Abstract
Operationally, reverse mutations are defined as mutations that fully or partially restore the activity of a mutant gene. In the early days of mutation research, the occurrence of reverse mutations was used as an argument against the presence-absence theory (Chapter 1). Subsequently, the same argument was used to prove that X-rays can produce intragenic changes. However, in Drosophila the evidence for reverse mutation is meagre, and in maize — the only other object of mutation studies at that time — the then best authenticated case of reverse mutation appears to be due to loss of a controlling element rather than to true gene mutation (see Chapter 22). Moreover, it was soon realized that apparent reversions may be due to suppressor mutations in other genes. The distinction between true reversion and reversion by a suppressor mutation can be made easily when the mutant gene and the suppressor are not closely linked, for then the mutant gene will again segregate out unsuppressed in crosses to wild-type. If, however, linkage between mutant gene and suppressor is close, separation between them by crossing-over will be correspondingly rare. Large experiments are necessary to detect linked suppressors, and failure of the mutant gene to reappear in the progeny cannot usually exclude the possibility of very close linkage.
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© 1976 Charlotte Auerbach
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Auerbach, C. (1976). Reverse mutations. Suppressors. In: Mutation research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3103-0_4
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DOI: https://doi.org/10.1007/978-1-4899-3103-0_4
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