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Niacin and tryptophan

  • Chapter
Bioavailability and Analysis of Vitamins in Foods

Abstract

The human disease of pellagra was first described in Spain by Casal in 1735 after the introduction of maize into Europe from the Americas. In the 1920s, Goldberger (USA) reported that pellagra and black tongue in dogs responded to treatment with animal protein and also to boiled protein-free extracts of yeast. In 1937, Elvehjem found that the active component in liver extracts used to successfully treat canine black tongue was nicotinamide, and reports that nicotinic acid cured pellagra soon followed.

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Ball, G.F.M. (1998). Niacin and tryptophan. In: Bioavailability and Analysis of Vitamins in Foods. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3414-7_9

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