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Pulmonary Physiology of Acute Lung Injury

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ARDS Acute Respiratory Distress in Adults

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Abstract

Regardless of the precipitating cause, the pathophysiology of acute lung injury is relatively uniform and characterized by an abnormal increase in pulmonary endothelial and epithelial permeability [1] (Chapter 4). This results in the accumulation of fluid in the pulmonary interstitial and alveolar spaces, reducing ventilated lung volume and resulting in impaired gas exchange, a large increase in intrapulmonary shunt and reduced lung compliance [21. Other processes including damage to the surfactant system [3] (Chapter 17) and progressive pulmonary fibrosis [4] may further influence gas exchange and lung compliance adversely.

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Authors
  1. Peter D. Macnaughton
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Editors and Affiliations

  1. National Heart & Lung Institute, USA

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  2. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  3. University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK

    Christopher Haslett FRCP, FRCP (Edin) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories)

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Macnaughton, P.D. (1996). Pulmonary Physiology of Acute Lung Injury. In: Evans, T.W., Haslett, C. (eds) ARDS Acute Respiratory Distress in Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3430-7_15

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  • DOI: https://doi.org/10.1007/978-1-4899-3430-7_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-56910-4

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