Abstract
Granulocyte activation during hemodialysis with cuprophane membranes has conclusively been shown to be mediated by complement activation inside the hemodialyzer1,2. Synthetic hemodialysis membranes cause little alteration of the complement system as indicated by low levels of C3a3, C5a4, or C5b-95 at the hemodialyzer blood outlet. However, we previously demonstrated that one of these synthetic membranes made from polymethylmethacrylate (PMMA), very strongly activates granulocytes in patients during HD-treatment despite minimal complement activation6. To determine whether this observation is specific for the PMMA polymer or seen in other synthetic membranes as well, we studied 3 synthetic membranes in comparison to cuprophane.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Craddock PR, Fehr J, Dalmasso AP, Brighaiti KL, Jacob HS. Hemodialysis leukopenia- Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. J Clin Invest 1977; 59: 879–888.
Hammerschmidt DE, Harris PD, Wayland JH, Craddock PR, Jacob HS. Complement-induced granulocyte aggregation in vivo. Amer J Pathol 1981; 102: 146–150.
Chenoweth DE, Cheung AK, Ward DM, Henderson LW. Anaphylatoxin formation during hemodialysis: effect of different dialyzer membranes. Kidney Int 1983; 24: 764–769.
Jorstad S, Smeby LC, Balstad T, Wideroe TE. Generation and removal of anaphylatoxins during hemofiltration with five different membranes. Blood Purif 1988; 6:325–335.
Deppisch R, Schmitt V, Bommer J, Hansen GM, Ritz E, Rauterberg EW. Fluid phase generation of terminal complement complex as a novel index of bioincompati-bility. Kidney Int 1990; 37: 696–706.
Hörl WH, Riegel W, Schollmeyer P, Rauterberg W, Neumann S. Different complement and granulocyte activation in patients dialyzed with PMMA dialyzers. Clin Nephrol 1986; 25: 304–307.
Neumann S, Hennrich N, Gunzer G, Lang H. Enzyme-linked immunoassay for human granulocyte elastase in complex with a.j-proteinase inhibitor, in Proteases: Potential Role in Health and Disease, Hörl WH, Heidland A (eds), Plenum Press, New York, London 1984, pp 379–390.
Hugli TE: Techniques and significance of C3a and C5a measurements, in: Immunoassays: Clinical Laboratory Techniques for the 1980s, Nakamura RM, Dito WR, Tucker III, ES (eds), Alan R Liss Inc. New York 1980, pp 443–460.
Kandus A, Kladnik S, Ponikvar R, Ivanovich P, Drinovec J. Adsorption of anaphylatoxins C3a and C5a on AN69 membrane of hollow fiber and plate dialyzer — in vivo study (Abstract). Blood Purif 1988; 6:355.
Röckel A, Hertel J, Perschel WT, Walb D, Fiegel P, Panitz N, Abdelhamid S. Polyacrylonitrile complement activation attenuated by simultaneous ultrafiltration and adsorption. Nephrol Dial Transplant 1987; 2: 251–253.
Klinkmann H, Falkenhagen D. Biocompatibility — a system approach. in: New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis, Hörl WH, Schollmeyer PJ (eds), Plenum Press, New York, London 1989, pp 39–52.
Hakim RM, Fearon DT, Lazarus JM. Biocompatibility of dialysis membranes: effects of chronic complement activation. Kidney Int 1984; 26:194–200.
Hörl WH, Steinhauer HB, Schollmeyer P. Plasma levels of granulocyte elastase during hemodialysis: Effects of different dialyzer membranes. Kidney Int 1985; 28:791–796.
Lonnemann G, Bingel M, Floege J, Koch KM, Shaldon S, Dinarello CA. Detection of endotoxin-like interleukin-1-inducing activity during in vitro dialysis. Kidney Int 1988; 33: 29–35.
Brubaker LH, Jensen D, Johnson C., Nothum R, Nolph KD. Kinetics of stagnation-induced neutropenia during hemodialysis. Trans Amer Soc Artif Intern Organs 1972; 18: 305–311.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Böhler, J., Donauer, J., Schollmeyer, P., Hörl, W.H. (1991). Blood Flow Dependent Granulocyte Activation in Membranes with and Without Complement Activation. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Aspects of Human Polymorphonuclear Leukocytes. Advances in Experimental Medicine and Biology, vol 297. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3629-5_19
Download citation
DOI: https://doi.org/10.1007/978-1-4899-3629-5_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-3631-8
Online ISBN: 978-1-4899-3629-5
eBook Packages: Springer Book Archive