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Metabolic, endocrine and drug-induced myopathies

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Part of the book series: Biopsy Pathology Series ((BPS))

Abstract

The metabolic, endocrine and drug-induced myopathies are discussed in this chapter as a related group of disorders because, in a general sense, they share a common pathogenetic mechanism. The metabolic myopathies result from a biochemical defect in muscle metabolism itself, the endocrine myopathies from an abnormal hormonal environment, probably affecting muscle metabolism, and the drug-induced myopathies from a direct toxic effect of the drug on muscle metabolism. In some drug-induced myopathies, e.g. malignant hyperpyrexia myopathy, the drug effect is manifest only in susceptible individuals.

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References

  • Afifi, A. K., Bergman, R. A. and Harvey, J. C. (1968), Steroid myopathy: clinical, histological and cytological observations. Johns Hopkins Med. J., 123, 158–74.

    CAS  PubMed  Google Scholar 

  • Askari, A., Vignos, P. J. Jr, and Moskowitz, R. W. (1976), Steroid myopathy in connective tissue diseases. Am. J. Med., 61, 485–92.

    Article  CAS  PubMed  Google Scholar 

  • Bank, W. J., Di Mauro, S., Bonilla, E. et al. (1975), A disorder of lipid metabolism and myoglobinuria. New Engl. J. Med., 292, 443–9.

    Article  CAS  PubMed  Google Scholar 

  • Berenberg, R. A., Pellock, J. M., Di Mauro, S. et al. (1977), Lumping or splitting? ‘Ophthalmoplegia plus’ or Kearns-Sayre syndrome? Ann. Neurol., 1, 37–54.

    Article  CAS  PubMed  Google Scholar 

  • Bonilla, E. and Schotland, D. L. (1970), Histochemical diagnosis of muscle phosphofructokinase deficiency. Arch. Neurol., 22, 8–12.

    Article  CAS  PubMed  Google Scholar 

  • Brunberg, J.. A., McCormick, W. F. and Schochet, S. S. (1971), Type III glycogenosis. An adult with diffuse weakness and muscle wasting. Arch. Neurol., 25, 171–8.

    Article  CAS  PubMed  Google Scholar 

  • Busch, H. F. M., Koster, J. F. and van Weerden, T. W. (1979), Infantile and adult-onset acid maltase deficiency occurring in the same family. Neurology (NY), 29, 415–16.

    Article  CAS  Google Scholar 

  • Denborough, M. A., Dennett, X. and Anderson, P. M. (1973), Central core disease and malignant hyperpyrexia. Br. Med. J., 1, 272–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Di Mauro, S., Arnold, S., Miranda, A. and Rowland, L. P. (1978), McArdle’s disease: the mystery of reappearing phosphorylase activity in muscle culture–a fetal isoenzyme. Ann. Neurol., 3, 60–6.

    Article  Google Scholar 

  • Di Mauro, S., Hartwig, G. B., Hayes, A. et al. (1979), Debranching deficiency: neuromuscular disorders in 5 adults. Ann. Neurol., 5, 422–36.

    Article  Google Scholar 

  • Dubowitz, V. and Brooke, M. H. (1973), Muscle Biopsy - A Modern Approach, W. B. Saunders, London.

    Google Scholar 

  • Ellis, F. R. and Halsall, P. J. (1980), Malignant hyperpyrexia. Br. J. Hosp. Med., 24, 318–27.

    CAS  PubMed  Google Scholar 

  • Engel, A. G. (1966), Electron microscopic observations in thyrotoxic and corticosteroid-induced myopathies. Mayo Clin. Proc., 41, 785–96.

    CAS  PubMed  Google Scholar 

  • Engel, A. G. (1970a), Acid maltase deficiency in adults. Brain, 93, 599–606. Engel, A. G. (1970b), Evolution and content of vacuoles in primary hypokalaemic periodic paralysis. Mayo Clin. Proc., 45, 774–814.

    CAS  PubMed  Google Scholar 

  • Engel, A. G. and Angelini, C. (1973), Carnitine deficiency of human muscle with associated lipid storage myopathy: a new syndrome. Science, 179, 899–902.

    Article  CAS  PubMed  Google Scholar 

  • Engel, W. K. (1971), ‘Ragged-red fibres’ in ophthalmoplegia syndromes and their differential diagnosis. In Muscle Diseases (ed. B. A. Kakulas), ICS 237, Exerpta Medica, Amsterdam, p. 28.

    Google Scholar 

  • Godet-Guillain, J. and Fardeau, M. (1970), Hypothyroid myopathy: histological and ultrastructural study of an atrophic form. In Muscle Diseases (eds J. N. Walton, N. Canal and S. Scarlato), ICS 199, Excerpta Medica, Amsterdam, pp. 512–15.

    Google Scholar 

  • Harriman, D. G. F. and Reid, R. (1972), The incidence of lipid droplets in human skeletal muscle in neuromuscular disorders: a histochemical, electron microscopic and freeze-etch study. J. Pathol., 106, 1–24.

    Article  CAS  PubMed  Google Scholar 

  • Hogan, G. R. Gutamann L., Schmidt, R., and Gilbert, E. (1969), Pompe’s disease. Neurology (Minneap.), 19, 894–900.

    Article  CAS  Google Scholar 

  • Karpati, G., Carpenter, S., Engel, A. G. et al. (1975): The syndrome of systemic carnitine deficiency. Neurology (Minneap.), 25, 16–24.

    Article  CAS  Google Scholar 

  • Karpati, G., Carpenter, S., Eisen, A. et al. (1977), The adult form of acid maltase (a 1:4 glucosidase) deficiency. Ann. Neurol., 1, 276–80.

    Article  CAS  PubMed  Google Scholar 

  • Markowitz, H. and Wobig, G. H. (1977), Quantitative method for estimating myoglobin in urine. Clin. Chem., 23, 1689–93.

    CAS  PubMed  Google Scholar 

  • Mastaglia, F. L. and Argov, Z. (1981), Drug-induced neuromuscular disorders in man. In Disorders of Voluntary Muscle, 4th edn (ed. J. N. Walton ), Churchill Livingstone, Edinburgh, pp. 873–906.

    Google Scholar 

  • Mastaglia, F. L., Barwick, D. D. and Hall, R. (1970), Myopathy in acromegaly. Lancet, ii, 907–9.

    Google Scholar 

  • McArdle, B. (1951), Myopathy due to a defect in muscle glycogen breakdown. Clin. Sci., 10, 13–33.

    CAS  Google Scholar 

  • McKeran, R. O., Slavin, G., Ward, P. et al. (1980), Hypothyroid myopathy: a clinical and pathological study. J. Pathol., 132, 35–54.

    Article  CAS  PubMed  Google Scholar 

  • Morgan-Hughes, J. A. (1982), Defects of the energy pathways of skeletal muscle. In Recent Advances in Clinical Neurology, Vol. 3 (eds W. B. Matthews and G. H. Glaser ), Churchill Livingstone, Edinburgh., pp. 1–46.

    Google Scholar 

  • Morgan-Hughes, J. A., Hayes, D. J., Clark, J. B. et al. (1982), Mitochondrial encephalomyopathies: biochemical studies in two cases revealed defects in the respiratory chain. Brain, 105, 553–82.

    Article  PubMed  Google Scholar 

  • Nagulesparen, M., Trickey, R., Davies, M. J. and Jenkins, J. S. (1976), Muscle changes in acromegaly. Br. Med. J., 2, 914–15.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Olson, W., Engel, W. K., Walsh, G. O. and Einaugler, R. (1972), Oculo cranio somatic neuromuscular disease with ‘ragged-red fibres’. Histochemical and ultrastructural changes in limb muscles of a group of patients with idiopathic progressive external ophthalmoplegia. Arch. Neurol., 26, 193–211.

    Article  CAS  PubMed  Google Scholar 

  • Pleasure, D. E., Walsh, G. O. and Engel, W. K. (1970), Atrophy of skeletal muscles in patients with Cushing’s syndrome. Arch. Neurol., 22, 118–25.

    Article  CAS  PubMed  Google Scholar 

  • Rubenstein, A. E. and Wainapel, S. F. (1977), Acute hypokalaemic myopathy in alcoholism. Arch. Neurol., 34, 553–5.

    Article  CAS  PubMed  Google Scholar 

  • Schiller, H. H. and Mair, W. G. P. (1974), Ultrastructural changes of muscle in malignant hyperthermia. J. Neurol. Sci., 21, 93–100.

    Article  CAS  PubMed  Google Scholar 

  • Schott, G. D. and Wills, M. R. (1975), Myopathy in hypophosphataemic

    Google Scholar 

  • Metabolic, endocrine and drug-induced myopathies 157 osteomalacia presenting in adult life. J. Neurol. Neurosurg. Psychiatry,38 297–304.

    Google Scholar 

  • Shirabe, T., Tawara, S., Terao, A. and Araki, S. (1975), Myxoedematous polyneuropathy. J. Neurol. Neurosurg. Psychiatry, 38, 241–7.

    Article  CAS  PubMed  Google Scholar 

  • Swash, M. and Schwartz, M. S. (1981), Neuromuscular Diseases: A Practical Approach to Diagnosis and Management, Springer-Verlag, Berlin, Heidelberg, New York.

    Google Scholar 

  • Swash, M. and Schwartz, M. S. (1983) Iatrogenic neuromuscular disorders: are view. Proc. R. Soc. Med., 76, 149–51.

    CAS  Google Scholar 

  • Swash, M., Schwartz, M. S. and Sargeant, M. K. (1978), The significance of ragged-red fibres in neuromuscular disease. J. Neurol. Sci., 36, 347–55.

    Article  Google Scholar 

  • Tarui, S., Kono, N., Nasu, T. and Nishikawa, M. (1969), Enzymatic basis for the co-existence of myopathy and haemolytic disease in inherited muscle phosphofructokinase deficiency. Biochem. Biophys. Res. Comm., 34, 77–83.

    Article  CAS  PubMed  Google Scholar 

  • Tarvik, A., Dietrichson, P. K., Svaar, H. and Hudgson, P. (1974), Myopathy with tremor and dementia: a metabolic disorder? J. Neurol. Sci., 21, 181–90.

    Article  Google Scholar 

  • Tassin, S. and Brucher, J. M. (1982), The mitochondrial disorders: pathogenesis and aetiological classification. Neuropathol. Appl. Neurobiol., 8, 251–63.

    Google Scholar 

  • Tassin, S., Walter, G. F., Brucher, J. M. and Rousseau, J. J. (1980), Histochemical and ultrastructural analysis of the mitochondrial changes in a familial mitochondrial myopathy. Neuropathol. Appl. Neurobiol., 6, 337–47.

    Article  CAS  PubMed  Google Scholar 

  • Tobin, W. E., Hijing, F., Porro, R. S. and Salzman, R. T. (1973), Muscle phosphofructokinase deficiency. Arch. Neurol., 28, 128–30.

    Article  CAS  PubMed  Google Scholar 

  • Weller, R. O. and McArdle, B. (1971), Calcification within muscle fibres in the periodic paralyses. Brain, 94, 263–72.

    Article  CAS  PubMed  Google Scholar 

  • Willner, J., Di Mauro, S., Eastwood, A. et al. (1979), Muscle carnitine deficiency: genetic heterogeneity. J. Neurol. Sci., 41, 235–46.

    Article  CAS  PubMed  Google Scholar 

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© 1984 M. Swash and M. S. Schwartz

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Swash, M., Schwartz, M.S. (1984). Metabolic, endocrine and drug-induced myopathies. In: Biopsy Pathology of Muscle. Biopsy Pathology Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3402-4_8

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  • DOI: https://doi.org/10.1007/978-1-4899-3402-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-24420-9

  • Online ISBN: 978-1-4899-3402-4

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