Skip to main content
SpringerLink
Log in

Tumour imaging

  • Chapter
Clinical Nuclear Medicine

  • 98 Accesses

Abstract

The adequate management of any malignancy depends on several factors. The first is an accurate diagnosis. For the diagnosis to be accurate, not only must the site of the tumour be identified, but the exact tissue in which the tumour is arising must be determined. Although the histogenic type of the tumour may be readily apparent on light microscopy, more detailed investigations including histochemical techniques of resected tumour are often necessary to correctly characterize the malignancy in terms of tissue origin and degree of differentiation of the tumour. A further factor in contributing to decisions on management is the stage of the malignancy at the time of presentation or at the time of investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackery, D. M., Tillett, P. A., Condon, B. R. et al. (1984) New approach to the localization of phaeochromocy-toma imaging with 131MIBG. Br. Med. J., 288, 1587–91.

    CAS  Google Scholar 

  • Alazraki, M. P., Ramsdell, J. W., Taylor A. et al. (1978) The reliability of gallium scan, chest radiography compared with mediastinoscopy for evaluating mediastinal spread in lung cancer. Am. Rev. Resp. Dis., 117, 415–20.

    PubMed  CAS  Google Scholar 

  • Alexander, J. L., Gillespie, P. J. and Edelstyn, G. A. (1976) Serial bone scanning using 99mtechnetium diphosphonate in patients undergoing cyclical combination chemotherapy for advanced breast cancer. Clin. Nucl. Med., 1, 13–17.

    Google Scholar 

  • Anderson, R. J., Sizemore, G. W. and Wahner, H. W. (1978) Thyroid scintigraphy in familial medullary Ca of the thyroid gland. Clin. Nucl. Med., 3, 147.

    PubMed  CAS  Google Scholar 

  • Anscombe, A. and Walkenden, S. B. (1983) An interesting bone scan in multiple myeloma: ?myeloma super scan. Br. J. Radiol., 56, 489–92.

    PubMed  CAS  Google Scholar 

  • Baulieu, J. C., Guilloteau, D., Calmettes, C. et al. (1986) MIBG uptake in MTC: a feature of multiple endocrine neoplasia. J. Nucl. Med., 27, 1009.

    Google Scholar 

  • Baulieu, J. L., Guilloteau, D., Baulieu, F. et al. (1988) Therapeutic effectiveness of iodine-13I MIBG metastases of a non-secreting paraganglioma. J. Nucl. Med., 29, 2008–13.

    PubMed  CAS  Google Scholar 

  • Becherman, C., De Meester, T. R. and Skinner D. R. (1976) in Medical Radionuclide Imaging (Vol. II), IAEA, Vienna, p. 351.

    Google Scholar 

  • Beckerman, C., Hoffer, P. B. and Bitran, J. D. (1985) The role of gallium 67 in the clinical evaluation of cancer. Semin. Nucl. Med., 15, 72–103.

    Google Scholar 

  • Bestagno, M., Guerra, P., Puricelli, G. P. et al. (1987) Treatment of neuroblastoma with 131I MIBG: the experience of an Italian study group. Med. Paediatr. Oncol, 15, 203–5.

    CAS  Google Scholar 

  • Bomani, J., Levison, D. A., Flatman, W. D. et al. (1987) Uptake of iodine-123 MIBG by phaeochromocytomas, paragangliomas and neuroblastomas: a histo-pathological comparison. J. Nucl Med., 28, 973–8.

    Google Scholar 

  • Boucher, B. J. and Sear, R. (1980) A summary of the results of radioisotope brain scans on a large series of patients. Br. J. Radiol., 53, 1174–6.

    PubMed  CAS  Google Scholar 

  • Boxer, D., Todd, C., Coleman, R. and Fogelman, I. (1989) Bone secondaries in breast cancer: the solitary metastases. J. Nucl. Med., 30, 1318–20.

    PubMed  CAS  Google Scholar 

  • Brechbiel, M. W., Gansow, O. A., Atcher, R. W. et al. (1986) Synthesis of l-(p-isothiocyanotobenzyl) derivatives of DTPA and EDTA: antibody labelling and tumour imaging studies. Chemistry, 25, 2772–81.

    CAS  Google Scholar 

  • Carrasquillo, J. A., Foon, K. A., Mulshine, J. M. et al. (1987) Radioimmunoscintigraphy of chronic lymphocytic leukaemia with monoclonal antibodies. J. Nucl. Med., 28, 602.

    Google Scholar 

  • Carril, J. M., Macdonald, A. F., Dendy, P. P., et al. (1979) Cranial scintigraphy: value of added emission computed tomographic sections to conventional per-technetate images. J. Nucl. Med., 20, 117–23.

    Google Scholar 

  • Cellerino, A., Filippi, P. G. and Chian Taretto, A. (1973) Operative and pathologic survey of 50 cases of peripheral lung tumours scanned with gallium 67. Chest, 64, 700.

    PubMed  CAS  Google Scholar 

  • Charkes, N. D., Young, I. and Sklaroff, D. M. (1968) The pathological basis of the strontium bone scan. JAMA, 206, 2482–88.

    PubMed  CAS  Google Scholar 

  • Chew, F. S. and Hudson, T. M. (1982) Radionuclide bone scanning of osteosarcoma: falsely extended uptake patterns. Am. J. Roentgenol, 139, 49–54.

    CAS  Google Scholar 

  • Citrin, D. L. and McKillop, J. H. (1978) Atlas of Technetium Bone Scans. Saunders, Philadelphia.

    Google Scholar 

  • Clarke, S. E. M., Lazarus, C. R., Edwards, S. et al. (1987a) Scintigraphy and treatment of MCT with 131I MIBG. J. Nucl Med., 28, 1820.

    PubMed  CAS  Google Scholar 

  • Clarke, S. E. M., Lazarus, C. R., Watkinson, J. et al. (1987b) 99mTc(v) DMSA: experience in imaging. Nucl. Med. Commun., 8, 265.

    Google Scholar 

  • Clarke, S. E. M., Lazarus, C., Mistry, R. and Maisey, M. N. (1987c) The role of 99mTc (v) DMSA in the management of patients with MCT. Br. J. Radiol., 60, 1089–92.

    PubMed  CAS  Google Scholar 

  • Clarke, S. E. M., Lazarus, C., Wraight, P. et al. (1988) Pentavalent 99mTc DMSA, 131MIBG and 99mTc MDP: an evaluation of three imaging techniques in patients with MCT. J. Nucl. Med., 29, 33–8.

    PubMed  CAS  Google Scholar 

  • Clarke, S., Allen, S. J., Twelves, C. et al (1989) Immunoscintigraphy in breast cancer with 131 and 125 iodine labelled SM3. Eur. J. Nucl Med., 15, 548.

    Google Scholar 

  • Coakley, A. J. and Wraight, E. P. (1980) Selenomethine liver scanning in the diagnosis of hepatoma. Br. J. Radiol., 53, 538–43.

    PubMed  CAS  Google Scholar 

  • Colcher, D., Esteban, J., Carrasquillo, J. A. et al. (1987) Complementation of intra cavitary and intravenous administration of a monoclonal antibody B72.3 in patients with carcinoma. Cancer Res., 47, 4218–24.

    PubMed  CAS  Google Scholar 

  • Coleman, R. E., Habibollahi, F., Rubens, R. D. and Fogelman, I. (1986) Bone scintigraphy in early breast cancer: the relevance of tumour characteristics in identifying patients with serial scanning. Nucl. Med. Commun., 7, 292.

    Google Scholar 

  • Connel, J. C., Hilditch, T., Elliott, A. and Sample, P. (1984) 131I MIBG and medullary thyroid cancer. Lancet, ii, 1273–4.

    Google Scholar 

  • Cowan, R. J. and Watson, N. E. (1980) Special characteristics and potential of single photon emission computed tomography in the brain. Semin. Nucl. Med., 10, 335–44.

    PubMed  CAS  Google Scholar 

  • Cox, P. H., Belfer, A. J. and Van Der Pompe, W. B. (1976) Thallium 201 chloride uptake in tumours, a possible complication in heart scintigraphy. Br. J. Radiol., 49, 767–8.

    PubMed  CAS  Google Scholar 

  • DeChiro, G., Delapaz, R. L. and Brooks, R. M. (1982) Glucose utilization of cerebral gliomas measured by (18F)fluoro-deoxy-glucose and positron emission tomography. Neurology, 32, 1323–9.

    Google Scholar 

  • DeLand, F. M., Sauerbrunn, B. J. Z. and Boyd, C. (1974) 67 Gallium citrate in untreated primary lung cancer: preliminary report of a co-operative group. J. Nucl. Med., 15, 408.

    PubMed  CAS  Google Scholar 

  • Demeester, T. R., Golomb, H. M. and Kirchner, P. (1979) The role of gallium-67 scanning in the clinical staging and preoperative evaluation of patients with carcinoma of the lung. Ann. Thorac. Surg., 28, 451.

    PubMed  CAS  Google Scholar 

  • Dukes, C. E. (1942) J. Pathol. Bacterial., 50, 527.

    Google Scholar 

  • Dukes, C. E. (1958) in Cancer, (ed. R. W. Karen), Butter-worths, London, p. 136.

    Google Scholar 

  • Edward, C. L. and Hayes, R. L. (1969) Tumour scanning with 67 gallium citrate. J. Nucl. Med., 10, 103–105.

    Google Scholar 

  • Ell, P. J., and Khan, O. (1981) Emission computerized tomography clinical application. Semin. Nucl. Med., 11, 50–60.

    PubMed  CAS  Google Scholar 

  • Ell, P. J., Deacon, J. M. and Jarritt, P. H. (1980) Atlas of Computerised Emission Tomography, Churchill Livingstone, Edinburgh.

    Google Scholar 

  • Endo, K., Shiomi, K., Kasagi, K., et al. (1984a) Imaging of MTC with 131I MIBG. Lancet, ii, 233.

    Google Scholar 

  • Endo, K., Ohta, M. and Sakahara, M. (1984b) in Radiopharmaceuticals and Labelled Compounds, IAEA, Vienna, p. 201.

    Google Scholar 

  • Esselstyn, C. B. (1977) Parathyroid pathology: its relation to choice of operation for hyperparathyroidism. World J. Surg., 1, 701–8.

    PubMed  Google Scholar 

  • Ferlin, G., Borsato, N. and Camerani, N. (1983) New perspectives in localizing enlarged parathyroid by technetium-thallium substraction scan. J. Nucl. Med., 24, 438–41.

    PubMed  CAS  Google Scholar 

  • Fischer, M., Kamanabroo, D. and Sandercaup, H. (1984) Scintigraphic imaging of carcinoid tumours with l31I MIBG. Lancet, ii, 165.

    Google Scholar 

  • Fisher, B. (1976) Pathological findings from the national surgical adjuvant breast project (protocol no 4): significance of regional node histology other than sinus histiocytes in invasive mammary cancer. Am. J. Clin. Pathol, 65, 21–30.

    PubMed  CAS  Google Scholar 

  • Fisher, M., Wehinger, H., Kraus, C. et al. (1987) Treatment of neuroblastoma with 131I MIBG: experience of the Munster Kassel Group. Med. Paediatr. Oncol, 15, 196–9.

    Google Scholar 

  • Flower, M. A., Babich, J. W. and Keeling, F. (1986) Clinical evaluation of new radioactive tracer (99mTc-ceretex) for imaging regional cerebral blood flow in patients with brain tumours, Proceedings of the 26th Annual Scientific Conference of Biological Engineering Society, ‘Blood flow in the brain’. Strachclyde University, September 1986.

    Google Scholar 

  • Fogelman, I., McKillop, J. H., Grieg, W. R. and Boyle, I. T. (1977) Absent kidney sign associated with symmetrical and uniformly increased uptake of tracer by the skeleton. Eur. J. Nucl. Med., 2, 257–60.

    PubMed  CAS  Google Scholar 

  • Frankel, R. S., Jones, A. E., Cohen, J. A. et al. (1974) Clinical correlations of 67gallium radionuclide studies with radiography in Ewing’s sarcoma. Radiology, 110, 597–603.

    PubMed  CAS  Google Scholar 

  • Freitas, J. E., Gross, M. D., Ripley, S. and Shapiro, B. (1985) Radionuclide diagnosis and therapy of thyroid cancer: current status report. Semin. Nucl. Med., 15, 106–31.

    PubMed  CAS  Google Scholar 

  • Fujiwara, T., Matsuzawa, T., Kubota, K. et al. (1989) Relationship between histologic type of primary lung cancer and 11C methionine uptake with PET. J. Nucl. Med., 30, 33.

    PubMed  CAS  Google Scholar 

  • Gandsman, E. J., Deutsch, S. D. and Tyson, I. B. (1983) Use of dynamic bone scanning in the differential diagnosis of osteomyelitis, Paget’s disease and primary bone tumours. J. Nucl. Med., 24, 83.

    Google Scholar 

  • Geatti, O., Shapiro, B. and Sissan, J. C. (1985) 131I MIBG for the locating of neuroblastoma: preliminary experience in 10 cases. J. Nucl. Med., 26, 736–42.

    PubMed  CAS  Google Scholar 

  • Ghaed, N., Thrall, J. H., Pinsky, S. M. and Johnson, M. C. (1974) Detection of extra osseous metastases from osteosarcoma with 99mtechnetium pyrophosphate bone scanning. Radiology, 112, 373–5.

    PubMed  CAS  Google Scholar 

  • Gillespie, P. J., Alexander, J. L. and Edelstyn, G. A. (1975) Changes in 87mstrontium concentrations in skeletal metastases in patients responding to cyclical combination chemotherapy for advanced breast cancer. J. Nucl. Med., 16, 191–3.

    PubMed  CAS  Google Scholar 

  • Giulano, A. E., Feig, S. and Eilber, F. R. (1984) Changing metastatic patterns of osteosarcoma. Cancer, 54, 2160–4.

    Google Scholar 

  • Goldman, A. B., Becker, M. H., Braumstein, P. et al. (1975) Bone scanning: osteogenic sarcoma correlation with surgical pathology. Radiology, 124, 83–90.

    CAS  Google Scholar 

  • Goldstein, H., McNeil, B. J., Zinfall, E. and Treves, S. (1986) Is there still a place for bone scanning in Ewing’s sarcoma? J. Nucl. Med., 21, 10–12.

    Google Scholar 

  • Goodall, A. L. and Symington, T. (1983) Studies in phaeochromocytoma: clinical aspects: diagnosis by adrenergic blocking drugs and treatment. Glasgow Med. J., 34, 95–7.

    Google Scholar 

  • Goodgold, H. M., Chen, D. C., Majd, M. and Nolan, N. G. (1983) Scintigraphy of primary bone neoplasia. J. Nucl. Med., 24, 57.

    Google Scholar 

  • Goris, M. C., Basso, L. V. and Etcubanas, E. (1980) Photopaenic lesions in bone scintigraphy. Clin. Nucl. Med., 5, 299–301.

    PubMed  CAS  Google Scholar 

  • Gould, A. A., Hubner, K. F. and Greenlaw, R. H. (1978) Gallium 67 citrate imaging in malignant lymphoma: final report of a co-operative group. J. Nucl. Med., 19, 1013–19.

    Google Scholar 

  • Granowska, M., Mather, S. J., Britton, K. E. et al. (1989) Colorectal cancer immunoscintigraphy, RIS with a 99mTc-labelled monoclonal antibody, PR1A3. Nucl. Med. Commun., 10, 221.

    Google Scholar 

  • Greenberg, P. H. and Marks, C. (1978) Adrenal cortical carcinoma: a presentation of 22 cases and a review of the literature. Ann. Surg., 44, 81–5.

    CAS  Google Scholar 

  • Guerra, U. P., Pizzocaro, C., Terzi, A. et al. (1989) New tracers for the imaging of the medullary thyroid carcinoma. Nucl. Med. Commun., 10, 285–95.

    PubMed  CAS  Google Scholar 

  • Halpern, S. E., Dillman, R. O. and Witzun, K. F. (1985) Radioimmuno detection of melanoma using indium-111 96.5 monoclonal antibody: a preliminary report. Radiology, 155, 493–9.

    PubMed  CAS  Google Scholar 

  • Harvey Turner, J., Martindale, A., Sorby, P. et al. (1989) SM-153 EDTMP therapy of disseminated skeletal metastases. Eur. J. Nucl. Med., 15, 400.

    Google Scholar 

  • Hayes, R. L., Rafter, J. J. and Byrd, B. L. (1981) Studies of the in vivo entry of gallium 67 into normal and malignant tissue. J. Nucl. Med., 22, 325–32.

    PubMed  CAS  Google Scholar 

  • Higashi, T., Auyuma, W. and Mori, Y. (1977) Gallium 67 scanning in the differentiation of maxillary sinus carcinoma from chronic maxillary sinusitis. Radiology, 123, 117.

    PubMed  CAS  Google Scholar 

  • Higashi, T., Wakao, H. and Nakamura, K. (1980) Quantitative gallium 67 scanning for predictive value in primary lung cancer. J. Nucl. Med., 21, 628.

    PubMed  CAS  Google Scholar 

  • Hisada, K., Tonami, N., Miyamae, T. et al. (1978) Clinical evaluation of tumour imaging with 201thallium chloride. Radiology, 129, 497–500.

    PubMed  CAS  Google Scholar 

  • Hjelms, E. and Dyrbye, M. (1975) Uptake of 67gallium in malignant lesions of the lung and lymphatic tissue. Scand. J. Resp. Dis., 56, 251.

    CAS  Google Scholar 

  • Hoefnagel, C. A., Voute, P. A. and DeKraker, J. (1985) Total body scintigraphy for detection of neuroblastoma. Diagn. Imag. Clin. Med., 54, 21–7.

    CAS  Google Scholar 

  • Hoefnagel, C. A., Delprat, C. C., Marcuse, H. R. and DeVijlder, J. J. M. (1986a) Thallium-201 total body scintigraphy in follow up of thyroid cancer. J. Nucl. Med., 27, 1854–7.

    PubMed  CAS  Google Scholar 

  • Hoefnagel, C. A., DeKraker, J., Marcuse, H. R. and Voute, P. A. (1986b) in Nuklearmedizin: Nuclear Medicine in Research and Practice (eds H. A. E. Schmidt, P. J. Ell and K. E. Britton, Schattauer-Verlag, Stuttgart, pp. 473–6.

    Google Scholar 

  • Hoefnagel, C. A., Klumper, A. and Voute, P. A. (1987a) Single photon emission tomography using 131MIBG in malignant phaeochromocytoma and neuroblastoma case reports. J. Med. Imag., 1, 57–60.

    Google Scholar 

  • Hoefnagel, C. A., Voute, P. A., DeKraker, J. and Marcuse, H. R. (1987b) Radionuclide diagnosis and therapy of neural crest tumours using iodine-13I MIBG. J. Nucl. Med., 28, 308–14.

    PubMed  CAS  Google Scholar 

  • Hoefnagel, C. A., Marcuse, H. R., DeKraker, J. and Voute, P. A. (1987c) Methodik und problematik der 131I MIBG mit SPECT. Nuclearmediziner, 4, 317–23.

    Google Scholar 

  • Hoffer, P. B., Huberty, J. and Khayam-Bashi, J. (1977) The associated of gallium 67 and lactoferrin. J. Nucl. Med., 18, 713–17.

    PubMed  CAS  Google Scholar 

  • Iannotti, F., Fieschi, C. and Alphano, B. (1987) J. Corn-put. Assist. Tomogr., 11, 390–7.

    CAS  Google Scholar 

  • Johnston, G., Benna, R. S. and Teates, C. D. (1974) 67 Gallium citrate imaging in untreated Hodgkin’s disease: preliminary report of a co-operative group. J. Nucl. Med., 15, 399.

    PubMed  CAS  Google Scholar 

  • Jones, T., Chesler, D. A. and Ter-Pogossian, M. (1976) Continuous inhalation of 15oxygen for assessing regional oxygen extraction in the brain of man. Br. J. Radiol., 49, 339–43.

    PubMed  CAS  Google Scholar 

  • Kashima, H. K., McKusik, K. A. and Malmud, L. S. (1974) Gallium 67 scanning in patients with head and neck cancer. Laryngoscopy, 84, 1078.

    CAS  Google Scholar 

  • Keeling, A. A., Vaughan, A. T. M. and Beaney, R. P. (1989) Yttrium-90-EDTMP bone seeking radiothera-peutic agent. Nucl. Med. Commun., 10, 224.

    Google Scholar 

  • Khafagi, F., Egerton-Vernon, J., Van Doom, T. et al. (1987) Localization and treatment of familial malignant non-functional paraganglioma with 131iodine MIBG: report of two cases. J. Nucl. Med., 28, 528–32.

    PubMed  CAS  Google Scholar 

  • Kim, E. E., Bledin, A. G., Gutierre, Z. C. and Hayne, T. P. (1983) Comparison of radionuclide images and radiographs for skeletal metastases from renal cell carcinoma. Oncology, 40, 284–6.

    PubMed  CAS  Google Scholar 

  • Kinkier, I. H., Merrich, M. V. and Rodger, A. (1985) Bone scintigraphy in breast cancer: a nine year follow up. Clin. Radiol., 36, 279–82.

    Google Scholar 

  • Kirkwood, J. M., Myers, J. E. and Vlock, D. R. (1982) Tomographic gallium 67 citrate scanning: useful new surveillance for malignant melanoma. Ann. Intern. Med., 66, 694.

    Google Scholar 

  • Klapdor, R., Montz, R., Lauder, H. et al. (1985) Untersuchungen zur intratumeralen: Radio immunotherapie transplantierte pankreas karzinoma mit 131J-anti CA19–9/CEA. Nucl. Compact, 16, 424–7.

    CAS  Google Scholar 

  • Kohler, G. and Millstein, C. (1975) Continuous cultures of few cells secreting antibody of predefined specificity. Nature, 256, 495–7.

    PubMed  CAS  Google Scholar 

  • Kubota, K., Matsuzawa, J., Ito, M. et al. (1985) Lung tumour imaging by positron emission tomography using C-11 L-methionine. J. Nucl. Med. 26, 37–42.

    PubMed  CAS  Google Scholar 

  • Kyrento, A. L., Brownell, G. L., Schleiderburg, G. and Elmullay, D. R. (1983) Regional blood flow measurement in rabbit soft tissue tumour with positron imaging using the C15O2 study state and labelled microspheres. J. Nucl. Med., 24, 1135–42.

    Google Scholar 

  • Larson, S. M., Rasey, J. S. and Allen, D. R. (1979) A transferrin mediated uptake of gallium 67 by EMT-6 sarcoma: studies in tissue culture. J. Nucl. Med., 20, 837–42.

    PubMed  CAS  Google Scholar 

  • Larson, S. M., Brown, J. P. and Wright, P. W. (1983a) Imaging of melanoma with 131I labelled monoclonal antibodies. J. Nucl. Med., 24, 123–9.

    PubMed  CAS  Google Scholar 

  • Larson, S. M., Carrasquillo, J. A., Krohn, K. A. et al. (1983b) Localization of 131I labelled p. 97 specific Fab fragments in human melanoma as a basis for radiotherapy. J. Clin. Invest., 72, 2101–14.

    PubMed  CAS  Google Scholar 

  • Larson, S. M., Carrasquillo, J. A. and McGuffin, R. W. (1985) Use of 131I labelled muirine Fab against a high molecular weight antigen of human melanoma: preliminary experience. Radiology, 155, 487–92.

    PubMed  CAS  Google Scholar 

  • Larson, S. M., Milders, M. S. and Johnston, G. J. (1975) in Radiopharmaceuticals (eds G. Subramanian, B. A. Rhodes and J F. Cooper), Society of Nuclear Medicine, New York, p. 413.

    Google Scholar 

  • Lashford, L. S., Mosely, R., Richardson, R. et al. (1988) Intrathecal administration of radiolabeled antibodies for therapy of malignant meningitis. Nucl. Med. Commun. 9, 181.

    Google Scholar 

  • Lavender, J. O., Lowe, J. and Barker, J. R. (1971) Gallium 67 citrate scanning in neoplastic and inflammatory lesions. Br. J. Radiol., 44, 361.

    PubMed  CAS  Google Scholar 

  • Lewington, V. J. (1989) Strontium-89 therapy in disseminated prostatic carcinoma. Nucl. Med. Commun., 10, 224.

    Google Scholar 

  • Lindegaard, M. W., Skretting, A. and Hager, B. (1986) Cerebral and cerebellar uptake of 99mTc-(d, l)hexa-methyl-propyleneamine oxime (HM-PAO) in patients with brain tumours studied by single photon emission computerised tomography. Eur. J. Nucl. Med., 12, 417–20.

    PubMed  CAS  Google Scholar 

  • Littenberg, R. L., Alazraki, N. P. and Taketa, R. M. (1973) A clinical evaluation of gallium 67 citrate scanning. Surg. Gynaecol. Obstet., 137, 424.

    CAS  Google Scholar 

  • Lomas, F., Dibso, P. E. and Wagner, H. M. (1972) Increased specificity of lung scanning with the use of gallium 67 citrate. N. Engl. J. Med., 286, 1323–9.

    PubMed  CAS  Google Scholar 

  • Lumbroso, J., Oberlin, O., Terrier, P. H. et al. (1989) May 123-I MIBG contribute to imaging Ewing’s sarcoma of bone. Eur. J. Nucl. Med., 15, 451.

    Google Scholar 

  • Lumia, S., Parthasarathy, K. L., Baksh, S. and Bender, M. A. (1957) An evaluation of 99mTc-sulfur colloid liver scintiscans and their usefulness in metastatic Nuclear Medicine in Clinical Oncology (ed. C. Winckler), Springer-Verlag, Berlin, pp. 129–37.

    Google Scholar 

  • Shapiro, B., Andrews, J., Fig, L. et al. (1989) Therapeutic intraarterial administration of yttrium-90 glass microspheres for hepatic tumours. Eur. J. Nucl. Med., 15, 401.

    Google Scholar 

  • Siccardi, A. G., Buraggi, G. L., Callegaro, L. et al. (1986) Multicentre study of immunoscintigraphy with radiolabelled monoclonal antibodies in patients with melanoma. Cancer Res., 46, 4817–22.

    PubMed  CAS  Google Scholar 

  • Siddiqui, A. R. and Ellis, J. H. (1982) Cold spots on bone scan at the site of osteosarcoma. Eur. J. Nucl. Med., 7, 480–1.

    PubMed  CAS  Google Scholar 

  • Siemsen, O. K., Grebe, S. F. and Waxman, A. D. (1978) The use of gallium-67 in pulmonary disorders. Semin. Nucl Med., 13, 235.

    Google Scholar 

  • Silberstein, E. B., Kornblut, A. and Shumrich, D. A. (1974) Gallium 67 as a diagnostic agent for detection of head and neck tumours and lymphoma. Radiology, 110, 605–8.

    PubMed  CAS  Google Scholar 

  • Silverberg, E. (1981) Cancer statistics. Cancer, 31, 20.

    Google Scholar 

  • Sisson, J. L., Shapiro, B. and Beier Walters, W. H. Radiopharmaceutical treatment of malignant phaeochromocytoma. J. Nucl. Med., 25, 197–206.

    Google Scholar 

  • Smith, T. W., Nandi, S. C. and Mills, K. (1982) Spinal chondrosarcoma demonstrated by 99mtechnetium MDP bone scan. Clin. Nucl. Med., 7, 111–12.

    PubMed  CAS  Google Scholar 

  • Sokoloff, L., Rivitch, M. and Kennedy, C. (1977) The 14C deoxyglucose method for the measurement of local cerebral glucose utilization: theory procedure and normal values on the conscious and anaesthetised rat. J.Neurochem., 28, 897–916.

    PubMed  CAS  Google Scholar 

  • Southee, A. E., McLaughlin, A. F., Joshua, D. E. et al. (1989) Gallium scanning as a predictor of outcome in mediastinal Hodgkin’s disease. Eur. J. Nucl. Med., 15, 547.

    Google Scholar 

  • Stadalnik, R. C. (1979) ‘Cold spot’: bone imaging. Semin. Nucl. Med., 9, 2–3.

    PubMed  CAS  Google Scholar 

  • Stewart, J. S. W., Griffiths, M., Munro, A. J. et al. (1987) Intraperitoneal radioimmunotherapy for ovarian cancer in immunotherapy and scintigraphy of tumours with monoclonal antibodies. Satellite Symposium 3rd International Conference in Hormones and Cancer, pp. 65–73.

    Google Scholar 

  • Stewart, J. S. W., Hird, V., Snook, D. et al. (1989) Intraperitoneal yttrium-90 labelled monoclonal antibody in ovarian cancer. Nucl. Med. Commun., 10, 226–89.

    Google Scholar 

  • Suzuki, T., Honjo, I. and Hamamoto, K. (1971) Positive scintophotography of cancer of the liver with 67 gallium citrate. Am. J. Roentgenol. Rad. Therapy Nucl. Med., 113, 92.

    CAS  Google Scholar 

  • Symington, T. (1969) in Functional Pathology of the Human Adrenal Gland, Livingstone, London, pp. 219–324.

    Google Scholar 

  • Taylor, A., Milton, W., Eyre, H. et al. (1988) Radioimmuno detection of human melanoma with indium-111 labelled monoclonal antibody. J.Nucl. Med., 29, 329–37.

    PubMed  Google Scholar 

  • Terni, S., Oyamada, H., Nishikawa, K. et al. (1984) Thallium-201 chloride scintigraphy for bone tumours and soft part sarcomas. J.Nucl. Med., 25, 114.

    Google Scholar 

  • Thrall, J., Freitas, J. E. and Beierwaltes, W. (1978) Adrenal scintigraphy. Semin. Nucl. Med., 8, 23–41.

    PubMed  CAS  Google Scholar 

  • Tjandra, T. J., Sacks, N. P., Thompson, C. A. et al. (1989) The detection of axillary lymph node metastases from breast cancer by radiolabelled monoclonal antibodies: a prospective study. Br. J. Cancer, 59, 296–302.

    PubMed  CAS  Google Scholar 

  • Togawa, T., Suziki, A. and Kato, K. (1985) Relation between thallium-201 to gallium-67 uptake ratio and histological type in primary lung cancer. Eur. J. Cancer Clin. Oncol., 21, 925.

    PubMed  CAS  Google Scholar 

  • Togawa, T., Yui, N., Koakubu, M. and Kinoshita, R. T. (1989) Two cases of adenocarcinoma of the lung in which thallium-201 gave a better delineation of metastatic lesions than gallium-67. Clin. Nucl. Med., 14, 197–200.

    PubMed  CAS  Google Scholar 

  • Tonami, N., Bunko, H., Mishi Gishi, T. et al. (1978) Clinical application of 201thallium scintigraphy in patients with cold thyroid nodules. Clin. Nucl. Med., 3, 217–21.

    PubMed  CAS  Google Scholar 

  • Tonami, N., Skuka, N., Yokoyama, K. et al. (1989) Thallium 201 single photon emission computed tomography in the evaluation of suspected lung cancer. J.Nucl. Med., 30, 997–1004.

    PubMed  CAS  Google Scholar 

  • Troncone, L., Rufini, V., Montemaggi, P., Danza, F. M., Lasorella, A. and Mastrangelo, R. (1990) The diagnostic and therapeutic utility of radioiodinated metaiodobenzylguanidine (MIBG) Eur. J. Nucl. Med., 16, 325–35.

    PubMed  CAS  Google Scholar 

  • Tsan, M. and Scheffel, U. (1986) Mechanism of gallium 67 accumulation in tumours. J.Nucl. Med., 27, 1215–19.

    PubMed  CAS  Google Scholar 

  • Tsan, M. F., Scheffel, E. U. and Tzen, K. Y. (1980) Factors affecting the binding of gallium 67 in serum. Int. J. Nucl. Med. Biol., 7, 270–3.

    PubMed  CAS  Google Scholar 

  • Vallabhajosula, S. R., Harwig, J. F. and Siemsen, J. K. (1980) Radiogallium localization in tumours: blood binding and transport and the role of transferrin. J.Nucl. Med., 21, 650–6.

    PubMed  CAS  Google Scholar 

  • Van Gils, A. P. G., Van der Mey, A. G. L., Hoogma, R. P. J. M. et al. (1989) Iodium-123 MIBG scintigrafie bij chemodactomen een oprallend resultaat. Nucl. Geneeskd. Bull., 11, 61.

    Google Scholar 

  • Vatz, R. D., Alderson, P. O. and Tochman, M. S. (1979) Ventilation perfusion imaging in the early detection of lung cancer. J.Nucl Med., 20, 612.

    Google Scholar 

  • Voute, P. A., Hoefnagel, C. A., De Kraker, J. et al. (1987). Radionuclide therapy of neural crest tumours. Med. Paediatr. Oncol., 15, 192–5.

    CAS  Google Scholar 

  • Wahner, H. W., Kyle, R. A. and Beabont, J. W. (1980) Scintigraphic evaluation of the skeleton in multiple myeloma. Mayo Clin. Proc, 55, 739–46.

    PubMed  CAS  Google Scholar 

  • Walleman, N. and Lajta, T. H. A. (eds) (1972) Handbook of Neurochemistry, Plenum Press, New York, p. 583.

    Google Scholar 

  • Watkinson, J. C., Clarke, S. E. M. and Shaheen, O. H. (1987) An evaluation of the uptake of Tc99m (v) DMSA in patients with squamous carcinoma of the head and neck. Clin. Otolaryngol, 12, 405–11.

    PubMed  CAS  Google Scholar 

  • Watkinson, J. C. and Maisey, M. N. (1988) Imaging head and neck cancer using radioisotopes: a review. J.R. Soc. Med., 81, 653–7.

    PubMed  CAS  Google Scholar 

  • Watkinson, J. C., Todd, C., Allen, S. et al. (1989) 99mTc(v) DMSA imaging: does it have a role in the management of patients with head and neck SCC? Nucl Med. Commun., 10, 239.

    Google Scholar 

  • Waxman, A. D., Richmond, R., Duffner, H. et al. (1980) Correlation of contract angiography and histologic pattern with gallium uptake in primary liver-cell carcinoma: non-correlation with alpha-feta protein. J.Nucl Med., 21, 324–7.

    PubMed  CAS  Google Scholar 

  • Waxman, A. D., Siemsen, J. K. and Levine, A. M. (1981) Radiographic and radionuclide imaging in multiple myeloma: the role of gallium scintigraphy. J.Nucl Med., 22, 232–6.

    PubMed  CAS  Google Scholar 

  • Waxman, A. D., Julian, P. J., Brackman, M. B. et al. (1984) Gallium scintigraphy and bronchogenic carcinoma: the effect of tumour location on sensitivity and specificity. Chest, 86, 178–83.

    PubMed  CAS  Google Scholar 

  • Weiner, R. E., Schrieber, G. J. and Hoffer, P. B. (1983) In-vitro transfer of gallium-67 from transferrin to fer-retin. J.Nucl. Med., 24, 608–14.

    PubMed  CAS  Google Scholar 

  • Weingrad, T., Heyman, S. and Alari, A. (1984) Cold lesions on bone scan in paediatric neoplasms. Clin. Nucl. Med., 9, 125–30.

    PubMed  CAS  Google Scholar 

  • Wieland, D. M., Wu, J. L., Brown, L. E., Mangner, T. J. et al. (1980) Radiolabelled adrenergic neuro-blocking agents: adreno-medullary imaging with 131iodobenzylguanidine. J. Nucl Med., 21, 349–53.

    PubMed  CAS  Google Scholar 

  • Wilson, G. S., Rich, M. A. and Brennan, M. J. (1980) Evaluation of bone scan in the preoperative clinical staging of breast cancer. Arch. Surg., 115, 415–19.

    PubMed  CAS  Google Scholar 

  • Woolfenden, J. M., Pitt, M., Durle, B. G. M. and Moon, T. E. (1980) Comparison of bone scintigraphy in radiology and multiple myeloma. Radiology, 134, 723–8.

    PubMed  CAS  Google Scholar 

  • Zimmer, A. M., Rosen, S. T. and Spies, S. M. (1985) Radioimmuno imaging of human cell lung carcinoma with I131 tumour specific monoclonal antibody. Hybridoma, 4, 1–14.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. S. E. M. Clarke
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Guy’s Hospital, London, UK

    M. N. Maisey

  2. St Bartholomew’s Hospital, London, UK

    K. E. Britton

  3. The Hospital for Sick Children, Toronto, Canada

    D. L. Gilday

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Clarke, S.E.M. (1991). Tumour imaging. In: Maisey, M.N., Britton, K.E., Gilday, D.L. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3358-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-3358-4_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-27900-3

  • Online ISBN: 978-1-4899-3358-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation