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Clinical Nuclear Medicine pp 277–286Cite as

Tracers

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Abstract

Imaging with radiolabeled tracers has revolutionized our understanding of brain chemistry, blood flow and metabolism. These powerful techniques now allow testing of neurochemical and clinical hypotheses in living human subjects.

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References

  1. Frackowiack, R.S.J., Lenzi, G.L., Jones, T. and Heather, J.D. (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure and normal values. J. Comput. Assist. Tomogr., 4, 727–36.

    Article  Google Scholar 

  2. Westera, G., Buck, A., Burger, C., Leenders, K.L., von-Schultess, G.K. and Schubiger, A.P. (1996) Car-bon-11 and iodine-123 labelled iomazenil: a direct PET-SPET comparison. Eur. J. Nucl. Med., 23, 5–12.

    Article  PubMed  CAS  Google Scholar 

  3. Lasagne, N. (1996) A reappraisal of the relative merits of SPET and PET in the quantitation of neuroreceptors: the advantage of a longer half life (editorial). Eur. J. Nucl. Med., 23, 1–4.

    Article  Google Scholar 

  4. Roy, C.S. and Sherrington, C.S. (1890) On the regulation of the blood supply of the brain, J. Physiol. Lond, 11, 85–100.

    PubMed  CAS  Google Scholar 

  5. Raichle, M.E. (1987) Circulatory and metabolic correlates of normal brain function in humans, in The Nervous System: Higher Functions of the Brain (ed. F. Plum), American Physiological Society, Bethesda, pp. 643–74.

    Google Scholar 

  6. Sokoloff, L. (1981) Localisation of functional activity in the central nervous system by measurement of glucose utilisation with radioactive deoxyglucose. J. Cereb. Blood Flow Metab., 1, 7–36.

    Article  PubMed  CAS  Google Scholar 

  7. Madsen, P.L. (1993) Cerebral blood flow(CBF) and cerebral metabolic rate (CMR) during sleep and wakefulness. Acta Neurol. Scand. (Suppl), 88.

    Google Scholar 

  8. Merrick, M.V. (1994) Xenon, red cell and transit time methods for cerebral blood flow and perfusion reserve measurement, in Nuclear Medicine in Clinical Diagnosis and Treatment, vol. 1 (eds I.P.C. Murray and P.J. Ell), Churchill Livingstone, pp. 535–49.

    Google Scholar 

  9. Kety, S.S. and Schmidt, C.F. (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man; theory, procedure and normal values. J. Clin. Invest, 27, 107–19.

    Google Scholar 

  10. Ingvar, D.H. and Lassen, N.A. (1963) Regional cerebral blood flow of the cerebral cortex determined by 85-krypton. Acta Physiol. Scand., 54, 325–38.

    Article  Google Scholar 

  11. Veall, N. and Mallett, B.L. (1965) The two compartment model using 133Xe inhalation and external counting. Acta Neurol. Scand., 14 (suppl), 83–4, 325–38.

    CAS  Google Scholar 

  12. Lassen, N.A., Sveindottir, E., Kanno, I., Stokeley, E.M. and Rommer, P. (1972) A fast moving, single photon emission tomography for regional cerebral blood flow studies in man. J. Comput. Assist. Tomogr., 2, 661–2.

    Article  Google Scholar 

  13. Costa, D.C. (1990) Single Photon Emission Tomography (SPET) with 99Tcm-hexamethyl-propyleneamineoxime (HMPAO) in research and clinical practise — a useful tool. Vase. Med. Rev., 1, 179–201.

    Article  Google Scholar 

  14. Perkins, A.C. (1995) The nature of nuclear medicine procedures, in Nuclear Medicine; Science and Safety, John Libbey & Co. Ltd, pp. 22–47.

    Google Scholar 

  15. Maziere, B. and Maziere, M. (1994) PET tracers for brain scanning, in Nuclear Medicine in Clinical Diagnosis and Treatment, vol. 1 (eds I.P.C. Murray and P.J. Ell), Churchill Livingstone, pp. 519–21.

    Google Scholar 

  16. Herscowitch, P., Mintun, MA. and Raichle, M.E. (1985) Brain oxygen utilisation measured with oxygen-15 radiotracers and positron emission tomography. J. Nucl. Med., 26, 416–17.

    Google Scholar 

  17. Phelps, M.E., Huang, S.C. and Hoffman, E.J. (1979) Tomographic measurements of local cerebral glucose metabolism in humans with (F-18)-2-fluoro-2-deoxy-D-glucose: validation of method. Ann. Neurol, 6, 371–88.

    Article  PubMed  CAS  Google Scholar 

  18. Langley, J.N. (1878) On the physiology of salivary secretion II. On the mutual antagonism of atropin and pilocarpin having special reference to their relations in the submaxillary gland of the cat. J. Physiol, 1, 339–69.

    PubMed  CAS  Google Scholar 

  19. Erlich, P. (1900) On immunity with special reference to cell life. Croonian Lecture. Proc. R. Soc. London, 66, 424–48.

    Google Scholar 

  20. Dean, P.M. (1991) Molecular Foundations of Drug-Receptor Interaction, Cambridge University Press, Cambridge.

    Google Scholar 

  21. Taylor, P. and Insel, P.A. (1990) Molecular basis of pharmacological selectivity, in Principles of Drug Action: the Basis of Pharmacology (eds W.B. Pratt and P. Taylor), Churchill Livingstone, London, pp. 1–103.

    Google Scholar 

  22. Kerwin, R.W. and Pilowsky, L.S. (1995) Traditional receptor theory and its application to neuroreceptor measurements in functional imaging. Eur. J. Nucl Med., 22, 699–710.

    Article  PubMed  CAS  Google Scholar 

  23. Pilowsky, L.S. and Kerwin, R.W. (1994) Nuclear medicine and drug studies in the brain, in Nuclear Medicine in Clinical Diagnosis and Treatment, Vol. 1 (eds I.P.C. Murray, P.J. Ell and H.W. Strauss), Churchill Livingstone, London, pp. 629–43.

    Google Scholar 

  24. Dolan, R., Bench, C. and Friston, K. (1990) Positron emission tomography in psychopharmacology. Int. Rev. Psychiatry, 2, 427–39.

    Article  Google Scholar 

  25. Woods, S.W., Pearsall, H.R., Seibyl, J.P. and Hoffer, P.B. (1991) The Quinn Essay: single photon emission computed tomography in neuropsychiatrie disorders, in The Year Book of Nuclear Medicine (ed. P.B. Hoffer), Mosby Year Book, St. Louis, XIII–XIV.

    Google Scholar 

  26. Young, A.B., Frey, K.A. and Agranoff, B.W. (1986) Receptor assays, in vitro and in vivo, in Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart (eds M.E. Phelps, J.C. M. zziotta and H.R. Schelbert), Raven Press, New York, pp. 73–113.

    Google Scholar 

  27. Stocklin, G. (1992) Tracers for metabolic imaging of brain and heart: radiochemistry and radio-pharmacology. Eur. J. Nucl. Med., 19, 527–51.

    Article  PubMed  CAS  Google Scholar 

  28. Verhoeff, N.P.L.G. (1994) Ligands for neuroreceptor imaging by single photon emission tomography (SPET) or positron emission tomography (PET), in Nuclear Medicine in Clinical Diagnosis and Treatment, vol. 1 (eds I.P.C. Murray and P.J. Ell), Churchill Livingstone, London, pp. 483–519.

    Google Scholar 

  29. Peroutka, S.J. and Snyder, S.H. (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha adrenergic and histamine receptors to clinical potency. Am. J. Psychiatry, 137, 1518–22.

    PubMed  CAS  Google Scholar 

  30. Farde, L., Weisel, F.-A., Nordstrom, A.-L. and Sedvall, G. (1989) Dl and D2 dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology, 99, S28–31.

    Article  Google Scholar 

  31. Pilowsky, L.S., Costa, D.C., Ell, P.J., Murray, R.M., Verhoeff, N.P.L.G. and Kerwin, R.W. (1993) Antipsychotic medication, D2 dopamine receptor blockade and clinical response — a 123I IBZM SPET (single photon emission tomography) study. Psychol. Med., 23, 791–9.

    Article  PubMed  CAS  Google Scholar 

  32. Cambon, H., Baron, J.C., Boulenger, J.P., Loe, C., Zarifian, E. and Maziere, B. (1987) In vivo assay for neuroleptic receptor binding in the striatum. Br. J. Psychiatry, 151, 824–30.

    Article  PubMed  CAS  Google Scholar 

  33. Farde, L., Nordstrom, A.L., Wiesel, F.-A. et al (1992) Positron emission tomographic analysis of central Dl and D2 receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch. Gen. Psychiatry, 49, 538–44.

    Article  PubMed  CAS  Google Scholar 

  34. Pilowsky, L.S., Costa, D.C., Ell, P.J., Murray, R.M., Verhoeff, N.P.L.G. and Kerwin, R.W. (1992) Clozapine, single photon emission tomography and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet, 340, 199–202.

    Article  PubMed  CAS  Google Scholar 

  35. Nordstrom, A.-L., Farde, L. and Halldin, C. (1993) High 5HT2 receptor occupancy in clozapine treated patients demonstrated by PET. Psychopharmacology, 110, 365–7.

    Article  PubMed  CAS  Google Scholar 

  36. Nyberg, S., Farde, L., Eriksson, L., Halldin, C. and Eriksson, B. (1993) 5HT2 and D2 dopamine receptor occupancy in the living human brain. Psychopharmacology, 110, 265–72.

    Article  PubMed  CAS  Google Scholar 

  37. Trichard, C., Paillere-Martinot, M.L., Attar-Levy, D., Recassens, C., Monnet, F., Blin, J. and Martinot, J.L. (1996) 5HT2 receptor measurement in schizophrenia by PET. Eur. Psychiatry, 11 (suppl. 4), S232.

    Article  Google Scholar 

  38. Busatto, G.F., Pilowsky, L.S., Costa, D.C. et al (1997) Initial evaluation of 123I-5-I-R91150, a selective 5-HT2a ligand for single photon emission tomography (SPET) in healthy human subjects. Eur. J. Nucl Med., 24, 119–25.

    Article  PubMed  CAS  Google Scholar 

  39. Sokoloff, P., Giros, B., Martres, M.P. et al (1990) Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature, 347, 146–51.

    Article  PubMed  CAS  Google Scholar 

  40. Van Tol, H.H.M., Bunzow, J.R., Guan, H.C., Sunahara, R.K., Seeman, P., Niznik, H.B. and Civelli, O. (1991) Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature, 350, 610–14.

    Article  PubMed  Google Scholar 

  41. Kessler, R.M., Mason, N.S., Votaw, J.R., De Paulis, T.D., Clanton, J.A., Sib Ansari, M., Schmidt, D.E., Manning, R.G. and Bell, R.L. (1992) Visualisation of extrastriatal dopamine D2 receptors in the human brain. Eur. J. Pharmacol, 223, 105–7.

    Article  PubMed  CAS  Google Scholar 

  42. Seibyl, J., Sybirska, E., Bremner, D. et al (1993) [I-123] Iomazenil SPECT brain imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain. J. Nucl Med., 34, 102P.

    Google Scholar 

  43. Innis, R.B. (1992) Neuroreceptor imaging with SPECT. J. Clin. Psychiatry, 53 (suppl. 11), 29–34.

    PubMed  Google Scholar 

  44. Jones, A.K.P., Cunningham, V.J., Ha-Kawa, S. et al. (1993) Increases in central opioid receptor binding with relief of inflammatory pain in man demonstrated by PET and [nC]diprenorphine. J. Cereb. Blood Flow Metab., 13 (suppl. 1), S792.

    Google Scholar 

  45. Snow, B.J., Tooyama, I., McGeer, E.G. and Calne, D.B. (1993) Premortem [18F] fluorodopa uptake correlates with post-mortem dopaminergic cell counts and striatal dopamine in humans. J. Cereb. Blood Flow Metab., 13 (suppl. 1), S251.

    Google Scholar 

  46. Leenders, K.L., Salmon, E.P., Tyrrell, P., Perani, D., Brooks, D.J., Sager, H., Jones, T., Marsden, C.D. and Frackowiack, R.S.J. (1990) The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson’s disease. Arch. Neurol, 47, 1290–8.

    Article  PubMed  CAS  Google Scholar 

  47. Brooks, D.J., Ibanez, V., Sawle, G.V. et al (1990) Differing patterns of striatal 18F DOPA uptake in Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy. Ann. Neurol, 28, 547–55.

    Article  PubMed  CAS  Google Scholar 

  48. Innis, R.B., Seibyl, J.P., Wallace, E. et al (1993) SPECT imaging demonstrates loss of dopamine transporters in Parkinson’s disease. J. Nucl. Med., 34, 31P.

    Google Scholar 

  49. Frost, J.J., Rosier, A.M., Reich, S., Smith, J., Ehlers, M., Snyder, S.H., Ravert, H.T. and Dannais, R.F. (1993) PET imaging of dopamine reuptake sites in Parkinson’s disease by C-11- WIN 35 428 and PET. J. Nucl. Med., 34, 31P.

    Google Scholar 

  50. Brooks, D. (1991) PET: its clinical role in neurology. J. Neurol. Neurosurg. Psychiatry, 54, 1–5.

    Article  PubMed  CAS  Google Scholar 

  51. Tatsch, K., Schwarz, J., Oertel, W.H. and Kirsch, C-M. (1992) 1–123 IBZM SPECT for imaging dopamine D2 receptors in idiopathic Parkinson syndrome, Parkinsonian-like syndromes and Wilson’s disease, in Nuclear Medicine; Nuclear Medicine in Research and Practice (eds H.A.E. Schmidt and R. Höfer), Schattauer, Stuttgart, New York, pp. 406–10.

    Google Scholar 

  52. Brücke, T., Podrecka, I., Angelberger, P., Wenger, S., Topitz, A., Kufferle, B., Müller, Ch. and Deecke, L. (1991) Dopamine D2 receptor imaging with SPECT: studies in different neuropsychiatrie disorders. J. Cereb. Blood Flow Metab., 11, 220–8.

    Article  PubMed  Google Scholar 

  53. Sawle, G.V., Brooks, D.J., Ibanez, V. and Frackowiack, R.S.J. (1990) Striatal D2 receptor density is inversely proportional to dopa uptake in untreated Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry, 53, 177.

    Article  Google Scholar 

  54. Rinne, U.K., Laihinen, A., Rinne, J.O. et al (1990) Positron Emission Tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson’s disease. Movement Disorders, 5, 55–9.

    Article  PubMed  CAS  Google Scholar 

  55. Van Royen, E.A., Verhoeff, N.P.L.G., Speelman, J.D., Wolters, E.Ch., Kuiper, M.A. and Janssen, A.G.M. (1993) Diminished striatal dopamine D2 receptor activity in multiple system atrophy and progressive supranuclear palsy demonstrated by 1231 IBZM SPECT. Arch. Neurol, 50, 513–16.

    Article  PubMed  Google Scholar 

  56. Burn, D.J., Mathias, C.J., Cunningham, V.J., Waters, S., Quinn, N., Marsden, C.D. and Brooks, D.J. (1993) Striatal opiate receptor binding in Parkinson’s disease and multiple system atrophy: a 11C diprenorphine study. J. Cereb. Blood Flow Metab., 13, S367.

    Google Scholar 

  57. Holthoff, V.A., Koeppe, R.A., Frey, K.A., Penney, J.B., Markel, D.S., Kuhl, D.E. and Young, A.B. (1993) Positron emission tomography measures of benzodiazepine receptors in Huntington’s disease. Ann. Neurol, 34, 76–81.

    Article  PubMed  CAS  Google Scholar 

  58. Sawle, G.V., Playford, E.D., Brooks, D.J., Quinn, N. and Frackowiack, R.S.J. (1993) Asymmetrical presynaptic and post-synaptic changes in the striatal dopamine projection in dopa naive parkinsonism. Brain, 116, 853–67.

    Article  PubMed  Google Scholar 

  59. Hierholzer, J., Cordes, M., Schelosky, L., Schräg, A., Richter, W., Poewe, W., Semmeir, W. and Felix, R. (1993) Functional receptor testing in patients with iodiopathic Parkinson’s syndrome versus Parkinson’s plus syndrome. J. Nucl. Med., 34, 31P.

    Google Scholar 

  60. Schwarz, J., Tatsch, K., Arnold, G., Gasser, T., Trenkwalder, C., Kirsch, C.M. and Oertel, W.H. (1992) 1231 iodobenzamide-SPECT predicts dopaminergic responsiveness in patients with de novo parkinsonism. Neurology, 42, 556–61.

    Article  PubMed  CAS  Google Scholar 

  61. Ruottinen, H., Rinne, J.O., Laihinen, A., Rinne, U.K., Oikenen, V., Ruotsalainen, U., Bergman, J. and Solin, O. (1993) The effect of COMT inhibition with entacapone on 18F-6-fluorodopa PET in Parkinson’s disease. J. Cereb. Blood Flow Metab., 13, S359.

    Article  Google Scholar 

  62. Sawle, G. and Myers, R. (1993) Combined PET and MRI studies following neural cell transplantation for Parkinson’s disease. J. Cereb. Blood Flow Metab., 13, S366.

    Google Scholar 

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Authors
  1. L. S. Pilowsky
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Editors and Affiliations

  1. Division of Radiological Sciences, Guy’s and St Thomas’ Hospital, London, UK

    M. N. Maisey BSc MD FRCR FRCP

  2. Department of Nuclear Medicine, St Bartholomew’s Hospital, London, UK

    K. E. Britton MD MSc FRCR FRCP

  3. Nuclear Medicine Department, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    B. D. Collier BA MA MD

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Pilowsky, L.S. (1998). Tracers. In: Maisey, M.N., Britton, K.E., Collier, B.D. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3356-0_21

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  • DOI: https://doi.org/10.1007/978-1-4899-3356-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-75180-6

  • Online ISBN: 978-1-4899-3356-0

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