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Atypical Mycobacteria in AIDS

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Abstract

Diseases caused by atypical mycobacteria were once obscure and of occasional interest to the clinician. Better laboratory techniques and heightened awareness of their clinical importance, focused by the HIV epidemic, have highlighted their potential as serious pathogens. No longer are they unclassified, anonymous or simply environmental. They are still grouped together, separately from M. tuberculosis. For this reason they will be referred to generically as ‘nontuberculous’ rather than ‘atypical’ as M. tuberculosis can present ‘atypically’ in the immunosuppressed. This chapter will concern itself with the diseases caused by these fascinating organisms, as well as their isolation and treatment. It will discuss in some detail individual mycobacteria that have caused disease in HIV-positive patients. The discussion is of course dominated by M. avium.

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References

  • Agy, M.B., Wallis, C.K., Plorde, J.J. et al. (1989) Evaluation of four mycobacterial blood culture media: Bactec 13A, IsolatorBactec 12B, Isolator/Middlebrook agar and a biphasic medium. Diagnostic Microbiology and Infectious Diseases, 12, 303–8.

    Article  CAS  Google Scholar 

  • Arbeit, R.D., Slutsky, A., Barber, T.W. et al. (1993) Genetic diversity among strains of Mycobacterium avium causing monoclonal and polyclonal bacteremia in patients with AIDS. Journal of Infectious Diseases, 167, 1384–90.

    Article  PubMed  CAS  Google Scholar 

  • Armstrong, D., Gold, J.W.M., Dryjanski, J. et al. (1985) Treatment of infections in patients with acquired immunodeficiency syndrome. Annals of Internal Medicine, 103, 738–43.

    Article  PubMed  CAS  Google Scholar 

  • Armstrong, D., Kiehn, T., Boone, N. et al. (1991) Mycobacterium haemophilum infections — New York City metropolitan area, 1990–91. Morbidity and Mortality Weekly Reports, 40, 636–43.

    Google Scholar 

  • Ausina, V., Barrio, J., Luquin, M. et al. (1988) Mycobacterium xenopi infections in the acquired immunodeficiency syndrone. Annals of Internal Medicine, 109, 927–8.

    Article  CAS  Google Scholar 

  • Baess, I. (1983) Deoxyribonucleic acid relationships between different serovars of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum. Acta Pathologica, Microbiologica, Immunologica Scandinavica, 91, 201–3.

    CAS  Google Scholar 

  • Bamberger, D.M., Driks, MR., Gupta, M.R. et al. (1994) Mycobacterium kansasii among patients infected with human immunodeficiency virus in Kansas City. Clinical Infectious Diseases, 18, 395–400.

    CAS  Google Scholar 

  • Banks, J., Jenkins, P.A. and Smith, A.P. (1985) Pulmonary infection with Mycobacterium malmoense: a review of treatment and response. Tubercle, 66, 197–203.

    Article  PubMed  CAS  Google Scholar 

  • Barbaro, D.J., Orcutt, V.L. and Coldiron, B.M. (1989) Mycobacterium avium-Mycobacterium intra-cellulare infection limited to the skin and lymph nodes in patients with AIDS. Review of Infectious Diseases, 11, 1145–8.

    Google Scholar 

  • Baron, E.J. and Young, L.S. (1986) Amikacin, ethambutol and rifampin for treatment of disseminated Mycobacterium avium-intracellulare infections in patients with AIDS. Diagnostic Microbiology and Infectious Diseases, 5, 215–20.

    Article  CAS  Google Scholar 

  • Bautista, G., Alcid, D. and Gocke, D. (1991) Quantitative blood culture for mycobacteria in patients with acquired immunodeficiency syndrome (abstract 242, p. 139). Program Abstract. 31st Interscience Conference of Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington DC.

    Google Scholar 

  • Becherer, P. and Hopfer, R.L. (1992) Infection with Mycobacterium haemophilum [Letter]. Clinical Infectious Diseases, 14, 793.

    Article  PubMed  CAS  Google Scholar 

  • Bell, R.C., Higuchi, J.H., Donovan, W.N. et al. (1983) Mycobacterium simiae: clinical features and follow-up of twenty-four patients. American Review of Respiratory Disease, 127, 35–8.

    CAS  Google Scholar 

  • Bermudez, L.E., Martinelli, J., Petrofsky, M. et al. (1994) Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model. Journal of Infectious Diseases, 169, 575–80.

    Article  PubMed  CAS  Google Scholar 

  • Bermudez, L.E., Young, L.S., Martinelli, J. et al. (1993). Exposure to ethanol up-regulates the expression of Mycobacterium avium complex proteins associated with bacterial virulence. Journal of Infectious Diseases, 168, 961–8.

    Article  PubMed  CAS  Google Scholar 

  • Bessesen, M.T., Berry, C.D., Johnson, M.A. et al. (1990) Site of origin of disseminated MAC infection in AIDS (abstract 1268, p. 297). Program Abstract. 31st Interscience Conference of Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington DC.

    Google Scholar 

  • Bessesen, M.T., Shlay, J., Stone-Venohr, B. (1993) Disseminated Mycobacterium genavense infection: clinical and microbiological features and response to therapy. AIDS, 7, 1357–61.

    Article  PubMed  CAS  Google Scholar 

  • Bishai, W.R., Graham, N.M.H., Harrington, S. et al. (1996) Rifampicin-resistant tuberculosis in a patient receiving rifabutin prophylaxis. New England Journal of Medicine, 334, 1573–6.

    Article  PubMed  CAS  Google Scholar 

  • Blumenthal, D.R., Zucker, J.R. and Hawkins, C.A. (1990) Mycobacterium avium complex-induced septic arthritis and osteomyelitis in a patient with the acquired immunodeficiency syndrome. Arthritis and Rheumatism, 33, 757–8.

    CAS  Google Scholar 

  • Bottger, E.C., Teske, A., Kirschner, P. et al. (1992) Disseminated Mycobacterium genavense infection in patients with AIDS. Lancet, 340, 76–80.

    Article  PubMed  CAS  Google Scholar 

  • Brady, M.T., Marcon, M.J. and Maddux, H. (1987) Broviac catheter-related infection due to Mycobacterium fortuitum in a patient with acquired immunodeficiency syndrome. Pediatric Infectious Diseases, 6, 492–4.

    Article  CAS  Google Scholar 

  • Brennan, P.J. (1989) Structure of mycobacteria; recent developments in defining cell wall carbohydrates and proteins. Review of Infectious Diseases, II: S420–5430.

    Google Scholar 

  • Bull, T.J., Shanson, D.C., Yates, M.D. et al. (1995) A new group (type 3) of Mycobacterium celatum isolated from AIDS patients in the London area. International Journal of Systematic Bacteriology, 45, 861–2

    Article  PubMed  CAS  Google Scholar 

  • Butler, W.R., O’Connor, S.P., Yakrus, M.A. et al. (1993) Mycobacterium celatum sp. nov. International Journal of Systematic Bacteriology, 43, 1540–50.

    Google Scholar 

  • Cârcaba, V., Cartón, J.A., Fernandez León, A. et al. (1989) Peritonitis por Mycobacterium gordonae en un paciente infectado por el virus de la immunodeficiencia humana. Medicina Clinica (Barcelona), 93, 598.

    Google Scholar 

  • Chaisson, R.E. and Levine, B. (1991) Mycobacterium kansasii infection [letter]. Annals of Internal Medicine, 115, 496–7.

    Google Scholar 

  • Chaisson, R.E., Moore, R.D., Richman, D.D. et al. (1992) Incidence and natural history of Mycobacterium avium-complex infections in patients with acquired immunodeficiency virus disease treated with zidovudine. American Review of Respiratory Disease, 146, 285–9.

    Article  PubMed  CAS  Google Scholar 

  • Chaisson, R.E., Benson, C., Dube, M. et al. (1994) Clarithromycin therapy for bacteremic Mycobacterium avium complex disease in patients with AIDS. Annals of Internal Medicine, 121, 905–11.

    Article  PubMed  CAS  Google Scholar 

  • Chan, J., McKitrick, J.C. and Klein, R.S. (1984) Mycobacterium gordonae in the acquired immunodeficiency syndrome [letter]. Annals of Internal Medicine, 100, 400.

    Article  Google Scholar 

  • Chin, D.P., Reingold, A.L., Stone, E.N. et al. (1994) The impact of Mycobacterium avium complex bacteremia and its treatment on survival of AIDS patients — a prospective study. Journal of Infectious Diseases, 170, 578–84.

    Article  PubMed  CAS  Google Scholar 

  • Chiu, J., Nussbaum, J., Bozzette, S. et al. (1990) Treatment of disseminated Mycobacterium avium complex infection in AIDS with amikacin, ethambutol, rifampin, and ciprofloxacin. Annals of Internal Medicine, 113, 358–61.

    Article  PubMed  CAS  Google Scholar 

  • Choo, P.S. and McCormack, J.G. (1995) Mycobacterium avium: a potentially treatable cause of pericardial effusions. Journal of Infection, 30, 55–8.

    CAS  Google Scholar 

  • Claydon, E.J., Coker, R.J. and Harris, J.R.W. (1991) Mycobacterium malmoense infection in HIV positive patients. Journal of Infection, 23, 195–6.

    Google Scholar 

  • Colebunders, R., Nambunzu, M., Portaels, F. et al. (1990) Isolation of mycobacteria from HIV seropositive and HIV seronegative patients with and without diarrhoea in Kinshasa, Zaire: preliminary results. Annales de la Société Belge de Medecine Tropicale, 70, 303–9.

    PubMed  CAS  Google Scholar 

  • Costrini, A.M., Mahler, D.A., Gross, W.M. et al. (1981) Clinical and roentgenographic features of nosocomial pulmonary disease due to Mycobacterium xenopi. American Review of Respiratory Disease, 123, 105–9.

    Google Scholar 

  • Coyle, M.B., Carlson, L.D.C., Wallis, C.K. et al. (1992) Laboratory aspects of Mycobacterium genavense, a proposed species isolated from AIDS patients. Journal of Clinical Microbiology, 30, 3206–12.

    PubMed  CAS  Google Scholar 

  • Crawford, J.T. and Bates, J.H. (1985) Phage typing of the Mycobacterium avium-intracellularescrofulaceum complex: a study of strains of diverse geographic and host origin. American Review of Respiratory Disease, 132, 386–9.

    PubMed  CAS  Google Scholar 

  • Cuttino, J.T. and McCabe, A.M. (1949) Pure granulomatous nocardiosis: A new fungus disease distinguished by intracellular parasitism. A description of a new disease in man due to a hitherto undescribed organism, Nocardia intracellularis, N. Sp., including a study of the biologic and pathogenic properties of this species. American Journal of Pathology, 25, 1.

    CAS  Google Scholar 

  • Dautzenberg, B., Truffot, C., Legris, S. et al. (1991) Activity of clarithromycin against Mycobacterium avium infection in patients with the acquired immune deficiency syndrome. A controlled clinical trial. American Review of Respiratory Disease, 144, 564–9.

    Article  PubMed  CAS  Google Scholar 

  • Delaporte, E., Savage, C., Alfandari, S. et al. (1994) Buruli Ulcer in a Zairian woman with HIV infection. Annals of Dermatology and Venereology, 121, 557–60.

    CAS  Google Scholar 

  • De Paepe, M.E., Guerrieri, C. and Waxman, M. (1990) Opportunistic infections of the testis in the acquired immunodeficiency syndrome. Mt Sinai Journal of Medicine, 57, 25–9.

    Google Scholar 

  • Dever, L.L., Martin, J.W., Seaworth, B. et al. (1992) Varied presentations and responses to treatment of infections caused by Mycobacterium haemophilum in patients with AIDS. Clinical Infectious Diseases, 14, 1195–200.

    Article  PubMed  CAS  Google Scholar 

  • Dwork, A.J., Chin, S. and Boyce, L. (1994) Intracerebral Mycobacterium avium-intracellulare in a child with acquired immune deficiency syndrome. Journal of Paediatric Infectious Diseases, 13, 1149–51.

    Article  CAS  Google Scholar 

  • Eng, R.H.K., Forrester, C., Smith, S.M. et al. (1984) Mycobacterium xenopi infection in a patient with acquired immunodeficiency syndrome. Chest, 86, 145–7.

    CAS  Google Scholar 

  • Fakih, M., Chapalmadugu, S., Ricard, A. et al. (1996) Mycobacterium malmoense bacteremia in two AIDS patients. Journal of Clinical Microbiology, 34, 731–3.

    CAS  Google Scholar 

  • Falkinham, J.O. III, Parker, B.C. and Gruft, H. (1980) Epidemiology of infection by non-tuberculous mycobacteria. American Review of Respiratory Disease, 121, 931–7.

    PubMed  Google Scholar 

  • Fraser, V.J., Jones, M., Murray, P.R. et al. (1992) Contamination of flexible fiberoptic bronchoscopes with Mycobacterium chelonae linked to an automated bronchoscope disinfection machine. American Review of Respiratory Disease, 145, 853–5.

    Article  PubMed  CAS  Google Scholar 

  • Gangadharam, P.R., Perumal, V.K., Crawford, J.T. et al. (1988) Association of plasmids and virulence of Mycobacterium avium complex. American Review of Respiratory Disease, 137, 212–4.

    Article  PubMed  CAS  Google Scholar 

  • Gilks, C.F., Brindle, R.J., Mwachari, C. et al. (1995) Disseminated Mycobacterium avium infection among HIV-infected patients in Kenya. Journal of Acquired Immune Deficiency Syndrome and Human Retrovirology, 8, 195–8.

    Article  CAS  Google Scholar 

  • Girard, A.E., Girard, D., English A.R. et al. (1987) Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrobial Agents and Chemotherapy, 31, 1948–54.

    Article  PubMed  CAS  Google Scholar 

  • Good, R. (1985) Opportunistic pathogens in the genus Mycobacterium. Annual Review of Microbiology, 39, 347–69.

    Article  CAS  Google Scholar 

  • Gordon, S.M., Horsburgh, C.R. Jr, Peloquin, C.A. et al. (1993) Low serum levels of oral antimycobacterial agents in patients with disseminated Mycobacterium avium complex disease. Journal of Infectious Diseases, 168, 1559–62.

    Article  PubMed  CAS  Google Scholar 

  • Grange, J.M. (1994) Is the incidence of AIDS-associated Mycobacterium avium-intracellulare disease affected by previous exposure to BCG, M. tuberculosis or environmental bacteria? Tubercle and Lung Disease, 75, 234–6.

    Article  PubMed  CAS  Google Scholar 

  • Grange, J.M., Yates, M.D. and Pozniak, A. (1995) Bacteriologically confirmed non-tuberculous mycobacterial lymphadenitis in southeast England: A recent increase in the number of cases. Archives of Disease in Childhood, 72, 516–7.

    Article  PubMed  CAS  Google Scholar 

  • Gray, J.R. and Rabeneck, L. (1989) Atypical mycobacterial infection of the gastrointestinal tract in AIDS patients. American Journal of Gastroenterology, 84, 1521–4.

    PubMed  CAS  Google Scholar 

  • Greene, J.B., Sidhu, G.S., Lewin, S. et al. (1982) Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers. Annals of Internal Medicine, 97, 539–46.

    CAS  Google Scholar 

  • Gruft, H., Katz, J. and Blanchard, D.C. (1975) Postulated source of Mycobacterium intracellulare (Battey) infection. American Journal of Epidemiology, 102, 311–8.

    PubMed  CAS  Google Scholar 

  • Gupta, S., Blahunka, K., Dellerson, M. et al. (1992) Interim results of safety and efficacy of clarithromycin (C) in the treatment of disseminated Mycobacterium avium complex (MAC) infection in patients (Pts) with AIDS (abstract No. 892). Program Abstract. 32nd Interscience Conference of Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington DC.

    Google Scholar 

  • Haase, G. Skopnik, H. Batge, S. et al. (1994) Cervical lymphadenitis caused by Mycobacterium celatum. Lancet, 344, 1020–1 [letter].

    Google Scholar 

  • Hampson, S.J., Thompson, J., Moss, M.T. et al. (1989) DNA probes demonstrate a single highly conserved strain of Mycobacterium avium infecting AIDS patients. Lancet, 1, 65–8.

    Article  PubMed  CAS  Google Scholar 

  • Hanau, L.H., Leaf, A., Soeiro, R. et al. (1994) Mycobacterium marinum infection in a patient with the acquired immune deficiency syndrome. CUTIS, 54, 103–5.

    CAS  Google Scholar 

  • Havlir, D., Keyes, L. and Davis, C. (1991) Measurement of Mycobacterium avium bacteremia: quantitative Isolator lysis centrifugation versus BACTEC 13A blood culture systems, abstr 661, p. 209. Program Abstract. 32nd Interscience Conference of Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington DC.

    Google Scholar 

  • Hawkins, C.C., Gold, J.W., Whimbey, E. et al. (1986) Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Annals of Internal Medicine, 105, 18–48.

    Google Scholar 

  • Heifets, L.B., Iseman, M.D. and Lindholm-Levy, P.J. (1988) Combination of rifampin or rifabutin plus ethambutol against Mycobacterium avium complex: bactericidal synergistic and bacteriostasis additive or synergistic effects. American Review of Respiratory Disease, 137, 11–5.

    Google Scholar 

  • Henriques, B., Hoffner, S.E., Petrini, B. et al. (1994) Infection with Mycobacterium malmoense in Sweden: report of 221 cases. Clinical Infectious Diseases, 18, 596–600.

    Article  PubMed  CAS  Google Scholar 

  • Hirasuna, J.D. (1987) Disseminated Mycobacterium kansasii infection in the acquired immunodeficiency syndrome (AIDS). Annals of Internal Medicine, 107, 784.

    Article  PubMed  CAS  Google Scholar 

  • Hirschel, B., Chang, H.R., Mach, N. (1990) Fatal infection with a novel, unidentified mycobacterium in a man with AIDS. New England Journal of Medicine, 323, 109–13.

    Article  PubMed  CAS  Google Scholar 

  • Holton, J., Nye, P. and Miller, R. (1991) Mycobacterium haemophilum infection in a patient with AIDS. Journal of Infection, 32, 303–6.

    Google Scholar 

  • Horsburgh, C.R. Jr, Cohn, D.L., Roberts, R.B. et al. (1986) Mycobacterium avium-M. intracellulare isolates from patients with or without the acquired immunodeficiency syndrome. Antimicrobial Agents and Chemotherapy. 30, 955–7.

    PubMed  CAS  Google Scholar 

  • Horsburgh, C.R. Jr, Metchock, B., Gordon, S.M. et al. (1994) Predictors of survival in patients with AIDS and disseminated Mycobacterium avium complex disease. Journal of Infectious Disease, 170, 573–7.

    Article  Google Scholar 

  • Horsburgh, C.R. Jr, Wynne, B., Bianchine, J. et al. (1992) Epidemiology of Mycobacterium avium complex (MAC) bacteremia in patients enrolled in a placebo-controlled study (abstract PoB 3190, pB118). 8th Int. Conf. AIDS 1992.

    Google Scholar 

  • Horsburgh, C.R. and Selik, R.M. (1989) The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS). American Review of Respiratory Disease, 139, 4–7.

    Article  PubMed  Google Scholar 

  • Horsburgh, C.R. Jr, Havlik, J.A., Ellis, D.A. et al. (1991a) Survival of patients with acquired immunodeficiency syndrome and disseminated Mycobacterium avium complex infection with and without antimycobacterial chemotherapy. American Review of Respiratory Disease, 144, 557–9

    Article  PubMed  Google Scholar 

  • Horsburgh, C.R., Jr, Metchock, B.G., McGowan, J.E. et al. (1991b) Progression to disseminated infection in HIV-infected persons colonised with mycobacteria other than tuberculosis (MOTT). American Review of Respiratory Disease, 143, A279

    Article  Google Scholar 

  • Hoy, J., Mijch, A., Sandland, M. et al. (1990) Quadruple-drug therapy for Mycobacterium avium-intracellulare bacteremia in AIDS patients. Journal of Infectious Diseases, 161, 801–5.

    Article  PubMed  CAS  Google Scholar 

  • Huebner, R.E., Schein, M.F., Cauthen, G.M. et al. (1992) Evaluation of the clinical usefulness of mycobacterial skin test antigens in adults with pulmonary mycobacterioses. American Review of Respiratory Disease, 145, 1160–6.

    Article  PubMed  CAS  Google Scholar 

  • Huminer, D., Schlomo, D., Zmira, S. et al. (1993) Mycobacterium simiae infection in Israeli patients with AIDS. Clinical Infectious Diseases, 17, 50–89.

    Google Scholar 

  • Inderlied, C.B., Kemper, C.A. and Bermudez, L.E.M. (1993) The Mycobacterium avium complex. Review of Clinical Microbiology, 6, 266–310.

    CAS  Google Scholar 

  • Iralu, J.V., Sritharan, V.K., Pieciak, W.S. et al. (1993) Diagnosis of Mycobacterium avium bacteremia by polymerase chain reaction. Journal of Clinical Microbiology, 31, 1811–4.

    PubMed  CAS  Google Scholar 

  • Jackson, K., Sievers, A., Ross, B.C. et al. (1992) Isolation of a fastidious Mycobacterium species from two AIDS patients. Journal of Clinical Microbiology, 30, 2934–7.

    PubMed  CAS  Google Scholar 

  • Jacob, C., Henein, S., Heurich, A. et al. (1991) Nontuberculous mycobacterial meningitis in patients with AIDS. American Review of Respiratory Disease, 143, 279A.

    Article  Google Scholar 

  • Jacobson, MA., Hopewell, P.C., Yajko, D.M. et al. (1991) Natural history of disseminated Mycobacterium avium complex infection in AIDS. Journal of Infectious Disease, 164, 994–8.

    Article  CAS  Google Scholar 

  • Jacobson, MA., Yajko, D., Borthfeld, D. et al. (1993) Randomized, placebo-controlled trial of rifampin, ethambutol, and ciprofloxacin for patients with disseminated Mycobacterium avium complex infection. Journal of Infectious Diseases, 168, 112–19.

    Article  PubMed  CAS  Google Scholar 

  • Jenkins, P.A. (1985) Mycobacterium malmoense. Tubercle, 66, 193–5.

    Article  CAS  Google Scholar 

  • Kahn, S.A., Saltzman, B.R., Klein, R.S. et al. (1986) Hepatic disorders in the acquired immunodeficiency syndrome: a clinical and pathological study. American Journal of Gastroenterology, 81, 1145–8.

    PubMed  CAS  Google Scholar 

  • Kallenius, G., Hoffner, S.E. and Svenson, S.B. (1989) Does vaccination with the bacille Calmette-Guérin protect against AIDS? Review of Infectious Diseases, 11, 349–51.

    Article  CAS  Google Scholar 

  • Kemper, C., Havlir, D., Bartok, A.E. et al. (1992a) Transient bacteremia due to Mycobacterium avium complex in patients with AIDS. Front. Mycobacteriology, 17 [A].

    Google Scholar 

  • Kemper, C.A., Meng, T.-C., Nussbaum, J. et al. (1992b) Treatment of Mycobacterium avium complex bacteremia in AIDS with a four-drug oral regimen. Annals of Internal Medicine, 116, 466–72 [B].

    Google Scholar 

  • Kiehn, T.E. and Cammarata, R. (1986) Laboratory diagnosis of mycobacterial infections in patients with acquired immunodeficiency syndrome. Journal of Clinical Microbiology, 24, 708–11.

    PubMed  CAS  Google Scholar 

  • Kirschner, P., Vogel, U., Hein, R. et al. (1994) Bias of culture techniques for diagnosing mixed Mycobacterium genavense and Mycobacterium avium infection in AIDS. Journal of Clinical Microbiology, 32, 828–31.

    PubMed  CAS  Google Scholar 

  • Krasnow, I. and Gross, W. (1975) Mycobacterium simiae infection in the United States: a case report and discussion of the organism. American Review of Respiratory Disease, 111, 357–60.

    CAS  Google Scholar 

  • Kristjansson, M., Bieluch, V.M. and Byeff, P.D. (1991) Mycobacterium haemophilum infection in immunocompromised patients: case report and review of the literature. Review of Infectious Diseases, 13, 906–10.

    CAS  Google Scholar 

  • Kuitert, L.M., Thomas, M.G. and Ellis-Pegler, R.B. (1991) Outcome of untreated Mycobacterium avium-intracellulare complex infection in AIDS. AIDS, 5, 1036–8.

    Article  PubMed  CAS  Google Scholar 

  • Kurzrock, R., Zander, A., Vellekoop, L. (1984) Mycobacterial pulmonary infections after allogeneic bone marrow transplantation. American Journal of Medicine, 77, 35–40.

    Article  PubMed  CAS  Google Scholar 

  • Kusunoki, S. and Ezaki, T. (1992) Proposal of Mycobacterium peregrinum sp. nov., nom. rev., and elevation of Mycobacterium chelonae subsp. abscessus (Kubica et al.) to species status: Mycobacterium abscessus comb. nov. International Journal of Systematic Bacteriology, 42, 240–5.

    Article  PubMed  CAS  Google Scholar 

  • Lavy, A. and Yoshpe-Purer, Y. (1982) Isolation of Mycobacterium simiae from clinical specimens in Israel. Tubercle, 63, 279–85.

    Article  PubMed  CAS  Google Scholar 

  • Levine, B., and Chaisson, R.E. (1991) Mycobacterium kansasii: a cause of treatable pulmonary disease associated with advanced human immunodeficiency virus (HIV) infection. Annals of Internal Medicine, 114, 861–8.

    CAS  Google Scholar 

  • Lévy-Frébault, V., Grimont, F., Grimont, P. et al. (1986) Deoxyribonucleic acid relatedness study of the Mycobacterium fortuitum-Mycobacterium chelonae complex. International Journal of Systematic Bacteriology, 36, 458–60.

    Article  Google Scholar 

  • Lévy-Frébault, V., Pagnon, B., Bure, A. et al. (1987) Mycobacterium simiae and Mycobacterium avium-Mycobacterium intracellulare mixed infection in acquired immunodeficiency syndrome. Journal of Clinical Microbiology, 25, 154–7.

    Google Scholar 

  • MacCallum, P., Tolhurst, J.C., Buckle, G. et al. (1948) A new mycobacterial infection in man. Journal of Pathology and Bacteriology, 60, 93.

    Article  PubMed  CAS  Google Scholar 

  • Males, B.M., West, T.E. and Bartholomew, W.R. (1987) Mycobacterium haemophilum infection in a patient with acquired immunodeficiency syndrome. Journal of Clinical Microbiology, 25, 186–90.

    CAS  Google Scholar 

  • Maloney, S., Welbel, S., Daves, B. et al. (1993) Mycobacterium abscessus pseudoinfection traced to an automated endoscope washer: utility of epidemiologic and laboratory investigation. Journal of Infectious Diseases, 169, 1166–9.

    Google Scholar 

  • Marinelli, D.L., Albelda, S.M., Williams, T.M. et al. (1986) Nontuberculous mycobacterial infection in AIDS: clinical, pathologic, and radiologic features. Radiology, 160, 77–82.

    PubMed  CAS  Google Scholar 

  • McSwiggan, D.A. and Collins C.H. (1974) The isolation of M. kansasii and M. xenopi from water systems. Tubercle, 55, 291–7.

    Article  PubMed  CAS  Google Scholar 

  • Mehle, M.E., Adamo, J.P., Mehta, A.C. et al. (1989) Endobronchial Mycobacterium avium-intracellulare infection in a patient with AIDS. Chest, 96, 199–201.

    Article  PubMed  CAS  Google Scholar 

  • Meissner, P.S. and Falkinham, J.O. III (1986) Plasmid DNA profiles as epidemiological markers for clinical and environmental isolates of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum. Journal of Infectious Diseases, 153, 325–31.

    Article  CAS  Google Scholar 

  • Modilevsky, T., Sattler, F.R. and Barnes, P.F. (1989) Mycobacterial disease in patients with human immunodeficiency virus infection. Archives of Internal Medicine, 149, 2201–5.

    Article  PubMed  CAS  Google Scholar 

  • Moore, R.D. and Chaisson, R.E. (1995) Survival analysis of two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex in AIDS. AIDS, 9, 1337–42.

    Article  PubMed  CAS  Google Scholar 

  • Mushatt, D.M. and Witzig, R.S. (1995) Successful treatment of Mycobacterium abscess us infections with multidrug regimens containing clarithromycin [letter].

    Google Scholar 

  • Naguib, MT., Byers, J.M. and Slater, L.N. (1994) Paranasal sinus infection due to atypical mycobacteria in two patients with AIDS. Clinical Infectious Diseases, 19, 789–91.

    Article  PubMed  CAS  Google Scholar 

  • Newshan, G. and Torres, R.A., (1994) Pulmonary infection due to a multidrug resistant Mycobacterium szulgai in a patient with AIDS. Clinical Infectious Diseases, 18, 1022–3.

    Article  PubMed  CAS  Google Scholar 

  • Nightingale, S.D., Byrd, L.T., Southern, P.M. et al. (1992) Incidence of Mycobacterium aviumintracellulare complex bacteremia in human immunodeficiency virus-positive patients. Journal of Infectious Diseases, 165, 1082–5.

    Article  PubMed  CAS  Google Scholar 

  • Nightingale, S.D., Cameron, D.W., Gordin, F.M. et al. (1993) Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. New England Journal of Medicine, 329, 828–33.

    Article  PubMed  CAS  Google Scholar 

  • Opravil, M., Pechere, M., Lazzarin, A. et al. (1995) Dapsone/pyrimethamine may prevent mycobacterial disease in immunosuppressed patients infected with the human immunodeficiency virus. Clinical Infectious Diseases, 20, 224–9.

    Article  Google Scholar 

  • Ozenna, G., Morel, A., Menard, J.F. et al. (1988) Susceptibility of Mycobacterium avium complex to various two-drug combinations of anti-tuberculous drugs. American Review of Respiratory Disease, 138, 878–81.

    Article  Google Scholar 

  • Pechere, M., Opravil, M., Wald, A. et al. (1995) Clinical and epidemiologic features of infection with Mycobacterium genavense. Swiss HIV Cohort Study. Archives of Internal Medicine, 55, 400–4.

    Article  Google Scholar 

  • Pierce, M., Crampton, S., Henry, D. et al. (1996) A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome. New England Journal of Medicine, 335, 384–91.

    Article  PubMed  CAS  Google Scholar 

  • Piersimoni, C., Tortoli, E., De Sio, G. (1994) Disseminated infection due to Mycobacterium celatum in patients with AIDS. Lancet, 344, 332.

    Article  PubMed  CAS  Google Scholar 

  • Pitchenik, A.E. and Fertel, D. (1992) Medical management of AIDS patients: tuberculosis and nontuberculous mycobacterial disease. Medical Clinics of North America, 76, 121–71.

    PubMed  CAS  Google Scholar 

  • Poropatich, C.O., Labriola, A.M. and Tuazon, C.U. (1987) Acid-fast smear and culture of respiratory secretions, bone marrow, and stools as predictors of disseminated Mycobacterium avium complex infection. Journal of Clinical Microbiology, 25, 929–30.

    PubMed  CAS  Google Scholar 

  • Quieffin, J., Poubeau, P., Laaban, J.P. et al. (1994) Mycobacterium kansasii infection presenting as an endobronchial tumor in a patient with the acquired immune deficiency syndrome. Tubercle Lung Disease, 75, 313–5.

    CAS  Google Scholar 

  • Reich, J.M. and Johnson, R.E. (1992) Mycobacterium avium complex pulmonary disease presenting as an isolated lingula or middle lobe pattern. The Lady Windermere syndrome. Chest, 10, 1605–9.

    Google Scholar 

  • Research Committee, British Thoracic Scoiety (1994) Mycobacterium kansasii pulmonary infection: a prospective study of the results of nine months of treatment with rifampicin and ethambutol. Thorax, 49, 442–5.

    Google Scholar 

  • Ries, K.M., White, G.L. Jr, and Murdock, R.T. (1990) Atypical mycobacterial infection caused by Mycobacterium marinum [Letter]. New England Journal of Medicine, 322, 633.

    PubMed  CAS  Google Scholar 

  • Roberts, C., Clague, H., Jenkins, P.A. et al. (1985) Pulmonary infection with Mycobacterium malmoense: a report of four cases. Tubercle, 66, 205–9.

    Article  PubMed  CAS  Google Scholar 

  • Rogers, P.L., Walker, R.E., Lane, H.C. et al. (1988) Disseminated Mycobacterium haemophilum infection in two patients with the acquired immunodeficiency syndrome. American Journal of Medicine, 84, 640–2.

    Article  PubMed  CAS  Google Scholar 

  • Rose, H.D., Dorff, G.J., Lauwasser, M. et al. (1982) Pulmonary and disseminated Mycobacterium simiae infection in humans. American Review of Respiratory Disease, 126, 1110–13.

    PubMed  CAS  Google Scholar 

  • Runyon, E.H. (1959) Anonymous mycobacteria in pulmonary disease. Medical Clinics of North America, 43, 273.

    PubMed  CAS  Google Scholar 

  • Sack, J.B. (1990) Disseminated infection due to Mycobacterium fortuitum in a patient with AIDS. Review of Infectious Diseases, 12, 961–3.

    Article  CAS  Google Scholar 

  • Sanders, J.W., Walsh, A.D., Snider, R.L. et al. (1995) Disseminated Mycobacterium scrofulaceum infection: a potentially treatable complication of AIDS.

    Google Scholar 

  • Schluger, N.W., Condos, R., Lewis, S. et al. (1994) Amplification of DNA of Mycobacterium tuberculosis from peripheral blood of patients with pulmonary tuberculosis. Lancet, 344, 232–3.

    Article  PubMed  CAS  Google Scholar 

  • Schwabacher, H. (1959) A strain of mycobacterium isolated from skin lesions of a cold-blooded animal, Xenopus laevis, and its relation to atypical acid-fast bacilli occurring in man. Journal of Hygiene (Cambridge), 57, 57.

    Article  CAS  Google Scholar 

  • Shafer, R.W. and Sierra, M.F. (1992) Mycobacterium xenopi, Mycobacterium fortuitum, Mycobacterium kansasii, and other nontuberculous mycobacteria in an area of endemicity for AIDS. Clinical Infectious Diseases, 15, 161–2.

    CAS  Google Scholar 

  • Shafran, S.D., Singer, J., Zarowny, D.P. et al. (1996) A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol and clarithromycin versus rifampicin, ethambutol, clofazamine and ciprofloxacin. New England Journal of Medicine, 335, 377–83.

    Article  PubMed  CAS  Google Scholar 

  • Sherer, R., Sable, R., Sonnenberg, M. et al. (1986) Disseminated infection with Mycobacterium kansasii in the acquired immunodeficiency syndrome. Annals of Internal Medicine, 105, 710–12.

    Article  PubMed  CAS  Google Scholar 

  • Sippola, A.A., Gillespie, S.L., Lewis, J.A. et al. (1993) Mycobacterium avium Antigenuria in patients with AIS and disseminated M. avium disease. Journal of Infectious Diseases, 168, 46–68.

    Google Scholar 

  • Slutsky, A.M., Arbeit, R.D., Barber, T.W. et al. (1994) Polyclonal infections due to Mycobacterium avium complex in patients with AIDS detected by pulsed-field gel electrophoresis of sequential clinical isolates. Clinical Microbiology, 32, 1773–8.

    CAS  Google Scholar 

  • Sompolinsky, D., Lagziel, A., Naveh, D. et al. (1978) Mycobacterium haemophilum sp. nov., a new pathogen of humans. International Journal of Systematic Bacteriology, 28, 67–75.

    Article  Google Scholar 

  • Steere, A.C., Corrales, J. and von Graevenitz, A. (1979) A cluster of Mycobacterium gordonae isolates from bronchoscopy specimens. American Review of Respiratory Disease, 120, 214–6.

    PubMed  CAS  Google Scholar 

  • Stormer, R.S. and Falkinham, J.O. III. (1989) Differences in antimicrobial susceptibility of pigmented and unpigmented colonial variants of Mycobacterium avium. Journal of Clinical Microbiology, 27, 2459–65.

    CAS  Google Scholar 

  • Straus, W.L., Ostroff, S.M., Jernigan, D.B. et al. (1994) Clinical and epidemiological characteristics of Mycobacterium haemophilum, an emerging pathogen in immunocompromised patients. Annals of Internal Medicine, 120, 118–25.

    Article  PubMed  CAS  Google Scholar 

  • Tecson-Tumang, F.T. and Bright, J.L. (1984) Mycobacterium xenopi and the acquired immunodeficiency syndrome. Annals of Internal Medicine, 100, 461–2.

    Article  CAS  Google Scholar 

  • Telenti, A., Marchesi, F., Balz, M. et al. (1993) Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. Journal of Clinical Microbiology, 31, 175–8.

    PubMed  CAS  Google Scholar 

  • Telles, M.A.S. and Yates, M.D. (1994) Single and double drug susceptibility testing of Mycobacterium avium complex and mycobacteria other than tubercle bacilli (MOTT) by a micro-dilution broth minimum inhibitory concentration (MIC) method. Tubercle, 75, 286–90.

    CAS  Google Scholar 

  • Thibert, L., Lebel, F. and Martineau, B. (1990) Two cases of Mycobacterium haemophilum infection in Canada. Journal of Clinical Microbiology, 28, 621–3.

    PubMed  CAS  Google Scholar 

  • Thierry, D., Baugé, S., Poveda, J.-D. et al. (1993) Rapid identification of Mycobacterium aviumintracellulare complex strains: clinical practice evaluation of DT6 and DT1 probes. Journal of Infectious Diseases, 168, 1337–8.

    Article  PubMed  CAS  Google Scholar 

  • Torres, R.A., Nord, J., Feldman, R. et al. (1991) Disseminated mixed Mycobacterium simiaeMycobacterium avium complex infection in acquired immunodeficiency syndrome. Journal of Infectious Diseases, 164, 432–3.

    Article  PubMed  CAS  Google Scholar 

  • Tortoli, E., Simonetti, T.M., Laccini, C. et al. (1994) Tentative evidence of AIDS-associated biotype of Mycobacterium kansasii. Journal of Clinical Microbiology, 32, 1779–82.

    CAS  Google Scholar 

  • Tsukamura, M. (1984) The ‘non-pathogenic’ species of mycobacteria: their distribution and ecology in non-living reservoirs, in The Mycobacteria. A Sourcebook. Park B (eds G.P. Kubica and L.G. Wayne ), Marcel Dekker, New York, pp. 1339–59.

    Google Scholar 

  • Valainis, G.T. (1991) Mycobacterium kansasii infection [letter]. Annals of Internal Medicine, 115, 496–7.

    Article  PubMed  CAS  Google Scholar 

  • Vaneechoutte, M., De Beenhouwer, H., Claeys, G. et al. (1993) Identification of Mycobacterium species by using amplified ribosomal DNA restriction analysis. Journal of Clinical Microbiology, 31, 2061–5.

    PubMed  CAS  Google Scholar 

  • von Reyn, C.F., Maslow, J.N., Barber, T.W. et al. (1994) Persistent colonisation of potable water as a source of Mycobacterium avium infection in AIDS. Lancet, 343, 1137–41.

    Article  Google Scholar 

  • Wald, A., Coyle, M.B., Carlson, L.C. et al. (1992) Infection with a fastidious mycobacterium resembling Mycobacterium simiae in seven patients with AIDS. Annals of Internal Medicine, 17, 586–9.

    Article  Google Scholar 

  • Wallace, R.J. Jr, Dunbar, D., Brown, B.A. et al. (1994) Rifampin-resistant Mycobacterium kansasii. Clinical Infectious Diseases, 18, 736–43.

    Article  CAS  Google Scholar 

  • Wallace, R.J., Brown, B.A. and Onyi, G.O. (1992) Skin, soft tissue, and bone infections due to M. chelonae chelonae: importance of prior corticosteroid therapy, frequency of disseminated infections, and resistance to oral antimicrobials other than clarithromycin. Journal of Infectious Diseases, 166, 405–12.

    Article  PubMed  Google Scholar 

  • Wallace, R.J., Jr, O’Brien, R., Glassroth, J. et al. (1990) Diagnosis and treatment of disease caused by nontuberculous mycobacteria. American Review of Respiratory Disease, 142, 940–53.

    Article  Google Scholar 

  • Wasem, C.F., McCarthy, C.M. and Murray, L.W. (1991) Multilocus enzyme electrophoresis analysis of the Mycobacterium avium complex and other mycobacteria. Journal of Clinical Microbiology, 29, 264–71.

    PubMed  CAS  Google Scholar 

  • Wayne, L.G. and Sramek, H.A. (1992) Agents of newly recognised or infrequently encountered mycobacterial diseases. Clinical Microbiology Reviews, 5, 1–25.

    PubMed  CAS  Google Scholar 

  • Weinberger, M., Berg, S.L., Feuerstein, I.R. et al. (1992) Disseminated infection with Mycobacterium gordonae: report of a case and critical review of the literature. Clinical Infectious Diseases, 14, 1229–39.

    Article  PubMed  CAS  Google Scholar 

  • Wendt, S.L., George, K.L., Parker, B.C. et al. (1980) Epidemiology of infection by nontuberculous mycobacteria. III. Isolation of potentially pathogenic mycobacteria from aerosols. American Review of Respiratory Disease, 122, 259–63.

    PubMed  CAS  Google Scholar 

  • Wiley, E.L., Perry, A., Nightingale, S.D. et al. (1992) Detection of M. avium-intracellulare using anti-BCG, anti-M. duvalii, Kenyon, and Fite stains in bone marrow biopsies (abstract PoB 3359, p.B146). 8th International Conference on AIDS.

    Google Scholar 

  • Willocks, L., Leen, C.L.S., Brettle, R.P. et al. (1993) Isolation of Mycobacterium malmoense from HIV-positive patients [letter]. Journal of Infection, 26, 345–6.

    Article  PubMed  CAS  Google Scholar 

  • Wolinsky, E. (1979) Nontuberculous mycobacteria and associated diseases. American Review of Respiratory Disease, 119, 107–59.

    PubMed  CAS  Google Scholar 

  • Wormser, G.P., Horowitz, H. and Dworkin, B. (1994) Low-dose dexamethasone as adjunctive therapy for disseminated Mycobacterium avium complex infections in AIDS patients. Antimicrobial Agents in Chemotherapy, 38, 2215–17.

    Article  CAS  Google Scholar 

  • Yajko, D.M., Nassos, P.S. and Hadley, W.K. (1987) Broth microdilution testing of susceptibilities to 30 antimicrobial agents of Mycobacterium avium strains from patients with acquired immunodeficiency syndrome. Antimicrobial Agents and Chemotherapy, 31, 1579–84.

    Article  PubMed  CAS  Google Scholar 

  • Yakrus, M., Butler, W., Kilburn, J. et al. (1992) Characterization of a possible novel drug resistant species of mycobacteria associated with pulmonary disease is AIDS patients (Abstr U-24. p. 169) Abst. 92nd Gen. Meet. American Society of Microbiology 1992.

    Google Scholar 

  • Yoganathan, K., Elliott, M.W., Moxham, J. et al. (1994) Pseudotumour of the lung caused by Mycobacterium malmoense infection in an HIV positive patient. Thorax, 49, 179–80.

    Article  PubMed  CAS  Google Scholar 

  • Young, L.S., Wiviott, L., Wu, M. et al. (1991) Azithromycin for treatment of Mycobacterium avium complex infection in patients with AIDS. Lancet, 338, 1107–9.

    Article  PubMed  CAS  Google Scholar 

  • Zaugg, M., Salfinger, M., Opravil, M. et al. (1993) Extrapulmonary and disseminated inections due to Mycobacterium malmoense: case report and review. Clinical Infectious Diseases, 16, 540–9.

    Article  PubMed  CAS  Google Scholar 

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  1. Anton Pozniak
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Editors and Affiliations

  1. Department of Medicine, University College London Medical School, London, UK

    Alimuddin Zumla BSc MB ChB MSc PhD FRCP (Director, Visiting Professor, Honorary Consultant in Infectious Diseases) (Director, Visiting Professor, Honorary Consultant in Infectious Diseases)

  2. Camden and Islington Community Health Services NHS Trust, London, UK

    Alimuddin Zumla BSc MB ChB MSc PhD FRCP (Director, Visiting Professor, Honorary Consultant in Infectious Diseases) (Director, Visiting Professor, Honorary Consultant in Infectious Diseases)

  3. Department of Medicine, University of Zambia School of Medicine, Lusaka, Zambia

    Alimuddin Zumla BSc MB ChB MSc PhD FRCP (Director, Visiting Professor, Honorary Consultant in Infectious Diseases) (Director, Visiting Professor, Honorary Consultant in Infectious Diseases)

  4. Department of Respiratory Medicine, The Royal Free Hospital, London, UK

    Margaret Johnson MD, FRCP (Consultant Physician) (Consultant Physician)

  5. Department of Sexually Transmitted Diseases, Division of Pathology and Infectious Diseases, University College London Medical School, London, UK

    Robert Miller MB FRCP (Senior Lecturer/Honorary Consultant Physician, Honorary Consultant Physician) (Senior Lecturer/Honorary Consultant Physician, Honorary Consultant Physician)

  6. Camden and Islington Community Health Services NHS Trust, London, UK

    Robert Miller MB FRCP (Senior Lecturer/Honorary Consultant Physician, Honorary Consultant Physician) (Senior Lecturer/Honorary Consultant Physician, Honorary Consultant Physician)

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Pozniak, A. (1997). Atypical Mycobacteria in AIDS. In: Zumla, A., Johnson, M., Miller, R. (eds) AIDS and Respiratory Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3446-8_13

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