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Clinical Aspects of Adult Tuberculosis in HIV-Infected Patients

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AIDS and Respiratory Medicine
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Abstract

Prior to the development of chemotherapy, tuberculosis frequently progressed, unabated, to cause severe cavitary lung disease. Persons with tuberculosis expectorated large numbers of bacilli from pulmonary foci and these highly infectious secretions could then directly infect the mucosa of the respiratory and gastrointestinal tracts. Thus, common features included indolent ulcers of the tongue and mouth, frequent involvement of the larynx and middle ear, and severe gastrointestinal disease (Marshall, 1993).

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References

  • Alland, D., Kalkut, G.E., Moss, A.R. et al. (1994) Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods [see comments]. N. Engl. J. Med., 330, 1710–16.

    Article  PubMed  CAS  Google Scholar 

  • Centers for Disease Control. (1991) Nosocomial transmission of multidrug-resistant tuberculosis among HIV-infected persons–Florida and New York, 1988–1991. MMWR. Morb. Mortal. Wkly. Rep., 40, 585–91.

    Google Scholar 

  • Centers for Disease Control. (1992) Transmission of multidrug-resistant tuberculosis among immunocompromised persons in a correctional system–New York, 1991. MMWR. Morb. Mortal. Wkly. Rep., 41, 507–9.

    Google Scholar 

  • Barnes, P.F., Bloch, A.B., Davidson, P.T. et al. (1991) Tuberculosis in patients with human immunodeficiency virus infection [see comments]. [Review]. N. Engl. J. Med., 324, 1644–50.

    Article  PubMed  CAS  Google Scholar 

  • Barnes, P.F., Le, H.Q. and Davidson, P.T. (1993) Tuberculosis in patients with HIV infection. [Review]. Med. Clin. N. Am., 77, 1369–90.

    PubMed  CAS  Google Scholar 

  • Berenguer, J., Moreno, S., Laguna, F. et al. (1992) Tuberculous meningitis in patients infected with the human immunodeficiency virus [see comments]. N. Engl. J. Med., 326, 668–72.

    Article  PubMed  CAS  Google Scholar 

  • Bishburg, E., Sunderam, G., Reichman, L.B. et al. (1986) Central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex. Ann. Intern. Med., 105, 210–13.

    Article  PubMed  CAS  Google Scholar 

  • Chaisson, R.E., Schecter, G.F., Theuer, C.P. et al. (1987) Tuberculosis in patients with the acquired immunodeficiency syndrome. Clinical features, response to therapy, and survival. Am. Rev. Respir. Dis., 136, 570–4.

    Article  PubMed  CAS  Google Scholar 

  • Chaisson, R.E. and Slutkin, G. (1989) Tuberculosis and human immunodeficiency virus infection. J. Infect. Dis., 159, 96–100.

    Article  PubMed  CAS  Google Scholar 

  • Colebunders, R.L., Ryder, R.W., Nzilambi, N. et al. (1989) HIV infection in patients with tuberculosis in Kinshasa, Zaire. Am. Rev. Respir. Dis., 139, 1082–5.

    Article  PubMed  CAS  Google Scholar 

  • Daley, C.L., Small, P.M., Schecter, G.F. et al. (1992) An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restriction-fragment-length polymorphisms. N. Engl. J. Med., 326, 231–5.

    Article  PubMed  CAS  Google Scholar 

  • De Cock, K.M., Gnaore, E., Adjorlolo, G. et al. (1991) Risk of tuberculosis in patients with HIV-I and HIV-II infections in Abidjan, Ivory Coast. Br. Med. J., 302, 496–9.

    Article  Google Scholar 

  • De Cock, K.M., Soro, B., Coulibaly, I.M. et al. (1992) Tuberculosis and HIV infection in sub-Saharan Africa. JAMA, 268, 1581–7.

    Article  PubMed  Google Scholar 

  • Dube, M.P., Holtom, P.D. and Larsen, R.A. (1992) Tuberculous meningitis in patients with and without human immunodeficiency virus infection. Am. J. Med., 93, 520–14.

    Article  PubMed  CAS  Google Scholar 

  • Edlin, B.R., Tokars, J.L., Grieco, M.H. et al. (1992) An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome [see comments]. N. Engl. J. Med., 326, 1514–21.

    Article  PubMed  CAS  Google Scholar 

  • Elliott, A.M., Luo, N., Tembo, G. et al. (1990) Impact of HIV on tuberculosis in Zambia: a cross sectional study [see comments]. Br. Med. J., 301, 412–15.

    Article  CAS  Google Scholar 

  • Elliott, A.M., Halwiindi, B., Hayes, R.J. et al. (1995) The impact of human immunodeficiency virus on mortality of patients treated for tuberculosis in a cohort study in Zambia. Trans. R. Soc. Trop. Med. Hyg., 89, 78–82.

    Article  PubMed  CAS  Google Scholar 

  • Forte, M., Maartens, G., Rahelu, M. et al. (1992) Cytolytic T-cell activity against mycobacterial antigents in HIV. AIDS, 6, 407–11.

    Article  PubMed  CAS  Google Scholar 

  • Gilks, C.F., Brindle, R.J., Otiena, L.S. et al. (1990) Extrapulmonary and disseminated tuberculosis in HIV-1 seropositive patients presenting to the acute medical services in Nairobi. AIDS, 4, 981–5.

    Article  PubMed  CAS  Google Scholar 

  • Githui, W., Nunn, P., Juma, E. et al. (1992) Cohort study of HIV-positive and HIV-negative tuberculosis, Nairobi, Kenya: comparison of bacteriological results. Tuber. Lung Dis., 73, 203–9.

    Article  PubMed  CAS  Google Scholar 

  • Houston, S., Ray, S., Mahari, M. et al. (1994) The association of tuberculosis and HIV infection in Harare, Zimbabwe. Tuber. Lung. Dis., 75, 220–6.

    Article  PubMed  CAS  Google Scholar 

  • Kamanfu, G., Mlika Cabanne, N., Girard, P.M. et al. (1993) Pulmonary complications of human immunodeficiency virus infection in Bujumbura, Burundi. Am. Rev. Respir. Dis., 147, 658–63.

    Article  PubMed  CAS  Google Scholar 

  • Kelly, P., Burnham, G. and Radford, C. (1990) HIV seropositivity and tuberculosis in a rural Malawi hospital. Trans. R. Soc. Trop. Med. Hyg., 84, 725–7.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, D.H. and Fallon, R.J. (1979) Tuberculous meningitis. JAMA, 241, 264–8.

    Article  PubMed  CAS  Google Scholar 

  • Kielhofner, M.A. and Hamill, R.J. (1991) Focal hepatic tuberculosis in a patient with acquired immunodeficiency syndrome. [Review]. S. Med. J., 84, 401–4.

    CAS  Google Scholar 

  • Kramer, F., Modilevsky, T., Waliany, A.R. et al. (1990) Delayed diagnosis of tuberculosis in patients with human immunodeficiency virus infection [see comments]. Am. J. Med., 89, 451–6.

    Article  PubMed  CAS  Google Scholar 

  • Lucas, S.B., Hounnou, A., Peacock, C. et al. (1993) The mortality and pathology of HIV infection in a west African city [see comments]. AIDS, 7, 1569–79.

    Article  PubMed  CAS  Google Scholar 

  • Lucas, S. and Nelson, A.M. (1994) Pathogenesis of tuberculosis in human immunodeficiency virus-infected people, in Tuberculosis. Pathogenesis, Protection and Control. (ed. B.R. Bloom ). American Society for Microbiology, Washington DC, pp. 503–13.

    Google Scholar 

  • Mantzoros, C.S., Brown, P.D., and Dembry, L. (1993) Extraosseous epidural tuberculoma: case report and review. [Review]. Clin. Infect. Dis., 17, 1032–6.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J.B. (1993) Tuberculosis of the gastrointestinal tract and peritoneum. [Review.] Am. J. Gastroent., 88, 989–99.

    PubMed  CAS  Google Scholar 

  • Modilevsky, T., Sattler, F.R. and Barnes, P.F. (1989) Mycobacterial disease in patients with human immunodeficiency virus infection. Arch. Intern. Med., 149, 2201–5.

    Article  PubMed  CAS  Google Scholar 

  • Nunn, P.P., Porter, J. and Winstanley, P. (1993) Thiacetazone - avoid like poison or use with care? Trans. R. Soc. Trop. Med. Hyg., 87, 57882.

    Article  Google Scholar 

  • Nunn, P.P., Elliott, A.M. and McAdam, K.P.W.J. (1994) Impact of human immunodeficiency virus on tuberculosis in developing countries. Thorax, 49, 511–18.

    Article  PubMed  CAS  Google Scholar 

  • Pape, J.W., Jean, S.S., Ho, J.L. et al. (1993) Effect of isoniazid prophylaxis on incidence of active tuberculosis and progresssion of HIV infection. Lancet, 342, 268–72.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, M.L., Jereb, J.A., Frieden, T.R. et al. (1992) Nosocomial transmission of multidrugresistant Mycobacterium tuberculosis. A risk to patients and health care workers [see comments]. Ann. Intern. Med., 117, 191–6.

    Article  PubMed  CAS  Google Scholar 

  • Pithie, A.D. and Chicksen, B. (1992) Fine-needle extrathoracic lymph-node aspiration in HIV-associated sputum-negative tuberculosis [see comments]. Lancet, 340, 1504–5.

    Article  PubMed  CAS  Google Scholar 

  • Pozniak, A.L., Weinberg, J., Mahari, M. et al. (1994) Tuberculous pericardial effusion associated with HIV infection: a sign of disseminated disease. Tuber. Lung Dis., 75, 297–300.

    Article  PubMed  CAS  Google Scholar 

  • Roper, W.H. and Waring, J.J. (1955) Primary serofibrinous pleural effusion in military personnel. Am. Rev. Tuberc., 71, 616–34.

    PubMed  CAS  Google Scholar 

  • Selwyn, P.A., Hartel, D., Wasserman, W. et al. (1989) Impact of the AIDS epidemic on morbidity and mortality among intravenous drug users in a New York City methadone maintenance program. Am. J. Public Health, 79, 1358–62.

    Article  PubMed  CAS  Google Scholar 

  • Shafer, R.W., Goldberg, R., Sierra, M. et al. (1989) Frequency of Mycobacterium tuberculosis bacteremia in patients with tuberculosis in an area endemic for AIDS. Am. Rev. Respir. Dis., 140, 1611–13.

    Article  PubMed  CAS  Google Scholar 

  • Shafer, R.W., Kim, D.S., Weiss, J.P. et al. (1991) Extrapulmonary tuberculosis in patients with human immunodeficiency virus infection. Medicine Baltimore, 70, 384–97.

    PubMed  CAS  Google Scholar 

  • Sherman, M.D. and Nozik, R.A. (1992) Other infections of the choroid and retina. Toxoplasmosis, histoplasmosis, Lyme disease, syphilis, tuberculosis, and ocular toxocariasis. [Review.] Infect. Dis. Clin. N. Am., 6, 893–908.

    CAS  Google Scholar 

  • Small, P.M., Hopewell, P.C., Singh, S.P. et al. (1994) The epidemiology of tuberculosis in San Francisco. A population-based study using conventional and molecular methods [see comments]. N. Engl. J. Med., 330, 1703–9.

    Article  PubMed  CAS  Google Scholar 

  • Snider, Jr, D.E. and Roper, W.L. (1992) The new tuberculosis [editorial; comment]. N. Engl. J. Med, 326, 703–5.

    Article  PubMed  Google Scholar 

  • Stein, D.S. and Libertin, C.R. (1990) Disseminated intravascular coagulation in association with cavitary tuberculosis. [Review]. S. Med. J., 83, 60–3.

    Article  CAS  Google Scholar 

  • Toossi, Z., Sierra Madero, J.G., Blinkhorn, R.A. et al. (1993) Enhanced susceptibility of blood monocytes from patients with pulmonary tuberculosis to productive infection with human immunodeficiency virus type 1. J. Exp. Med., 177, 1511–16.

    Article  PubMed  CAS  Google Scholar 

  • Valway, S.E., Richards, S.B., Kovacovich, J. et al. (1994) Outbreak of multi-drug-resistant tuberculosis in a New York State prison, 1991. Am. J. Epidemiol., 140, 113–22.

    PubMed  CAS  Google Scholar 

  • Vugia, D.J., Kiehlbauch, J.A., Yeboue, K. et al. (1993) Pathogens and predictors of fatal septicemia associated with human immunodeficiency virus infection in Ivory Coast, west Africa. J. Infect. Dis., 168, 564–70.

    Article  PubMed  CAS  Google Scholar 

  • Whalen, C., Horsburgh, C.R., Hom, D. et al. (1995) Accelerated course of human immunodeficiency virus infection after tuberculosis. Am. J. Respir. Crit. Care Med., 151, 129–35.

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization (1995) Tuberculosis and HIV research: working towards solution. WHO/TB/95, 193.

    Google Scholar 

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© 1997 Springer Science+Business Media Dordrecht

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Malin, A.S., De Cock, K.M. (1997). Clinical Aspects of Adult Tuberculosis in HIV-Infected Patients. In: Zumla, A., Johnson, M., Miller, R. (eds) AIDS and Respiratory Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3446-8_9

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  • DOI: https://doi.org/10.1007/978-1-4899-3446-8_9

  • Publisher Name: Springer, Boston, MA

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