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Pathology

  • Chapter
Chronic Obstructive Pulmonary Disease

Abstract

The pathologic changes found in the lungs of patients with COPD and in particular those who progress to respiratory failure and death are complex and show poor correlation with the clinical patterns of functional abnormalities in life [1,2].

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References

  1. Mitchell, R.S., Stanford, R., Johnson, J.M. et al. (1976) The morphologie features of the bronchi, bronchioles, and alveoli in chronic airway obstruction. A clinicopathological study. Am. Rev. Respir. Dis., 114, 137–45.

    PubMed  CAS  Google Scholar 

  2. Nagai, A., West, W.M. and Thurlbeck, W.M. (1985). The National Institutes of Health Intermittent Positive-Pressure Breathing Trial: Pathology Studies. II. Correlations between morphologic findings, clinical findings and evidence of expiratory airflow obstruction. Am. Rev. Respir. Dis., 132, 946–53.

    PubMed  CAS  Google Scholar 

  3. Linhartova, A., Anderson, A.E. and Foraker, A.G. (1974) Topology of nonrespiratory bronchioles of normal and emphysematous lungs. Hum. Pathol., 5, 729–35.

    PubMed  CAS  Google Scholar 

  4. Hogg, J.C., Macklem, P.T. and Thurlbeck, W.M. (1968) Site and nature of airway obstruction in chronic obstructive lung disease. N. Engl. J. Med., 278, 1355–60.

    PubMed  CAS  Google Scholar 

  5. Gelb, A.F., Gobel, P.H., Fairshter, R. and Zamel, N. (1981) Predominant site of airway resistance in chronic obstructive pulmonary disease. Chest, 79, 273–6.

    PubMed  CAS  Google Scholar 

  6. Miller, W.S. (1937) The Lung. Thomas, Springfield, Ill. pp. 27–37.

    Google Scholar 

  7. Murray, J.F. (1986) The Normal Lung. The Basis for Diagnosis and Treatment of Pulmonary Disease 2nd edn, Saunders, Philadelphia, pp. 43–6.

    Google Scholar 

  8. Dunnill, M.S. (1962) Post natal growth of the lung. Thorax, 17, 329–33.

    Google Scholar 

  9. Macklem, P.T. (1971) Airway obstruction and collateral ventilation. Physiol. Rev., 51, 368–436.

    PubMed  CAS  Google Scholar 

  10. Thurlbeck, W.M. (1975) Post natal growth and development of the lung. Am. Rev. Respir. Dis., 111, 803–44.

    PubMed  CAS  Google Scholar 

  11. Thurlbeck, W.M. and Angus, G.E. (1975) Growth and aging of the normal human lung. Chest, 67 (suppl): 3s–6s.

    PubMed  CAS  Google Scholar 

  12. Ciba Foundation Guest Symposium (1959) Terminology, definitions and classification of chronic pulmonary emphysema and related conditions. Thorax, 14, 286–99.

    Google Scholar 

  13. Medical Research Council (1965) Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the aetiology of chronic bronchitis. Lancet, i, 775–9.

    Google Scholar 

  14. Thurlbeck, W.M. and Angus, G.E. (1964) A distribution curve for chronic bronchitis. Thorax, 19, 436–42.

    PubMed  CAS  Google Scholar 

  15. Lamb, D. and Reid, L. (1968) Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide. J. Pathol. Bacteriol., 96, 97–111.

    PubMed  CAS  Google Scholar 

  16. Lamb, D. and Reid, L. (1969) Goblet cell increase in rat bronchiolar epithelium after exposure to cigarette and cigar smoke. Br. Med. J., i, 33–5.

    Google Scholar 

  17. Lumsden, A.B., McLean, A. and Lamb, D. (1984) Goblet and Clara cells of human distal airways: Evidence for smoking induced changes in their numbers. Thorax, 39, 844–9.

    PubMed  CAS  Google Scholar 

  18. Reid, L. (1960) Measurements of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax, 15, 132–41.

    PubMed  CAS  Google Scholar 

  19. Peto, R., Speizer, F.E., Moore, C.F. et al. (1983) The relevance in adults of airflow obstruction, but not of mucous hypersecretion to mortality from chronic lung disease. Am. Rev. Respir. Dis., 128, 491–500.

    PubMed  CAS  Google Scholar 

  20. American Thoracic Society (1962) Chronic bronchitis, asthma and pulmonary emphysema. A statement by the committee on diagnostic standards for non-tuberculous respiratory diseases. Am. Rev. Respir. Dis., 85, 762–8.

    Google Scholar 

  21. Snider, G.L., Kleinerman, J. and Thurlbeck, W.M. (1985) The definition of emphysema. Report of a National Heart, Lung and Blood Institute, Division of Lung Diseases Workshop. Am. Rev. Respir. Dis., 132, 182–5.

    Google Scholar 

  22. Reid, L. (1967) The Pathology of Emphysema. Lloyd-Luke, London, pp. 1–21.

    Google Scholar 

  23. Saetta, M., Shiner, R.J., Angus, G.E. et al. (1985) Destructive Index: A measurement of lung parenchymal destruction in smokers. Am. Rev. Respir. Dis., 131, 764–9.

    PubMed  CAS  Google Scholar 

  24. Eidelman, D.H., Ghezzo, H., Kim, W.D. and Cosio, M.G. (1991) The destructive index and early lung destruction in smokers. Am. Rev. Respir. Dis., 144, 156–9.

    PubMed  CAS  Google Scholar 

  25. Thurlbeck, W.M. (1976) Chronic airflow obstruction in lung disease. In Major Problems in Pathology. Series No. 5, (ed. J.L. Bennington) Saunders, Philadelphia.

    Google Scholar 

  26. Mitchell, R.S., Silvers, G.W., Goodman, N. et al. (1970) Are centrilobular and panlobular emphysema two different diseases? Hum. Pathol., 1, 433–41.

    PubMed  CAS  Google Scholar 

  27. Pratt, P.C. and Kilburn, K.H. (1970) A modern concept of the emphysemas based on correlations of structure and function. Hum. Pathol., 1, 443–53.

    PubMed  CAS  Google Scholar 

  28. Anderson, A.E. and Foraker, A.G. (1973) Centrilobular and panlobular emphysema: two different diseases. Thorax, 28, 547–50.

    PubMed  Google Scholar 

  29. Thurlbeck, W.M. (1963) The incidence of pulmonary emphysema with observations on the relative incidence and spatial distribution of various types of emphysema. Am. Rev. Respir. Dis., 87, 206–15.

    PubMed  CAS  Google Scholar 

  30. Gillooly, M. and Lamb, D. (1993) Cigarette smoking and the susceptibility to microscopic emphysema. Thorax, 48, 445.

    Google Scholar 

  31. Gillooly, M. and Lamb, D. (1993) The relationship between centriacinar emphysema and microscopically assessed emphysema. Am. Rev. Respir. Dis., 147 (suppl.), A864.

    Google Scholar 

  32. Kim, W.D., Eidelman, D.H., Izquierdo, J.L. et al. (1991) Centrilobular and panlobular emphysema in smokers. Two distinct morphologic and functional entities. Am. Rev. Respir. Dis., 144, 1385–90.

    PubMed  CAS  Google Scholar 

  33. Dunnill, M.S. (1962) Quantitative methods in the study of pulmonary pathology. Thorax, 17, 320–9.

    Google Scholar 

  34. Heard, B.E. (1960) Pathology of pulmonary emphysema. Methods of study. Am. Rev. Respir. Dis., 82, 792–99.

    PubMed  CAS  Google Scholar 

  35. Thurlbeck, W.M., Horowitz, I., Siemiatycki, J. et al. (1969) Intra-and interobserver variations in the assessment of emphysema. Arch. Environ. Health, 18, 646–59.

    PubMed  CAS  Google Scholar 

  36. Thurlbeck, W.M., Dunnill, M.S., Hartung, W. et al. (1970) A comparison of three methods of measuring emphysema. Hum. Pathol., 1, 215–26.

    PubMed  CAS  Google Scholar 

  37. Thurlbeck, W.M. (1988) Chronic airflow obstruction. In Pathology of the Lung (ed. W.M. Thurlbeck) Thieme, New York, pp. 538–75.

    Google Scholar 

  38. Dunnill, M.S. (1970) The recognition and measurement of pulmonary emphysema. Path. Microbiol., 35, 138–45.

    CAS  Google Scholar 

  39. Thurlbeck, W.M. (1967) The internal surface area of non-emphysematous lungs. Am. Rev. Respir. Dis., 95, 765–73.

    PubMed  CAS  Google Scholar 

  40. Gillooly, M., Lamb, D. and Farrow, A.S.J. (1991) A new automated technique for the assessment of emphysema on histological sections. J. Clin. Pathol, 44, 1007–11.

    PubMed  CAS  Google Scholar 

  41. Aherne, W.A. and Dunnill, M.S. (1982) Morphometry, Arnold, London.

    Google Scholar 

  42. Gould, G.A., MacNee, W.M., McLean, A. et al. (1988) CT measurements of lung density in life can quantitate distal air space enlargement — an essential defining feature of human emphysema. Am. Rev. Respir. Dis., 137, 380–92.

    PubMed  CAS  Google Scholar 

  43. McLean, A., Warren, P.M., Gillooly, M. et al. (1992) Microscopic and macroscopic measurements of emphysema: relation to carbon monoxide gas transfer. Thorax, 47, 144–9.

    PubMed  CAS  Google Scholar 

  44. Gillooly, M. and Lamb, D. (1993) Airspace size in lungs of life long non-smokers: effect of age and sex. Thorax, 48, 39–43.

    PubMed  CAS  Google Scholar 

  45. Gillooly, M. and Lamb, D. (1993) Microscopic emphysema in relation to age and smoking habit. Thorax, 48, 491–5.

    PubMed  CAS  Google Scholar 

  46. Linhartova, A., Anderson, A.E. and Foraker, A.G. (1971) Radial traction and bronchiolar obstruction in pulmonary emphysema. Arch. Pathol., 92, 384–91.

    PubMed  CAS  Google Scholar 

  47. Linhartova, A., Anderson, A.E. and Foraker, A.G. (1974) Topology of nonrespiratory bronchioles of normal and emphysema tous lungs. Hum. Pathol., 5, 729–35.

    PubMed  CAS  Google Scholar 

  48. Linhartova, A., Anderson, A.E. and Foraker, A.G. (1982) Affixment arrangements of per-bronchiolar alveoli in normal and emphysematous lungs. Arch. Pathol. Lab. Med., 106, 499–502.

    PubMed  CAS  Google Scholar 

  49. Niewoehner, D.E., Kleinerman, J. and Rice, D.B. (1974) Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med., 291, 755–8.

    PubMed  CAS  Google Scholar 

  50. Myers, J.L., Weil, C.F., Shin, M.S. et al. (1987) Respiratory bronchiolitis causing interstitial lung disease: a clinicopathological study of 6 cases. Am. Rev. Resp. Dis., 135, 880–4.

    PubMed  CAS  Google Scholar 

  51. Lang, M.R., Fiaux, G.W., Hulmes, D.J.S. et al. (1993) Quantitative studies of human lung airspace wall in relation to collagen and elastin content. Matrix, 13, 471–80.

    PubMed  CAS  Google Scholar 

  52. Lang, M.R., Fiaux, G.W., Gillooly, M. et al. (1993) Alveolar collagen in non-emphysematous and emphysematous lungs. Am. Rev. Respir. Dis., 147 (suppl.), A864.

    Google Scholar 

  53. Cardoso, W.V., Sekhon, H.S., Hyde, D.M. and Thurlbeck, W.M. (1993) Collagen and elastin in human pulmonary emphysema. Am. Rev. Respir. Dis., 147, 975–81.

    PubMed  CAS  Google Scholar 

  54. Nagai, A. and Thurlbeck, W.M. (1991) Scanning electron microscopic observations of emphysema in humans. Am. Rev. Respir. Dis., 144, 901–8.

    PubMed  CAS  Google Scholar 

  55. Thurlbeck, W.M. and Simon, G. (1978) Radiographic appearance of the chest in emphysema. Am. J. Radiol., 130, 429–40.

    CAS  Google Scholar 

  56. MacNee, W., Gould, G. and Lamb, D. (1991) Quantifying emphysema by CT scanning. Clinicopathologic correlations. Ann. N.Y. Acad. Sci., 624, 179–94.

    PubMed  CAS  Google Scholar 

  57. Murata, K., Itoh, H., Todo, G. et al. (1986) Centrilobular lesions of the lung. Demonstration by high resolution CT and pathologic correlation. Radiology, 161, 641–5.

    PubMed  CAS  Google Scholar 

  58. Moudgil, H., Morrison, D., Skevarski, K. et al. (1993) Change in CT lung density. Measurement of microscopic emphysema with age. Thorax, 48, 1075.

    Google Scholar 

  59. Heremans, A., Verschakelen, J.A., Fraeyenhoven, L. and van Demedts, M. (1992) Measurement of lung density by means of quantitative CT scanning. A study of correlations with pulmonary function tests. Chest, 102, 805–11.

    PubMed  CAS  Google Scholar 

  60. Colby, T.V. and Myers, J.L. (1992) The clinical and histological spectrum of bronchiolitis obliterans including bronchiolitis obliterans organising pneumonia (BOOP). Semin. Respir. Med., 13, 119–33.

    Google Scholar 

  61. Wright, J.L., Cargel, P., Churg, A. et al. (1992) State of the art. Diseases of the small airway. Am. Rev. Respir. Dis., 140, 240–62.

    Google Scholar 

  62. Woodford, D.M., Coutu, R.E. and Gaensler, E.A. (1979) Obstructive lung disease from acute sulphur dioxide exposure. Respiration, 38, 238–45.

    PubMed  CAS  Google Scholar 

  63. Burke, C.M., Theodore, J., Dawkins, K.D. et al. (1984) Post transplant obliterative bronchiolitis and other late lung sequelae in human heart lung transplantation. Chest, 86, 824–9.

    PubMed  CAS  Google Scholar 

  64. Theodore, J., Starnes, B.A. and Lewiston, N.J. (1990) Obliterative bronchiolitis. Clin. Chest Med., 11, 309–21.

    PubMed  CAS  Google Scholar 

  65. Epier, G.R. (1988) Bronchiolitis obliterans and airways obstruction associated with graft versus host disease. Clin. Chest Med., 9, 551–6.

    Google Scholar 

  66. Geddes, D.M., Webley, M. and Emerson, P.A. (1979) Airways obstruction in rheumatoid arthritis. Ann. Rheum. Dis., 38, 222–5.

    PubMed  CAS  Google Scholar 

  67. Reid, L.M. (1950) Reduction in bronchiolar subdivision in bronchiectasis. Thorax, 5, 233–47.

    PubMed  Google Scholar 

  68. Cosio, M.G., Ghezzo, H., Hogg, J.C. et al. (1978) The relations between structural changes in small airways and pulmonary function tests. N. Engl. J. Med., 298, 1277–81.

    PubMed  CAS  Google Scholar 

  69. Wright, J.L., Cosio, M., Wiggs, B. and Hogg, J.C. (1985) A morphologic grading scheme for membranous and respiratory bronchioles. Arch. Pathol. Lab. Med., 109, 163–5.

    PubMed  CAS  Google Scholar 

  70. Nagai, A., West, W.W., Paul, J.L. and Thurlbeck, W.M. (1985) The National Institutes of Health Positive Pressure Breathing Trial: Pathology studies. 1. Inter-relationship between morphologic lesions. Am. Rev. Respir. Dis., 132, 937–45.

    PubMed  CAS  Google Scholar 

  71. Ryder, R., Dunnill, M.S. and Anderson, J.A. (1971) A quantitative study of bronchial mucous gland volume, emphysema and smoking in a necropsy population. J. Pathol., 104, 59–71.

    PubMed  CAS  Google Scholar 

  72. Greaves, I.A. and Colebatch, H.J.H. (1986) Observations on the pathogenesis of chronic airflow obstruction in smokers: implications for the detection of ‘early’ lung disease. Thorax, 41, 81–7.

    PubMed  CAS  Google Scholar 

  73. Matsuba, K. and Thurlbeck, W.M. (1971) The number and dimensions of small airways in non-emphysematous lungs. Am. Rev. Respir. Dis., 104, 516–24.

    PubMed  CAS  Google Scholar 

  74. Matsuba, K. and Thurlbeck, W.M. (1972) The number and dimensions of small airways in emphysematous lungs. Am. J. Pathol., 67, 265–75.

    PubMed  CAS  Google Scholar 

  75. Linhartova, A., Anderson, A.E. and Foraker, A.G. (1973) Non-respiratory bronchiolar deformities. Arch. Pathol., 95, 45–8.

    PubMed  CAS  Google Scholar 

  76. Petty, T.L., Silvers, G.W. and Stanford, R.E. (1986) Radial traction and small airways disease in excised human lungs. Am. Rev. Respir. Dis., 133, 132–5.

    PubMed  CAS  Google Scholar 

  77. Saetta, M., Ghezzo, H., Kim, W.D. et al. (1985) Loss of alveolar attachments in smokers. A morphometric correlate of lung function impairment. Am. Rev. Respir. Dis., 132, 894–900.

    PubMed  CAS  Google Scholar 

  78. Lamb, D., McLean, A., Gillooly, M. et al. (1993) Relation between distal airspace size, bronchiolar attachments and lung function. Thorax, 48, 1012–7.

    PubMed  CAS  Google Scholar 

  79. Nagai, A., Yamawaki, I., Takizawa, T. and Thurlbeck, W.M. (1991) Alveolar attachments in emphysema of human lungs. Am. Rev. Respir. Dis., 144, 888–91.

    PubMed  CAS  Google Scholar 

  80. Buist, A.S. and Ross, B.B. (1973) Quantitative analysis of the alveolar plateau in the diagnosis of early airway obstruction. Am. Rev. Respir. Dis., 108, 1078–87.

    PubMed  CAS  Google Scholar 

  81. Thurlbeck, W.M., Henderson, J.A., Fraser, R.G. and Bates, D.V. (1970) Chronic obstructive lung disease. Medicine, 49, 81–145.

    Google Scholar 

  82. Paré, P.D., Brooks, L.A., Bates, J. et al. (1982) Experimental analysis of the lung pressure-volume curve as a predictor of pulmonary emphysema. Am. Rev. Respir. Dis., 126, 54–61.

    PubMed  Google Scholar 

  83. Berend, N., Skoog, C. and Thurlbeck, W.M. (1980) Pressure-volume characteristics of excised human lungs: effects of sex, age and emphysema. J. Appl. Physiol., Respirat. Environ. Exercise Physiol., 49, 558–65.

    CAS  Google Scholar 

  84. Silvers, G.W., Petty, T.L. and Stanford, R.E. (1980) Elastic recoil changes in early emphysema. Thorax, 35, 490–5.

    PubMed  CAS  Google Scholar 

  85. Petty, T.L., Silvers, G.W. and Stanford, R.E. (1981) Functional correlations with mild and moderate emphysema in excised human lung. Am. Rev. Respir. Dis., 124, 700–4.

    PubMed  CAS  Google Scholar 

  86. Wright, J.L., Wiggs, B.J. and Hogg, J.C. (1984) Airway disease in upper and lower lobes in lungs of patients with and without emphysema. Thorax, 39, 282–5.

    PubMed  CAS  Google Scholar 

  87. Berend, N., Woolcock, A.J. and Martin, G.E. (1978) Correlation between the function and structure of the lung in smokers. Am. Rev. Respir. Dis., 119, 695–705.

    Google Scholar 

  88. Wright, J.L., Hobson, J., Wiggs, B.R. et al. (1987) Effect of cigarette smoking on structure of the small airways. Lung, 165, 91–100.

    PubMed  CAS  Google Scholar 

  89. Cosio, M.G., Hale, K.A. and Niewoehner, D.E. (1980) Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am. Rev. Respir. Dis., 122, 265–71.

    PubMed  CAS  Google Scholar 

  90. Bosken, C.H., Wiggs, B.R., Paré, P.D. and Hogg, J.C. (1990) Small airway dimensions in smokers with obstruction to airflow. Am. Rev. Respir. Dis., 142, 563–70.

    PubMed  CAS  Google Scholar 

  91. Matsuba, K., Wright, J.L., Wiggs, B.R. et al. (1989) The changes in airways structure associated with reduced forced expiratory volume in one second. Eur. Respir. J., 2, 834–9.

    PubMed  CAS  Google Scholar 

  92. Fletcher, C.M., Peto, R., Tinker, C.M. et al. (1976) The Natural History of Chronic Bronchitis and Emphysema. Oxford University Press, Oxford.

    Google Scholar 

  93. Gillooly, M. and Lamb, D. (1993) The effect of age on the alveolar support of peripheral bronchioles in non-smokers. Am. Rev. Respir. Dis., 147 (suppl), A864.

    Google Scholar 

  94. Calverley, P.M., Howatson, R., Flenley, D.C. and Lamb, D. (1992) Clinicopathological correlations in cor pulmonale. Thorax, 47, 494–8.

    PubMed  CAS  Google Scholar 

  95. Burrows, B., Fletcher, C.M., Heard, B.E. et al. (1966). The emphysematous and bronchial types of chronic airways obstruction. Lancet, i, 830–5.

    Google Scholar 

  96. Flenley, D.C. (1986) Long term oxygen therapy and the pulmonary circulation. In: Aspects of Hypoxia (ed. D. Heath), Liverpool University Press, Liverpool, pp. 45–59.

    Google Scholar 

  97. Samet, J.M., Humble, C.G. and Pathak, D.R. (1986) Personal and family history of respiratory disease and lung cancer risk. Am. Rev. Respir. Dis., 134, 466–70.

    PubMed  CAS  Google Scholar 

  98. Skillrid, D.M., Offord, K.P. and Miller R.D. (1986) Higher risk of lung cancer in chronic pulmonary disease: a prospective matched case-control study. Ann. Intern. Med., 105, 503–7.

    Google Scholar 

  99. Fishman, A.P. (1976) Hypoxia on the pulmonary circulation: how and where it acts. Circ. Res., 38, 221–31.

    PubMed  CAS  Google Scholar 

  100. Sylvester, J.T., Gottlieb, J.E., Rock, P. and Wetzel, R.C. (1986) Acute hypoxic responses. In: Abnormal Pulmonary Circulation (ed. E.H. Bergofsky), Churchill Livingstone, Edinburgh, pp. 127–65.

    Google Scholar 

  101. Hazelton, P.S., Heath, D. and Brewer, D.B. (1968) Hypertensive pulmonary vascular disease in states of chronic hypoxia. J. Pathol. Bacteriol., 95, 431–40.

    Google Scholar 

  102. Hicken, P., Heath, D., Brewer, D.B. and Whitaker, W. (1965) The small pulmonary arteries in emphysema. J. Pathol. Bacteriol., 90, 107–14.

    PubMed  CAS  Google Scholar 

  103. Wagenvoort, C.A. and Wagenvoort, N. (1973) Hypoxic pulmonary vascular lesion in man at high altitude and in patients with chronic respiratory diseases. Pathol. Microbiol., 39, 276.

    CAS  Google Scholar 

  104. Hale, K.A., Niewoehner, D.E. and Cosio, M.G. (1980) Morphologic changes in the muscular pulmonary arteries: Relationship to cigarette smoking, airway disease and emphysema. Am. Rev. Respir: Dis., 122, 273–8.

    CAS  Google Scholar 

  105. Fernie, J.M., McLean, A. and Lamb, D. (1988) Significant intimai abnormalities in muscular pulmonary arteries of patients with early obstructive lung disease. J. Clin. Pathol., 41, 730–3.

    PubMed  CAS  Google Scholar 

  106. Fernie, J.M. and Lamb, D. (1985) New method for quantitating the medial component of pulmonary arteries. Arch. Pathol. Lab. Med., 109, 843–8.

    PubMed  CAS  Google Scholar 

  107. Fernie, J.M. and Lamb, D. (1985) New method for measuring intimai component of pulmonary arteries. J. Clin. Pathol., 38, 1374–9.

    PubMed  CAS  Google Scholar 

  108. Fernie, J.M. and Lamb, D. (1988) Assessment of the effects of age and smoking on the media of the muscular pulmonary arteries. J. Pathol, 155, 241–6.

    PubMed  CAS  Google Scholar 

  109. Fulton, R.M., Hutchinson, E.C. and Jones, A.M. (1952) Ventricular weight in cardiac hypertrophy. Br. Heart J., 14, 413–20.

    PubMed  CAS  Google Scholar 

  110. Lamb, D. (1973) Heart weight and assessment of ventricular hypertrophy. In: Recent Advances in Clinical Pathology, Series 6 (ed. S.C. Dyke), Churchill Livingstone, Edinburgh, pp. 133–48.

    Google Scholar 

  111. Heath, D., Smith, P. and Jago, R. (1982) Hyperplasia of the carotid body. J. Pathol., 138, 115–27.

    PubMed  CAS  Google Scholar 

  112. Bee, D. and Howard, P. (1993) The carotid body: a review of its anatomy, physiology and clinical importance. Monaldi Arch. Chest. Dis., 48, 48–53.

    PubMed  CAS  Google Scholar 

  113. Campbell, J.L., Calverley, P.M.A., Lamb, D. and Flenley, D.C. (1982) The renal glomerulus in hypoxic cor pulmonale. Thorax, 37, 607–11.

    PubMed  CAS  Google Scholar 

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  1. D. Lamb
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Editors and Affiliations

  1. Aintree Chest Clinic, Regional Thoracic Unit, Fazakerley Hospital, Longmoor Lane, Liverpool, L9 7AL, UK

    P. M. A. Calverley (Consultant Physician, Senior Fellow) (Consultant Physician, Senior Fellow)

  2. Department of Medicine, University of Liverpool, UK

    P. M. A. Calverley (Consultant Physician, Senior Fellow) (Consultant Physician, Senior Fellow)

  3. Department of Medicine, (Respiratory Division), Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

    N. B. Pride (Consultant Physician, Professor of Respiratory Medicine) (Consultant Physician, Professor of Respiratory Medicine)

  4. Royal Postgraduate Medical School, London, UK

    N. B. Pride (Consultant Physician, Professor of Respiratory Medicine) (Consultant Physician, Professor of Respiratory Medicine)

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Lamb, D. (1995). Pathology. In: Calverley, P.M.A., Pride, N.B. (eds) Chronic Obstructive Pulmonary Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4525-9_2

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