Abstract
Ventricular arrhythmias are spatial phenomena which result from one or more activation fronts travelling at a given time across the cardiac muscle. Two basic mechanisms have been postulated for the genesis and/or perpetuation of such depolarization wavefronts: (i) the activity of local pacemakers, referred to as ectopic foci [23, 24]; and (ii) the formation of reentrant circuits, whereby the wavefront circles around an electrically excitable ventricular pathway [24]. Both mechanisms require that individual excitable cells involved in the arrhythmias be able to sustain high frequency pacing, and both mechanisms demand a description of the phase-locking behaviour of such cells when subjected to external driving.
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Vinet, A., Chialvo, D.R., Michaels, D.C., Jalife, J. (1991). Nonlinear Dynamics and Ionic Mechanisms of Excitation Patterns in Models of the Cardiac Myocyte. In: Holden, A.V., Markus, M., Othmer, H.G. (eds) Nonlinear Wave Processes in Excitable Media. NATO ASI Series, vol 244. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3683-7_28
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DOI: https://doi.org/10.1007/978-1-4899-3683-7_28
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