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Clinical Nuclear Medicine pp 237–244Cite as

Other pulmonary applications

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Abstract

Airway diseases are a major cause of morbidity and mortality in the UK, accounting for a large number of visits of patients to the primary care physicians. The variety of diseases include pulmonary inflammation and infection, as well as lung cancer, the most common cancer in men. The lung presents a huge exposed surface to the air allowing the entrance of a variety of particulate matter onto the epithelial surfaces. These particulate substances encompass a range of pathogens (e.g. bacteria, viruses, fungi, etc.) as well as particulate matter, which may promote an antigenic response (e.g. pollens, house dust, mite, etc.), particles that are potentially carcinogenic as in cigarette smoke, or fibres such as asbestos producing other responses in the pleura.

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References

  1. O’Doherty, M.J. and Miller, R.F. (1993) Aerosols for therapy and diagnosis. Eur. J. Nucl. Med., 20, 1201–13.

    PubMed  Google Scholar 

  2. Staub, N.C., Hyde, R.W. and Crandall, E. (1990) Workshop on techniques to evaluate lung alveolar-micro vascular injury. Am. Rev. Respir. Dis., 141, 1071–7.

    Article  PubMed  CAS  Google Scholar 

  3. Taplin, G.V., Chopra, S.K. and Uszler, J.M. (1978) Imaging experimental pulmonary ischaemic lesions after inhalation of a diffusible radioaerosol. Recent experience and further developments. J. Nucl. Med., 19, 567–8.

    PubMed  CAS  Google Scholar 

  4. Jones, J.G., Minty, B.D., Lawler, P., Hulands, G., Crawley, J.C.W. and Veall, N. (1980) Increased epithelial permeability in cigarette smokers. Lancet, i, 66–8.

    Article  Google Scholar 

  5. Barrowcliffe, M.P. and Jones, J.G. (1989) Pulmonary clearance of 99mTc-DTPA in the diagnosis and evolution of increased permeability pulmonary oedema. Anaesth. Intens. Care, 17, 422–32.

    CAS  Google Scholar 

  6. Jefferies, A.L., Coates, G. and O’Brodovich, H. (1984) Pulmonary epithelial permeability in Hyaline-Membrane disease. N. Engl. J. Med., 311, 1075–80.

    Article  PubMed  CAS  Google Scholar 

  7. O’Doherty, M.J., Page, C.J., Bradbeer, C.S. et al. (1987) Alveolar permeability in HIV patients with Pneumocystis carinii pneumonia. Genitourin. Med., 63, 268–70.

    PubMed  Google Scholar 

  8. O’Doherty, M.J., Page, C.J., Bradbeer, C.S. et al. (1989) The place of lung 99mTc DTPA aerosol transfer in the investigation of lung infections in HIV positive patients. Resp. Med., 83, 395–401.

    Article  Google Scholar 

  9. Mason, G.R., Effros, R.M., Uszler, J.M. et al (1985) Small solute clearance from the lungs of patients with cardiogenic and noncardiogenic pulmonary edema. Chest, 88, 327–34.

    Article  PubMed  CAS  Google Scholar 

  10. Oberdorster, G., Utell, M.J., Weber, D.A., Ivanovich, M., Hyde, R.W. and Morrow, P.E. (1984) Lung clearance of inhaled 99m-Tc DTPA in the dog. J. Appl. Physiol, 57, 589–95.

    PubMed  CAS  Google Scholar 

  11. Langford, J.A., Lewis, C.A., Geliert, A.R., Tolfree, S.E.J., and Rudd, R.M. (1986) Pulmonary epithelial permeability: vascular background effects on whole lung and regional half-time values. Nucl Med. Commun., 7(3), 183–90.

    Article  PubMed  CAS  Google Scholar 

  12. Kohn, H., Kohn, B., Klech, H., Pohl, W. and Mostbeck, A. (1990) Urine excretion of inhaled technetium-99m-DTPA: an alternative method to assess lung epithelial transport. J. Nucl Med., 31(4), 4419.

    Google Scholar 

  13. Groth, S. and Pedersen, M. (1989) Pulmonary permeability in primary ciliary dyskinesia. Eur. Respir. J., 2, 64–70.

    PubMed  CAS  Google Scholar 

  14. Barrowcliffe, M. P., Otto, C and Jones, J.G. (1988) Pulmonary clearance of 99mTc-DTPA: influence of background activity. J. Appl. Physiol, 64(3), 1045–9.

    PubMed  CAS  Google Scholar 

  15. O’Doherty, M.J., Page, CT., Croft, D.N. and Bateman, N.T. (1985) Lung 99WTc DTPA transfer: a method for background correction. Nucl. Med. Commun., 6, 209–15.

    Article  PubMed  Google Scholar 

  16. O’Doherty, M.J., Page, C.J., Croft, D.N. and Bateman, N.T. (1985) Regional lung ‘leakiness’ in smokers and nonsmokers. Nucl. Med. Commun., 6, 353–7.

    Article  PubMed  Google Scholar 

  17. Basran, G.S., Byrne, A.J. and Hardy, J.G. (1985) A noninvasive technique for monitoring lung vascular permeability in man. Nucl Med. Commun., 3, 3–10.

    Article  Google Scholar 

  18. Braude, S., Apperley, J., Krausz, T., Goldman, J.M. and Royston, D. (1985) Adult Respiratory Distress Syndrome after allogeneic bone marrow transplantation: evidence for a neutrophil independent mechanism. Lancet, i, 1239–42.

    Article  Google Scholar 

  19. Kaplan, J.D., Calandrino, F.S. and Schuster, D.P. (1991) A positron emission tomographic comparison of pulmonary vascular permeability during the adult respiratory distress syndrome and pneumonia. Am. Rev. Respir. Dis., 143, 150–4.

    Article  PubMed  CAS  Google Scholar 

  20. Velazquez, M., Weibel, E.R., Kuhn, C. et al. (1991) PET evaluation of pulmonary vascular permeability: a structure-function correlation. J. Appl. Physiol. 70, 2206–16.

    PubMed  CAS  Google Scholar 

  21. Mintun, M.A., Dennis, D.R., Welch, M.J., Mathias, C.J. and Schuster, D.P. (1987) Measurements of pulmonary vascular permeability with PET and gallium-68-transferrin. J. Nucl. Med., 28, 1704–16.

    PubMed  CAS  Google Scholar 

  22. Mintun, M.A., Warfel, T.E. and Schuster, D.P. (1990) Evaluating pulmonary vascular permeability with radiolabeled proteins: an error analysis. J. Appl Physiol, 68, 1696–706.

    PubMed  CAS  Google Scholar 

  23. Bekerman, C., Hoffer, P.B., Bitran, J.D. and Gupta, R.G. (1980) Gallium-67 citrate imaging studies of the lung. Semin. Nucl. Med., 10, 286–301.

    Article  PubMed  CAS  Google Scholar 

  24. Chinet, T., Jaubert, F., Dusser, D., Danei, C., Chretien, J. and Huchon, G.J. (1990) Effects of inflammation and fibrosis on pulmonary function in diffuse lung fibrosis. Thorax, 45, 675–8.

    Article  PubMed  CAS  Google Scholar 

  25. Dusser, D.J., Collignon, M.A., Stanislas-Leguern, G., Barritault, L.G., Chretien, J. and Huchon, G.J. (1986) Respiratory clearance of 99mTc DTPA and pulmonary involvement in sarcoidosis. Am. Rev. Respir. Dis., 134, 493–7.

    PubMed  CAS  Google Scholar 

  26. Watanabe, N., Inoue, T., Oriuchi, H., Suzuki, H., Hirano, T. and Endo, K. (1995) Increased pulmonary clearance of aerosolised 99mTc-DTPA in patients with a subset of stage I sarcoidosis. Nucl Med. Commun., 16, 464–7.

    Article  PubMed  CAS  Google Scholar 

  27. Line, B.R., Hunninghake, G.W., Keogh, B.A. et al (1981) Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical studies, pulmonary function studies and bronchoalveolar lavage. Am. Rev. Respir. Dis., 123, 440–6.

    PubMed  CAS  Google Scholar 

  28. Sulavik, S.B., Spencer, R.P., Palestro, C.J. et al (1993) Specificity and sensitivity of distinctive chest radiographic and / or 67Ga images in the noninvasive diagnosis of sarcoidosis. Chest, 103, 403–9.

    Article  PubMed  CAS  Google Scholar 

  29. Sulavik, S.B., Spencer, R.P., Weed, D.A., Shapiro, H.R., Shiue, S. and Castriotta, R.J. (1990) Recognition of distinctive patterns of gallium-67 distribution in sarcoidosis. J. Nucl. Med., 31, 1909–14.

    PubMed  CAS  Google Scholar 

  30. Baughman, R.P., Fernandez, M. and Bosken, C. (1984) Comparison of gallium-67 scanning, bronchoalveolar lavage and serum angiotensin-converting enzyme levels in pulmonary sarcoidosis: predicting response to therapy. Am. Rev. Respir. Dis., 129, 676–81.

    PubMed  CAS  Google Scholar 

  31. Lawrence, E.C., Teague, R.B. and Gottlieb, M.S. (1983) Serial changes in markers of disease activity with corticosteroid treatment in sarcoidosis. Am. J. Med., 74, 747–56.

    Article  PubMed  CAS  Google Scholar 

  32. Alberts, C. and Van der Schoot, J.B. (1988) Standardized quantitative 67Ga scintigraphy in pulmonary sarcoidosis. Sarcoidosis, 5, 111–18.

    PubMed  CAS  Google Scholar 

  33. Vanhagen, P.M., Krenning, E.P., Reubi, J.C. et al (1994) Somatostatin analogue scintigraphy in granulomatous disease. Eur. J. Nucl. Med., 21, 497–502.

    Article  PubMed  CAS  Google Scholar 

  34. Diot, R., Lemarie, E., Baulie, J.L. et al. (1992) Scintigraphy with J001 macrophage targeting glycolipeptide. A new approach for sarcoidosis imaging. Chest, 102, 670–6.

    Article  PubMed  CAS  Google Scholar 

  35. Kubota, R., Yamada, S., Kubota, K., Ishiwata, K., Tamahashi, N. and Ido, T. (1992) Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulocytes studied by microautoradiography. J. Nucl Med., 33, 1972–80.

    PubMed  CAS  Google Scholar 

  36. Lewis, P.J. and Salama, A. (1994) Uptake of fluorine-18-fluorodeoxyglucose in sarcoidosis. J. Nucl Med., 35, 1647–9.

    PubMed  CAS  Google Scholar 

  37. Valind, S.O., Rhodes, C.G., Paltin, C., Suzuki, T. and Hughes, J.M.B. (1984) Measurements of pulmonary glucose metabolism in patients with cryptogenic fibrosing alveolitis and pulmonary sarcoidosis. Am. Rev. Respir. Dis., 129, A53.

    Google Scholar 

  38. Brudin, L.H., Valind, S.O., Rhodes, C.G. et al (1994) Fluorine-18 deoxyglucose uptake in sarcoidosis measured with positron emission tomography. Eur.]. Nucl. Med., 21, 297–305.

    Article  CAS  Google Scholar 

Further Reading

  • Clarke, D., Mitchell, A.W.M., Dick, R. and James, G.D. (1994) The radiology of sarcoidosis. Sarcoidosis, 11, 90–9.

    PubMed  CAS  Google Scholar 

  • O’Doherty, M.J. and Peters, A.M. (1997) Pulmonary technetium-99m diethylene triamine pentaacetic acid aerosol clearance as an index of lung injury. Eur. J. Nucl. Med., 24, 81–7.

    Article  PubMed  Google Scholar 

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Authors
  1. M. J. O’Doherty
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Editor information

Editors and Affiliations

  1. Division of Radiological Sciences, Guy’s and St Thomas’ Hospital, London, UK

    M. N. Maisey BSc MD FRCR FRCP

  2. Department of Nuclear Medicine, St Bartholomew’s Hospital, London, UK

    K. E. Britton MD MSc FRCR FRCP

  3. Nuclear Medicine Department, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    B. D. Collier BA MA MD

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© 1998 Springer Science+Business Media Dordrecht

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O’Doherty, M.J. (1998). Other pulmonary applications. In: Maisey, M.N., Britton, K.E., Collier, B.D. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3356-0_19

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  • DOI: https://doi.org/10.1007/978-1-4899-3356-0_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-75180-6

  • Online ISBN: 978-1-4899-3356-0

  • eBook Packages: Springer Book Archive

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