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Clinical Nuclear Medicine pp 158–197Cite as

The brain

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Abstract

It is interesting to reflect on the present growth of radionuclide brain scanning. Not so many years ago, and in particular in the mid-1970s, after the peak effect of X-ray computed tomography (CT) brain scanning, radionuclide brain studies significantly declined in frequency and clinical importance. Now, after a decade, radionuclide studies of the brain have gained renewed interest.

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References

  • Ackerman, R. H., Correia, J. A., Alpert, N. M. et al. (1981) Positron imaging in ischaemic stroke disease using compounds labelled with oxygen-15. Arch. Neurol., 38, 537–43.

    Article  PubMed  CAS  Google Scholar 

  • Ancri, G., Basset, J.-Y., Leuchamp, Y. and Eavard, C. (1978) Diagnosis of cerebral lesions by thallium-201. Radiology, 128, 417–22.

    PubMed  CAS  Google Scholar 

  • Austin, G., Laffin, D., Roche, S. et al. (1973) A noninvasive i.v. isotope method for measuring cerebral blood flow. Stroke, 4, 362–3.

    Google Scholar 

  • Bach, M. C. and Boothby, J. A. (1986) Dementia associated with human immunodeficiency virus with a negative ELISA. N. Engl.J. Med., 315, 891–2.

    PubMed  CAS  Google Scholar 

  • Baron, J. C. (1985) Positron tomography ischemia: a review. Neuroradiology, 27, 509–16.

    Article  PubMed  CAS  Google Scholar 

  • Baron, J. C. (1987a) in Journal of Functional Imaging in Neurology and Psychiatry (eds J. Wade, S. Knezevic, V. A. Maximilian et al.), J. Libbey, pp. 91–100.

    Google Scholar 

  • Baron, J. C. (1987b) in Clinical Efficacy of Positron Emission Tomography (eds W. D. Heiss, G. Pawlik, K. Herholz and K. Wierhard), Martinus Nijhoff, Amsterdam.

    Google Scholar 

  • Biersack, H. J., Reichmann, K., Stefan, H. et al. (1987) SPECT: Befunde bei Epilepsie und Migrane. Nucl. Med., 26, 100–4.

    Google Scholar 

  • Boucher, B. J. and Sear, R. (1980) A summary of the results of radioisotope brain scans on a large series of patients. Br. J. Radiol., 53, 1174–6.

    Article  PubMed  CAS  Google Scholar 

  • Boyd, R. E., Robson, J., Hunt, F. C. et al. (1973) 99mTc gluconate complexes for renal scintigraphy. Br.J. Radiol., 46, 604–12.

    Article  PubMed  CAS  Google Scholar 

  • Britton, K. E., Nimmon, C. C., Jarritt, P. H., Granowska, M. et al. (1977) in Advanced Medicine, Vol. 13 (ed. G. M. Besser), Pitman Medical, London, pp. 444–61.

    Google Scholar 

  • Britton, K. E., Granowska, M., Rutland, M. et al. (1979a) in Progress in Stroke Research, Vol. 1 (eds R. M. Greenhalgh and F. C. Rose), Pitman Medical, London, pp. 307–15.

    Google Scholar 

  • Britton, K. E., Granowska, M., Nimmon, C. C. et al. (1985) Cerebral blood flow in hypertensive patients with cerebrovascular disease. Nucl. Med. Commun., 6, 251–61.

    Article  PubMed  CAS  Google Scholar 

  • Britton, K. E., Nimmon, C. C., Granowska, M. and Lee, T. Y. (1979b) in Information Processing in Medical Imaging, INSERM, Paris, pp. 469–86.

    Google Scholar 

  • Britton, K. E., Granowska, M. and Nimmon, C. C. (1981) in Proceedings of the International Symposium on Medical Radionuclide Imaging, Heidelberg 1980, International Atomic Agency, Vienna.

    Google Scholar 

  • Bruine, J. F., van Royen, E. A., Vyth, A. et al. (1985) Thallium-201 diethyldithiocarbamate: an alternative to iodine-123 N-isopropyl-p-iodoamphetamine.J. Nucl. Med., 26, 925–30.

    PubMed  Google Scholar 

  • Buell, U., Moser, E. A., Schmiedek, P. et al. (1984) Dynamic SPECT with Xe-133: regional cerebral blood flow in patients with unilateral cerebrovascular disease: concise communication.J. Nucl. Med., 25, 441–6.

    PubMed  CAS  Google Scholar 

  • Buell, U., Stirner, H., Ferbert, D. et al. (1987) Cerebral blood flow/volume-SPECT with Tc-99m labelled hexamethylpropyleneamine oxime (HMPAO) and red blood cells in cerebrovascular disease (CVD) or epilepsy (E).J. Nucl. Med., 28, 600.

    Google Scholar 

  • Carne, C. A. (1987) Neurological manifestations: ABC of AIDS. Br. Med. J., 294, 1399–402.

    Article  CAS  Google Scholar 

  • Carril, J. M., MacDonald, A. F., Dendy, P. P. et al. (1979) Cranial scintigraphy: value of adding emission computed tomographic sections to conventional pertechnetate images.J. Nucl. Med., 20, 117–23.

    Google Scholar 

  • Chase, T. N., Foster, N. L., Fedio, P. et al. (1984) Regional cortical dysfunction in Alzheimer’s disease as determined by positron emission tomography. Ann. Neurol., 15 (Suppl. S), 170–4.

    Article  Google Scholar 

  • Chawluk, J. B., Alavi, A., Dann, R. et al. (1987) Positron emission tomography in aging and dementia: effect of cerebral atrophy. J. Nucl. Med., 28, 431–7.

    PubMed  CAS  Google Scholar 

  • Costa, D. C., Ell, P. J., Cullum, I. D. et al. (1986a) The in vivo ditribution of 99Tcm-HMPAO in normal man. Nucl. Med. Commun., 7, 647–58.

    PubMed  CAS  Google Scholar 

  • Costa, D. C., Jones, B. E., Steiner, T. J. et al. (1986b) Relative 99mTc-HMPAO and 113Sn-microspheres distribution in dog brain. Nuklearmedizin, 25, A53.

    Google Scholar 

  • Costa, D. C., Lui, D., Sinha, A. K. et al. (1987a) Tc-99m-d, l-HMPAO vs. Tl-201-DDC: subcellular distribution in rat brain.J. Nucl. Med., 28, 593.

    Google Scholar 

  • Costa, D. C., Davies, P. T. G., Jones, B. E. et al. (1987b) Cerebral blood flow imaging in migraine patients with 99mTc-HM-PAO and single photon emission tomography: preliminary findings and a report on its efficacy. Adv. Headache Res., 75–80.

    Google Scholar 

  • Costa, D. C. Ell, P. J., Stibe, C. M. A. et al. (1987c) Tc-99m-HMPAO rCBF/SPET in Parkinsonians with the ‘on-off’ syndrome: preliminary results. Nuklearmedizin, 26, 111.

    Google Scholar 

  • Davies, K. L. and Mohs, R. C. (1986) Cholinergic drugs in Alzheimer’s disease. N. Engl. J. Med., 315, 1286–7.

    Article  Google Scholar 

  • DeBoulay, G. H. and Marshall, J. (1975) Comparison of E. M. I. and radioisotope imaging in neurological disease. Lancet, ii, 1294–7.

    Article  Google Scholar 

  • De Roo, M., Mortelmans, L., Devos, P. et al. (1987) Clinical experience with Tc-99m-HMPAO high resolution SPECT of the brain in patients with cerebrovascular disease. Nuklearmedizin, 26, 148.

    Google Scholar 

  • Di Chiro, G., Ommaya, A. K., Ashbvurn, W. L. and Briner, W. H. (1968) Isotope cisternography in the diagnosis and follow up of cerebrospinal fluid rhinorrhoea.J. Neurosurg., 28, 522–9.

    Article  PubMed  Google Scholar 

  • Drayer, B. P., Wilkins, R. H., Boehnke, M. et al. (1977) Cerebrospinal fluid rhinorrhoea demonstrated by metrizamide CT cisternography. Am. J. Roentgenol, 129, 149–51.

    Article  CAS  Google Scholar 

  • Ell, P. J., Deacon, J. M. and Jarritt, P. H. (1980) Atlas of Computerized Emission Tomography, Churchill Livingstone, Edinburgh.

    Google Scholar 

  • Ell, P. J., Harrison, M. and Lui, D. (1983) Cerebral blood flow with iodine-123 labelled amines. Lancet,ii, 1348–52.

    Article  Google Scholar 

  • Ell, P. J., Cullum, I., Costa, D. C. et al. (1985a) A new regional cerebral blood flow mapping with 99Tcm-labelled compound. Lancet, ii, 50–1.

    Article  Google Scholar 

  • Ell, P. J., Hocknell, J. M. L., Jarritt, P. H. et al. (1985b) A 99Tcm-labelled radiotracer for the investigation of cerebral vascular disease. Nucl. Med. Commun., 6, 437–41.

    Article  PubMed  CAS  Google Scholar 

  • Ell, P. J., Cullum, I. D., Lui, D. et al. (1987a) in Journal of Functional Imaging in Neurology and Psychiatry (eds J. Wade, S. Knezevic, V. A. Maximilian et al.), John Libbey, pp. 54–70.

    Google Scholar 

  • Ell, P. J., Costa, D. C., Cullum, I. et al. (1987b) The Clinical Application of rCBF Imaging by SPECT. Amersham, Little Chalfont, UK.

    Google Scholar 

  • Ell, P. J., Costa, D. C. and Harrison, M. (1987c) Imaging cerebral damage in HIV infection. Lancet, i, 569–70.

    Article  Google Scholar 

  • Frackowiak, R. S. J., Pozzilli, C., Legg, N. J. et al. (1981) Regional cerebral oxygen supply and utilization in dementia: a clinical and physiological study with oxygen-15 and positron tomography. Brain, 104, 753–78.

    Article  PubMed  CAS  Google Scholar 

  • Gemmell, H. G., Sharp, P. F., Evans, N. T. S. et al. (1984) Single photon emission tomography with 123I-isopropyleamphetamine in Alzheimer’s disease and multi-infarct dementia. Lancet, ii, 1348.

    Article  Google Scholar 

  • George, R. O. and Wagner, H. N. (1975) in Non-Invasive Brain Imaging (eds H. J. DeBlanc and J. A. Sorenson), Society of Nuclear Medicine, New York, pp. 3–23.

    Google Scholar 

  • Gibbs, J. M., Wise, R. J. S., Leeuders, K. L. and Jones, T. (1984) Evaluation of cerebral perfusion reserve in patients with carotid artery occlusion. Lancet, i, 310–14.

    Article  Google Scholar 

  • Granowska, M., Britton, K. E., Afshar, F. et al. (1980) Total and regional cerebral flow non-invasive quantitation in patients with subarachnoid haemorrhage.J. Neurosurg., 53, 153–9.

    Article  PubMed  CAS  Google Scholar 

  • Gray, W. R., Hickey, D., Parkey, R. W. et al. (1979) Clinical Nuclear Cardiology (eds R. W. Parkey, F. J. Bonte, L. M. Buja and J. T. Willerson), Appleton Century Crofts, New York, pp. 297–308.

    Google Scholar 

  • Gustafson, L., Brun, A. and Ingvar, D. H. (1977) in Cerebral Vascular Disease (eds J. D. Meyer, H. Lechner and M. Reivich), Excerpta Medica, Amsterdam, pp. 5–9.

    Google Scholar 

  • Hackinski, V. (1978) Cerebral blood flow: differentiation of Alzheimer’s disease and multi-infarct dementia, in Alzheimer’s Disease: Senile Dementia and related disorders (eds R. Katzman, R. D. Terry and K. L. Bick) Raven Press, New York, pp. 97–103.

    Google Scholar 

  • Hauser, W. et al. (1970) Technetium-99m DTPA: a new radiopharmaceutical for brain and kidney scanning. Radiology, 94, 679.

    PubMed  CAS  Google Scholar 

  • Hill, T. C., Holman, L., Lovett, R. et al. (1982) Initial experience with SPECT (single photon computerised tomography) of the brain using N-isopropyl-I-123 p-iodoamphetamine: concise communication.J. Nucl. Med., 23, 3.

    Google Scholar 

  • Hill, T. C., Magistretti, P. L. Holman, B. L. et al. (1984) Assessment of regional cerebral blood flow (rCBF) in stroke using SPECT and N-isopropyl-(I-123)-p-iodoamphetamine (IMP), Stroke, 40–5.

    Google Scholar 

  • Holm, S., Andersen, A. R., Vorstrup, S. et al. (1985) Dynamic SPECT of the brain using a lipophilic technetium-99m complex, PnAO. J. Nucl. Med., 26, 1129–34.

    PubMed  CAS  Google Scholar 

  • Holman, B. L., Hellmon, R. S., Goldsmith, S. J. et al. (1989) Biodistribution, dosimetry and clinical evaluation of Technetium 99m ethyl cysteinate driver in normal subjects and in patients with chronic cerebral infarction.J. Nucl. Med., 30, 1018–24.

    PubMed  CAS  Google Scholar 

  • Ingvar, D. H. (1975) Brain work: Alfred Benzon Symposium VIII (eds D. H. Ingvar and N. A. Lassen), Munksgaard, Copenhagen, pp. 397–413.

    Google Scholar 

  • Ingvar, D. H. and Lassen, N. A. (1961) Quantitative determination of regional cerebral blood flow in man. Lancet, ii, 806–7.

    Article  Google Scholar 

  • Ingvar, D. H. and Risberg, J. (1965) Influence of mental activity upon regional cerebral blood flow in man. Acta Neurol. Scand., 41 (Suppl. 43), 42–73.

    Google Scholar 

  • Ingvar, D. H. and Risberg, J. (1967) Increase of regional cerebral blood flow during mental effort in normals and in patients with focal brain disorders. Exp. Brain Res., 3, 195–211.

    Article  PubMed  CAS  Google Scholar 

  • Ingvar, D. H., Risberg, J. and Schwartz, M. S. (1975) Evidence of subnormal function of association cortex in presenile dementia. Neurology, 10, 964–74.

    Article  Google Scholar 

  • Jarritt, P. H., Ell, P. J., Myers, M. J. et al. (1979) A new transverse section brain imager for single gamma emitters.J. Nucl. Med., 20, 319–27.

    PubMed  CAS  Google Scholar 

  • Keeling, F., Babich, J., Flower, M. A. et al. (1986) Early experience with 99TcmHMPAO in patients with brain tumours. Nucl. Med. Commun., 7, 274.

    Google Scholar 

  • Kety, S. S. and Schmidt, C. F. (1945) The determination of cerebral blood flow in man by use of nitrous oxide in low concentrations. Am. J. Phys., 143, 53–66.

    CAS  Google Scholar 

  • Knapp, W. H., von Kummen, R. and Kubler, W. (1986) Imaging of cerebral blood flow to volume distribution using SPECT.J. Nucl. Med., 27, 465–70.

    PubMed  CAS  Google Scholar 

  • Kung, K. F., Pan, S., Kung, M. P., Billings, J., Kasliwal, R., Reilley, J., Alavi, A. (1989) In vitro and In vivo evaluation of 123I-IBZM. A potential CNS D-2 dopamine receptor imaging agent. J. Nucl. Med., 30, 88–92.

    PubMed  CAS  Google Scholar 

  • Kung, H. F., Tramposch, K. M. and Blau, M. (1983) A new brain perfusion imaging agent: N, N, N′-trimethyl-N′ -(2-hydroxy-3-methyl-5-iodobenzyl)-1, 3 propanediamine (HIPDM).J. Nucl. Med., 24, 66–72.

    PubMed  CAS  Google Scholar 

  • Langen, K.-J., Roosen, N., Kuwert, T. et al. (1987) 99mTc-HMPAO SPECT in the study of cerebral tumours: results in 40 patients. Nuklearmedizin, 26, 118.

    Google Scholar 

  • Lassen, N. A. (1966) The luxury perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain. Lancet, ii, 1113–15.

    Article  Google Scholar 

  • Lassen, N. A. and Munck, O. (1955) The cerebral blood flow in man determined by the use of radioactive krypton. Acta Phys. Scand., 33, 30.

    Article  CAS  Google Scholar 

  • Lassen, N.A., Roland, P. E., Larsen, B. et al. (1977) Mapping of human cerebral functions: a study of the regional cerebral blood flow pattern during rest, its reproducibility and the activations seen during basic sensory and motor functions. Acta Neurol. Scand., 56 (Suppl. 64), 262–3.

    Google Scholar 

  • Lassen, N. A., Henriksen, L. and Paulson, O. (1981) Regional cerebral blood flow in stroke by 133xenon inhalation and emission tomography. Stroke, 12, 3.

    Article  Google Scholar 

  • Lauritzen, M. (1987) in Journal of Functional Imaging of Neurology and Psychiatry (eds J. Wade, S. Knezevic, V. A. Maximilian et al.), John Libbey, London.

    Google Scholar 

  • Lenzi, G. L., Frackowiak, R. S. J. and Jones, T. (1982) Cerebral oxygen metabolism and blood flow in human cerebral ischemic infarction.J. Cereb. Blood Flow Metab., 2, 321–35.

    Article  PubMed  CAS  Google Scholar 

  • Leonard, J.-P., Nowotnik, D. P. and Neirinckx, R. D. (1987) Technetium-99m-d, l-HM-PAO: a new radiopharmaceutical for imaging regional brain perfusion using SPECT: a comparison with iodine-123 HIPDM.J. Nucl. Med., 27, 1819–1823.

    Google Scholar 

  • Lucignani, C., Nehlig, A., Blasberg, R. et al. (1985) Metabolic and kinetic considerations in the use of 125I-HIPDM for quantitative measurement of regional cerebral blood flow.J. Cereb. Blood Flow Metab., 5, 86–96.

    Article  PubMed  CAS  Google Scholar 

  • Mallet, B. L. and Veall, N. (1965) The measurement of regional cerebral clearance rates in man using xenon-133 inhalation and extracranial recording. Clin. Sci., 29, 179–91.

    Google Scholar 

  • Matsuda, H., Seki, H., Sumiya, H. et al. (1986) Quantitative cerebral blood flow measurements using N-isopropyl-(iodine-123)p-iodoamphetamine and single photon emission computed tomography with rotating gamma camera. Am. J. Phys. Imaging, 1, 186–94.

    CAS  Google Scholar 

  • Maximilian, V. A., Prohovnik, I., Risberg, J. and Hakansson, K. (1978) Regional blood flow changes in the left cerebral hemisphere during word pair learning and recall. Brain Lang., 6, 22–31.

    Article  PubMed  CAS  Google Scholar 

  • Maziere, B. and Maziere, M. (1990) Where have we got to with neuroreceptor mapping of the human brain? European Journal of Nuclear Medicine, 16, no. 11, 817–837.

    Article  PubMed  CAS  Google Scholar 

  • Mazziotta, J. C. and Phelps, M. E. (1986) in Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart (eds M. Phelps, J. Mazziotta and H. Schelbert), Raven Press, New York, pp. 493–570.

    Google Scholar 

  • Meurman, O. H., Irjal, K., Suonpaa, J. and Laurent, B. (1979) A new method for the identification of cerebrospinal fluid leakage. Acta Otolaryngol, 87, 366–9.

    Article  PubMed  CAS  Google Scholar 

  • Moretti, J. L., Defer, G., Cesaro, P. et al. (1985) Early and late SPECT with n-isopropyl-p-iodoamphetamine-I-123 (IAMP) in cerebral ischaemia. Eur. J. Nucl. Med., 11 (suppl.): A24.

    Google Scholar 

  • Moretti, J. L., Cinotti, L., Cesaro, P. et al. (1987) Amines for brain tomoscintigraphy. Nucl. Med. Commun., 8, 581–95.

    PubMed  CAS  Google Scholar 

  • Moses, D. C., Natarajan, T. K., Previosi, T. J. et al. (1973) Quantitative cerebral circulation studies with sodium pertechnetate.J. Nucl. Med., 14, 142–8.

    PubMed  CAS  Google Scholar 

  • Mueller, S. P., Johnson, K. A., Hamil, D. et al. (1986) Assessment of I-123 IMP SPECT in mild/moderate and severe Alzheimer’s disease.J. Nucl. Med., 27, 889.

    Google Scholar 

  • Nagle, C.E. (1980) Use of immediate static scans in combination with radionuclide cerebral angiography as a confirmatory test in the diagnosis of brain death. Clin. Nucl. Med., 5, 152–3.

    Article  PubMed  CAS  Google Scholar 

  • Navia, B. A., Jordan, B. D. and Price, R. W. (1986a) The AIDS dementia complex: I. Clinical features. Ann. Neurol., 19, 517–24.

    Article  PubMed  CAS  Google Scholar 

  • Navia, B. A., Cho, E.-S., Petito, C. K. et al. (1986b) The AIDS dementia complex: II. Neuropathology. Ann. Neurol., 19, 525–35.

    Article  PubMed  CAS  Google Scholar 

  • Neirinckx, R. D., Canning, L. R., Piper, I. M. et al. (1987) Technetium-99m d, l-HM-PAO: a new radiopharmaceutical for SPEC imaging of regional cerebral blood perfusion.J. Nucl. Med., 29, 191–202.

    Google Scholar 

  • Obrist, W. D., Thomson, H. K., Wang, H. S. and Wilkinson, W. E. (1975) Regional cerebral blood flow activated by 133Xe-inhalation. Stroke, 6, 245–56.

    Article  PubMed  CAS  Google Scholar 

  • Oldendorf, W. H. (1975) in Non-invasive Brain Imaging (eds H. J. De Blanc and J. A. Sorenson), Society of Nuclear Medicine, New York, pp. 17–23.

    Google Scholar 

  • Olesen, J. (1971) Contralateral focal increase of cerebral blood flow in man during arm work. Brain, 94, 635–46.

    Article  PubMed  CAS  Google Scholar 

  • Potchen, E. J. and McCready, V. R. (1972) Neuronuclear medicine. Prog. Nucl. Med., 1, 2.

    Google Scholar 

  • Potchen, E. J., Holman, B. L. Evans, R. G. et al. (1971) in Proceedings of the 4th International Symposium in Brain and Blood Flow (ed. R. W. R. Russell), Pitman, London, pp. 94–7.

    Google Scholar 

  • Prohovnik, I., Hakansson, K. and Risberg, J. (1980) Observations on the functional significance of regional blood flow in ‘resting’ normal subjects. Neuropsychologia, 18 (2), 203–17.

    Article  PubMed  CAS  Google Scholar 

  • Razzak, M. A., Muddaris, F. and Christie, J. H. (1980) Sensitivity of radionuclide brain scan imaging and computerized axial tomography in detecting subdural haematoma. Clin. Nucl. Med., 5, 154–8.

    Article  PubMed  CAS  Google Scholar 

  • Riccio, M. (1987) Aids and dementia. Br. J. Hosp. Med., 11 July, 38, 11.

    PubMed  CAS  Google Scholar 

  • Risberg, J. (1987) in Journal of Functional Imaging in Neurology and Psychiatry (eds J. Wade, S. Knezevic, V. A. Maximilian et al.), John Libbey, London, pp. 35–43.

    Google Scholar 

  • Risberg, J. and Ingvar, D. H. (1972) Multibolus technique for measuring the distribution of cerebral blood flow over short intervals in man. Circ. Res., 31, 889–98.

    Article  PubMed  CAS  Google Scholar 

  • Risberg, J., Halsey, J. H., Wills, E. L. and Wilson, E. M. (1975) Hemispheric specialization in normal man studied by bilateral measurements of the regional cerebral blood flow: a study with the 133-Xe inhalation technique. Brain, 98, 511–24.

    Article  PubMed  CAS  Google Scholar 

  • Risberg, J., Maximilian, A. V. and Prohovnik, I. (1977) Changes of cortical activity patterns during habituation to a reasoning test: a study with the 133Xe inhalation technique for measurement of regional cerebral blood flow. Neuropsychologia, 15, 793–8.

    Article  PubMed  CAS  Google Scholar 

  • Roine, R. O., Launes, J., Lindroth, L. and Nikkinen, P. (1986) 99mTc-hexamethylpropyleneamine oxime scans to confirm brain death. Lancet, ii, 1223–4.

    Article  Google Scholar 

  • Rossor, M. (1987) Dementia. Br. J. Hosp. Med., 38, 46–50.

    PubMed  CAS  Google Scholar 

  • Royal, H. O., Hill, Th. C. and Holman, B. L. (1985) in Seminars in Nuclear Medicine XV (eds L. M. Freeman and M. D. Blaufox), Grune and Stratton, New York, pp. 357–76.

    Google Scholar 

  • Rutland, M. D., Lee, T. Y., Nimmon, C. C. et al. (1980) Measurement of the effects of a single dose of Prazosin on the cerebral blood flow in hypertensive patients. Postgrad. Med. J., 56, 818–22.

    Article  PubMed  CAS  Google Scholar 

  • Schall, G. L., Zeiger, L. S. and Di Chino, G. (1971) Clinical comparison of 2 99mTc tracers for brain scanning: pertechnetate versus labelled albumin. Radiology, 99, 361–8.

    PubMed  CAS  Google Scholar 

  • Sharp, P. F., Smith, F. W., Gemmell, H. G. et al. (1986) Technetium-99m HMPAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies. J. Nucl. Med., 27, 171–7.

    PubMed  CAS  Google Scholar 

  • Shields, R. A., Burjon, A. W., Prescott, M. C. et al. (1986) Tc-99m-HMPAO: a new brain imaging agent: biodistribution studies and initial clinical trials in dementia. Nucl. Med. Commun., 7, 284–5.

    Google Scholar 

  • Suess, E., Podreka, I., Goldenberg, G. et al. (1986) Initial experience with 99Tcm-hexamethylpropylene-amineoxime brain SPECT. Nucl. Med. Commun., 7, 285.

    Google Scholar 

  • Suess, E., Podreka, I., Baumgartner, Ch. et al. (1987) 99Tcm-HMPAO brain SPECT in partial complex seizures. Nucl. Med. Commun., 8, 240.

    Google Scholar 

  • Summers, W. K., Majovski, L. V., Marsh, G. M. et al. (1986) Oral tetrahydroaminoacridine in long term treatment of senile dementia, Alzheimer type. N. Engl. J. Med., 315, 1241–5.

    Article  PubMed  CAS  Google Scholar 

  • Symon, L. and Dorsch, N. W. C. (1975) Use of long term intracranial pressure measurement to assess hydrocephalic patients prior to surgery.J. Neurosurg., 42, 258–73.

    Article  PubMed  CAS  Google Scholar 

  • Testa, H. J., Shields, R. A., Burjan, A. W. I. et al. (1987) Investigation of dementia using 99Tcm-HMPAO and single photon emission tomography. Nucl. Med. Commun., 8, 241.

    Google Scholar 

  • Tramposch, K. M., Kung, H. F. and Blau, M. (1980) Brain imaging with 1–123 labelled amines for brain studies: localisation of 1–123 iodophenylakyl amines in rat brain.J. Nucl. Med., 21, 940–6.

    Google Scholar 

  • Vallabhajosula, S., Zimmermon, R. E., Micord, M. et al. (1989) Technetium-99m ECD: A new brain imaging agent: In vivo kinetics and biodistribution studies in normal subjects.J. Nucl. Med., 30, 599–604.

    PubMed  CAS  Google Scholar 

  • Van Duyl, W. A. and Volkers, A. C. W. (1980) Measurement of cerebral blood flow in the pig by Xe-133 clearance technique: failure of the two compartmental clearance model. Eur. J. Nucl. Med., 5, 86–96.

    Article  Google Scholar 

  • Vangelista, R., Visentin, E., Dalla Pozza, F. et al. (1987) Brain SPECT with 99mTc-labelled hexamethyl propylene amine oxime (99mTc-HM-PAO): our experience.J. Nucl. Med. Allied Sci., 31, 166.

    Google Scholar 

  • Van Horn, G. (1987) Dementia. Am. J. Med., 83, 101–10.

    Article  PubMed  Google Scholar 

  • Verhoeff, N. P. L. G., Bobeldijk, M., Van Royen, E. A., Feenstra, M. G. P., Boer, G. J., Van Doremalen, P.A.P.M. (1989) In Vitro and In Vivo binding of dopamine D2 receptors with 123I-Iodobenzamide in rat brain. Pharmaceutisch Weekblad Scientific Edition, 11, Suppl. J: J13.

    Article  Google Scholar 

  • Verhoeff N. P. L. G., Van Royen, E. A., Costa, D. C., Cullum, I. D., Lui, D., Ell, P. J., Sved, G. M. S., Barrett, J. J., Toone, B. (1990) A study of the dopamine D2 receptor in human brain with 123I-IBZM SPET. Nucl. Med. Commun., 3, 246.

    Google Scholar 

  • Volkert, W. A., Hoffman, T. J., Seger, R. M. et al. (1984) Tc-99m propylene amine oxime (Tc-99m-PnAO): a potential brain radiopharmaceutical. Eur. J. Nucl. Med., 9, 511–16.

    Article  PubMed  CAS  Google Scholar 

  • Winchell, H. S., Horst, W. D., Braun, L. et al. (1980) N-Isopropyl (iodine-123) p-iodoamphetamine: single paps brain uptake and washout: binding to brain synaptosomes and localisation in dog and monkey brain. J. Nucl. Med., 21, 947–52.

    PubMed  CAS  Google Scholar 

  • Wise, R. J. S., Bernardi, S., Frackowiak, R. S. J. et al. (1983) Serial observations on the pathophysiology of acute stroke: the transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain, 106, 197–222.

    Article  PubMed  Google Scholar 

  • Woolley, J. L., Williams, B. and Ventakesh, S., (1977) Cranial isotope section scanning. Clin. Radiol., 28, 517–28.

    Article  PubMed  CAS  Google Scholar 

Further Reading

  • Editorial (1989) SPECT and PET in epilepsy, Lancet, i, 135–7.

    Google Scholar 

  • Kung, H. F. (1990) New technetium-99m labelled brain perfusion imaging agents, Semin. Nucl. Med., 20, 150–8.

    Article  PubMed  CAS  Google Scholar 

  • Maziere, B. and Maziere, M. (1990) Where have we got to with neuroceptor mapping of the human brain?, Eur. J. Nucl. Med., 16, 817–35.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. P. J. Ell
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  2. K. E. Britton
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Editors and Affiliations

  1. Guy’s Hospital, London, UK

    M. N. Maisey

  2. St Bartholomew’s Hospital, London, UK

    K. E. Britton

  3. The Hospital for Sick Children, Toronto, Canada

    D. L. Gilday

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© 1991 Springer Science+Business Media Dordrecht

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Ell, P.J., Britton, K.E. (1991). The brain. In: Maisey, M.N., Britton, K.E., Gilday, D.L. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3358-4_7

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  • DOI: https://doi.org/10.1007/978-1-4899-3358-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-27900-3

  • Online ISBN: 978-1-4899-3358-4

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