer, R.W. and McCarthy, B.J., Biochem., 6, 283, 1967.

    Article  Google Scholar 

  41. Harris, H., Nature, 213, 809, 1967.

    Article  PubMed  CAS  Google Scholar 

  42. Virmaux, N., Garel, J.P. and Mandel, P., unpublished data.

    Google Scholar 

  43. Goswamy, S., Mandel, P. and Karli, P., In: Biochemistry of the Eye, U. Dardenne and J. Nordmann (Eds.), S. Karher, Basel, 514, 1966.

    Google Scholar 

  44. Jarlstedt, J., In: Macromolecules and the function of the neurons, Z. Lodin and S.P.R. Rose (Eds.) Excerpta Medica Foundation, Amsterdam, 1968.

    Google Scholar 

  45. Hyden, H. and Pigon, A., J. Neurochem., 6, 57, 1960.

    Article  PubMed  CAS  Google Scholar 

  46. Rappoport, D.A. and Daginawala, H.F., Abstr. 1st. Intern. Meeting of the Intern. Soc. Neurochem., Strasbour, 175, 1967.

    Google Scholar 

  47. Hyden, H., this Symposium.

    Google Scholar 

  48. Agranoff, B.W., this Symposium.

    Google Scholar 

Download references

Authors
  1. Paul Mandel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Foundation for Research on the Nervous System, Boston, Massachusetts, USA

    Samuel Bogoch

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mandel, P. (1969). Problems of Genetic Expression in the Nervous System. In: Bogoch, S. (eds) The Future of the Brain Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6323-9_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-6323-9_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-6166-2

  • Online ISBN: 978-1-4899-6323-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation