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The genetics of schizophrenia

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Schizophrenia

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Abstract

Schizophrenia has traditionally tended to occupy a special position in the nature versus nurture debate. The suggestion that genes could influence a disorder such as schizophrenia has aroused apprehension in some quarters (Rose et al., 1984): perhaps this has been because of the idea that if a disease is substantially ‘genetic’ then there is the implication that it is untreatable. Perhaps apprehension has also arisen because a genetic hypothesis for schizophrenia conflicts with ideologically attractive notions of self determination of the mind. However, not all political commentators on schizophrenia have chosen to view schizophrenia as a product of the environment: for example, Sedgwick (1976) argues strongly in favour of a medical model and that better resources for the mentally ill and better psychiatry are needed. Foucault argues that we may not be able to define ‘normality’ of the mind without first understanding and defining madnesses such as schizophrenia (Foucault, 1976).

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References

  • Andrew, B., Watt, D.C., Gillespie, C. and Chapel, H. (1987) A study of genetic linkage in schizophrenia. Psychol. Med., 17, 363–70.

    Article  PubMed  CAS  Google Scholar 

  • Axelsson, R. and Wahlstrom, J. (1981) Mental Disorder and Inversion on Chromosome 9. Hereditas, 95, 337.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M. (1976) Albinism and Schizophreniform Psychosis, a Pedigree Study. Am. J. Psychiatry, 133, 1070–2.

    PubMed  CAS  Google Scholar 

  • Baron, M. (1977) Linkage Between an Chromosome Marker (Deuxan Colour Blindness) and Affective Illness. Arch. Gen. Psychiatry, 24, 721–7.

    Article  Google Scholar 

  • Baron, M. (1986) Genetics of schizophrenia: II. Vulnerability Traits and Gene Markers. Biol. Psychiatry, 21, 1189–211.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M., Gruen, R., Asnis, L. and Kane, J. (1982) Schizoaffective Illness, Schizophrenia and Affective Disorders, Morbidity Risks and Genetic Transmission. Acta Psychiatr. Scand., 65, 253–62.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M., Asnis, L., Gruen, R. and Levitt, M. (1983) Plasma Amine Oxidase and Genetic Vulnerability to Schizophrenia. Arch. Gen. Psychiatry, 40, 275–9.

    Article  PubMed  Google Scholar 

  • Baron, M., Gruen, R., Levitt, M. et al. (1984) Erythrocyte Catechol O-Methyltransferase Activity in Schizophrenia: Analysis of Family Data. Am. J. Psychiatry, 1418, 29–32.

    Google Scholar 

  • Baron, M., Gruen, R., Rainer, J.D. et al. (1985) A Family Study of Schizophrenic and Normal Control Probands. Am. J. Psychiatry, 142, 447–55.

    PubMed  CAS  Google Scholar 

  • Baron, M., and Risch, N. (1987) The Spectrum Concept of Schizophrenia, Evidence for a Genetic-Environmental Continuum. J. Psychiatr. Res., 21, 257–68.

    Article  PubMed  CAS  Google Scholar 

  • Baron, M., Risch, N., Hamburger, R. et al. (1987) Genetic Linkage between X. Chromosome Markers and Bipolar Affective Disorder, Nature, 326, 289–92.

    Article  PubMed  CAS  Google Scholar 

  • Bassett, A.S. (1989) Chromosome 5 and Schizophrenia: Implications for Genetic Linkage Studies, Schizophr. Bull., 15, 393–402.

    Article  PubMed  CAS  Google Scholar 

  • Bassett, A.S., McGillivray, B.C., Jones, B. et al. (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet, 8589, 799–801.

    Article  Google Scholar 

  • Blackwood, D.H.R., Whalley, L.J. and Christie, J.E. (1987) Changes in P3 Auditory Evoked Potential in Schizophrenia and Depression. Br. J. Psychiatry, 150, 154–60.

    Article  PubMed  CAS  Google Scholar 

  • Bohman, M. (1978) Some genetic aspects of alcoholism and criminality. Arch. Gen. Psychiatry, 35, 269–76.

    Article  PubMed  CAS  Google Scholar 

  • Bunzow, J.R., Van Tol, H.H.M., Grandy, D.K. et al. (1988) Cloning and Expression of a Rat D2 Dopamine Receptor cDNA. Nature, 336, 783–5.

    Article  PubMed  CAS  Google Scholar 

  • Chodirker, B., Chudley, A., Ray, M. et al. (1987) Fragile 19p13 in a Family with Mental Illness. Clin. Genet. 31, 1–6.

    Article  PubMed  CAS  Google Scholar 

  • Crow, T.J. (1980) Molecular Pathology of Schizophrenia; More than One Disease Process. Br. Med. J., 1, 66–8.

    Article  Google Scholar 

  • Crow, T.J. (1986) The Continuum of Psychosis and its Implication for the Structure of the Gene. Br. J. Psychiatry, 149, 419–29.

    Article  PubMed  CAS  Google Scholar 

  • Crow, T.J. (1988) Sex Chromosomes and Psychosis. Br. J. Psychiatry, 153, 675–83.

    Article  PubMed  CAS  Google Scholar 

  • Dasgupta, J., Dasgupta, D. and Balasubrahmanyan, M. (1973) XXY Syndrome XY/XO Mosaicisms and Acentric Chromosomal Fragments in Male Schizophrenics. Ind. J. Med. Res., 61, 62–70.

    CAS  Google Scholar 

  • Delisi, L.E., Goldin, L.R., Maxwell, L.W. et al. (1987) Clinical Features of Illness in Siblings with Schizophrenia or Schizoaffective Disorder. Arch. Gen. Psychiatry, 44, 891–7.

    Article  PubMed  CAS  Google Scholar 

  • Del Zompo, M., Brochetta, A., Goldin, L.R. and Corsini, G.U. (1984) Linkage Between X Chromosome Markers and Manic Depressive Illness: Two Sardinian Pedigrees. Acta Psychiatr. Scand., 70, 282–7.

    Article  PubMed  Google Scholar 

  • Detera-Wadleigh, S.D., Goldin, L.R., Sherrington, R. et al. (1989) Exclusion of Linkage to 5q11–13 in Families with Schizophrenia and Other Psychiatric Disorders. Nature, 340, 391–3.

    Article  PubMed  CAS  Google Scholar 

  • Donis-Keller, H., Green, P., Helms, C. and Cartinhour, S. (1987) A Genetic Linkage Map of the Human Genome. Cell, 51, 319–37.

    Article  PubMed  CAS  Google Scholar 

  • Dworkin, R.H. and Lenzenweger, M.F. (1984) Symptoms and Genetics of Schizophrenia, Implications for Diagnosis. Am. J. Psychiatry, 141, 1541–5.

    PubMed  CAS  Google Scholar 

  • Elston, R.C., Kringlen, E. and Namboodiri, K.K. (1973) Possible Linkage Relationship between Certain Blood Groups and Schizophrenia. Behav. Genet., 3, 101–6.

    Article  PubMed  CAS  Google Scholar 

  • Farmer, A.E., McGuffin, P. and Gottesman, I.I. (1987) Twin Concordance for DSM-111 Schizophrenia. Arch. Gen. Psychiatry, 44, 634.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, M.W. and Cavalli-Sforza, L.L. (1977) The evolution of continuous variation. II. Complex transmission and assortative mating. Theor. Popul. Biol, 11, 161–81.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, M.W. and Cavalli-Sforza, L.L. (1979) Aspects of variance and covariance analysis with cultural inheritance. Theor. Popul. Biol., 15, 276–307.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, M. (1971) Psychoses in the Offspring of Schizophrenic Monozygotic Twins and their Normal Co-twins. Br. J. Psychiatry, 118, 43–52.

    Article  PubMed  CAS  Google Scholar 

  • Foucault, M. (1976) Mental Illness and Psychology. Harper Colophon, New York.

    Google Scholar 

  • Frangos, E. and Athenassenas, G. (1985) Prevalence of DSM HI Schizophrenia Among First Degree Relatives of Schizophrenic Probands. Acta Psychiatr. Scand., 72, 382–6.

    Article  PubMed  CAS  Google Scholar 

  • Fulker, D.W. (1973) A Biometrical Genetic Approach to Intelligence and Schizophrenia. Soc. Biol., 20, 266–75.

    PubMed  CAS  Google Scholar 

  • Gershon, E.S., Targum, S.D., Matthyse, S. and Bunney, W.E. (1979) Color blindness not Closely Linked to Bipolar Illness. Arch. Gen. Psychiatry, 36, 1423.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, V., Green, R., Whybrown, P. and Jackson, L. (1974) X linkage revisited, a further study of manic depression. Arch. Gen. Psychiatry, 31, 665–72.

    Article  PubMed  CAS  Google Scholar 

  • Gottesman, I.I. and Bertlesen, A. (1988) Personal Communication, Cold Spring Harbor Meeting on the Genetics of Schizophrenia.

    Google Scholar 

  • Gottesman, I.I. and Shields, J. (1972) Schizophrenia and Genetics, A Twin Study Vantage Point. Academic Press, London.

    Google Scholar 

  • Gottesman, I.I., and Shields, J. (1976) Critical Review of Recent Adoption, Twin and Family Studies. Schizophr. Bull., 21, 360–364.

    Article  Google Scholar 

  • Gottesman, I.I. and Shields, J. (1982) Schizophrenia, The Epigenetic Puzzle. Cambridge University Press, Cambridge.

    Google Scholar 

  • Gurling, H.M.D. (1986) Candidate Genes and Favoured Loci. Psychiatr. Dev., 4, 289–309.

    PubMed  CAS  Google Scholar 

  • Gurling, H.M.D., Read, T., Sherrington, R. et al. (1989) Recent and Future Molecular Genetic Research into Schizophrenia. Schizophr. Bull., 15, 373–82.

    Article  PubMed  CAS  Google Scholar 

  • Gurling, H.M.D., Sherrington, R., Brynjolfsson, J. et al. (1988) Genetic Linkage Studies of Schizophrenia Using the M13, 33.15 and 33.6 Hypervariable DNA Polymorphisms. In: A Genetic Perspective for Schizophrenia and Related Disorders, E. Smeraldi and K. Kidd, (eds), Edi-Hermes, Milan, pp. 43–8.

    Google Scholar 

  • Henderson, N. (1982) Behaviour genetics. Ann. Rev. Psychol., 33, 403–40.

    Article  CAS  Google Scholar 

  • Hodgkinson, S., Sherrington, R., Gurling, H.M.D. et al. (1987) Molecular Genetic Evidence for Heterogeneity in Manic Depression. Nature, 325, 805–6.

    Article  PubMed  CAS  Google Scholar 

  • Holmes, D., Sherrington, R.P., Hodgkinson, S. et al. (1989) Linkage Analysis in Manic Depression Families Identifies a Non 11p/nonX Type. Am. J. Hum. Genet. 45, A195.

    Google Scholar 

  • Holzman, P.S. (1985) Eye Movement Dysfunction and Psychosis. Int. Rev. Neurobiol. 27, 179–205.

    Article  PubMed  CAS  Google Scholar 

  • Holzman, P.S., Kringlen, E., Mattysse, S. et al. (1988) A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins. Arch. Gen. Psychiatry, 45, 641–7.

    Article  PubMed  CAS  Google Scholar 

  • Hong, M.L. (1986) Pericentric Inversions of Chromosome 9 in Patients and Controls, Chin. J. Neurol. Psychiatry, 19, 188–91.

    CAS  Google Scholar 

  • Johnstone, E.C., Crow, T.J., Frith, C.D. et al. (1976) Cerebral Ventricle Size and Cognitive Impairment in Chronic Schizophrenia. Lancet, ii, 924–6.

    Article  Google Scholar 

  • Kane, J.M., Honigfeld, G., Singer, J. and Meltzer, H. (1988) Clozapine in Treatment Resistant Schizophrenics. Arch. Gen. Psychiatry, 15, 789–96.

    Article  Google Scholar 

  • Kaplan, A. (1970) Chromosomal Mosaicisms and Occasional Acentric Chromosomal Fragments in Schizophrenic Patients. Biol. Psychiatry, 2, 89–94.

    PubMed  CAS  Google Scholar 

  • Karlsson, J.L. (1988) Partly Dominant Transmission of Schizophrenia in Iceland. Br. J. Psychiatry, 152, 324–9.

    Article  PubMed  CAS  Google Scholar 

  • Keefe, R.S.E, Mohs, R.C., Losonczy, M.F. et al. (1987) Characteristics of Very Poor Outcome Schizophrenia. Am. J. Psychiatry, 144, 889–94.

    PubMed  CAS  Google Scholar 

  • Kendler, K.S. (1983) Overview: A Current Perspective on Twin Studies of Schizophrenia. Am. J. Psychiatry, 140, 1413–25.

    PubMed  CAS  Google Scholar 

  • Kendler, K. (1986) The Feasibility of Linkage Studies in Schizophrenia. Dahlem Konferenzen, Biological Perspectives in Schizophrenia. Dahlem Foundation-Wallostr., 10, 1000 Berlin 33.

    Google Scholar 

  • Kendler, K.S. and Hays, P. (1981) Paranoid Psychosis and Schizophrenia. Arch. Gen. Psychiatry, 38, 547–51.

    Article  PubMed  CAS  Google Scholar 

  • Kendler, K.S. and Greunberg, A.M. (1984) An Independent Analysis of the Danish Adoption Study of Schizophrenia. Arch. Gen. Psychiatry, 41, 982–4.

    Google Scholar 

  • Kendler, K.S. Gruenberg, A.M. and Strauss, J.S. (1984) An Independent Analysis of the Copenagen Sample of the Danish Adoption Study of Schizophrenia. Arch. Gen. psychiatry, 38, 392–9.

    Google Scholar 

  • Kendler, K.S, Gruenberg, A.M. and Tsuang, M.T. (1985) Psychiatric Illness in First Degree Relatives of Schizophrenic and Surgical Control Patients. Arch. Gen. Psychiatry, 42, 770–9.

    Article  PubMed  CAS  Google Scholar 

  • Kendler, K.S., Gruenberg, A.M. and Tsuang, M.T. (1986) A DSM-III Family Study of Non Schizophrenic Psychotic Disorders. Am. J. Psychiatry, 143, 1098–105.

    PubMed  CAS  Google Scholar 

  • Kendler, K.S., Gruenberg, A.M. and Tsuang, M.T. (1988) A Family Study of the Subtypes of Schizophrenia. Am. J. Psychiatry, 45, 57–62.

    Google Scholar 

  • Kennedy, J.L., Giuffa, L.A., Moises, H.W. et al. (1988) Evidence Against Linkage of Schizophrenia to Markers on Chromosome 5 in a Northern Swedish Pedigree. Nature, 336, 167–70.

    Article  PubMed  CAS  Google Scholar 

  • Kety, S.S. (1983) Mental Illness in the Biological and Adoptive Relatives of Schizophrenic Adoptees. Am. J. Psychiatry, 140, 720–7.

    PubMed  CAS  Google Scholar 

  • Kety, S.S., Rosenthal, D. and Wender, P.H. (1968) Mental Illness in the Biological and Adoptive Relatives of Adopted Schizophrenics. J. Psychiatr. Res., 6, 345–62.

    Article  Google Scholar 

  • Kety, S.S., Rosenthal, D. and Wender, P.H. (1975) Mental Illness in the Biological and Adoptive Families of Adopted Individuals who have become Schizophrenic. In Genetic Research in Psychiatry. R.R. Fieve, N. Rosenthal and H. Brill (eds), Johns Hopkins University Press, Baltimore, pp. 95–105.

    Google Scholar 

  • Lalouel, J.M., Rao, D.C., Morton, N.E. and Elston, R.C. (1983) A Unified Model of Complex Segregation Analysis. Am. J. Hum. Genet., 35, 816–26.

    PubMed  CAS  Google Scholar 

  • Lange, K. (1982) Genetic Markers for Schizophrenia Subgroups. Psychiatr. Clin., 15, 133–44.

    CAS  Google Scholar 

  • Lange, K. and Boehnke, M. (1982) How Many Polymorphic Genes will it Take to Span the Human Genome? Am. J. Hum. Genet., 34, 842–5.

    PubMed  CAS  Google Scholar 

  • Lowing, P.A., Mirsky, A.F. and Pereira, R. (1983) The Inheritance of Schizophrenia Spectrum Disorders. Reanalysis of the Danish Adoptee Study Data. Am. J. Psychiatry, 140, 1167–71.

    PubMed  CAS  Google Scholar 

  • McGue, M., Gottesman, I.I. and Rao, D.C. (1985) Resolving Genetic Models for the Transmission of Schizophrenia. Genet. Epidemiol, 46, 44–55.

    Google Scholar 

  • McGuffin, P. (1989) oral communication. First World Congress in Psychiatric Genetics, Cambridge. UK.

    Google Scholar 

  • McGuffin, P. and Sturt, E. (1986) Genetic Markers in Schizophrenia. Hum. Hered., 36, 65–8.

    Article  PubMed  CAS  Google Scholar 

  • McGuffin, P., Festenstein, H. and Murray, R. (1983) A Family Study of HLA Antigens and Other Genetic Markers in Schizophrenia. Psychol. Med., 13, 31–43.

    Article  PubMed  CAS  Google Scholar 

  • McGuffin, P., Farmer, A.E., Gottesman, I.I. et al. (1984) Twin Concordance for Operationally Defined Schizophrenia. Arch. Gen. Psychiatry, 41, 541–7.

    Article  PubMed  CAS  Google Scholar 

  • McGuffin, P., Farmer, A.E. and Gottesman, I.I. (1987) Is There Really a Split in Schizophrenia? The Genetic Evidence. Br. J. Psychiatry, 150, 581–92.

    Article  PubMed  CAS  Google Scholar 

  • McGuffin, P., Sargeant, M., Hetti, G. et al. (1990) Exclusion of susceptibility gene from the chromosome 5q11–q13 region: New Data and a reanalysis of previous reports. Am. J. Hum. Genet., 47, 524–35.

    PubMed  CAS  Google Scholar 

  • Mendlewicz, J. and Fleiss, J.L. (1974) Linkage studies with X chromosome markers in bipolar (manic-depressive) and unipolar (depressive) illness. Biol. Psychiatry, 9, 261–4.

    PubMed  CAS  Google Scholar 

  • Mendlewicz, J., Fleiss, J.L. and Gieve, R.R. (1972) Evidence for X Linkage in the Tranmission of Manic Depressive Illness. J. Am. Med. Assoc., 222, 1624–7.

    Article  CAS  Google Scholar 

  • Mendlewicz, J., Linkowski, P., Guroff, J.J. and Van Praag, H.M. (1979) Color Blindness Linkage to Bipolar Manic Depressive Illness. Arch. Gen. Psychiatry, 36, 1442–7.

    Article  PubMed  CAS  Google Scholar 

  • Mendlewicz, J., Linkowski, P. and Wilmotte J. (1980) Linkage Between 6-Phosphate Dehydrogenase Deficiency and Manic Depressive Psychosis. Br. J. Psychiatry, 134, 337–42.

    Article  Google Scholar 

  • Mendlewicz, J., Simon, P., Sevy, S. et al. (1987) Polymorphic Marker on X chromosome and manic depression. Lancet, 8544, 1230–1.

    Article  Google Scholar 

  • Morton, N.E. (1956) The Detection and Estimation of Linkage between the Genes for Rh Bloodtype. Am. J. Hum. Genet., 8, 80–96.

    PubMed  CAS  Google Scholar 

  • Morton, N.E. and Maclean, C.J. (1974) Analysis of Family Resemblance III. Complex Segregation Analysis. Am. J. Hum. Genet., 26, 489–503.

    PubMed  CAS  Google Scholar 

  • Morton, N.E., Rao, D.C. and Lalouel, J.M. (1983) Methods in Genetic Epidemiology. Karger, Basel.

    Google Scholar 

  • Murray, R.M., Lewis, S.W., Owen, M.J. and Foerster, A. (1988) The Neurodevelopmental Origins of Dementia Praecox. In Schizophrenia: the Major Issues, P. Bebbington and P. McGuffin (eds), Heinemann, London, pp. 90–107.

    Google Scholar 

  • Ott, J. (1985) Analysis of Human Genetic Linkage. Johns Hopkins University Press, Baltimore.

    Google Scholar 

  • Ott, J. (1986) The Number of Families Required to Detect or Exclude Linkage Heterogeneity. Am. J. Hum. Genet., 39, 159–65.

    PubMed  CAS  Google Scholar 

  • Owen, M.J., Lewis, S.W. and Murray, R.M. (1988) Obstetric Complications of Schizophrenia, A CT study. Psychol Med., 18, 331–40.

    Article  PubMed  CAS  Google Scholar 

  • Papiha, C.S., Roberts, D.F. and McLeigh, L. (1982) Group Specific Component (Gc) Subtypes and Schizophrenia. Clin. Genet., 22, 321–6.

    Article  PubMed  CAS  Google Scholar 

  • Ponder, B.A.J., Coffey, R., Gagel, R.F. et al. (1988) Risk Estimation and Screening in Families of Patients with Medullary Thyroid Carcinoma. Lancet, 1, 397–400.

    Article  PubMed  CAS  Google Scholar 

  • Reading, C.M. (1979) X Linked Dominant Manic Depressive Illness: Linkage with Xg Blood Group, Red Green Color Blindness and Vitamin B12 Deficiency. Orthomol Psychiatry, 8, 68–77.

    Google Scholar 

  • Reich, T., Clininger, C.R. and Guze, S.B. (1975) The multifactorial model of disease transmission. Br. J. Psychiatry, 127, 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Reveley, A.M., Reveley, M.A. and Murray, R.M. (1984) Cerebral Ventricular Enlargement in Non Genetic Schizophrenia: A Controlled Twin Study. Br. J. Psychiatry, 144, 89–93.

    Article  PubMed  CAS  Google Scholar 

  • Reveley, M.A., Reveley, A.M., Clifford, C. and Murray, R.M. (1986) Platelet MAO and Schizophrenia. In Contemporary Issues in Schizophrenia. A. Kerr and P. Snaith (eds), Gaskell Press, Ashford, Kent, pp. 310–26.

    Google Scholar 

  • Risch, N. and Baron, M. (1984) Segregation Analysis of Schizophrenia and Related Disorders. Am. J. Hum. Genet., 36, 1039–59.

    PubMed  CAS  Google Scholar 

  • Rommens, J.H., Tannuzzi, J.C., Karem, B.S. et al. (1989) Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping. Science, 245, 1059–65.

    Article  PubMed  CAS  Google Scholar 

  • Rose, S., Kamin, L.J. and Lewontin, R.C. (1984) Not in our Genes, Biology, Ideology and Human Nature. Pelican Books, Harmondsworth, Middx.

    Google Scholar 

  • Rosenthal, D., Wender, P.H., Kety, S.S. et al. (1975) Parent Child Relationships and Psychopathological Disorder in the Child. Arch. Gen Psychiatry, 32, 466–73.

    Article  PubMed  CAS  Google Scholar 

  • Rudduck, C. and Franzen, G. (1983) A New Heritable Fragile Site on Human Chromosome 3. Hereditas, 98, 297–9.

    Article  PubMed  CAS  Google Scholar 

  • Rudin, E. (1916) Zur Vererbung und Neuentstehung der Dementia Praecox. Springer. Verlag, Berlin and New York.

    Google Scholar 

  • St. Clair, D., Blackwood, D., Muir, W. et al. (1989) No Linkage to Chromosome 5q11–q13 Markers to Schizophrenia in Scottish Families. Nature, 339, 305–9.

    Article  PubMed  CAS  Google Scholar 

  • St. Clair, D., Blackwood, D., Muir, W. et al. (1990) Association of a Balanced Autosomal Translocation with Major Mental Illness. Lancet, 336, 13–6.

    Article  PubMed  CAS  Google Scholar 

  • Scharfetter, C. (1981) Subdividing the Functional Psychoses: a Family Hereditary Approach. Psychol. Med., 11, 637–40.

    Article  PubMed  CAS  Google Scholar 

  • Scharfetter, C. and Nusperli, M. (1980) The Group of Schizophrenias, Schizo-affective Psychoses and Affective Disorders. Schizophr. Bull., 6, 586–91.

    Article  PubMed  CAS  Google Scholar 

  • Scharfetter, C.(1981) Subdividing the Functional Psychoses; a Family Hereditary Approach. Psychol. Med., 11, 637–40.

    Google Scholar 

  • Sedgwick, P. (1976) Psychopolitics. Pluto Press, London.

    Google Scholar 

  • Sherrington, R., Brynjolfsson, J., Petursson, H. et al. (1988) The Localization of a Susceptibility Locus for Schizophrenia on Chromosome 5. Nature, 336, 164–7.

    Article  PubMed  CAS  Google Scholar 

  • Silverman, J.M., Mohs, R.C, Davidson, M. and Losonczy. M.F. (1987) Familial Schizophrenia and Treatment Response. Am. J. Psychiatry, 144, 1271–6.

    PubMed  CAS  Google Scholar 

  • Slater, E. and Cowie, V. (1972) The Genetics of Mental Disorders. Oxford University Press, London.

    Google Scholar 

  • Southern, E.M. (1975) Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis. J. Mol. Biol., 98, 503–17.

    Article  PubMed  CAS  Google Scholar 

  • Sperber, M.A. (1975) Schizophrenia and Organic Brain Syndrome with Trisomy 8 (group c — trisomy 8[47,××8 +]), Biol. Psychiatry, 10, 27–43.

    PubMed  CAS  Google Scholar 

  • Spitzer, R.L., Endicott, J. and Gibbon, M. (1979) Crossing the Border into Borderline Personality and Borderline Schizophrenia. Arch. Gen. Psychiatry, 36, 17–24.

    Article  PubMed  CAS  Google Scholar 

  • Sturt, E. and McGuffin, P. (1985) Can Linkage and Marker Association Resolve the Genetic Aetiology of Psychiatric Disorders? Review and Argument. Psychol. Med., 15, 455–62.

    Article  PubMed  CAS  Google Scholar 

  • Tsuang, M.T. and Winokur, G. (1974) Criteria for Subtyping Schiozophrenia. Clinical Differentiation of Hebephrenic and Paranoid Schizophrenia. Arch. Gen. Psychiatry, 31, 43–7.

    Article  PubMed  CAS  Google Scholar 

  • Tsuang, M.T., Dempsey, G.M. and Rauscher, F. (1976) A study of atypical schizophrenia. Arch. Gen. Psychiatry, 33, 1157–60.

    Article  Google Scholar 

  • Tsuang, M.T., Fowler, R.C, Cadoret, R.J. and Monnelly, E. (1974) Schizophrenia among Relatives of Paranoid and Non Paranoid Schizophrenics. Compr. Psychiatry, 15, 295–302.

    Article  PubMed  CAS  Google Scholar 

  • Turner, B. and Jennings, A.N. (1961) Trisomy for Chromosome 22, Lancet. 2, 49–50.

    Article  Google Scholar 

  • Turner, S.W., Toone, B.K. and Brett-Jones, J.R. (1986) Computerized tomography Scan Changes in Early Schizophrenia Preliminary Findings. Psychol. Med., 16, 219–25.

    Article  PubMed  CAS  Google Scholar 

  • Turner, W.J. (1979) Genetic markers for schizotaxia. Biol. Psychiatry, 14, 177–206.

    PubMed  CAS  Google Scholar 

  • Walinder, J. (1972) Recurrent Familial Psychosis of the Schizoaffective Type. Acta Psychiatr. Scand., 48, 274–9.

    Article  PubMed  CAS  Google Scholar 

  • Wender, P.H., Rosenthal, D., Kety, S. et al. (1974) Cross Fostering, A Research Strategy for Clarifying the Role of Genetic and Experiential Factors in the Aetiology of Schizophrenia. Arch. Gen. Psychiatry, 30, 121–8.

    Article  PubMed  CAS  Google Scholar 

  • Winokur, G. and Tanna, V.L. (1969) Possible Role of X Linked Dominant Factor in Manic Depressive Disease. Dis. Nerv. Sys., 30, 89–93.

    CAS  Google Scholar 

  • Winokur, G., Morrison, J., Clancy, J. and Crowe, R. (1974) The Iowa 500. The Clinical and Genetic Distinction of Hebephrenic and Paranoid Schizophrenia. J. Nerv. Ment. Dis., 15, 12–9.

    Article  Google Scholar 

  • Winokur, G., Clayton, P.J. and Reich, T. (1969) Manic Depressive Illness. C.V. Mosby, St. Louis.

    Google Scholar 

  • Wright, S. (1983) On ‘Path Analysis in Genetic Epidemiology’: A critique. Am. J. Hum. Genet., 35, 757–68.

    PubMed  CAS  Google Scholar 

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Authors
  1. T. Read
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  2. M. Potter
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  3. H. M. D. Gurling
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Editors and Affiliations

  1. Department of Psychology, University of Sydney, Australia

    David J. Kavanagh Dip.Psychol. PhD (Senior Lecturer in Psychology) (Senior Lecturer in Psychology)

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© 1992 Springer Science+Business Media Dordrecht

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Read, T., Potter, M., Gurling, H.M.D. (1992). The genetics of schizophrenia. In: Kavanagh, D.J. (eds) Schizophrenia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4457-3_8

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  • DOI: https://doi.org/10.1007/978-1-4899-4457-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-38900-9

  • Online ISBN: 978-1-4899-4457-3

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