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Effects of HIV infection on the immune system

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Book cover Blood, Blood Products — and AIDS —

Abstract

The acquired immune deficiency syndrome (AIDS) is characterized by progressive lymphopenia, predominantly of T helper/inducer cells, which renders the patient susceptible to a variety of opportunistic infections and malignancies. AIDS itself remains a clinical diagnosis and is but one manifestation of a spectrum of clinical and subclinical immunologic disorders caused by the human immunodeficiency virus (HIV), also known as HTLV-III, LAV, or ARV (Barré-Sinoussi et al., 1983; Gallo et al., 1984; Levy et al., 1984; Coffin et al, 1986).

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References

  • Abrams, D. I., Lewis, B. J., Beckstead, J. H., Casavant, C. A. and Drew, W. L. (1984) Persistent diffuse lymphadenopathy in homosexual men: endpoint or prodrome? Ann. Intern. Med., 100, 801–8.

    PubMed  CAS  Google Scholar 

  • Alocer-Varela, J., Alarcon-Segovia, D. and Abud-Mendoza, C. (1985) Immuno-regulatory circuits in the acquired immune deficiency syndrome and related complex. Production of and response to interleukins 1 and 2, NK function and its enhancement by interleukin-2 and kinetics of the autologous mixed lymphocyte reactions. Clin. Exp. Immunol., 60, 31–8.

    Google Scholar 

  • Ammann, A. J., Abrams, D., Conant, M., Chudwin, D., Cowan, M., Volberding, P., Lewis, B. and Casavant, C. (1983) Acquired immune dysfunction in homosexual men: immunologic profiles. Clin. Immunol. Immunopath., 27, 315–25.

    CAS  Google Scholar 

  • Ammann, A. J., Schiffman, G., Abrams, D., Volberding, P., Ziegler, J. and Conant, M. (1984) B-cell immunodeficiency syndrome in acquired immune deficiency syndrome. JAMA, 251, 1447–9.

    PubMed  CAS  Google Scholar 

  • Armstrong, J. A. and Horne, R. (1985) Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet, ii, 370–2.

    Google Scholar 

  • Arya, S. K. and Gallo, R. C. (1985) Human T cell growth factor (interleukin 2) and α-interferon genes: expression in human T lymphotropic virus type III and type I cells. Proc. Natl Acad. Sci. USA, 82, 8691–5.

    PubMed  CAS  Google Scholar 

  • Bank, I. and Chess, L. (1985) Perturbation of the T4 molecule transmits a negative signal to T cells. J. Exp. Med., 162, 1294–303.

    PubMed  CAS  Google Scholar 

  • Barin, F., McLane, M. F., Allan, J. S., Lee T. H., Groopman, J. E. and Essex, M. (1985) Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients. Science, 228, 1094–6.

    PubMed  CAS  Google Scholar 

  • Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Charmarat, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vezinet-Brun, F., Rouzioux, C., Rozenbaum, W. and Montagnier, L. (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for the acquired immunodeficiency syndrome (AIDS). Science, 220, 868–71.

    PubMed  Google Scholar 

  • Bender, B. S., Quinn, T. C., Lawley, T. J., Smith, W., Brickman, C. and Frank, M. M. (1984) Acquired immune deficiency syndrome: a defect in Fc-receptor specific clearance. Clin. Res., 32, 511 A.

    Google Scholar 

  • Bender, B. S., Arger, F. A., Quinn, T. C., Redfield, R., Gold, J., and Folks, T. M. (1986) Impaired antibody-dependent cell-mediated cytotoxic activity acquired immunodeficiency syndrome. Clin. Exp. Immunol., 64, 166–72.

    PubMed  CAS  Google Scholar 

  • Benveniste, E., Schroff, R., Stevens, R. H. and Gottlieb, M. S. (1983) Immunoregulatory T cells in men with a new acquired immunodeficiency syndrome. J. Clin. Immunol., 3, 359–67.

    PubMed  CAS  Google Scholar 

  • Biddison, W. E., Rao, P. E., Talle, M. A., Goldstein, G. and Shaw, S. (1984) Possible involvement of the T4 molecule in T cell recognition of class II HLA antigens. J. Exp. Med., 159, 783–97.

    PubMed  CAS  Google Scholar 

  • Biggar, R. J., Taylor, P. H., Goldstein, A. L., Melbye, M., Ebbesen, P., Mann, D. L. and Strong, D. M. (1983) Thymosin α1 levels and helper: suppressor ratios in homosexual men. N. Engl. J. Med., 309, 49.

    PubMed  CAS  Google Scholar 

  • Biggar, R. J., Melbye, M., Ebbesen, P., Alexander, S., Nielsen, J. O., Sarin, P. and Faber, V. (1985) Variation in HTLV-III antibodies in homosexual men: decline before onset of illness related to acquired immune deficiency syndrome (AIDS). Brit. Med. J., 291, 997–8.

    CAS  Google Scholar 

  • Birx, D. L., Redfield, R. R. and Tosato, G. (1986) Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N. Engl. J. Med., 314, 874–9.

    PubMed  CAS  Google Scholar 

  • Boumpas, D., Harris, C., Hooks, J., Popovic, M. and Mann, D. (1984) A human T cell lymphoma virus infected B lymphocyte line produces acid labile interferon alpha. Clin. Res., 32, 343A.

    Google Scholar 

  • Chan, W. C., Brynes, R. K., Spira, T. J., Banks, P. M., Thurmond, C. C., Ewing, E. P. and Chandler, F. W. (1985) Lymphocyte subsets in lymph nodes of homosexual men with generalized lymphadenopathy correlation with morphology and blood changes. Arch. Pathol. Lab. Med., 107, 133–7.

    Google Scholar 

  • Ciobanu, N., Weite, K., Kruger, G., Venuta, S., Gold, J., Feldman, S. P., Wang, C. Y., Koziner, B., Moore, M. A. S., Safai, B. and Mertelsmann, R. (1983) Defective T-cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and its in vitro correction by interleukin 2. J. Clin. Immunol, 3, 332–40.

    PubMed  CAS  Google Scholar 

  • Clement, L. T., Grossi, C. E. and Gartland, L. J. (1984) Morphologic and phenotypic features of the subpopulation of Leu2+ cells that suppresses B cell differentiation. J. Immunol, 133, 2461–8.

    PubMed  CAS  Google Scholar 

  • Clement, L. T., Dagg, M. K. and Landay, A. (1984) Characterization of human lymphocyte subpopulations: alloreactive cytotoxic T lymphocyte precursor and effector cells are phenotypically distinct from Leu2+ suppressor cells. J. Clin. Immunol, 4, 395–402.

    PubMed  CAS  Google Scholar 

  • Coffin, J., Haase, A., Levy, J. A., Montagnier, L., Oroszlan, S., Teich, N., Temin, H., Toyoshima, K., Varmus, H., Vogt, P. and Weiss, R. (1986) Human immunodeficiency viruses. Science, 232, 697.

    PubMed  CAS  Google Scholar 

  • Cooper, D. A., Gold, J., Maclean, P., Donovan, B., Finlyason, R., Barnes, T. G., Michelmore, H. M., Brooke, P. and Penny, R. (1985) Acute AIDS retrovirus infection: definition of a clinical illness associated with seroconversion. Lancet, i, 537–40.

    Google Scholar 

  • Crawford, D. H., Weiler, I. and Iliescu, V. (1984) Polyclonal activation of B cells in homosexual men. N. Engl. J. Med., 311, 536–7.

    Google Scholar 

  • Creemers, P. C., Stark, D. F. and Boyko, W. J. (1985) Evaluation of natural killer cell activity in patients with persistent generalized lymphadenopathy and acquired immune deficiency syndrome. Clin. Immunol. Immunopathol., 36, 141–50.

    PubMed  CAS  Google Scholar 

  • Cunningham-Rundles, S., Michelis, M. A. and Masur, H. (1983) Serum suppression of lymphocyte activation in vitro in acquired immune deficiency syndrome. N. Engl. J. Med., 310, 1279–82.

    Google Scholar 

  • Curran, J. W. (1983) AIDS-two years later. N. Engl. J. Med., 309, 609–10.

    PubMed  CAS  Google Scholar 

  • Dalgleish, A. G., Beverely, P. C. L., Clapham, P. R., Crawford, D. H., Greaves, M. F. and Weiss, R. A. (1985) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature, Lond., 312, 763–7.

    CAS  Google Scholar 

  • Dalgleish, A. G. and Clapham, P. (1985) B cells in the pathogenesis of AIDS. Immunol. Today, 6, 71.

    Google Scholar 

  • Elie, R., Laroche, A. C., Arnous, E., Guerin, J.-M., Pierre, G. and Malebauche, R. (1983) Thymic dysplasia in acquired immunodeficiency syndrome (Haiti). N. Engl. J. Med., 308, 841–2.

    PubMed  CAS  Google Scholar 

  • Eyster, M. E., Goedert, J. J., Poon, M.-C. and Preble, O. T. (1983) Acid-labile alpha interferon. A possible preclinical marker for the acquired immunodeficiency syndrome in hemophilia. N. Engl. J. Med., 309, 583–6.

    PubMed  CAS  Google Scholar 

  • Eyster, M. E., Goedert, J. J., Sarnagadharan, M. G., Weiss, S. H., Gallo, R. C. and Blattner, W. A. (1985) Development and early natural history of HTLV-III antibodies in persons with hemophilia. JAMA, 253, 2219–23.

    PubMed  CAS  Google Scholar 

  • Fahey, J. L., Prince, H., Weaver, M. M., Groopman, J., Visscher, B., Schwartz, K. and Detels, R. (1984) Quantitative changes in the Th or Ts lymphocyte subsets that distinguish AIDS syndromes from other immune subset disorders. Am. J. Med., 76, 95–100.

    PubMed  CAS  Google Scholar 

  • Fauci, A. S. (1984a) Immunologic abnormalities in the acquired immunodeficiency syndrome (AIDS). Clin. Res., 32, 491–9.

    PubMed  CAS  Google Scholar 

  • Fauci, A. S., Macher, H., Longo, D. L., Lane, H. C., Masur, M. and Gelman, E. P. (1984b) Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann. Intern. Med., 100, 92–106.

    PubMed  CAS  Google Scholar 

  • Fauci, A. S., Masur, H., Gelmann, E. P., Markham, P. D., Hahn, B. H. and Lane, H. C. (1985) The acquired immunodeficiency syndrome: an update. Ann. Intern. Med., 102, 800–13.

    PubMed  CAS  Google Scholar 

  • Feorino, P. M., Kalyanaraman, V. S., Haverkos, H. W., Cabradilla, C. D., Warfield, D. T., Jaffe, H. W., Harrison, A. K., Gottlieb, M. S., Goldfinger, D., Chermann, J.-C., Barre-Sinoussi, F., Spira, T. J., McDougal, J. S., Curran, J. W., Montagnier, L., Murphy, F. A. and Francis, D. P. (1984) Lymphadenopathy-associated virus (LAV) infection of a blood donor-recipient pair with acquired immunodeficiency syndrome (AIDS). Science, 225, 69–72.

    PubMed  CAS  Google Scholar 

  • Feorino, P. M., Jaffe, H. W., Palmer, E., Peterman, T. A., Francis, D. P., Kalyanaraman, V. S., Weistein, R. A., Stoneburner, R. L., Alexander, W. J., Raevskey, C., Getchell, J. P., Warfield, D., Haverkos, H. W., Kilbourne, B. W., Nicholson, J. K. A. and Curran, J. W. (1985) Transfusion-associated AIDS: evidence for persistent infection in blood donors. N. Engl. J. Med., 312, 1293–6.

    PubMed  CAS  Google Scholar 

  • Fishbein, D. B., Kaplan, J. E., Spira, T. J., Miller, B., Schonberger, L. B., Pinsky, P. F., Getchell, J. P., Kalyanaraman, V. S. and Braude, J. S. (1985) Unexplained lymphadenopathy in homosexual men: a longitudinal study. JAMA, 254, 930–5.

    PubMed  CAS  Google Scholar 

  • Fisher, A. G., Collalti, E., Ratner, L., Gallo, R. C. and Wong-Staal, F. (1985) A molecular clone of HTLV-III with biological activity. Nature, Lond., 316, 262–5.

    CAS  Google Scholar 

  • Fitzgerald, P. A., von Wussow, P. and Lopez, C. (1982) Role of interferon in natural kill of HSV-1-infected fibroblasts. J. Immunol., 129, 819–23.

    PubMed  CAS  Google Scholar 

  • Folks, T., Benn, S., Rabson, A., Theodore, T., Hoggan, M. D., Martin, M., Lightfoote, M. and Sell, K. (1985) Characterization of a continuous T-cell line susceptible to the cytopathic effect of the AIDS-associated virus. Proc. Natl Acad. Sci. USA, 82, 4539–43.

    PubMed  CAS  Google Scholar 

  • Friedman, S. R., Des Jarlais, D. C., Marmor, D., Yancovitz, S., Zolla-Pazner, S., El-Sadr, W., Cohen, H., Garber, J., Spira, T. J. and Beatrice, S. (1986) HTLV-III/ LAV, in vivo immunologic stimulation, and T4 cell loss, submitted.

    Google Scholar 

  • Friedman-Kein, A. E., Laubenstein, L., Dubin, R., Marmor, M. and Zolla-Pazner, S. (1982) Disseminated Kaposi’s sarcoma in homosexual men. Ann. Intern. Med., 96, 693–700.

    Google Scholar 

  • Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, A. M., Kaplan, M., Haynes, B. F., Palker, T. J., Redfield, R., Oleske, J., Safai, B., White, G., Foster, P. and Markham, P. D. (1984) Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science, 224, 500–2.

    PubMed  CAS  Google Scholar 

  • Gatenby, P. A., Kausas, G. S., Xian, G. Y., Evans, R. L. and Engleman, E. G. (1982) Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man. J. Immunol., 129, 1997–2000.

    PubMed  CAS  Google Scholar 

  • Gerstoft, J., Dickmeiss, E. and Mathiesen, L. (1985) Cytotoxic capabilities of lymphocytes from patients with the acquired immune deficiency syndrome. Scand. J. Immunol., 22, 463–70.

    PubMed  CAS  Google Scholar 

  • Gidlund, M., Orn, A., Wigzell, H., Senik, A. and Gresser, I. (1978) Enhanced NK cell activity in mice injected with interferon inducers. Nature, Lond., 273, 759–61.

    CAS  Google Scholar 

  • Gluckman, J.-C., Kaltzmann, D., Cavaille-Coll, M., Brisson, E., Messiah, A., Lachiver, D. and Rozenbaum, W. (1985) Is there correlation of T cell proliferative functions and surface marker phenotypes in patients with acquired immune deficiency syndrome or lymphadenopathy syndrome? Clin. Exp. Immunol., 60, 8–16.

    PubMed  CAS  Google Scholar 

  • Goedert, J. J., Sarngadharan, M. G., Biggar, R. J., Weiss, S. H., Winn, D., Grossman, R. J., Greene, M. H., Bodner, A., Mann, D. L., Strong, D. M., Gallo, R. C. and Blattner, W. A. (1984) Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men. Lancet, ii, 711–16.

    Google Scholar 

  • Goedert, J. J., Biggar, R. J., Weiss, S. H., Eyster, M. E., Melbye, M., Wilson, S., Ginzburg, H. M., Grossman, R. J., DiGiola, R. A., Sanchez, W. C., Giron, J. A., Ebbesen, P., Gallo, R. C. and Blattner, W. A. (1986) Three year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. Science, 231, 992–7.

    PubMed  CAS  Google Scholar 

  • Gottlieb, M. S., Schroff, R., Schanker, H. M., Weissman, D. O., Fan, P. T., Wolf, R. A. and Saxon, A. (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence for a new acquired cellular immunodeficiency. N. Engl. J. Med., 305, 1425–31.

    PubMed  CAS  Google Scholar 

  • Gottlieb, M. S., Groopman, J. E., Weinstein, W. M., Fahey, J. L. and Detels, R. (1983) The acquired immunodeficiency syndrome. Ann. Intern. Med., 99, 208–20.

    PubMed  CAS  Google Scholar 

  • Greene, W. C., Fleisher, T. A., Nelson, D. L. and Waldmann, T. A. (1982) Production of human suppressor T cell hybridomas. J. Immunol., 129, 1986–92.

    PubMed  CAS  Google Scholar 

  • Grieco, M. H., Reddy, M. M., Kothari, H. B., Lange, M., Buimovici-Klein, E. and William, D. (1984) Elevated β2-microglobulin and lysozyme levels in patients with acquired immune deficiency syndrome. Clin. Immunol. Immunopathol., 32, 174–84.

    PubMed  CAS  Google Scholar 

  • Groopman, J. E., Salahuddin, S. Z., Sarngadharan, M. B., Mullins, M. G., Sullivan, J. L., Mulder, C., O’Hara, C. J., Cheeseman, S. H., Haverkos, H., Forgacs, P., Riedel, N., McLane, M. F., Essex, M. and Gallo, R. C. (1984) Virologic studies in a case of transfusion-associated AIDS. N. Engl. J. Med., 311, 1419–22.

    PubMed  CAS  Google Scholar 

  • Gupta, S. and Safai, B. (1983) Deficient autologous mixed lymphocyte reaction in Kaposi’s sarcoma associated with deficiency of Leu3+ responder cells. J. Clin. Invest., 71, 296–300.

    PubMed  CAS  Google Scholar 

  • Gupta, S. and Licorish, K. (1984) Circulating immune complexes in AIDS. N. Engl. J. Med., 311, 1530–1.

    Google Scholar 

  • Gyorkey, F., Meinich, J. L., Sinkovics, J. G. and Gyorkey, P. (1985) Retrovirus resembling HTLV in macrophages of patients with AIDS. Lancet, i, 106.

    Google Scholar 

  • Hauser, G. J., Bino, T., Rosenberg, H., Zakuth, V., Geller, E. and Spirer, Z. (1984) Interleukin-2 production and response to exogenous interleukin-2 in a patient with the acquired immune deficiency syndrome (AIDS). Clin. Exp. Immunol., 56, 14–17.

    PubMed  CAS  Google Scholar 

  • Heagy, W., Kelley, V. E., Strom, T. B., Mayer, K., Shapiro, H. M., Mandel, R. and Finberg, R. (1984) Decreased expression of human Class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-γ. J. Clin. Invest., 74, 2089–96.

    PubMed  CAS  Google Scholar 

  • Hersch, E. M., Reuben, J. M., Rios, A., Mansell, W. A., Newell, G. R., McClure, J. E. and Goldstein, A. L. (1983) Elevated serum thymosin α1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi’s sarcoma. N. Engl. J. Med., 308, 45–6.

    Google Scholar 

  • Ho, D. D., Rota, T. R., Schooley R. T., Kaplan, J. C., Allan, J. D., Groopman, J. E., Resnich, L., Felsenstein, D., Andrews, C. A. and Hirsch, M. S. (1985a) Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N. Engl. J. Med., 313, 1493–7.

    PubMed  CAS  Google Scholar 

  • Ho, D. D., Hartshorn, K. L., Rota, T. R., Andrews, C. A., Kaplan, J. C., Schooley, R. T. and Hirsch, M. S. (1985b) Recombinant human interferon alpha-A suppresses HTLV-III replication in vitro. Lancet, i, 602–4.

    Google Scholar 

  • Ho, D. D., Rota, T. R. and Hirsch, M. S. (1986) Infection of monocyte/macrophages by human T lymphotropic virus type III. J. Clin. Invest., 77, 1712–15.

    PubMed  CAS  Google Scholar 

  • Hoxie, J. A., Haggarty, B. S., Rackowski, J. L., Pillsbury, N. and Levy, J. A. (1985) Persistent noncytopathic infection of normal human lymphocytes with AIDS-associated retrovirus. Science, 229, 1400–2.

    PubMed  CAS  Google Scholar 

  • Incefy, G. S., Dardenne, M., Pahwa, S., Grimmes, E., Pahwa, R. N., Smithwich, E., O’Reilly, R. and Good, R. A. (1977) Thymic activity in severe combined immunodeficiency diseases. Proc. Natl Acad. Sci., 74, 1250–3.

    PubMed  CAS  Google Scholar 

  • Isobe, M., Huecner, K., Maddon, P. J., Littman, D. R., Axel, R., Crobe, C. M. (1986) Proc. Natl Acad. Sci. USA, 83, 4399–402.

    PubMed  CAS  Google Scholar 

  • Jaffe, H. W., Feorino, P. M., Darrow, W. W., O’Malley, P. M., Getchell, J. P., Warfield, D. T., Jones, B. M., Echenberg, D. F., Francis, D. P. and Curran, J. W. (1985) Persistent infection with HTLV-III/LAV in apparently healthy homosexual men. Ann. Intern. Med., 102, 627–8.

    PubMed  CAS  Google Scholar 

  • Jason, J., McDougal, J. S., Holman, R. C., Stein, S. F., Lawrence, D. N., Nicholson, J. K. A., Dixon, G., Doxey, M. and Evatt, B. L. (1985) HTLV-III/LAV-associated antibody: association with hemophiliacs immune status and blood component usage. JAMA, 753, 3409–15.

    Google Scholar 

  • Joshi, V. V. and Oleske, J. M. (1985) Pathologic appraisal of the thymus gland in acquired immunodeficiency syndrome in children. Arch. Pathol. Lab. Med., 109, 142–6.

    PubMed  CAS  Google Scholar 

  • Jothy, S., Gilmore, N., El’Gabalaway, H. and Purchal, J. (1985) Decreased population of Leu7+ natural killer cells in lymph nodes of homosexual men with AIDS-related persistent lymphadenopathy. Can. Med. Assoc. J., 132, 141–4.

    PubMed  CAS  Google Scholar 

  • Kaminsky, L. S., McHugh, T., Stites, D., Volberding, P., Henle, G., Henle, W. and Levy, J. A. (1985) High prevalence of antibodies to acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) in AIDS and related conditions but not in other disease states. Proc. Natl Acad. Sci. USA, 82, 5535–9.

    PubMed  CAS  Google Scholar 

  • Kitchen, L., Malone, G., Orgad, S., Barin, F., Zaizov, R., Ramot, B., Gazit, E., Kreiss, J., Leal, M., Wichmann, I., Martinowitz, U. and Essex, M. (1986) Viral envelope protein of HTLV-III is the major target antigen for antibodies in hemophiliac patients. J. Infect. Dis., 153, 788–90.

    PubMed  CAS  Google Scholar 

  • Klatzmann, D., Barre-Sinoussi, F., Nugeyre, M. T., Dauguet, C., Vilmer, E., Griscelli, C., Brun-Vezinet, F., Rouzioux, C., Gluckman, J. C., Chermann, J.-C. and Montagnier, L. (1984) Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science, 225, 59–62.

    PubMed  CAS  Google Scholar 

  • Klatzmann, D., Champagne, E., Charmarat, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.-C. and Montagnier, L. (1985) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature, Lond., 312, 767–8.

    Google Scholar 

  • Kolata, G. (1986) Where is the AIDS virus harbored?. Science, 232, 1197.

    Google Scholar 

  • Landesman, S. H., Ginzburg, H. M. and Weiss, S. H. (1985) The AIDS epidemic. N. Engl. J. Med., 312, 521–3.

    PubMed  CAS  Google Scholar 

  • Lane, H. C., Masur, H., Edgar, L. C., Whalen, G., Rook, A. H. and Fauci, A. S. (1983) Abnormalities of B cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med., 309, 453–8.

    PubMed  CAS  Google Scholar 

  • Lane, H. C. and Fauci, A. S. (1985) Immunologic abnormalities in the acquired immunodeficiency syndrome. Ann. Rev. Immunol., 3, 477–500.

    CAS  Google Scholar 

  • Lane, H. C., Masur, H., Gelmann, E. P., Longo, D. L., Steis, R. G., Chused, T., Whalen, G., Edgar, L. and Fauci, A. S. (1985a) Correlation between immunologic function and clinical subpopulations of patients with the acquired immune deficiency syndrome. Am. J. Med., 78, 417–22.

    PubMed  CAS  Google Scholar 

  • Lane, H. C., Depper, J. M., Greene, W. C., Whalen, G., Waldmann, T. A. and Fauci, A. S. (1985b) Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med., 313, 79–84.

    PubMed  CAS  Google Scholar 

  • Lanier, L. L., Le, A. M., Phillips, J. H., Warner, N. L. and Babcock, G. F. (1983) Subpopulations of human natural killer cells defined by expression of the Leu7 (HNK-1) and Leull (NK-15) antigens. J. Immunol., 131, 1789–96.

    PubMed  CAS  Google Scholar 

  • Lanier, L. L. and Loken, M. R. (1984) Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu2, Leu3, Leu7, Leu8, and Leull cell surface antigen expression. J. Immunol., 132, 151–6.

    PubMed  CAS  Google Scholar 

  • Laurence, J., Gottlieb, A. B. and Kunkel, H. G. (1983) Soluble suppressor factors in patients with acquired immune deficiency syndrome and its prodrome. Elaboration in vitro by T lymphocyte-adherent cell interactions. J. Clin. Invest., 72, 2072–81.

    PubMed  CAS  Google Scholar 

  • Laurence, J. and Mayer, L. (1984) Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors. Science, 225, 66–9.

    PubMed  CAS  Google Scholar 

  • Ledbetter, J. A., Evans, R. L., Lipinski, M., Cunningham-Rundles, C., Good, R. A. and Herzenberg, L. A. (1981) Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J. Exp. Med., 153, 310–23.

    PubMed  CAS  Google Scholar 

  • Lederman, M. M., Ratnoff, O. D., Evatt, B. L. and McDougal, J. S. (1985) Acquisition of antibody to lymphadenopathy-associated virus in patients with classic hemophilia (Factor VIII deficiency). 102, 753–7.

    CAS  Google Scholar 

  • Levy, J. A., Hoffman, A. D., Kramer, S. M., Landis, J. A., Shimabukuro, J. M. and Oschiro, L. S. (1984) Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science, 225, 840–2.

    PubMed  CAS  Google Scholar 

  • Levy, J. A., Kaminsky, L. S., Morrow, J. W., Steimer, K., Luciw, P., Dina, D., Hoxie, J. and Oshiro, L. (1985a) Infection by the retrovirus associated with the acquired immunodeficiency syndrome. Ann. Intern. Med., 103, 694–9.

    PubMed  CAS  Google Scholar 

  • Levy, J. A., Shimabukuro, J., McHugh, T., Casavant, C., Stites, D. P. and Oshiro, L. S. (1985b) AIDS-associated retroviruses (ARV) can productively infect other cells besides human T helper cells. Virology, 147, 441–8.

    PubMed  CAS  Google Scholar 

  • Levy, J. A., Shimabukuro, J., Hollander, H., Mills, J. and Kaminsky, L. (1985c) Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet, ii, 586–8.

    Google Scholar 

  • Levy, J. A., Cheng-Mayer, C., Dina, D. and Luciw, P. A. (1986) AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts. Science, 232, 998–1000.

    PubMed  CAS  Google Scholar 

  • Lewis, D. E., Puck, J. M., Babcock, G. F. and Rich, R. R. (1985) Disproportionate expansion of a minor T cell subset in patients with lymphadenopathy syndrome and acquired immune deficiency syndrome. J. Infect. Dis., 151, 555–9.

    PubMed  CAS  Google Scholar 

  • Lifson, J. D., Mark, D. F., Benike, C. J., Koths, K. and Engleman, E. G. (1984) Human recombinant interleukin-2 partly reconstitutes deficient in vitro immune responses of lymphocytes from patients with AIDS. Lancet, i, 698–702.

    Google Scholar 

  • Lifson, J. D., Reyes, G. R., McGrath, M. S., Stein, B. S. and Engleman, E. G. (1986) AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science, 232, 1123–6.

    PubMed  CAS  Google Scholar 

  • Lightfoote, M. M., Folks, T. M. and Sell, K. W. (1984) Analysis of immune complex components isolated from serum of AIDS patients. Fed. Proc, 43, 1921.

    Google Scholar 

  • Lopez, C., Fitzgerald, P. A. and Siegal, F. P. (1983) Severe acquired immune deficiency syndrome in male homosexuals: diminished capacity to make interferon-a in vitro associated with severe opportunistic infections. J. Infect. Dis., 148, 962–6.

    PubMed  CAS  Google Scholar 

  • Martin, L. S., McDougal, J. S., Spira, T. J. and Loskoski, S. L. (1986) Cell surface pheno-type of the spontaneous immunoglobulin-secreting cells in peripheral blood from homosexual men with generalized lymphadenopathy. Diag. Immunol., 4, 117–23.

    CAS  Google Scholar 

  • Masur, H., Michelis, M. A., Greene, J., Onorato, I., Vande Stouwe, R. A., Holtzman, R. S., Wormser, G., Brettman, L., Lange, M., Murray, H. W. and Cunningham-Rundles, S. (1981) An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N. Engl. J. Med., 305, 1431–8.

    PubMed  CAS  Google Scholar 

  • Mathur-Wagh, U., Enlow, R. E., Spigland, I., Winchester, R. J., Sacks, H. S., Rorat, E., Yancovitz, S. R., Klein, M. J., William, D. C. and Mildvan, D. (1984) Longitudinal study of persistent generalized lymphadenopathy in homosexual men: relation to AIDS. Lancet, i, 1033–7.

    Google Scholar 

  • Mawle, A. C., Scheppler-Campbell, J. A. and McDougal, J. S. (1985) Regression as a measure of EBV-specific T cell cytotoxicity in AIDS, AIDS-related complex, and normal homosexual men compared with heterosexual controls. Ann. Intern. Med., 103, 777.

    Google Scholar 

  • McDougal, J. S., Cort, S. P., Kennedy, M. S., Cabradilla, C. D., Feorino, P. M., Francis, D. P., Hicks, D., Kalyanaraman, V. S. and Martin, L. S. (1985a) Immunoassay for the detection and quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV). J. Immunol. Methods, 76, 171–83.

    PubMed  CAS  Google Scholar 

  • McDougal, J. S., Mawle, A., Cort, S. P., Nicholson, J. K. A., Cross, G. D., Scheppler-Campbell, J. A., Hicks, D. and Sligh, J. (1985b) Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 molecule. J. Immunol., 135, 3151–62.

    PubMed  CAS  Google Scholar 

  • McDougal, J. S., Hubbard, M., Nicholson, J. K. A., Jones, B. M., Holman, R. C., Roberts, J., Fishbein, D. B., Jaffe, H. W., Kaplan, J. E., Spira, T. J. and Evatt, B. L. (1985c) Immune complexes in the acquired immunodeficiency syndrome (AIDS): relationship to disease manifestation, risk group, and immunologic defect. J. Clin. Immunol., 5, 130–8.

    PubMed  CAS  Google Scholar 

  • McDougal, J. S., Kennedy, M. S., Sligh, J. M., Cort, S. P., Mawle, A. and Nicholson, J. K. A. (1986a) Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule. Science, 231, 382–5.

    PubMed  CAS  Google Scholar 

  • McDougal, J. S., Nicholson, J. K. A., Cross, G. D., Kennedy, M. S., Cort, S. P., Rao, P., Goldstein, L., Goldstein, G. and Mawle, A. (1986b) Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry. J. Immunol., 137, 2937–44.

    PubMed  CAS  Google Scholar 

  • Melbye, M., Biggar, R. J., Ebbesen, P., Sarngadharan, M. G., Weiss, S. H., Gallo, R. C. and Blattner, W. A. (1984) Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. Brit. Med. J., 289, 573–5.

    CAS  Google Scholar 

  • Melbye, M., Biggar, R. J., Ebbesen, P., Neuland, C., Goedert, J. J., Faber, V., Lorenzen, I., Skinhoj, P., Gallo, R. C. and Blattner, W. A. (1986) Long-term seropositivity for human T-lymphotropic virus type III in homosexual men without the acquired immunodeficiency syndrome: development of immunologic and clinical abnormalities. Ann. Intern. Med., 104, 496–500.

    PubMed  CAS  Google Scholar 

  • Metroka, C. E., Cunningham-Rundles, S., Pollack, M. S., Sonnabend, J. A., Davis, J. M., Gordon, B., Fernandez, R. D. and Mouradian, J. (1983) Generalized lymphadenopathy in homosexual men. Ann. Intern. Med., 99, 585–91.

    PubMed  CAS  Google Scholar 

  • Meuer, S. C., Schlossman, S. F. and Reinherz, E. L. (1982) Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc. Natl Acad. Sci. USA, 79, 4395–9.

    PubMed  CAS  Google Scholar 

  • Mildvan, D., Mathur, U., Enlow, R. W., Roman, P. L., Winchester, R. J., Colp, C., Singman, H., Adelsberg, B. R. and Spigland, I. (1982) Opportunistic infections and immune deficiency in homosexual men. Ann. Intern. Med., 96, 700–4.

    PubMed  CAS  Google Scholar 

  • Modlin, R. L., Meyer, P. R., Hofman, F. M., Mehlmauer, M., Levy, N. B., Lukes, R. J., Parker, J. W., Ammann, A. J., Conant, M. A., Rea, T. H. and Taylor, C. R. (1983) T-lymphocyte subsets in lymph nodes from homosexual men. JAMA, 250, 1302–5.

    PubMed  CAS  Google Scholar 

  • Montagnier, L., Gruest, J., Charmaret, S., Dauguet, C., Axler, C., Guetard, D., Nugeyre, M. T., Barre-Sinoussi, F., Chermann, J. C., Brunet, J. B., Klatzmann, D. and Gluckman, J. C. (1984) Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B-lymphoblastoid cell lines. Science, 225, 63–7.

    PubMed  CAS  Google Scholar 

  • Montagnier, L., Clavel, F., Krust, B., Charmaret, S., Rey, F., Barre-Sinoussi, F. and Chermann, J. C. (1985) Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus. Virology, 141, 283–9.

    Google Scholar 

  • Morris, L., Distenfeld, A., Amorosi, E. and Karpatkin, S. (1982) Autoimmune thrombocytopenic purpura in homosexual men. Ann. Intern. Med., 96, 714–17.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., Rubin, B. Y., Masur, H. and Roberts, R. B. (1984) Impaired production of lymphokines and immune (gamma) interferon in the acquired-immunodeficiency syndrome. N. Engl. J. Med., 310, 883–9.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., Weite, K., Jacobs, J. L., Rubin, B. Y., Mertelsmann, R. and Roberts, R. B. (1985) Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome. J. Clin. Invest., 76, 1959–64.

    PubMed  CAS  Google Scholar 

  • Nicholson, J. K. A., McDougal, J. S., Spira, T. J., Cross, G. D., Jones, B. M. and Reinherz, E. L. (1984) Immunoregulatory subsets of the T helper and T suppressor cell population in homosexual men with chronic unexplained lymphadenopathy. J. Clin. Invest., 73, 191–201.

    PubMed  CAS  Google Scholar 

  • Nicholson, J. K. A., McDougal, J. S. and Spira, T. J. (1985a) Alterations of functional subsets of T helper and T suppressor cell populations in acquired immunodeficiency syndrome (AIDS) and chronic unexplained lymphadenopathy. J. Clin. Immunol, 5, 269–74.

    PubMed  CAS  Google Scholar 

  • Nicholson, J. K. A., McDougal, J. S., Jaffe, H. W., Spira, T. J., Kennedy, M. S., Jones, B. M., Darrow, W. W., Morgan, M. and Hubbard, M. (1985b) Exposure to human T-lymphotropic virus type III/lymphadenopathy associated virus and immunologic abnormalities in asymptomatic homosexual men. Ann. Intern. Med., 103, 37–42.

    PubMed  CAS  Google Scholar 

  • Nicholson, J. K. A., Cross, G. D., Callaway, C. S. and McDougal, J. S. (1986a) In vitro infection of human monocytes with human T-lymphotropic virus type III/lym-phadenopathy-associated virus (HTLV-III/LAV). J. Immunol., 137, 323–9.

    PubMed  CAS  Google Scholar 

  • Nicholson, J. K. A., Echenberg, D. F., Jones, B. M., Jaffe, H. W., Feorino, P. M. and McDougal, J. S. (1986b) T cytotoxic/suppressor cell phenotypes in a group of asymptomatic homosexual men with and without exposure to HTLV-III/LAV. Clin. Immunol. Immunopathol, 40, 505–14.

    PubMed  CAS  Google Scholar 

  • Pahwa, S. G., Quilop, M. T. J., Lange, M., Pahwa, R. N. and Grieco, M. H. (1984) Defective B lymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome. Ann. Intern. Med., 101, 757–63.

    PubMed  CAS  Google Scholar 

  • Pahwa, S., Pahwa, R., Saxinger, C., Gallo, R. C. and Good, R. A. (1985) Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: Evidence for immunosuppressive effects and polyclonal B cell activation by banded viral preparations. Proc. Natl Acad. Sci. USA, 82, 8198–202.

    PubMed  CAS  Google Scholar 

  • Pinching, A. J., McManus, T. J., Jeffries, D. J., Moshtael, O., Donaghy, M., Parkin, J. M., Munday, P. E. and Harris, J. R. W. (1983) Studies of cellular immunity in male homosexuals in London. Lancet, ii, 126–9.

    Google Scholar 

  • Poli, G., Introna, M., Zanaboni, F., Peri, G., Carbonari, M., Aiuti, F., Lazzarin, A., Moroni, M. and Mantovani, A. (1985a) Natural killer cells in intravenous drug abusers with lymphadenopathy syndrome. Clin. Exp. Immunol., 62, 128–35.

    PubMed  CAS  Google Scholar 

  • Poli, G., Bottazzi, B., Acero, R., Bersani, L., Ross, V., Introna, M., Lazzarin, A., Galli, M. and Mantovani, A. (1985b) Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of Chemotaxis. Clin. Exp. Immunol., 62, 136–42.

    PubMed  CAS  Google Scholar 

  • Popovic, M., Gallo, R. C. and Mann, D. L. (1984) OKT4 bearing molecule is a receptor for the human retrovirus HTLV-III. Clin. Res., 33, 560A.

    Google Scholar 

  • Popovic, M., Read-Connole, E. and Gallo, R. C. (1984) T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III. Lancet, ii, 1472.

    Google Scholar 

  • Prince, H. E., Kermani-Arab, V. and Fahey, J. L. (1984) Depressed interleukin-2 receptor expression in acquired immunodeficiency and lymphadenopathy syndromes. J. Immunol., 133, 1313–17.

    PubMed  CAS  Google Scholar 

  • Prince, H. E., Kressi, J. K., Kasper, C. K., Kleinman, S., Saunders, A. M., Waldbeser, L., Manding, O. O. and Kaplan, H. S. (1985a) Distinctive lymphocyte subpopulation abnormalities in patients with congenital coagulation disorders who exhibit lymph node enlargement. Blood, 66, 64–8.

    PubMed  CAS  Google Scholar 

  • Prince, H. E., Moody, D. J., Shubin, B. I. and Fahey, J. L. (1985b) Defective monocyte function in acquired immune deficiency syndrome (AIDS): evidence from a monocyte-dependent T-cell proliferative system. J. Clin. Immunol., 5, 21–5.

    PubMed  CAS  Google Scholar 

  • Quinnan, G. V., Masur, H., Rook, A. H., Armstrong, G., Frederick, W. R., Epstein, I., Manischewitz, J. F., Macher, A. M., Jackson, L., Ames, J., Smith, H. A., Parker, M., Pearson, G. R., Parillo, J., Mitchell, C. and Strauss, S. E. (1984) Herpes virus infections in the acquired immune deficiency syndromes. JAMA, 252, 72–7.

    PubMed  Google Scholar 

  • Rabson, A. B., Daugherty, D. F., Venkatesan, S., Boulukos, K. E., Benn, S., Folks, T. M., Feorino, P. M. and Martin, M. A. (1985) Transfection of novel open reading frame of AIDS retrovirus during infection of lymphocytes. Science, 229, 1388–90.

    PubMed  CAS  Google Scholar 

  • Rao, T. K. S., Filippone, E. J., Nicastri, A. D., Landesman, S. H., Frank, E., Chen, C. K. and Friedman, E. A. (1984) Associated focal and segmental glomerulosclerosis in the acquired immunodeficiency syndrome. N. Engl. J. Med., 310, 669–73.

    PubMed  CAS  Google Scholar 

  • Reddy, M. M., Pinyavat, N. and Greico, M. H. (1984) Interleukin 2 augmentation of natural killer cell activity in homosexual men with acquired immune deficiency syndrome. Infect. Immun., 44, 339–43.

    PubMed  CAS  Google Scholar 

  • Redfield, R. R., Wright, D. C. and Tramont, E. C. (1986) The Walter Reed staging classifications for HTLV-III/LAV infection. N. Engl. J. Med., 314, 131–2.

    PubMed  CAS  Google Scholar 

  • Reinherz, E. L., Kung, P. C., Goldstein, G. and Schlossman, S. F. (1979a) Separation of functional subsets of human T cells by a monoclonal antibody. Proc. Natl. Acad. Sci. USA, 76, 4061–5.

    PubMed  CAS  Google Scholar 

  • Reinherz, E. L., Kung, P. C., Pesando, J. M., Ritz, J., Goldstein, G. and Schlossman, S. F. (1979b) la determinants on human T cell subsets defined by monoclonal antibody: activation stimuli required for expression. J. Exp. Med., 150, 1472–82.

    PubMed  CAS  Google Scholar 

  • Reinherz, E. L. and Schlossman, S. F. (1980) The differentiation and function of human T lymphocytes. Cell, 19, 821–7.

    PubMed  CAS  Google Scholar 

  • Reinherz, E. L., Morimoto, C., Penta, A. C. and Schlossman, S. F. (1981) Subpopulations of the T4+ inducer T cell subset in man: evidence for an amplifier population preferentially expressing la antigen upon activation. J. Immunol., 126, 67–70.

    PubMed  CAS  Google Scholar 

  • Reinherz, E. L., Morimoto, C., Fitzgerald, K. A., Hussey, R. E., Daley, J. F. and Schlossman, S. F. (1982) Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J. Immunol., 128, 463–8.

    PubMed  CAS  Google Scholar 

  • Robert-Guroff, M., Brown, M. and Gallo, R. C. (1985) HTLV-III neutralizing antibodies in patients with AIDS and AIDS-related complex. Nature, Lond., 316, 72–4.

    CAS  Google Scholar 

  • Rogers, M. F., Morens, D. M., Stewart, J. A., Kaminski, R. M., Spira, T. J., Feorino, P. M., Larsen, S. A., Francis, D. P., Wilson, M. and Kaufman, L. (1983) National case-control study of Kaposi’s sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 2, laboratory results. Ann. Intern. Med., 99, 151–8.

    PubMed  CAS  Google Scholar 

  • Rook, A. H., Masur, H., Lane, H. C., Frederick, W., Kasahara, T., Macher, A. M., Djeu, J. Y., Manischewitz, J. F., Jackson, L., Fauci, A. S. and Quinnan, G. V. (1983) Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. J. Clin. Invest., 72, 398–403.

    PubMed  CAS  Google Scholar 

  • Rook, A. H., Hooks, J. J., Quinnan, G. V., Lane, H. C., Manischewitz, J. F., Macher, A. M., Fauci, A. S. and Djeu, J. Y. (1985a) Interleukin 2 enhances the natural killer cell activity of acquired immunodeficiency syndrome patients through a a-interferon-independent mechanism. J. Immunol., 134, 1503–7.

    PubMed  CAS  Google Scholar 

  • Rook, A. H., Manischewitz, J. F., Frederick, W. R., Epstein, J. S., Jackson, L., Gelmann, E., Steis, R., Masur, H. and Quinnan, G. V. (1985b) Deficient HLA-restricted, cytomegalovirus-specific cytotoxic T cells and natural killer cells in patients with the acquired immune deficiency syndrome. J. Infect. Dis., 152, 627–30.

    PubMed  CAS  Google Scholar 

  • Rosen, C. A., Sodroski, J. G. and Haseltine, W. A. (1985) The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/ LAV) long terminal repeat. Cell, 41, 813–23.

    PubMed  CAS  Google Scholar 

  • Rosen, F. S., Cooper, M. D. and Wedgewood, R. J. P. (1984) The primary immunodeficiencies (parts 1 and 2). N. Engl. J. Med., 311, 235–42, 300–10.

    PubMed  CAS  Google Scholar 

  • Ruscetti, F. W., Mikouits, J. A., Kalyanaraman, V. S., Overton, R., Stevenson, H., Stromberg, K., Herberman, R. B., Farrar, W. L. and Ortaldo, J. R. (1986) Analysis of effector mechanisms against HTLV-I and HTLV-III/LAV infected lymphoid cells. J. Immunol., 136, 3619–24.

    PubMed  CAS  Google Scholar 

  • Safai, B., Sarngadharan, M. G., Groopman, J. E., Arnett, K., Popovic, M., Slinski, A., Schupbach, J. and Gallo, R. C. (1984) Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. Lancet, i, 1438–40.

    Google Scholar 

  • Salahuddin, S. Z., Markham, P. D., Lindner, S. G., Gootenberg, J. and Popovic, M. (1984) Lymphokine production by cultured human T cells transformed by HTLV-I. Science, 223, 703–7.

    PubMed  CAS  Google Scholar 

  • Salazar-Gonzales, J. F., Moody, D. J., Giorgi, J. V., Martinez-Maza, O., Mitsuyasu, R. T. and Fahey, J. L. (1985) Reduced ecto-5′-nucleotidase activity and enhanced OKTIO and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: Evidence of CD8 immaturity. J. Immunol, 135, 1778–85.

    Google Scholar 

  • Sarin, P. S., Sun, D. K., Thornton, A. H., Naylor, P. H. and Goldstein, A. L. (1986) Neutralization of HTLV-III/LAV replication by antiserum to thymosin α1. Science, 232, 1135–7.

    PubMed  CAS  Google Scholar 

  • Sarngadharan, M. G., Popovic, M., Bruch, L., Schupbach, J. and Gallo, R. C. (1984) Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science, 224, 506–8.

    PubMed  CAS  Google Scholar 

  • Schroff, R. W., Gottlieb, M. S., Prince, H. E., Chai, L. L. and Fahey, J. L. (1983) Immunological studies of homosexual men with immunodeficiency and Kaposi’s sarcoma. Clin. Immunol. Immunopathol., 27, 300–14.

    PubMed  CAS  Google Scholar 

  • Schupbach, J., Haller, O., Vogt, M., Lathy, R., Joller, H., Oelz, O., Popovic, M., Sarngadharan, M. G. and Gallo, R. C. (1985) Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N. Engl. J. Med., 312, 265–70.

    PubMed  CAS  Google Scholar 

  • Schwartz, K., Visscher, B. R., Detels, R., Taylor, J., Nisharian, P. and Fahey, J. L. (1985) Immunological changes in lymphadenopathy virus positive and negative symptomless male homosexuals: two years of observation. Lancet, ii, 831–2.

    Google Scholar 

  • Sharma, B. and Gupta, S. (1985) Antigen-specific primary cytotoxic T lymphocyte (CTL) responses in acquired immune deficiency syndrome (AIDS) and AIDS-related complexes (ARC). Clin. Exp. Immunol., 62, 296–303.

    PubMed  CAS  Google Scholar 

  • Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., Navia, B. A., Petito, C. K., O’Hara, C. J., Groopman, J. E., Cho, E.-S., Oleske, J. M., Wong-Staal, F. and Gallo, R. C. (1985) HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science, 227, 177–82.

    PubMed  CAS  Google Scholar 

  • Shearer, G. M., Salahuddin, S. Z., Markham, P. D., Joseph, L. J., Payne, S. M., Kriebel, P., Bernstein, D. C., Biddison, W. E., Sarngadharan, M. G. and Gallo, R. C. (1985) Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-Ill in homosexual men. J. Clin. Invest., 76, 1699–1704.

    PubMed  CAS  Google Scholar 

  • Siegal, F. P., Lopez, C., Hammer, G. S., Brown, A. E., Kornfeld, S. J., Gold, J., Hassett, J., Hirschman, S. Z., Cunningham-Rundles, C., Adelsberg, B. R., Parkham, D. M., Siegal, M., Cunningham-Rundles, S. and Armstrong, D. (1981) Severe acquired immunodeficiency in homosexual males, manifested by chronic perianal ulcerative herpes simplex lesions. N. Engl. J. Med., 305, 1439–44.

    PubMed  CAS  Google Scholar 

  • Siegal, F. P., Lopez, C., Fitzgerald, P. A., Shah, K., Baron, P., Leiderman, I. Z., Imperato, D. and Landesman, S. (1986) Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity. J. Clin. Invest., in press.

    Google Scholar 

  • Siegel, J. P., Djeu, J. Y., Stocks, N. I., Masur, H., Fauci, A. S., Lane, H. C., Gelmann, E. P. and Quinnan, G. P. (1984) Serum from patients with the acquired immune deficiency syndrome suppresses production of interleukin-2 by normal peripheral blood lymphocytes. Clin. Res., 32, 358A.

    Google Scholar 

  • Smith, P. D., Ohura, K., Masur, H., Lane, H. C., Fauci, A. S. and Wahl, S. M. (1984) Monocyte function in the acquired immune deficiency syndrome: defective Chemotaxis. J. Clin. Invest., 74, 2121–8.

    PubMed  CAS  Google Scholar 

  • Smolen, J. S., Bettelheim, P., Koller, U., McDougal, S., Graninger, W., Luger, T. A., Knapp, W. and Lechner, K. (1985) Deficiency of the autologous mixed lymphocyte reaction in patients with classic hemophilia treated with commercial factor VIII concentrate. J. Clin. Invest., 75, 1828–34.

    PubMed  CAS  Google Scholar 

  • Sodroski, J., Patarca, R., Rosen, C., Wong-Staal, F. and Haseltine, W. (1985) Location of the transactivating region on the genome of human T-cell lymphotropic virus type III. Science, 229, 74–7.

    PubMed  CAS  Google Scholar 

  • Sodroski, J., Goh, W. C., Rosen, C., Tartar, A., Porteteile, D., Burny, A. and Haseltine, W. (1986a) Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions. Science, 231, 1549–53.

    PubMed  CAS  Google Scholar 

  • Sodroski, J., Goh, W. C., Rosen, C., Dayton, A., Terwilliger, E. and Haseltine, W. (1986b) A second post-transcriptional trans-activator gene required for HTLV-III replication, Nature, Lond., 321, 412–17.

    CAS  Google Scholar 

  • Stahl, R. E., Friedman-Kein, A. E., Dubin, R., Marmor, M. and Zolla-Pazner, S. (1982) Immunologic abnormalities in homosexual men: relationship to Kaposi’s sarcoma. Am. J. Med., 73, 171–8.

    PubMed  CAS  Google Scholar 

  • Stein, S. F., Evatt, B. L., McDougal, J. S., Lawrence, D. N., Holman, R. C., Ramsey, R. B. and Spira, T. J. (1985) A longitudinal study of patients with hemophilia: immunologic correlates of infection with HTLV-III/LAV and other viruses. Blood, 66, 973–9.

    PubMed  CAS  Google Scholar 

  • Stites, D. P., Casavant, C. H., McHugh, T. M., Moss, A. R., Beal, S. L., Ziegler, J. L., Saunders, A. M. and Warner, N. L. (1986) Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence. Clin. Immunol. Immunopathol., 38, 161–77.

    PubMed  CAS  Google Scholar 

  • Tersmette, M., Van Dongen, J. J. M., De Goede, R. E. Y., Van Kessel, A. G., Huisman, H. G. and Miedema, F. (1986) T4+ human-murine T cell hybrids cannot be productively infected with HTLV-III. International AIDS Conference, Paris, June 21–3.

    Google Scholar 

  • Thomas, Y., Rogozinski, L., Irigoyen, O. H., Shen, H. H., Talle, M. A., Goldstein, G. and Chess, L. (1982) Functional analysis of human T cell subsets defined by monoclonal antibodies. V. Suppressor cells within the activated OKT4+ population belong to a distinct subset. J. Immunol., 128, 1386–90.

    PubMed  CAS  Google Scholar 

  • Tomar, R. H., John, P. A., Hennig, A. K. and Kloster, B. (1985) Cellular targets of antilymphocyte antibodies in AIDS and LAS. Clin. Immunol. Immunopathol., 37, 37–47.

    PubMed  CAS  Google Scholar 

  • Tsoukas, C., Gervais, F., Shuster, J., Gold, P., O’Shaughnessy, M. and Robert-Guroff, M. (1984) Association of HTLV-III antibodies and cellular immune status of hemophiliacs. N. Engl. J. Med., 311, 1514–15.

    PubMed  CAS  Google Scholar 

  • Wachter, H., Fuchs, D., Hausen, A., Huber, C., Kuosp, O., Reibnegger, G. and Spira, T. J. (1983) Elevated urinary neopterin levels in patients with the acquired immunodeficiency syndrome (AIDS). Hoppe-Seyler’s Z. Physiol. Chem., 364, 1345–6.

    PubMed  CAS  Google Scholar 

  • Wallace, L. E., Moss, D. J., Rickinson, A. B., McMichael, A. J. and Epstein, M. A. (1981) Cytotoxic T cell recognition of Epstein-Barr virus-infected cells. II. Blocking studies with monoclonal antibodies to HLA determinants. Eur. J. Immunol., 11, 694–9.

    PubMed  CAS  Google Scholar 

  • Washburn, R. G., Tuazon, C. U. and Bennett, J. E. (1984) Phagocytic and fungicidal activity of monocytes from patients with acquired immunodeficiency syndrome. J. Infect. Dis., 151, 565–6.

    Google Scholar 

  • Weiss, R. A., Clapham, P. R., Cheingsong-Popov, R., Dalgleish, A. G., Carne, C. A., Weiler, I. V. D. and Tedder, R. S. (1985) Neutralization of human T-lymphotropic virus type HI by sera of AIDS and AIDS-risk patients. Nature, Lond., 316, 69–72.

    CAS  Google Scholar 

  • Williams, R. C., Masur, H. and Spira, T. J. (1984) Lymphocyte-reactive antibodies in acquired immune deficiency syndrome. J. Clin. Immunol., 4, 118–23.

    PubMed  Google Scholar 

  • Wong-Staal, F. and Gallo, R. C. (1985) Human T-lymphotropic retroviruses. Nature, Lond., 317, 395–403.

    CAS  Google Scholar 

  • Wood, G. S., Warner, N. L. and Warke, R. A. (1983) Anti-Leu3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J. Immunol., 131, 212–16.

    PubMed  CAS  Google Scholar 

  • Wood, G. S., Burnes, B. F., Dorfman, R. F. and Warnke, R. A. (1986) In situ quantitation of lymph node helper, suppressor, and cytotoxic T cell subsets in AIDS. Blood, 67, 596–603.

    PubMed  CAS  Google Scholar 

  • Yachie, A., Miyawaki, T., Yokoi, T., Nagaoki, T. and Taniguchi, N. (1982) 1α positive cells generated by PWM-stimulation within the OKT4+ subset interact with OKT8+ cells for inducing active suppression on B cell differentiation in vitro. J. Immunol., 129, 103–6.

    PubMed  CAS  Google Scholar 

  • Zagury, D., Bernard, J., Leonard, R., Cheynier, R., Feldman, M., Sarin, P. S. and Gallo, R. C. (1986) Long-term cultures of HTLV-III infected T cells: a model of cytopathology of T cell depletion in AIDS. Science, 231, 850–3.

    PubMed  CAS  Google Scholar 

  • Ziegler-Heitbrock, H. W. L., Schramm, W., Satchel, D., Rumpold, H., Kraft, D., Wernicke, D., Von Der Helm, K., Eberle, J., Deinhardt, F., Rieber, G. P. and Rietmuller, G. (1985) Expansion of a minor subpopulation of peripheral blood lymphocytes (T8+/Leu7+) in patients with hemophilia, Clin. Exp. Immunol., 61, 633–41.

    PubMed  CAS  Google Scholar 

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Authors
  1. J. Steven McDougal
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  2. Janet K. A. Nicholson
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  3. Alison Mawle
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Editors and Affiliations

  1. University Department of Medicine, Royal Infirmary, Glasgow, UK

    R. Madhok MD  & C. D. Forbes MD  & 

  2. Centers for Disease Control, Atlanta, USA

    B. L. Evatt MD

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© 1987 Springer Science+Business Media Dordrecht

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McDougal, J.S., Nicholson, J.K.A., Mawle, A. (1987). Effects of HIV infection on the immune system. In: Madhok, R., Forbes, C.D., Evatt, B.L. (eds) Blood, Blood Products — and AIDS —. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3394-2_4

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  • DOI: https://doi.org/10.1007/978-1-4899-3394-2_4

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