Abstract
For many patients, the diagnosis of multiple sclerosis is evident from their clinical characteristics. A remitting and relapsing illness in a young adult with signs reflecting scattered white matter dysfunction, hardly requires investigation, though the picture so defined is not unique to multiple sclerosis. Greater uncertainty occurs in the early course of the illness before a remitting and relapsing pattern has been established, or where the disability is progressive from the outset. Previous classifications of the disease allowed for such uncertainties by designating definite, probable or possible categories [1] or definite, early probable/latent and progressive probable/possible cases [2]. The latter criteria include data based on electrophysiological studies. More recently, a classification incorporating CSF data has been introduced [3]. There are no tests which infallibly identify patients with multiple sclerosis. Certainly CSF changes, for example oligoclonal IgG, and abnormalities of central conduction time are seen in other neurological disorders. Even the demonstration of paraventricular pathology by magnetic resonance imagery does not allow a certain diagnosis, since identical appearances are encountered in some patients with cerebrovascular disease [4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
McAlpine, D., Lumsden, C.E. and Acheson, E.D. (1972) Multiple Sclerosis. A Reappraisal. 2nd edn, Churchill Livingstone, Edinburgh, London.
McDonald, W.I. and Halliday, A.M. (1977) Diagnosis and classification of multiple sclerosis. Br. Med. Bull., 33, 4–8.
Poser, C.M., Paty, D.M., Scheinberg, L. et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research proposals. Ann. Neurol., 13, 227–31.
Ormerod, I.E.C., Roberts, R.C., du Boulay, E.P.G.H. et al. (1984) NMR in multiple sclerosis and cerebral vascular disease. Lancet, 11, 1334–5.
Traugott, U. and Raine, C.S. (1981) Antioligodendrocyte antibodies in cerebrospinal fluid of multiple sclerosis and other neurologic diseases. Neurology, 31, 695–700.
Ryberg, B. (1982) Antibrain antibodies in multiple sclerosis. Relation to clinical variables. J. Neurol. Sci., 54, 239–61.
Panitch, H.S., Hooper, C.J. and Johnson, K.P. (1980) CSF antibody to myelin basic protein. Measurement in patients with multiple sclerosis and subacute sclerosing panencephalitis. Arch. Neurol., 37, 206–9.
Biber, A., Englert, D., Dommasch, D. and Hempel, K. (1981) Myelin basic protein in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. J. Neurol., 225, 231–6.
Garcia-Merino, A., Persson, M.A.A., Ernerudh, J. et al. (1986) Serum and cerebrospinal fluid antibodies against myelin basic protein and their IgG subclass distribution in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 49, 1066–70.
Warren, K.G. and Catz, I. (1986) Diagnostic value of cerebrospinal fluid anti-myelin basic protein in patients with multiple sclerosis. Ann. Neurol. 20, 20–5.
Tachousky, T.G., Lisak, R.P., Koprowski, H. et al. (1976) Circulating immune complexes in multiple sclerosis and other neurological diseases. Lancet, 11, 997–9.
Compston, D.A.S., Morgan, B.P., Oleesky, D. et al. (1986) Cerebrospinal fluid C9 in demyelinating disease. Neurology, 36, 1503–5.
Dore-Duffy, P., Donaldson, J.O., Rothman, B.L. and Zurier, R.B. (1982) Antinuclear antibodies in multiple sclerosis. Arch. Neurol., 39, 504–6.
Selmaj, K., Alam, R., Perkin, G.D. and Clifford Rose, F. (1987) T lymphocyte-derived demyelinating activity in multiple sclerosis patients in acute relapse. J. Neurol. Neurosurg. Psychiatry, 50, 532–7.
Cremer, N.E., Johnson, K.P., Fein, G. and Likosky, W.H. (1980) Analysis of serum and CSF antibodies by standard serologic methods. Arch. Neurol, 37, 610–15.
Mehta, P.D., Thormar, H. and Wisniewski, H.M. (1980) Quantitation of measles-specific IgG. Its presence in CSF and brain extracts of patients with multiple sclerosis. Arch. Neurol., 37, 607–9.
Appel, M.J., Glickman, L.T., Raine, C.S. and Tourtellotte, W.W. (1981) Canine viruses and multiple sclerosis. Neurology, 31, 944–9.
Batchelor, J.R., Compston, A. and McDonald, W.I. (1978) The significance of the association between HLA and multiple sclerosis. Br. Med. Bull., 34, 279–84.
Müller, R. (1951) The correlation between the state of the cerebrospinal fluid and the clinical picture in disseminated sclerosis. Acta Med. Scand., 139, 153–63.
Hart, R.G. and Sherman, D.G. (1982) The diagnosis of multiple sclerosis. J. Am. Med. Assoc., 247, 498–503.
Johnson, K.P. (1980) Cerebrospinal fluid and blood assays of diagnostic usefulness in multiple sclerosis. Neurology, 30, 106–9.
Link, H. and Müller, R. (1971) Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch. Neurol., 25, 326–44.
Caroscio, J.T., Kochwa, S., Sacks, H. et al. (1983) Quantitative CSF IgG measurements in multiple sclerosis and other neurologic diseases. An update. Arch. Neurol., 40, 409–13.
Caroscio, J.T., Kochwa, S., Sacks, H. et al. (1986) Quantitative cerebrospinal fluid IgG measurements as a marker of disease activity in multiple sclerosis. Arch. Neurol., 43, 1129–31.
Perkin, G.D., Sethi, K. and Muller, B.R. (1983) IgG ratios and oligoclonal IgG in multiple sclerosis and other neurological disorders. J. Neurol. Sci., 60, 325–36.
Kolar, O.J., Rice, P.H., Jones, F.H. et al. (1980) Cerebrospinal fluid immunoelectrophoresis in multiple sclerosis. J. Neurol. Sci., 47, 221–30.
Kostulas, V.K. and Link, H. (1982) Agarose isoelectric focusing of unconcentrated CSF and radioimmunofixation for detection of oligoclonal bands in patients with multiple sclerosis and other neurological diseases. J. Neurol. Sci., 54, 117–27.
Laurenzi, M.A., Mavra, M., Kam-Hansen, S. and Link, H. (1980) Oligocloncal IgG and free light chains in multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing and immunofixation. Ann. Neurol., 8, 241–7.
Thompson, E.J., Kaufmann, P. and Rudge, P. (1983) Sequential changes in oligoclonal patterns during the course of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 46, 115–18.
Easmark, B. and Sidén, A. (1984) Isoelectric focusing of CSF proteins and the future evolution of multiple sclerosis: a clinical follow-up. J. Neurol., 231, 117–21.
Kostulas, V.K., Henriksson, A. and Link, H. (1986) Monosymptomatic sensory symptoms and cerebrospinal fluid immunoglobulin levels in relation to multiple sclerosis. Arch. Neurol., 43, 447–51.
Perkin, G.D. and Muller, B.K. (1987) The influence of abnormal IgG ratios in the CSF on further development of the disease in single lesion multiple sclerosis in Multiple Sclerosis. Immunological, diagnostic and therapeutic aspects. Eds F.C. Rose and R. Jones. John Libbey, London, Paris pp 115–119.
Grimaldi, L.M.E., Roos, R.P., Nalefski, E.A. and Arnason, B.G.W. (1985) Oligoclonal IgA bands in multiple sclerosis and subacute sclerosing panencephalitis. Neurology, 35, 813–17.
Rudick, R.A., Jacobs, L., Kinkel, P.R. and Kinkel, W.R. (1986) Isolated idiopathic optic neuritis. Analysis of free K-light chains in cerebrospinal fluid and correlation with nuclear magnetic resonance findings. Arch. Neurol., 43, 456–8.
Patterson, V.H. and Heron, J.R. (1980) Visual field abnormalities in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 43, 205–8.
Meienberg, O., Flammer, J. and Ludin, H.-P. (1982) Subclinical visual field defects in multiple sclerosis. Demonstration and quantification with automated perimetry and comparison with visual evoked potentials. J. Neurol., 227, 125–33.
Halliday, A.M., McDonald, W.I. and Mushin, J. (1973) Visual evoked response in diagnosis of multiple sclerosis. Br. Med. J., 4, 661–4.
Aminoff, M.J. and Ochs, A.L. (1981) Pattern-onset visual evoked potentials in suspected multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 44, 608–14.
Hennerici, M., Wenzel, D. and Freund, H.-J. (1977) The comparison of small-sized rectangle and checkerboard stimulation for the evaluation of delayed visual evoked responses in patients suspected of multiple sclerosis. Brain, 100, 119–36.
Hammond, S.R. and Yiannikas, C. (1986) Contribution of pattern reversal foveal and half-field stimulation to analysis of VEP abnormalities in multiple sclerosis. Electroencephalogr. Clin. Neurophysiol., 64, 101–18.
Regan, D., Bartol, S., Murray, T.J. and Beverley, K.I. (1982) Spatial frequency discrimination in normal vision and in patients with multiple sclerosis. Brain, 105, 735–54.
Kupersmith, M.J., Nelson, J.I., Seiple, W.H. et al. (1983) The 20/20 eye in multiple sclerosis. Neurology, 33, 1015–20.
Camisa, J., Mylin, L.H. and Bodis-Wollner, I. (1981) The effect of stimulus orientation on the visual evoked potential in multiple sclerosis. Ann. Neurology, 10, 532–9.
Kempster, P.A., Iansek, R., Balla, J.I. et al. (1987) Value of visual evoked response and oligoclonal bands in cerebrospinal fluid in diagnosis of spinal multiple sclerosis. Lancet, 1, 769–71.
Perkin, G.D. and Rose, F.C. (1979) Optic Neuritis and its Differential Diagnosis. Oxford University Press, Oxford.
Regan, D. and Neima, D. (1984) Visual fatigue and visual evoked potentials in multiple sclerosis, glaucoma, ocular hypertension and Parkinson’s disease. J. Neurol. Sci., 47, 673–8.
Robinson, K. and Rudge, P. (1980) The use of the auditory evoked potential in the diagnosis of multiple sclerosis. J. Neurol. Sci., 45, 235–44.
Chiappa, K.H., Harrison, J.L., Brooks, E.B. and Young, R.R. (1980) Brainstem auditory evoked responses in 200 patients with multiple sclerosis. Ann. Neurol., 17, 135–43.
Prasher, D.K., Sainz, M. and Gibson, W.P.R. (1982) Binaural voltage summation of brain stem auditory evoked potentials: an adjunct to the diagnostic criteria for multiple sclerosis. Ann. Neurol., 11, 86–91.
Kayamori, R., Dickins, Q.S., Yamada, T. and Kimura, J. (1984) Brainstem auditory evoked potential and blink reflex in multiple sclerosis. Neurol., 34, 1318–23.
Kofler, B., Oberascher, G. and Pommer, B. (1984) Brain-stem involvement in multiple sclerosis: a comparison between brain-stem auditory evoked potentials and the acoustic stapedius reflex. J. Neurol., 231, 145–7.
Sanders, E.A.C.M., Ongerboer de Visser, B.W., Barendswaard, E.C. and Arts, R.J.H.M. (1985) Jaw, blink and corneal reflex latencies in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 48, 1284–9.
Abbruzzese, G., Cocito, L., Ratto, S. et al. (1981) A reassessment of sensory evoked potential parameters in multiple sclerosis: a discriminant analysis approach. J. Neurol. Neurosurg. Psychiatry, 44, 133–9.
Chiappa, K.H. (1980) Pattern shift visual, brainstem auditory, and short-latency somatosensory evoked potentials in multiple sclerosis. Neurology, 30, 110–23.
Walsh, J.C., Garrick, R., Cameron, J. and McLeod, J.G. (1982) Evoked potential changes in clinically definite multiple sclerosis: a two year follow up study. J. Neurol. Neurosurg. Psychiatry, 45, 494–500.
Phillips, K.R., Potvin, A.R., Syndulko, K. et al. (1983) Multimodality evoked potentials and neurophysiological tests in multiple sclerosis. Arch. Neurol., 40, 159–64.
Cowan, J.M.A., Rothwell, J.C., Dick, J.P.R. et al. (1984) Abnormalities in central motor pathway conduction in multiple sclerosis. Lancet, 11, 304–7.
Snooks, S.J. and Swash, M. (1985) Motor conduction velocity in the human spinal cord: slowed conduction in multiple sclerosis and radiation myelopathy. J. Neurol. Neurosurg. Psychiatry., 48, 1135–9.
Hess, C.W., Mills, K.R. and Murray, N.M.F. (1986) Measurement of central motor conduction in multiple sclerosis by magnetic brain stimulation. Lancet, 11, 355–8.
Sanders, E.A.C.M., Reulen, J.P.H. and Hogenhuis, L.A.H. (1984) Central nervous system involvement in optic neuritis. J. Neurol. Neurosurg. Psychiatry, 47, 241–9.
Reisner, T. and Maida, E. (1980) Computerized tomography in multiple sclerosis. Arch. Neurol., 37, 475–7.
Loizou, L.A., Rolfe, E.B. and Hewazy, H. (1982) Cranial computed tomography in the diagnosis of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 45, 905–12.
Barrett, L., Drayer, B. and Shin, C. (1985) High-resolution computed tomography in multiple sclerosis. Ann. Neurol., 17, 33–8.
Lodder, J., de Weerd, A.W., Koetsier, J.C. and van der Lugt, P.J.M. (1983) Computed tomography in acute cerebral multiple sclerosis. Arch. Neurol., 40, 320–2.
Young, I.R., Hall, A.S., Pallis, C.A. et al. (1981) Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet, 11, 1063–6.
Lukes, S.A., Crooks, L.E., Aminoff, M.J. et al. (1983) Nuclear magnetic resonance imaging in multiple sclerosis. Ann. Neurol., 13, 592–601.
Farlow, M.R., Markand, O.N., Edwards, M.K. et al. (1986) Multiple sclerosis: magnetic resonance imaging, evoked responses, and spinal fluid electrophoresis. Neurology, 36, 828–31.
Jacobs, L., Kinkel, W.R., Polachini, I. and Kinkel, R.P. (1986) Correlation of nuclear magnetic resonance imaging, computerized tomography, and clinical profiles in multiple sclerosis. Neurology, 36, 27–34.
Runge, V.M., Price, A.C., Kirschner, H.S. et al. (1984) Magnetic resonance imaging of multiple sclerosis: a study of pulse-technique efficiency. Am. J. Roentgenol., 143, 1015–26.
Miller, D.H., Johnson, G., McDonald, W.I. et al. (1986) Detection of optic nerve lesions in optic neuritis with magnetic resonance imaging. Lancet, 1, 1490–1.
Jacobs, L., Kinkel, P.R. and Kinkel, W.R. (1986) Silent brain lesions in patients with isolated idiopathic optic neuritis. A clinical and nuclear magnetic resonance imaging study. Arch. Neurol., 43, 452–5.
Johns, K., Lavin, P., Elliot, J.H. and Partain, L. (1986) Magnetic resonance imaging of the brain in isolated optic neuritis. Arch. Ophthalmol., 104, 1486–8.
Ormerod, I.E.C., Bronstein, A., Rudge, P. et al. (1986) Magnetic resonance imaging in clinically isolated lesions of the brain stem. J. Neurol. Neurosurg. Psychiatry, 49, 737–43.
Rudick, R.A., Schiffer, R.B., Schwetz, K.M. and Herndon, R.M. (1986) Multiple sclerosis. The problem of incorrect diagnosis. Arch. Neurol., 43, 578–83.
Beller, A.J., Sahar, A. and Praiss, I. (1973) Brain abscess. Review of 89 cases over a period of 30 years. J. Neurol. Neurosurg. Psychiatry, 36, 757–68.
Yang, S.-Y. (1981) Brain abscess: a review of 400 cases. J. Neurosurg., 55, 794–9.
Garfield, J. (1969) Management of supratentorial intracranial abscess: a review of 200 cases. Br. Med. J., 2, 7–11.
Bhandari, Y.S. and Sarkari, N.B.S. (1970) Subdural empyema. A review of 37 cases. J. Neurosurg., 32, 35–9.
Davis, D.O. and Potchen, E.J. (1970) Brain scanning and intracranial inflammatory disease. Radiology, 95, 345–6.
Brewer, N.S., MacCarty, C.S. and Wellman, W.E. (1975) Brain abscess: a review of recent experience. Ann. Intern. Med., 82, 571–6.
Weisberg, L.A. (1980) Cerebral computerized tomography in intra-cranial inflammatory disorders. Arch. Neurol., 37, 137–42.
Britt, R.H. and Enzmann, D.R. (1983) Clinical stages of human brain abscesses on serial CT scans after contrast infusion. Computerized tomographic, neuropathological, and clinical correlations. J. Neurosurg., 59, 972–89.
Dunker, R.O. and Khakoo, R.A. (1981) Failure of computed tomo-graphic scanning to demonstrate subdural empyema. J. Am. Med. Assoc., 246, 1116–18.
Mauser, H.W., van Huffelen, A.C. and Tulleken, C.A.F. (1986) The EEG in the diagnosis of subdural empyema. Electroencephalogr. Clin. Neurophysiol., 64, 511–16.
Sharif, H.S. and Ibrahim, A. (1982) Intracranial epidural abscess. Br. J. Radiol., 55, 81–4.
Bashir, R., Zuheir Al-Kawi, M. and Harder, E.J. (1985) Nervous system brucellosis: diagnosis and treatment. Neurology, 35, 1576–81.
Shakir, R.A., Al-Din, A.S.N., Araj, G.F. et al. (1987) Clinical categories of neurobrucellosis. A report on 19 cases. Brain, 110, 213–24.
Simon, R.P. (1985) Neurosyphilis. Arch. Neurol., 42, 606–13.
Multiple sclerosis. CNS infection
Kinnunen, E. and Hillbom, M. (1986) The significance of cerebrospinal fluid routine screening for neurosyphilis. J. Neurol. Sci., 75, 205–11.
Dans, P.E., Cafferty, L., Otter, S.E. and Johnson, R.J. (1986) Inappropriate use of the cerebrospinal fluid venereal disease research laboratory (VDRL) test to exclude neurosyphilis. Ann. Intern. Med., 104, 86–9.
Harrigan, E.P., McLaughlin, T.J. and Feldman, R.G. (1984) Transverse myelitis due to meningovascular syphilis. Arch. Neurol., 41, 337–8.
Conrad, B., Benecke, R., Müsers, H. et al. (1983) Visual evoked potentials in neurosyphilis. J. Neurol. Neurosurg. Psychiatry, 46, 23–7.
Cobb, W. and Hill, D. (1950) Electroencephalogram in subacute progressive encephalitis. Brain, 73, 392–404.
Krawiecki, N.S., Dyken, P.R., El Gammal, T. et al. (1984) Computed tomography of the brain in subacute sclerosing panencephalitis. Ann.’ Neurol., 15, 489–93.
Bale, J.F. Jr (1984) Human cytomegalovirus infection and disorders of the nervous system. Arch. Neurol., 41, 310–20.
Levy, J.D., Cottingham, K.L., Campbell, R.J. et al. (1986) Progressive multifocal leukoencephalopathy and magnetic resonance imaging. Ann. Neurol., 19, 399–401.
Little, B.W., Brown, P.W., Rodgers-Johnson, P. et al. (1986) Familial myoclonic dementia masquerading as Creutzfeldt—Jakob disease. Ann. Neurol., 20, 231–9.
May, W.W. (1968) Creutzfeldt—Jakob disease. Acta Neurol. Scand., 44, 1–32.
Abbott, J. (1959) The EEG in Jakob—Creutzfeldt’s disease. Electroencephalogr. Clin. Neurophysiol., 11, 184–5.
Chiofalo, N., Fuentes, A. and Gâlvez, S. (1980) Serial EEG findings in 27 cases of Creutzfeldt—Jakob disease. Arch. Neurol., 37, 143–5.
Gâlvez, S. and Cartier, L. (1984) Computed tomography findings in 15 cases of Creutzfeldt—Jakob disease with histological verification. J. Neurol. Neurosurg. Psychiatry, 47, 1244–6.
Harrington, M.G., Merril, C.R., Asher, D.M. and Gajdusek, D.C. (1986) Abnormal proteins in the cerebrospinal fluid of patients with Creutzfeldt—Jakob disease. N. Engl. J. Med., 315, 279–82.
Brown, P., Rodgers-Johnson, P., Cathala, F. et al. (1984) Creutzfeldt Jakob disease of long duration: clinico-pathological characteristics, transmissibility, and differential diagnosis. Ann. Neurol., 16, 295–304.
Brown, P., Coker-Vann, M., Pomeroy, K. et al. (1986) Diagnosis of Creutzfeldt—Jakob disease by western blot identification of marker protein in human brain tissue. N. Engl. J. Med., 314, 547–51.
Walsh, T.J., Hier, D.B. and Caplan, L..R. (1985) Aspergillosis of the central nervous system: clinico-pathological analysis of 17 patients. Ann. Neurol., 18, 574–82.
Beal, M.F., O’Carroll, C.P., Kleinman, G.M. and Grossman, R.I. (1982) Aspergillosis of the nervous system. Neurology, 32, 473–9.
Garcia, C.A., Weisberg, L.A. and Lacorte, W.S.J. (1985) Cryptococcal intracerebral mass lesions: CT-pathologic considerations. Neurology, 35, 731–4.
Scrimgeour, E.M. and Gajdusek, D.C. (1985) Involvement of the central nervous system in Schistosoma mansoni and S. haematobium infection. A review. Brain, 108, 1023–38.
McCormick, G.F., Zee, C.-S. and Heiden, J. (1982) Cysticercosis cerebri. Review of 127 cases. Arch. Neurol., 39, 534–9.
Torrealba, G., Villar, S.D., Tagle, P. et al. (1984) Cysticercosis of the central nervous system: clinical and therapeutic considerations. J. Neurol. Neurosurg. Psychiatry, 47, 784–90.
Miller, B., Goldberg, M.A., Heiner, D. et al. (1984) A new immunologic test for CNS cysticercosis. Neurology, 34, 695–7.
Estrada, J.J. and Kuhn, R.E. (1985) Immunochemical detection of antigens of larval Taenia solium and anti-larval antibodies in the cerebrospinal fluid of patients with neurocysticercosis. J. Neurol. Sci., 71, 39–48.
Minguetti, G. and Ferreira, M.V.C. (1983) Computed tomography in neurocysticercosis. J. Neurol. Neurosurg. Psychiatry, 46, 936–42.
Snider, W.D., Simpson, D.M., Nielsen, S. et al. (1983) Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann. Neurol., 14, 403–18.
Navia, B.A., Petito, C.K., Gold, J.W.M. et al. (1986) Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients. Ann. Neurol., 19, 224–38.
Alonso, R., Heiman-Patterson, T. and Mancall, E.L. (1984) Cerebral toxoplasmosis in acquired immune deficiency syndrome. Arch. Neurol., 41, 321–3.
Horowitz, S.L., Bentson, J.R., Benson, F. et al. (1983) CNS toxoplasmosis in acquired immunodeficiency syndrome. Arch. Neurol., 40, 649–52.
Luft, B.J., Brooks, R.G., Conley, F.K. et al. (1984) Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome. J. Am. Med. Assoc., 252, 913–17.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1988 G.D. Perkin
About this chapter
Cite this chapter
Perkin, G.D. (1988). Multiple sclerosis CNS infection. In: Diagnostic Tests in Neurology. Diagnostic Tests Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3320-1_6
Download citation
DOI: https://doi.org/10.1007/978-1-4899-3320-1_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-412-28400-7
Online ISBN: 978-1-4899-3320-1
eBook Packages: Springer Book Archive