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Secondary Infections in Acute Lung Injury

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Book cover ARDS Acute Respiratory Distress in Adults

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Abstract

Infection and sepsis syndrome were recognized as common and severe complications of the syndrome of acute respiratory distress in adults (ARDS) shortly after the term ARDS was coined [1]. Infections, particularly pulmonary infections, are the leading cause of death in patients who survive for more than 3 days after the onset of their ARDS [2]. This association between secondary infections and lung injury probably results because: (1) the presence of a critical illness is a predisposing factor for the entry of microbes into the lung; and/or (2) the lung injury of ARDS impairs pulmonary host defenses. The interaction between microbes and the pulmonary defenses is dynamic. During this interaction the host utilizes many defensive strategies to prevent microbes from getting a foothold within the respiratory tract.

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Authors
  1. Galen B. Toews
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Editors and Affiliations

  1. National Heart & Lung Institute, USA

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  2. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  3. University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK

    Christopher Haslett FRCP, FRCP (Edin) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories)

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Toews, G.B. (1996). Secondary Infections in Acute Lung Injury. In: Evans, T.W., Haslett, C. (eds) ARDS Acute Respiratory Distress in Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3430-7_14

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  • DOI: https://doi.org/10.1007/978-1-4899-3430-7_14

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