Abstract
Following section of the peripheral nerve muscle atrophy takes place with subsequent degeneration of muscle fibres innervated by this nerve. This is considered to be due to a disturbance in the trophic function of the nervous system. “Trophic functions” were originally used to designate changes described in patho-anatomical or clinical studies, characterized by either an increase (hypertrophy) or a decrease (atrophy) of these functions, without analysing or defining exactly the mechanisms subserving these “trophic functions”. The efforts of physiological investigations should be aimed at giving these functions a concrete meaning. How does this trophic function manifest itself and in which way is it regulated?
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Gutmann, E., Hník, P. (1962). Denervation Studies in Research of Neurotrophic Relationships. In: Gutmann, E. (eds) The Denervated Muscle. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4854-0_2
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