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The genetics of familial colon cancer

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Genetic Predisposition to Cancer

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Abstract

In developed countries, colorectal cancer is the second most common cause of death due to malignancy after lung cancer in males and third most common after lung and breast cancer in females. In the UK this manifests as a death rate due to colorectal cancer of more than 20 000 annually. Understanding the fundamental molecular genetic basis of colorectal carcinogenesis may allow the development of novel treatment approaches and may also lead to the identification of those who are at high risk of developing the disease when intensive screening combined with prophylactic surgery or drug therapy can be undertaken. In addition, colorectal carcinogenesis provides a model system in which to study the molecular events involved in the development of a number of epithelial cancers and may lead to an understanding of genetic predisposition to these common diseases.

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Authors
  1. Susan M. Farrington
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  2. Malcolm G. Dunlop
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Editors and Affiliations

  1. Cancer Genetics and Clinical Oncology, Institute of Cancer Research and Royal Marsden Hospital, Surrey, UK

    Rosalind A. Eeles (Senior Lecturer and Honorary Consultant) (Senior Lecturer and Honorary Consultant)

  2. CRC Human Cancer Genetics Research Group, University of Cambridge, UK

    Bruce A. J. Ponder (Director) (Director)

  3. CRC Genetic Epidemiology Unit, University of Cambridge, UK

    Douglas F. Easton (Director) (Director)

  4. Academic Unit of Radiotherapy and Oncology, Institute of Cancer Research and Royal Marsden Hospital, Surrey, UK

    Alan Horwich (Director of Clinical Research) (Director of Clinical Research)

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© 1996 Springer Science+Business Media Dordrecht

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Farrington, S.M., Dunlop, M.G. (1996). The genetics of familial colon cancer. In: Eeles, R.A., Ponder, B.A.J., Easton, D.F., Horwich, A. (eds) Genetic Predisposition to Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4501-3_21

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  • DOI: https://doi.org/10.1007/978-1-4899-4501-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-56580-9

  • Online ISBN: 978-1-4899-4501-3

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