Abstract
The term ‘cryoglobulin’ was introduced to define a group of proteins which have the common property of forming a reversible precipitate or gel in the cold [1]. Three groups of cryoglobulins have been identified. Type I cryoglobulins are monoclonal, the most common one being immunoglobulin M (IgM), a protein associated with immunoprolifera-tive disorders, such as Waldenstrom’s macroglobulinemia, lymphopro-liferative disorders and multiple myeloma.
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References
Lospalluto, J., Dorward, B., Miller, W. Jr. and Ziff, M. (1962) Cryoglobulinemia based on interaction between a gamma macroglobulin and 7S gammaglobulin. Am. J. Med., 32, 142.
Brouet, J.C., Clouvel, J.P., Danon, F. et al. (1974) Biologic and clinical significance of cryoglobulins. Am. J. Med., 57, 775.
Meltzer, M. and Franklin, E.C. (1966) Cryoglobulinemia: a study of twenty-nine patients. I. IgG and IgM cryoglobulins and factors affecting cryopreci-pitability. Am. J. Med., 40, 828.
Gorevic, P.D., Kassab, H.J., Levo, Y. et al. (1980) Mixed cryoglobulinemia: clinical aspects and long term follow-up of 40 patients. Am. J. Med., 69, 287.
Gorevic, P.D. and Frangione, B. (1991) Mixed cryoglobulinemia cross reactive idiotypes: implication for relationships of MC to rheumatic and lymphopro-lipherative diseases. Semin. Hematol., 28, 79.
Migliorini, P., Bombardieri, S., Castellani, A. and Ferrara, G.B. (1981) HLA antigens in essential mixed cryoglobulinemia. Arthritis Rheum., 24, 932.
Zignego, A.L., Macchia, D., Monti, M. et al. (1992) Infection of peripheral mononuclear blood cells by hepatitis C virus. J. Hepatol, 15, 382.
Bombardieri, S., Ferri, C., Di Munno, O. and Pasero, G. (1979) Liver involvement in essential mixed cryoglobulinemia. Ric. Clin. Lab., 9, 361.
Inman, R.D., Hodge, M., Johnston, M.E. et al. (1986) Arthritis, vasculitis and cryoglobulinemia associated with relapsing hepatitis A virus infection. Ann. Intern. Med., 105, 700.
Fiorini, G.F., Sinico, R.A., Winearls, C. et al. (1988) EBV infection in patients with type 2 essential MC. Clin. Immunol. Immunopathol., 47, 262.
Realdi, G., Alberti, A., Rigoli, A. and Tremolada, F. (1974) Immune complexes and Australia antigen in cryoglobulinemic sera. Z. Immunitatsfortsch Exp. Klin. Immunol., 147, 114.
Galli, M. and the GISC members (1991) Cryoglobulinemia and serological markers of hepatitis viruses. Lancet, 758.
Hosein, B., Fang, C.T., Popowskj, M.A. et al. (1991) Improved serodiagnosis of HCV infection with synthetic peptide antigen from capside protein. Proc. Nat. Acad. Sci. USA, 88, 3647.
Pascual, M., Perrin, L., Giostra, E. and Schifer, J.A. (1990) Hepatitis C virus in patients with cryoglobulinemia type 2. J. Infect. Dis., 162, 569.
Ferri, C., Greco, F., Longombardo, G. et al. (1991) Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. Arthritis Rheum., 34, 1606–10.
Ferri, C., Greco, F., Longombardo, G. et al. (1991) Antibodies against hepatitis C virus in mixed cryoglobulinemia patients. Infection, 19, 417–20.
Ferri, C., Greco, F., Longombardo, G., et al. (1991) Association between hepatitis C virus and mixed cryoglobulinemia. Clin. Exp. Rheumatol., 9, 621–4.
Bambara, L.M., Biasi, D., Caramaschi, P. et al. (1991) Cryoglobulinemia and hepatitis C virus infection. Clin. Exp. Rheumatol., 9, 95.
Harle, J.R., Disdier, P. and Durand, J.M. (1991) Cryoglobuliéme mixed au cours de l’infection par le virus de l’hepatite C. Dix cas. Presse Méd., 20, 1233.
Disdier, P., Harle, J.R. and Weiller, P.J. (1991) Cryoglobulinemia and hepatitic infection. Lancet, 338, 1151.
Agnello, V., Chung, R.T., Dienstag, J.L. et al. (1991) Evidence for the association of hepatitic C virus with essential mixed cryoglobilinemia. Arthritis Rheum., 34 (Suppl. 9), S45, Abstract 78.
Agnello, V, . Chung, R.T. and Kaplan, L.M. (1992) A role for hepatitis C virus infection in type 2 cryoglobulinemia. N. Engl. J. Med., 327, 1490.
Ferri, C., Longombardo, G., La Civita, L., Bombardieri, S. et al. (1992) Hepatitis C virus, autoimmune liver diseases and cryoglobulinemic hepatitis. J. Hepatol., 16, 242–3.
Ferri, C., Longombardo, G., La Civita, L. et al. (1992) Hepatitis C virus infection in mixed cryoglobulinemia. Gastroentérology, 103, 1108–10.
Ferri, C., La Civita, L., Longombardo, G. et al. (1993) Hepatitis C virus and mixed cryoglobulinemia. Eur. J. Clin. Invest., 23, 399–405.
Ferri, C., Monti, M., La Civita, L. et al. (1993) Infection of peripheral mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood, 82, 3701–4.
Abel, G., Zhang, Q. and Agnello, V. (1993) Hepatitis C virus infection in type II mixed cryoglobulinemia. Arthritis Rheum., 36, 1341–9.
Monteverde, A., Rivano, M.T., Allegra, G.C. et al. (1988) Essential mixed cryoglobulinemia, type II: a manifestation of a low grade malignant lymphoma? Acta Haematol. (Basel), 79, 20.
Bombardieri, S., Puccetti, A. and Pilo, A. (1989) A method for retracing the putative antigen/antibody ratio of immune complexes in biological fluids. Clin. Exp. Rheumatol., 7/S-3 (Suppl), 109.
Bombardieri, S., Caponi, L., Pilo, A. et al. (1989) Changes in the putative antigen/antibody ratio of circulating immune complexes in mixed cryoglobulinemia and systemic lupus erythematosus following selected removal of macromolecules. Int. J. Art. Org., 12/S4, 87.
Vitali, C., Tavoni, S. and Bombardieri, S. (1984) La fonction réticulo-endothé-liale splénique dans les maladies à complexes immuns. Médecine Hyg., 42, 109.
Ferri, C., Pietrogrande, M., Cecchetti, R. et al. (1989) Low-antigen-content diet in the treatment of mixed cryoglobulinemia patients. Am. J. Med., 87, 519.
Schifferli, J.A., Morris, S.M., Dash, A. and Peters, D.K. (1981) Complement mediated solubilization in patients with systemic lupus erythematosus, nephritis or vasculitis. Clin. Exp. Immunol., 46, 557.
Schifferli, J.A., Wood, P. and Peters, D.K. (1982) Complement mediated inhibition of immune precipitation I. Role of the classical and al.ternative pathways. Clin. Exp. Immunol., 47, 555.
Balestrieri, G., Tincani, A., Migliorini, P. et al. (1984) Inhibitory effect of IgM rheumatoid factor on immune complex solubilization capacity and inhibition of immune precipitation. Arthritis Rheum., 27, 1130.
Ferri, C., Mannini, L., Bartoli, V. et al. (1990) Blood viscosity and filtration abnormalities in mixed cryoglobulinemia patients. Clin. Exp. Rheumatol., 8, 271.
Ferri, C., La Civita, L., Cirafisi, C. et al. (1992) Peripheral neuropathy in mixed cryoglobulinemia: clinical and electro-physical investigations. J. Rheumatol., 19, 889–95.
Kefalides, N.A., Pegg, M.T., Ohno, N. et al. (1986) Antibodies to basement membrane collagen and to laminin are present in sera from patients with post-streptococcal glomerulonephritis. J. Exp. Med., 163, 588.
Dolcher, M.P., Marchini, B., Sabbatini, A. et al. (in press) Autoantibodies from mixed cryoglobulinemia patients bind glomerular antigens. Clin. Exp. Immunol., (In press).
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Bombardieri, S. et al. (1996). Mixed cryoglobulinemia: the role of HCV and organ-specific antibodies. In: Ansell, B.M., Bacon, P.A., Lie, J.T., Yazici, H. (eds) The Vasculitides. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2889-4_20
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DOI: https://doi.org/10.1007/978-1-4899-2889-4_20
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