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Nitrous acid. Other chemical mutagens

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Mutation research

Abstract

In this chapter, I am going to deal with a miscellany of mutagens. During the more than 30 years since the discovery of the first mutagenic chemicals, new ones have been found at an accelerated frequency, so that I shall not be able even to mention all of them. However, most of those that are omitted can be fitted into one or the other of the categories discussed in this chapter and the preceding ones. With a few exceptions, of which nitrous acid is the most important, the substances now to be dealt with play no prominent role in present-day mutation research. Most of them were discovered in the pre-Watson-Crick era, and their mode of action on DNA is not understood. Some certainly, and others probably, act in indirect ways. Yet even these have not been included only for historical reasons. I believe that the time has come to resume the study of at least some of these now neglected mutagens. If in some sections of this chapter, I present what may appear a catalogue of disjointed and incompletely analysed observations, I do this in the hope that some of them may be used as starting points for investigations by modern techniques and on the basis of modern concepts.

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  1. Institute of Animal Genetics, University of Edinburgh, UK

    Charlotte Auerbach F.R.S. (Professor Emeritus)

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© 1976 Charlotte Auerbach

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Auerbach, C. (1976). Nitrous acid. Other chemical mutagens. In: Mutation research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3103-0_18

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  • DOI: https://doi.org/10.1007/978-1-4899-3103-0_18

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