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Hyperplasia, metaplasia and carcinoma in situ

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Biopsy Pathology of the Bronchi

Part of the book series: Biopsy Pathology Series ((BPS))

Abstract

When the tracheobronchial epithelium is damaged, mucous cells and basal cells proliferate in response to the injury. Mucous cells appear to play the dominant proliferative role and, resulting from a marked increase in their mitotic rate, pathological lesions are produced which include ‘goblet’ cell hyperplasia, stratification and noncornifying and cornifying epidermoid (squamous) metaplasias. These lesions, although morphologically dissimilar, are brought about by the wide and varied spectrum of phenotypic expression of mucous cells. Depending on the nature and extent of the injury, one or more of these lesions may be expressed simultaneously in the same specimen, and one lesion may change into another.

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Authors and Affiliations

  1. School of Medicine, University of Maryland, Baltimore, Maryland, USA

    Elizabeth M. Mcdowell B Vet Med, PhD (Cantab) (Professor of Pathology)

  2. Veterans Administration Medical Center, University of Michigan School of Medicine, Ann Arbor, Michigan, USA

    Theodore F. Beals MD (Assistant Professor of Pathology, Director of Clinical Electron Microscopy Program)

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  1. Elizabeth M. Mcdowell B Vet Med, PhD (Cantab)
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  2. Theodore F. Beals MD
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© 1986 E.M. McDowell and T.F. Beals

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Mcdowell, E.M., Beals, T.F. (1986). Hyperplasia, metaplasia and carcinoma in situ . In: Biopsy Pathology of the Bronchi. Biopsy Pathology Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3398-0_9

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  • DOI: https://doi.org/10.1007/978-1-4899-3398-0_9

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