Skip to main content
SpringerLink
Log in

Chemotaxonomy and Morphology of Aspergillus Fumigatus and Related Taxa

  • Chapter
Modern Concepts in Penicillium and Aspergillus Classification

Part of the book series: NATO ASI Series ((NSSA,volume 185))

Summary

Many isolates of Aspergillus fumigatus and related taxa in Aspergillus sect. Fumigati were examined morphologically and for profiles of secondary metabolites. The isolates of secondary metabolite production by A. fumigatus was very homogeneous: tryptiquivalins, fumigaclavine A, verruculogen, other fumitremorgins and fumagillin were produced by all isolates tested, Fumigatin and sulochrin like metabolites were produced, less frequently, while gliotoxin and helvolic acid were not detected. A. brevipes, A. viridinutans, A. duricaulis and A. unilateralis, produced unique profiles of secondary metabolites different from those above. A. brevipes and A. viridinutans produced viriditoxin, while A. duricaulis produced cyclopaldic acid and chromanols 1, 2 and 3. It is concluded that species of Aspergillus sect. Fumigati are well defined, both morphologically and by their profiles of secondary metabolites.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Achenbach, H., Mühlenfeld, A., Weber, B., Kohl, W. and Brillinger, G.U. 1982a. Stoffwechselprodukte von Mikroorganismen, Xxvii. Cyclopaldsaüre und 3-O-Methyl-cyclopolsaüre, zwei antibiotisch wirksame Substanzen aus Aspergillus duricaulis. Zeitschrift für Naturforschung 37b: 1091–1097.

    CAS  Google Scholar 

  • Achenbach, H., Mühlenfeld, A., Weber, B. and Brillinger, G.U. 1982b. Stoffwechselprodukte von Mikroorganismen. Xxviii. Highly substituted chromanols from Aspergillus duricaulis. Tetrahedron Letters 23: 4659–4660.

    Article  CAS  Google Scholar 

  • Aldridge, D.C., Grove, J.F. and Turner, W.B. 1966. 4-acetyl-6,8-dihydroxy-5-methyl-2-benzopyran-1-one, a metabolite of Aspergillus viridi-nutans. Journal of the Chemical Society, C 1966: 126–129.

    Article  Google Scholar 

  • Anslow, W.K. and Raistrick, H. 1938a. The biochemistry of microorganisms. LVII. Fumigatin (3-hydroxy-4-methoxy-2,5-toluquinone) and spinulosin, metabolic products respectively of Aspergillus fumigatus Fresenius and Penicillium spinulosum Thorn. Biochemical Journal 32: 687–696.

    PubMed  CAS  Google Scholar 

  • Anslow, W.K. and Raistrick, H. 1938b. The biochemistry of microorganisms. LIX. Spinulosin (3,6-dihydroxy-4-methoxy-2,5-toluquinone) a metabolic product of a strain of Aspergillus fumigatus Fresenius. Biochemical Journal 32: 2288–2289.

    PubMed  CAS  Google Scholar 

  • Balan, J., Kjaer, A., Kovacs, S. and Shapiro, R.H. 1965. The structure of trypacidin. Acta Chemica Scandinavica 19: 528–530.

    Article  PubMed  CAS  Google Scholar 

  • Brillinger, G.-U., Heberle, W., Weber, B. and Achenbach, H. 1978. Metabolic products of microorganisms. 167. Cyclopaldic acid from Aspergillus duricaulis. 1. Production, isolation and biological properties. Archives of Microbiology 116: 245–252.

    Article  PubMed  CAS  Google Scholar 

  • Chain, E., Florey, H.W. Jennings, M.A. and Williams, T.I. 1943. Helvolic acid, an antibiotic produced by Aspergillus fumigatus mut. helvola Yuill. British Journal of Experimental Pathology 24: 108–118.

    CAS  Google Scholar 

  • Cole, R.J. and Cox, R.H. 1981. Handbook of Toxic Fungal Metabolites. New York: Academis Press.

    Google Scholar 

  • Cole, R.J., Kirksey, J.W., Dorner, J.W., Wilson, D.M., Johnson, J.C., Johnson, A.N., Bedell, D.M., J.P. Springer, K.K. Chexal, J.C. Clardy and R.J. Cox. 1977. Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage. Journal of Agricultural and Food Chemistry 25: 826–830.

    Article  PubMed  CAS  Google Scholar 

  • Cole, G.R. and Samson, R.A. 1984. The conidia. In Mould allergy, eds. Y. Al-Doory and J.F. Domson, pp. 66–103. Philadelphia: Lea and Febiger

    Google Scholar 

  • Debeaupuis, J.P. and Lafont, P. 1978. Toxinogenese in vitro & Aspergillus du groupe fumigatus. Production de fumitoxins. Mycopathologia 66: 10–16.

    Article  Google Scholar 

  • De Vries, G.A. and Cormane, R.H. 1969. A study on the possible relationships between certain mophological and physiological properties of Aspergillus fumigatus Fres. and its presence in or on human and animal (pulmonary) tissues. Mycologia Mycopathologiga applicata 39: 241–253.

    Article  Google Scholar 

  • Frisvad, J.C. 1986. Taxonomic approaches to mycotoxin identification. In Modern Methods in the Analysis and Structural Elucidation of Mycotoxins, ed. R.J. Cole, pp. 415–457. New York: Academic Press.

    Chapter  Google Scholar 

  • — 1989. The use of high-performance liquid chromatography and diode array detection in fungal chemotaxonomy based on profiles of secondary metabolites. Botanical Journal of the Linnean Society 99: 81–95.

    Article  Google Scholar 

  • Frisvad, J.C. and Thrane, U. 1987. Standardized high-performance liquid chromatography of 182 mycotoxins and other fungal metabolites based on alkylphenone retention indices and UV-VIS spectra (diode array detection). Journal of Chromatography 404: 195–214.

    Article  PubMed  CAS  Google Scholar 

  • Frisvad, J.C, Filtenborg, O. and Thrane, U. 1989. Analysis and screening for mycotoxins and other secondary metabolites in fungal cultures by thin-layer chromatography and high performance liquid chromatography. Archives of Environmental Contamination and Toxicology 18: 331–335.

    Article  PubMed  CAS  Google Scholar 

  • Gams, W., Christensen, M., Onions, A.H.S., Pitt, J.I. and Samson, R.A. 1985. Infragenic taxa of Aspergillus. In Advances in Penicillium and Aspergillus Systematics, eds. R.A. Samson and J.I. Pitt pp. 55–62. New York and London: Plenum Press.

    Google Scholar 

  • Kozakiewicz, Z. 1989. Aspergillus species on stored products. Mycologkal Papers 161: 1–188.

    Google Scholar 

  • Nielsen, P.V., Beuchat, L.R. and Frisvad J.C. 1988. Growth of and fumitremorgin production by Neosartorya fischeri as affected by temperature, light and water activity. Applied and Environmental Microbiology 54: 1504–1510.

    PubMed  CAS  Google Scholar 

  • Raper, K.B. and D.I. Fennell. 1965. The Genus Aspergillus. Baltimore: Williams and Wilkins.

    Google Scholar 

  • Samson, R.A. 1979. A compilation of the Aspergilli described since 1965. Studies in Mycology, Baarn 18: 1–38.

    Google Scholar 

  • Samson, R.A. and Pitt, J.I. eds. 1985 Advances in Penicillium and Aspergillus Systematics. New York and London: Plenum Press.

    Google Scholar 

  • Samson, R.A., Nielsen, P. and Frisvad, J.C. 1989. The genus Neosartorya: differentiation on the basis of ascospore morphology and secondary metabolites. In Modern Concepts in Penicillium and Aspergillus Classification, eds. R.A. Samson and J.I. Pitt, pp. 455–467. New York and London: Plenum Press.

    Google Scholar 

  • Schonheyder, H. 1987. Pathogenic and serological aspects of pulmonary aspergillosis. Scandinavian Journal of Infectious Diseases Supplementum 51: 1–62.

    PubMed  CAS  Google Scholar 

  • Spilsbury, J.F. and Wilkinson, S. 1961. Isolation of festudavine and two new clavine alkaloids from Aspergillus fumigatus. Journal of the Chemical Society 1961: 2085–2091.

    Article  Google Scholar 

  • Tarbell, D.S., Carman, R.M., Chapman, D.D., Huffman, K.R. and McCorkindale, N.J. 1960. The structure of fumagillin. Journal of the American Chemical Society 82: 1005–1007.

    Article  CAS  Google Scholar 

  • Turner, W.B. 1965. The production of trypacidin and monomethylsulochrin by Aspergillus fumigatus. Journal of the Chemical Society 1965: 6658–6659.

    Article  Google Scholar 

  • — 1971. Fungal Metabolites. London: Academic Press.

    Google Scholar 

  • Turner, W.B. and Aldridge, D.C. 1983. Fungal metabolites. II. London: Academic Press.

    Google Scholar 

  • Varsney, J.L. and Sarbhoy, A.K. 1981. A new species of Aspergillus fumigatus group and comments upon its synonomy. Mycopathologia 73: 89–92.

    Article  Google Scholar 

  • Waksman, S.A. and Geiger, W.B. 1944. The nature of the antibiotic substances produced by Aspergillus fumigatus. Journal of Bacteriology 47: 391–395.

    PubMed  CAS  Google Scholar 

  • Weisleder, D. and Lillehoj, E.B. 1971. Structure of viriditoxin, a toxic metabolite of Aspergillus viridinutans. Tetrahedron Letters 48: 4705–4706.

    Article  Google Scholar 

  • Wilken-Jensen, K. and Gravesen, S. 1984. Atlas of moulds in Europe causing respiratory allergy. ASK Publishing, Copenhagen.

    Google Scholar 

  • Yamamoto, Y., Kinyama, N. and Arahata, S. 1968. Studies on the metabolic products of Aspergillus fumigatus (J-4). Chemical structure of metabolic products. Chemical and Pharmaceutical Bulletin 16: 304–310.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, Y., Nittai, K., Oohata, Y. and Furukawa, T. 1972. Studies of the metabolic products of Aspergillus fumigatus DH 413. V. A new metabolite produced by ethionine inhibition. Chemical and Pharmaceutical Bulletin 20: 931–935.

    Article  CAS  Google Scholar 

  • Yamazaki, M., Suzuki, S. and Miyaki, K. 1971. Tremorgenic mycotoxins from Aspergillus fumigatus. Chemical and Phamaceutical Bulletin 19: 1739–1740.

    Article  CAS  Google Scholar 

  • Yamazaki, M., Fujimoto, H. and Okuyama, E. 1976. Structure determination of six tryptoquivaline related metabolites from Aspergillus fumigatus. Tetrahedron Letters 33: 2861–2864.

    Article  Google Scholar 

  • Fujimoto, H. and Okuyama, E. — 1977. Structure of tryptoquivaline C and D. Novel fungal metabolites from Aspergillus fumigatus. Chemical and Pharmaceutical Bulletin 25: 2554–2560.

    Article  CAS  Google Scholar 

  • Fujimoto, H. and Okuyama, E. — 1978. Structure determination of six fungal metabolites, tryptoquivaline E, F, G, H, I, J from Aspergillus fumigatus. Chemical and Pharmaceutical Bulletin 26: 111–117.

    Article  CAS  Google Scholar 

  • Yamazaki, M., Okuyama, E. and Maebayashi, Y. 1979. Isolation of some new tryptoquivaline-related metabolites from Aspergillus fumigatus. Chemical and Pharmaceutical Bulletin 27: 1611–1617.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biotechnology, Technical University of Denmark, 2800, Lyngby, Denmark

    J. C. Frisvad

  2. Centraalbureau voor Schimmelcultures, 3740 AG, Baarn, The Netherlands

    R. A. Samson

Authors
  1. J. C. Frisvad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. Samson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centraalbureau voor Schimmelcultures, Baarn, The Netherlands

    Robert A. Samson

  2. Division of Food Processing, CSIRO, North Ryde, New South Wales, Australia

    John I. Pitt

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media New York

About this chapter

Cite this chapter

Frisvad, J.C., Samson, R.A. (1990). Chemotaxonomy and Morphology of Aspergillus Fumigatus and Related Taxa. In: Samson, R.A., Pitt, J.I. (eds) Modern Concepts in Penicillium and Aspergillus Classification. NATO ASI Series, vol 185. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3579-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-3579-3_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-3581-6

  • Online ISBN: 978-1-4899-3579-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation