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Neuroanatomical factors in schizophrenia

  • Chapter
Schizophrenia

Abstract

Attempts to find neuroanatomical bases for schizophrenia began soon after the first descriptions of the syndrome. Since that time, brain structure in chronic schizophrenic patients has been examined using a variety of histopathological techniques; and more recently, medical imaging methods have been used to visualize the brain in living patients. The gross structure of the brain is remarkably normal in most schizophrenic patients, and no consistent structural aberration, at any level of anatomical analysis, has been found to be present in the brains of all patients with schizophrenia. Nevertheless, some consistency does exist regarding the increased prevalence in schizophrenia of certain anatomical features. Thus, hopes are raised that while no single abnormality may prove to be specific to schizophrenia, perhaps some pattern of anatomical factors may be; and that if this pattern were known, useful neurobehavioural models might be developed to explain the symptoms of the disorder. This chapter will not attempt an exhaustive review of anatomical studies in schizophrenia. Rather, the review will focus on those studies particularly relevant to the dominant themes that arise in the discussions that go on in the field today: namely, whether the abnormalities cluster in certain functional systems, whether they are present before the onset of the disorder, and whether they are static or progressive.

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  1. Terry L. Jernigan
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  1. Department of Psychology, University of Sydney, Australia

    David J. Kavanagh Dip.Psychol. PhD (Senior Lecturer in Psychology) (Senior Lecturer in Psychology)

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Jernigan, T.L. (1992). Neuroanatomical factors in schizophrenia. In: Kavanagh, D.J. (eds) Schizophrenia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4457-3_7

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