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Bioavailability and Analysis of Vitamins in Foods pp 439–496Cite as

Folate

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Abstract

In 1931, a research group led by Lucy Wills showed that an autolysed yeast preparation (Marmite), which was therapeutically ineffective against the pernicious anaemia caused by vitamin B12 deficiency, was effective against nutritional megaloblastic anaemia in pregnant women. These researchers induced a similar anaemia in monkeys which then responded to crude liver extracts. Other substances that cured specific deficiency anaemias in monkeys and chicks were isolated from yeast by different research groups and assigned the names ‘vitamin M’ and ‘vitamin Bc’. Another substance isolated from liver was shown to be essential to the growth of Lactobacillus casei and was therefore called the ‘L. casei factor’. In 1941, Mitchell and co-workers processed four tons of spinach leaves to obtain a purified substance with acidic properties which was an active growth factor for rats and L. casei. They named the factor ‘folic acid’ (from folium, the Latin word for leaf). Eventually, all of the above substances proved to be the same when Angier’s group in 1946 accomplished the synthesis and chemical structure of folic acid.

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Ball, G.F.M. (1998). Folate. In: Bioavailability and Analysis of Vitamins in Foods. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3414-7_13

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