Skip to main content

Abstract

This chapter deals with a variety of clinical conditions in which there is excessive effects of thyroid hormones on the tissues. Hyperthyroidism is the general term, although some workers restrict this to conditions where the thyroid, per se, is overactive. I use hyperthyroidism to imply that there is too much thyroid hormone in the circulation, irrespective of its source. A second term, thyrotoxicosis, literally means ‘toxic’ because of too much thyroid hormone. However, many patients with high serum thyroid levels are not toxic. Nevertheless, in this chapter the two terms are used interchangeably. Most frequently, there are high levels of total hormones and, most often, both T4 and T3 are above normal. On occasion, total hormone values are normal and only the free hormones are high.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Graves, R.J. (1835) London Med. Surg. J., 7 (2), 516.

    Google Scholar 

  2. Parry, C.H. (1825) Collections from the unpublished papers of the late Caleb Hillier Parry, Vol 2, pp. 11–128.

    Google Scholar 

  3. Von Basedow, C.A. (1840) Exophthalmos durch hypertrophie des Zellgewebes in der augenhohle. Wochenschrift Gesummte Heilkunde, 6, 197.

    Google Scholar 

  4. Major, R.H. (1945) Classic Descriptions of Disease: With Biographical Sketches of the Authors, 3rd edn, Charles C Thomas, Springfield.

    Google Scholar 

  5. Taylor, S. (1986) Graves of Graves’ disease, 1796–1853. J. Roy. Coll. Phys., 20, 298–300.

    Google Scholar 

  6. Taylor, S. (1989) Robert Graves: The Golden Years of Irish Medicine, The Royal Society of Medicine, London.

    Google Scholar 

  7. Committee on Nomenclature of the American Thyroid Association (1987) Revised nomenclature for test of thyroid hormones and thyroid-related proteins in the serum. J. Clin. Endocrinol. Metab., 64, 1089–94.

    Article  Google Scholar 

  8. Adams, D.D. and Purves, H.D. (1956) Abnormal responses in the assay of thyrot-rophin. Proc. Univ. Otago Med. Sch., 34, 11–12.

    Google Scholar 

  9. Kriss, J.P., Pleshakov, V. and Chien, J.R. (1964) Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J. Clin. Endocrinol. Metab., 24, 1005–28.

    Article  PubMed  CAS  Google Scholar 

  10. McKenzie, J.M. (1958) Delayed thyroid response to serum from thyrotoxic patients. Endocrinol, 62, 865–8.

    Article  CAS  Google Scholar 

  11. Kriss, J.P. (1968) The long-acting thyroid stimulator. Calif. Med., 109, 202–13.

    PubMed  CAS  Google Scholar 

  12. Ochi, Y. and DeGroot, L.J. (1968) Long acting thyroid stimulator of Graves’s disease. N. Engl. J. Med., 278, 718–21.

    Article  PubMed  CAS  Google Scholar 

  13. Adams, D.D. and Kennedy, T.H. (1967) The occurrence in thyrotoxicosis of a gamma globulin which protects LATS from neutralisation by an extract of thyroid gland. J. Clin. Endocrinol. Metab., 27, 173–7.

    Article  PubMed  CAS  Google Scholar 

  14. Adams, D.D. (1988) Long-acting thyroid stimulator: how receptor autoimmunity was discovered. Autoimmunity, 1, 3–9.

    Article  PubMed  CAS  Google Scholar 

  15. Adams, D.D., Fastier, F.N., Howie, J.B. et al. (1974) Stimulation of the human thyroid by infusions of plasma containing LATS protector. J. Clin. Endocrinol. Metab., 39, 826–32.

    Article  PubMed  CAS  Google Scholar 

  16. Zakarija, M., McKenzie, J.M. and Banovac, K. (1980) Clinical significance of thyroid-stimulating antibody in Graves’ disease. Ann. Intern. Med., 93, 28–32.

    Article  PubMed  CAS  Google Scholar 

  17. McKenzie, J.M. (1980) Thyroid-stimulating antibody (TSAb) in Graves’ disease. Thyroid Today, (ed. J.H. Oppenheimer) 2 (5), 1–5.

    Google Scholar 

  18. Morris, J.C. III. Hay, I.D., Nelson, R.E. et al. (1988) Clinical utility of thyrotropin-receptor antibody assays: comparison of radioreceptor and bioassay methods. Mayo Clin. Proc., 63, 707–17.

    Article  PubMed  Google Scholar 

  19. Wilson, R., McKillop, J.H., Pearson, D.W.M. et al. (1985) Relapse of Graves’ disease after medical therapy: predictive value of thyroidal technetium-99m uptake and serum thyroid stimulating hormone receptor antibody levels. J. Nucl. Med., 26, 1024–8.

    PubMed  CAS  Google Scholar 

  20. Madec, A.M., Laurent, M.C., Lorcy, Y. et al. (1984) Thyroid-stimulating antibodies: an aid to the strategy of treatment of Graves’ disease? Clin. Endocrinol., 21; 247–55.

    Article  CAS  Google Scholar 

  21. Rees-Smith, B. (1988) Autoantibodies to the thyrotropin receptor. Endocrine Rev., 9, 106–21.

    Article  CAS  Google Scholar 

  22. Munro, D.S., Dirmikis, S.M., Humphries, H. et al. (1978) The role of thyroid-stimulating immunoglobulins of Graves’ disease in neonatal thyrotoxicosis. Br. J. Obstet. Gyn., 85, 837–43.

    Article  CAS  Google Scholar 

  23. Volpé, R. (1981) Auto-immunity in the endocrine system. Monograph Endocrinol., 20, 19–111.

    Article  Google Scholar 

  24. Strakosch, C.R., Wenzel, B.E., Row, V.V. et al (1982) Immunology of autoimmune thyroid disease. N. Engl. J. Med., 307; 1499–504.

    Article  PubMed  CAS  Google Scholar 

  25. Bartrop, R.W., Lockhurst, E., Lazarus, L. et al. (1977) Depressed lymphocyte function after bereavement. Lancet, 1, 834–6.

    Article  PubMed  CAS  Google Scholar 

  26. Wilson, G.M. (1967) The Treatment of Thyrotoxicosis, Symposium Thyroid Disease and Calcium Metabolism, Royal College of Physicians, Edinburgh, pp. 51–76.

    Google Scholar 

  27. Wasnich, R.D., Grumet, F.C., Payne, R.O. et al. (1973) Graves’ ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease. J. Clin. Endocrinol Metab., 37, 703–13.

    Article  PubMed  CAS  Google Scholar 

  28. Davis, P.J., Rappeport, J.R., Lutz, J.H. et al. (1971) Three thyrotoxic criminals. Ann. Intern. Med., 74, 734–5.

    Article  Google Scholar 

  29. Rockey, P.H. and Griep, R.J. (1980) Behavioral dysfunction in hyperthyroidism: improvement with treatment. Arch. Intern. Med., 149, 1194–7.

    Article  Google Scholar 

  30. Rothberg, M.P., Shebert, R.T., Levey, G.S. et al. (1974) Propranolol and hyperthyroidism: reversal of upper motor signs. JAMA, 230, 1017.

    Article  PubMed  CAS  Google Scholar 

  31. Okinaka, S., Shizume, K., Lino. S. et al. (1957) The association of periodic paralysis and hyperthyroidism in Japan. J. Clin. Endocrinol Metab., 17, 1454–9.

    Article  PubMed  CAS  Google Scholar 

  32. Dyde, J.A. (1965) Hyperthyroidism complicated by periodic paralysis. Postgrad. Med. J., 41, 286–7.

    Article  PubMed  CAS  Google Scholar 

  33. Barnard, J.D., Larson, M.A., Norris, F.H. Jr (1972) Thyrotoxic periodic paralysis in Cali-fornians of Mexican and Filipino ancestry. Calif. Med., 116, 70–4.

    Google Scholar 

  34. Leung, A.K.C. (1985) Familial ‘hashitoxic’ periodic paralysis. J. Roy. Soc. Med., 78, 638–40.

    PubMed  CAS  Google Scholar 

  35. Sum, C.F., Fok, A.C.K., Tan, K.T. et al. (1988) Human leucocyte antigen in a Chinese family with thyrotoxic periodic paralysis in Singapore. Br. Med. J., 297, 594–5.

    Article  CAS  Google Scholar 

  36. McFadzean, A.J.S. and Yeung, R. (1967) Periodic paralysis complicating thyrotoxicosis in Chinese. Br. Med. J., 1, 451–5.

    Article  PubMed  CAS  Google Scholar 

  37. Ober, K.P. and Hennessey, J.F. (1981) Jod Basedow and thyrotoxic periodic paralysis. Arch, Intern. Med., 141, 1225–7.

    Article  CAS  Google Scholar 

  38. Layzer, R.B. and Goldfield, E. (1974) Periodic paralysis caused by abuse of thyroid hormone. Neurol., 24, 949–52.

    Article  CAS  Google Scholar 

  39. Edelman, J. and Stewart-Wynne, E.G. (1981) Respirarory and bulbar paralysis with relapsing hyperthyroidism. Br. Med. J., 283, 275–6.

    Article  CAS  Google Scholar 

  40. Guthrie, G.P. Jr, Curtis, J.J. and Beilman, K.M. (1978) Hypophosphatemia in thyrotoxic periodic paralysis. Arch. Intern. Med., 138, 1284–5.

    Article  PubMed  Google Scholar 

  41. Feely, J. (1981) Potassium shift in thyrotoxic periodic paralysis. Postgrad. Med. J., 57, 238–9.

    Article  PubMed  CAS  Google Scholar 

  42. Yeung, R.T.T. and Tse, T.F. (1974) Thyrotoxic periodic paralysis: effect of propranol. Am. J. Med., 57, 584–90.

    Article  PubMed  CAS  Google Scholar 

  43. Ramsay, I. (1966) Muscle dysfunction in hyperthyroidism. Lancet, 3, 931–5.

    Article  Google Scholar 

  44. Drachman, D.B. (1962) Myasthenia gravis and the thyroid gland. N. Engl. J. Med., 266, 330–3.

    Article  Google Scholar 

  45. Muggia, A.L., Stjernholm, M. and Houle, T. (1970) Complete heart block with thyrotoxic myocarditis; report of a case. N. Engl. J. Med., 283, 1099–100.

    Article  PubMed  CAS  Google Scholar 

  46. Campus, S., Rappelli, A., Malavasi, A. et al. (1975) Heart block and hyperthyroidism: report of two cases. Arch. Intern. Med., 135, 1091–5.

    Article  PubMed  CAS  Google Scholar 

  47. Stern, M.P., Jacobs, R.L., and Duncan, G.W. (1970) Complete heart block complicating hyperthyroidism. JAMA, 212, 2117–19.

    Article  PubMed  CAS  Google Scholar 

  48. Eraker, S.A., Wickamasekaran, R. and Goldman, S. (1978) Complete heart block with hyperthyroidism. JAMA, 239, 1644–6.

    Article  PubMed  CAS  Google Scholar 

  49. Wei, J.Y., Genecin, A., Greene, H.L. et al. (1979) Coronary spasm with ventricular fibrillation during thyrotoxicosis: response to attaining euthyroid state. Am. J. Cardiol., 43, 335–9.

    Article  PubMed  CAS  Google Scholar 

  50. Featherstone, H.J. and Stewart, D.K. (1983) Angina in thyrotoxicosis: thyroid-related coronary artery spasm. Arch. Intern. Med., 143, 554–5.

    Article  PubMed  CAS  Google Scholar 

  51. Kotler, M.N., Michaelides, K.M., Bouchard, R.J. et al. (1973) Myocardial infarction associated with thyrotoxicosis. Arch. Intern. Med., 132, 723–8.

    Article  PubMed  CAS  Google Scholar 

  52. Cobler, J.L., Williams, M.E. and Greenland, P. (1984) Thyrotoxicosis in institutionalised elderly patients with atrial fibrillation. Arch. Intern. Med., 144, 1758–60.

    Article  PubMed  CAS  Google Scholar 

  53. Williams, R.H. (1946) Thiouracil treatment in thyrotoxicosis. J. Clin. Endocrinol. Metab., 41, 354–61.

    Article  Google Scholar 

  54. Mornex, R. and Orgiazzi, J.J. (1980) Hyperthyroidism, in The Thyroid Gland, (ed. M. De Visscher), Raven Press, New York, pp. 279–63.

    Google Scholar 

  55. Wayne, E.J. (1954) The diagnosis of thyrotoxicosis. Br. Med. J., 1, 411–19.

    Article  PubMed  CAS  Google Scholar 

  56. Bar-Sela, S., Ehrenfeld, M. and Eliakim, M. (1981) Arterial embolism in thyrotoxicosis with atrial fibrillation. Arch. Intern. Med., 141, 1191–2.

    Article  PubMed  CAS  Google Scholar 

  57. Hausmann, W. (1974) Thyrotoxic cardiomyopathy complicated by systemic and pulmonary embolism. Proc. Roy. Soc. Med., 68, 327.

    Google Scholar 

  58. Giddings, H.B. and Surks, M.I. (1978) Cerebral embolization in atrial fibrillation complicating hyperthyroidism. JAMA, 240, 2567–8.

    Article  PubMed  CAS  Google Scholar 

  59. Staffurth, J., Gibberd, M., Tang Fui, S.N. (1977) Arterial embolism in thyrotoxicosis with atrial fibrillation. Br. Med. J., 2, 688–90.

    Article  PubMed  CAS  Google Scholar 

  60. Forfar, J.C., Miller, H.C. and Toft, A.D. (1979) Occult thyrotoxicosis: a correctable cause of idiopathic atrial fibrillation. Am. J. Cardiol, 44, 9–12.

    Article  PubMed  CAS  Google Scholar 

  61. Parker, J.L.W. and Lawson, D.H. (1973) Death from thyrotoxicosis. Lancet, 2, 894–5.

    Article  PubMed  CAS  Google Scholar 

  62. Magner, J.A., Clark, W. and Allenby, P. (1988) Congestive heart failure and death in a young woman with thyrotoxicosis. West J. Med., 149, 86–91.

    PubMed  CAS  Google Scholar 

  63. Rosenthal, F.D., Jones, C. and Lewis, S.I. (1977) Thyrotoxic vomiting. Br. Med. J., 2, 209–11.

    Article  Google Scholar 

  64. Parkin, A.J., Nisbet, A.P. and Bishop, N. (1981) Vomiting due to gastric stasis as the presenting feature in thyrotoxicosis. Postgrad. Med. J., 57, 405.

    Article  PubMed  CAS  Google Scholar 

  65. Miller, L.J., Gorman, C.A. and Go, V.L.W. (1978) Thyroid-gut interrelationships. Gastroenterology, 75, 901–11.

    PubMed  CAS  Google Scholar 

  66. Ashkar, F.S., Miller, R., Smoak, W.M. et al. (1971) Liver disease in hyperthyroidism. South Med. J., 64, 462–5.

    Article  PubMed  CAS  Google Scholar 

  67. Marks, P. and Ashraf, H. (1978) Apathetic hyperthyroidism with hypomagnesaemia and raised alkaline phosphatase concentration. Br. Med. J., 1, 821–2.

    Article  PubMed  CAS  Google Scholar 

  68. Herbert, V. (1986) The blood, in Werner’s The Thyroid, 5th edn, (eds S.H. Ingbar and L.E. Braverman), J.B. Lippincott Company, Philadelphia, pp. 878–84.

    Google Scholar 

  69. Dunlap, D.B., McFarland, K.F. and Lutcher, C.L. (1974) Graves’ disease and idiopathic thrombocytopenic purpura. Am. J. Med. Sci., 268, 107–11.

    Article  PubMed  CAS  Google Scholar 

  70. Grish, L.S. and Meyerson, R.M. (1957) Thyrotoxicosis associated with thrombocytopenia and hypersplenism. Am. J. Clin. Pathol., 27, 328–31.

    Google Scholar 

  71. Hymes, K., Blum, M., Lackner, H. et al. (1981) Easy bruising, thrombocytopenia, and elevated platelet immunoglobulin G in Graves’ disease and Hashimoto’s thyroiditis. Ann. Intern. Med., 94, 27–30.

    Article  PubMed  CAS  Google Scholar 

  72. Irvine, W.J., Wu, F.C.W., Urbaniac, S.J. et al. (1977) Peripheral blood leukocytes in thyrotoxicosis (Graves’) disease as studied by conventional light microscopy. Clin. Exp. Immunology, 27, 216–21.

    CAS  Google Scholar 

  73. Wall, J.R., Gray, B. and Greenswood, D.M. (1977) Total and activated peripheral blood T-lymphocytes in patients with Graves’ disease. Acta Endocrinol., 85, 753–9.

    PubMed  CAS  Google Scholar 

  74. Van Herle, A.J. and Chopra, I.J. (1971) Thymic hyperplasia in Graves’ disease. J. Clin. Endocrinol. Metab., 32, 140–6.

    Article  PubMed  Google Scholar 

  75. Mahaux, J.E., Chamla-Soumenkoff, J., Delcourt, R. et al. (1971) Painful enlargement of left subtrapezoid lymph nodes in Graves’ disease. Br. Med. J., 1, 384.

    Article  PubMed  CAS  Google Scholar 

  76. Baxter, J.D. and Bondy, P.K. (1966) Hypercalcemia of thyrotoxicosis. Ann. Intern. Med., 65, 429–42.

    Article  PubMed  CAS  Google Scholar 

  77. Mallette, L.E. and Tuma, S.N. (1984) A new radioimmunoassay for the midregion of canine parathyroid hormone. Mineral Electrol. Metabol., 10, 43–7.

    CAS  Google Scholar 

  78. Mallette, L.E., Rubenfeld, S. and Silverman, V. (1985) A controlled study of the effects of thyrotoxicosis and propranolol treatment on mineral metabolism and parathyroid hormone immunoreactivity. Metabolism, 34, 999–1006.

    Article  PubMed  CAS  Google Scholar 

  79. Cooper, D.S., Kaplan, M.M., Ridgway, E.C. et al. (1979) Alkaline phosphatase isoenzyme patterns in hyperthyroidism. Ann. Intern. Med., 90, 164–8.

    Article  PubMed  CAS  Google Scholar 

  80. Arem, R., Lim-Abrahan, M.A. and Mallette, L.E. (1986) Concomitant Graves’ disease and primary hyperthyroidism: influence of hyperthyroidism on serum calcium and parathyroid hormone. Am. J. Med., 80, 693–8.

    Article  PubMed  CAS  Google Scholar 

  81. Christensson, T. (1977) Hyperparathyroidism and radiation therapy. Ann. Intern. Med., 89, 216–17.

    Article  Google Scholar 

  82. Rao, S.D., Frame, B., Miller, M.J. et al. (1980) Hyperparathyroidism following head and neck irradiation. Arch. Intern. Med., 140, 205–7.

    Article  PubMed  CAS  Google Scholar 

  83. Rosen, I.B., Palmer, J.A., Rowen, J. et al. (1984) Induction of hyperparathyroidism by radioactive iodine. Am. J. Surg., 148, 441–5.

    Article  PubMed  CAS  Google Scholar 

  84. Fraser, S.A., Smith, D.A., Anderson, J.B. et al. (1975) Osteoporosis and fractures following thyrotoxicosis. Lancet, 1, 981–3.

    Google Scholar 

  85. Fallon, M.D., Perry, H.M. III, Bergfeld, M. et al. (1983) Exogenous hyperthyroidism with osteoporosis. Arch. Intern. Med., 143, 442–4.

    Article  PubMed  CAS  Google Scholar 

  86. Ross, D.S., Neer, R.M., Ridgway, E.C. et al. (1987) Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary thyroid axis with L-thyroxine. Am. J. Med., 82, 1167–70.

    Article  PubMed  CAS  Google Scholar 

  87. Auwerx, J. and Bouillon, R. (1986) Mineral and bone metabolism in thyroid disease: a review. Quart. J. Med., 232, 737–52.

    Google Scholar 

  88. Clyde, H.R., Walsh, P.C. and English, R.W. (1976) Elevated plasma testosterone and gonadotropin levels in infertile males with hyperthyroidism. Fertil. Steril., 27, 662–6.

    PubMed  CAS  Google Scholar 

  89. Becker, K.L., Winnacker, J.L., Matthews, M.J. et al. (1968) Gynecomastia and hyperthyroidism. An endocrine and histologic investigation. J. Clin. Endocrinol Metab., 28, 277–85.

    Article  PubMed  CAS  Google Scholar 

  90. Morgans, M.E. (1964) Hyperthyroidism, in The Thyroid Gland, Vol 2, (eds R.V. Pitt-Rivers and W.R. Trotter), Butterworth, London, p. 159.

    Google Scholar 

  91. Ochi, Y. and DeGroot, L.J. (1969) Vitiligo in Graves’ disease. Ann. Intern. Med., 71, 935–40.

    Article  PubMed  CAS  Google Scholar 

  92. Wyse, E.P., McConahey, W.M., Woolner, L.B. et al. (1968) Ophthalmopathy without hyperthyroidism in patients with histologic Hashimoto’s thyroiditis. J. Clin. Endocrinol. Metab., 28, 1623–9.

    Article  PubMed  CAS  Google Scholar 

  93. Rundle, F.F. and Pochin, E.E. (1944) The orbital tissues in thyrotoxicosis: a quantitative analysis relating to exophthalmos. Clin. Sci., 5, 51–74.

    Google Scholar 

  94. Hufnagel, T.J., Hickey, W.F., Cobbs, W.H. et al. (1984) Immunohistochemical and ultra-structural studies on the exenterated orbital tissues of a patient with Graves’ disease. Ophthalmology, 91, 1411–19.

    PubMed  CAS  Google Scholar 

  95. Werner, S.C., Coleman, D.J. and Franzen, L.A. (1974) Ultrasonographic evidence of a consistent orbital involvement in Graves’ disease. N. Engl. J. Med., 290, 1447–50.

    Article  PubMed  CAS  Google Scholar 

  96. Forrester, J.V., Sutherland, G.R. and McDougall, I.R. (1977) Dysthroid ophthalmopathy orbital evaluation with B-scan ultrasonography. J. Clin. Endocrinol. Metab., 45, 1353–6.

    Article  Google Scholar 

  97. Enzmann, D.R., Donaldson, S.S. and Kriss, J.P. (1979) Appearance of Graves’ disease on orbital computed tomography. J. Comput. Assist. Tomogr., 3, 815–19.

    PubMed  CAS  Google Scholar 

  98. Konishi, J., Hermann, M.M. and Kriss, J.P. (1974) Binding of thyroglobulin and thyroglobulin-antithyroglobulin immune complex to extraocular muscle membranes. Endocrinol., 95, 434–6.

    Article  CAS  Google Scholar 

  99. Tao, T.W., Cheng, P., Pham, H. et al. (1986) Monoclonal antithyroglobulin antibodies derived from immunisation of mice with human eye muscle and thyroid membranes. J. Clin. Endocrinol. Metab., 63, 577–82.

    Article  PubMed  CAS  Google Scholar 

  100. Kriss, J.P. (1970) Radioiosotope thyroidolymphography in patients with Graves’ disease. J. Clin. Endocrinol. Metab., 31, 315–24.

    Article  PubMed  CAS  Google Scholar 

  101. Werner, S.C. (1969) Classification of the eye changes of Graves’ disease. J. Clin. Endocrinol. Metabol., 29, 982–4.

    Article  CAS  Google Scholar 

  102. Donaldson, S.S., Bagshaw, M.A. and Kriss, J.P. (1973) Supervoltage orbital radiotherapy for Graves’ ophthalmopathy. J. Clin. Endocrinol. Metab., 37, 276–85.

    Article  PubMed  CAS  Google Scholar 

  103. Gorman, C.A. (1983) Temporal relationship between onset of Graves’ ophthalmopathy and diagnosis of thyrotoxicosis. Mayo Clin. Proc., 58, 515–19.

    PubMed  CAS  Google Scholar 

  104. Marcocci, C., Bartalena, L., Bogazzi, F. et al. (1989) Studies on the occurrence of ophthalmopathy in Graves’ disease. Acta Endocrinol., 120, 473–8.

    Article  PubMed  CAS  Google Scholar 

  105. Kriss, J.P., McDougall, I.R., Donaldson, S.S. (1987) Non-thyroidal complications of Graves’ disease: perspective on pathogenesis and treatment, in Thyroid Autoimmunity, (eds A. Pinchera, S.H. Ingbar, J.M. McKenzie and G.F. Fenzi), Plenum Publishing Corporation, New York and London, pp. 263–9.

    Chapter  Google Scholar 

  106. Kriss, J.P., Petersen, I.A., Donaldson, S.S. et al. (1989) Supervoltage orbital radiotherapy for progressive Graves’ ophthalmopathy: results of a twenty year experience. Acta Endocrinol., 121 (suppl. 2), 154–9.

    Google Scholar 

  107. Gwinup, G., Elias, A.N. and Ascher, A.S. (1982) Effect on exophthalmos of various treatment methods of Graves’ disease. JAMA, 247, 2135–8.

    Article  PubMed  CAS  Google Scholar 

  108. Sridama, V. and De Groot, L.J. (1989) Treatment of Graves’ disease and the course of ophthalmopathy. Am. J. Med., 87, 70–3.

    Article  PubMed  CAS  Google Scholar 

  109. De Juan, E., Hurley, D.B. and Sapira, J.D. (1980) Racial differences in normal values of proptosis. Arch. Intern. Med., 140, 1230–1.

    Article  PubMed  Google Scholar 

  110. Gamblin, G.T., Harper, D.G., Galentine, P. et al. (1983) Prevalence of increased intraocular pressure in Graves’ disease — evidence of frequent subclinical ophthalmopathy. N. Engl. J. Med., 308, 420–4.

    Article  PubMed  CAS  Google Scholar 

  111. Werner, S.C. (1966) Prednisone in emergency treatment of malignat exophthalmos. Lancet, 1, 1004–7.

    Article  Google Scholar 

  112. Prummel, M.F., Mouritis, M.P.H., Berghout, A. et al. (1989) Prednisone and cyclosporine in the treatment of severe Graves’ ophthalmopathy. N. Engl. J. Med., 321, 1353–9.

    Article  PubMed  CAS  Google Scholar 

  113. Jones, A. (1951) Orbital X-ray therapy of progressive exophthalmos. Br. J. Radiol., 29, 637–46.

    Article  Google Scholar 

  114. Ogura, J.H., Wessler, S. and Avioli, L.V. (1971) Surgical approach to the ophthalmopathy of Graves’ disease. JAMA, 216, 1627–31.

    Article  Google Scholar 

  115. Ogura, J.H. and Lucente, F.E. (1974) Surgical results of orbital decompression for malignant exophthalmos. Laryngoscope, 84, 637–44.

    Article  PubMed  CAS  Google Scholar 

  116. McCord, CD. Jr (1981) Orbital decompression for Graves’ disease: exposure through lateral canthal and inferior fornix incision. Ophthalmology, 88, 533–41.

    PubMed  Google Scholar 

  117. Wolfe, S.A. (1977) A rationale for the surgical treatment of exophthalmos and exorbitism. J. Maxillo-facial Surg., 5, 249–57.

    Article  CAS  Google Scholar 

  118. Wolfe, S.A. (1978) Modified three-wall orbital expansion to correct persistent exophthalmos or exorbitism. Plastic and Reconstruct. Surg., 64, 448–55.

    Article  Google Scholar 

  119. Utech, C., Cordes, M., Pfannensteil, P. et al. (1987) Immunosuppressive treatment of Graves’ ophthalmopathy with cyclosporin A and ciamexon, in Thyroid Autoimmunity, (eds A. Pinchera, S.H. Ingbar, J.M. McKenzie and G.F. Fenzi), Plenum Press, New York and London, pp. 541–4.

    Chapter  Google Scholar 

  120. Dandona, P., Marshall, N.J., Bidey, S.P. et al. (1979) Successful treatment of exophthalmos and pretibial myxoedema with plasm-pheresis. Br. Med. J., 1, 374–6.

    Article  PubMed  CAS  Google Scholar 

  121. Catz, B. and Perzik, S.L. (1969) Total thyroidectomy in the management of thyrotoxic and euthyroid Graves’ disease. Am. J. Surg., 118, 434–9.

    Article  PubMed  CAS  Google Scholar 

  122. Kriss, J.P. (1980) Pathogenesis and treatment of Graves’ ophthalmopathy. Thyroid Today7 (2), 1–7.

    Google Scholar 

  123. Jacobson, D.H. and Gorman, C.A. (1984) Endocrine ophthalmopathy: current ideas concerning etiology, pathogenesis, and treatment. Endocrin. Rev., 5, 200–20.

    Article  CAS  Google Scholar 

  124. Shine, B., Edwards, O.M. and Weetman, A. P. (1989) Graves’ ophthalmopathy and smoking. Acta Endocrinol., 121 (suppl. 2), 182–4.

    Google Scholar 

  125. Austin-Seymour, M.M., Donaldson, S.S., Egbert, P.R. et al. (1985) Radiotherapy of lymphoid diseases of the orbit. Int. J. Radiât. Oncol. Biol. Phys., 11, 371–9.

    Article  PubMed  CAS  Google Scholar 

  126. Kriss, J.P. (1987) Pathogenesis and treatment of pretibial myxedema. Endocrinol. Metab. Clin. N. Am., 16, 409–15.

    CAS  Google Scholar 

  127. Cheung, H.S., Nicoloff, J.T., Kamiel, M.B. et al. (1978) Stimulation of fibroblast biosynthetic activity by serum of patients with pretibial myxedema. J. Invest. Dermatol., 71, 12–17.

    Article  PubMed  CAS  Google Scholar 

  128. Sissons, J.C. (1968) Hyaluronic acid in localised myxedema. J. Clin. Endocrinol. Metab., 28, 433–41.

    Article  Google Scholar 

  129. Kriss, J.P., Pleshakov, V., Rosenblum, A. et al. (1967) Therapy with occlusive dressings of pretibial myxedema with fluocinolone aceto-nide. J. Clin. Endocrinol. Metab., 27, 595–604.

    Article  PubMed  CAS  Google Scholar 

  130. Freedberg, I.M. and Vogel, L.N. (1986) The skin, in Werner’s The Thyroid, 5th edn, (eds S.H. Ingbar and L.E. Braverman), The Lip-pincott Company, Philadelphia, pp. 811–16.

    Google Scholar 

  131. Goette, D.K. (1980) Thyroid acropachy. Arch. Dermatol., 116, 205–6.

    Article  PubMed  CAS  Google Scholar 

  132. Gimlette, T.M.D. (1960) Thyroid acropachy. Lancet, 1, 22–4.

    Article  PubMed  CAS  Google Scholar 

  133. Thomas, H.M. Jr (1933) Acropachy: secondary subperiosteal new bone formation. Arch. Intern. Med., 51, 571–87.

    Article  Google Scholar 

  134. Nixon, D. and Samols, E. (1970) Acral changes associated with thyroid diseases. JAMA, 212, 1175–81.

    Article  PubMed  CAS  Google Scholar 

  135. Diamond, M.T. (1959) The syndrome of exophthalmos, hypertrophic osteoarthropathy and localized myxedema: A review of the literature and report of a case. Ann. Intern. Med., 50, 206–19.

    Article  PubMed  CAS  Google Scholar 

  136. Parker, L.N., Wu, S-Y., Lai, M.K. et al. (1982) The early diagnosis of atypical thyroid acropachy. Arch. Intern. Med., 142, 1749–51.

    Article  PubMed  CAS  Google Scholar 

  137. Siegel, R., Thrall, J. and Sisson, J. (1976) 99mTc-pyrophosphate scan and radiographic correlation in thyroid acropachy: case report. J. Nucl. Med., 17, 791–3.

    Google Scholar 

  138. Engel, A.G. (1984) Myasthenia and myasthenic syndromes. Ann. Neurol., 16, 519–34.

    Article  PubMed  CAS  Google Scholar 

  139. Naqui, J. (1967) Co-existence of Addison’s disease and thyrotoxicosis. Postgrad. Med. J., 43, 129.

    Article  PubMed  CAS  Google Scholar 

  140. Goldring, S.R. and Krane, S.M. (1986) The skeletal system, in Werner’s The Thyroid, 5th edn, (eds S.H. Ingbar and L.E. Braverman) The Lippincott Company, Philadelphia, pp. 930–48.

    Google Scholar 

  141. Ross, D.S. (1988) Subclinical hyperthyroidism: possible danger of overzealous thyroxine replacement therapy. Mayo Clin. Proc., 63, 1223–9.

    Article  PubMed  CAS  Google Scholar 

  142. Wilson, G.M. (1967) The treatment of thyrotoxicosis, Symposium Thyroid Disease and Calcium Metabolism, Royal College of Physicians, Publication 33, Edinburgh, pp. 51–76.

    Google Scholar 

  143. Taurog, A. (1976) The mechanism of action of the thioureylene antithyroid drugs. Endocrinol., 98, 1031–46.

    Article  CAS  Google Scholar 

  144. Marchant, B., Lees, J.F.H. and Alexander, W.D. (1978) Antithyroid drugs. Pharmacol. Ther. B., 3, 305–48.

    PubMed  CAS  Google Scholar 

  145. Lazarus, J.H., Marchant, B., Alexander, W.D. et al. (1975) 35S-antithyroid drug concentration and organic binding of iodine in the human thyroid. Clin. Endocrinol., 4, 609–15.

    Article  CAS  Google Scholar 

  146. Cooper, D.S. (1986) Which antithyroid drug? Am. J. Med., 80, 1165–8.

    Article  PubMed  CAS  Google Scholar 

  147. Bouma, D.J. and Kammer, H. (1980) Single daily dose methimazole treatment of hyperthyroidism. West J. Med., 132, 13–15.

    PubMed  CAS  Google Scholar 

  148. MacFarlane, I.A., Davies, D., Longson, D. et al. (1983) Single daily dose short term Carbimazole therapy for hyperthyroid Graves’ disease. Clin. Endocrinol., 18, 557–61.

    Article  CAS  Google Scholar 

  149. Gwinup, G. (1978) Prospective randomized comparison of propylthiouracil. JAMA, 239, 2457–9.

    Article  PubMed  CAS  Google Scholar 

  150. McDougall, I.R. and Greig, W.R. (1972) Combined carbimazole-131I therapy for thyrotoxicosis. Scot. Med. J., 17, 57–61.

    PubMed  CAS  Google Scholar 

  151. Crooks, J. and Wayne, E.J. (1960) A comparison of potassium perchlorate, methyl-thiouracil and Carbimazole in the treatment of thyrotoxicosis. Lancet, 1, 401–4.

    Article  PubMed  CAS  Google Scholar 

  152. Cooper, D.S. (1985) Propylthiouracil levels in hyperthyroid patients unresponsive to large doses: evidence of poor patient compliance. Ann. Intern. Med., 102, 328–31.

    Article  PubMed  CAS  Google Scholar 

  153. Wood, L.C., Peterson, M. and Ingbar, S.H. (1972) Delayed hypothyroidism following antithyroid therapy in Graves’ disease Clin. Res., 20, 625.

    Google Scholar 

  154. Solomon, B.L., Evaul, J.E., Burman, K.D. et al. (1987) Remission rates with antithyroid drug therapy: continuing influence of iodine intake? Ann. Intern. Med., 102, 510–12.

    Article  Google Scholar 

  155. Alexander, W.D., Harden, R. McG., Koutras, D.A. et al. (1965) Influence of iodine intake after treatment with antithyroid drugs. Lancet, 2, 866–8.

    Article  PubMed  CAS  Google Scholar 

  156. Wartofsky, L. (1973) Low remission after therapy for Graves’ disease: possible relation of dietary iodine with antithyroid drugs. JAMA, 226, 1083–8.

    Article  PubMed  CAS  Google Scholar 

  157. Greer, M.A., Kammer, H. and Bouma, D.J. (1977) Short-term antithyroid drug therapy for the thyrotoxicosis of Graves’ disease. N. Engl. J. Med., 297, 173–6.

    Article  PubMed  CAS  Google Scholar 

  158. Burr, W.A., Fitzgerald, M.G. and Hoffen-berg, R. (1979) Relapse after short-term antithyroid therapy of Graves’ disease. N. Engl. J. Med., 300, 200.

    PubMed  CAS  Google Scholar 

  159. Slingerland, D.W. and Burrows, B.A. (1979) Long-term antithyroid treatment in hyperthyroidism. JAMA, 242, 2408–10.

    Article  PubMed  CAS  Google Scholar 

  160. Cooper, D.S. (1984) Antithyroid drugs. N. Engl. J. Med., 311, 1353–62.

    Article  PubMed  CAS  Google Scholar 

  161. Rosove, M.H. (1977) Agranulocytosis and antithyroid drugs. West J. Med., 126, 339–43.

    PubMed  CAS  Google Scholar 

  162. Cooper, D.S., Goldminz, D., Levin, A.A. et al. (1983) Agranulocytosis associated with antithyroid drugs: effects of patient age and drug dose. Ann. Intern. Med., 98, 26–9.

    Article  PubMed  CAS  Google Scholar 

  163. International agranulocytosis and aplastic anaemia study (1980) Risk of agranulocytosis and aplastic anaemia in relation to use of antithyroid drugs. Br. Med. J., 297, 262–5.

    Google Scholar 

  164. Weiss, M., Hassin, D. and Bank, H. (1980) Propylthiouracil-induced hepatic damage. Arch. Intern. Med., 140, 1184–5.

    Article  PubMed  CAS  Google Scholar 

  165. Hanson, J.S. (1984) Propylthiouracil and hepatitis: two cases and a review of the literature. Arch. Intern. Med., 144, 994–6.

    Article  PubMed  CAS  Google Scholar 

  166. Orrego, H., Blake, J.E., Blendis, L.M. et al. (1987) Long-term treatment of alcoholic liver disease with propylthiouracil. N. Engl. J. Med., 317, 1421–7.

    Article  PubMed  CAS  Google Scholar 

  167. Mazzaferri, E.L., Reynolds, J.C., Young, R.L. et al. (1976) Propranolol as primary therapy for thyrotoxicosis. Results of a long-term prospective trial. Arch. Intern. Med., 136, 50–6.

    Article  PubMed  CAS  Google Scholar 

  168. Jones, M.K., Birthwell, J., Owens, D.R. et al. (1981) Beta-adrenergic blocking drugs and thyroid hormones in hyperthyroid subjects. Postgrad. Med. J., 57, 207–9.

    Article  PubMed  CAS  Google Scholar 

  169. Eriksson, M., Rubenfeld, S., Garber, A.J. et al. (1977) Propranolol does not prevent thyroid storm. N. Engl. J. Med., 296, 263–4.

    Article  PubMed  CAS  Google Scholar 

  170. Rubenfeld, S., Silverman, V.E., Welch, K.M.A. et al. (1979) Variable plasma propranolol levels in thyrotoxicosis. N. Engl. J. Med., 300, 353–4.

    Article  PubMed  CAS  Google Scholar 

  171. Burrow, G.N., Burke, W.R., and Himmelhoch, J.M. (1971) Effect of lithium on thyroid function. J. Clin. Endocrinol. Metab., 32, 647–52.

    Article  PubMed  CAS  Google Scholar 

  172. James, R.J. and Darken, R.A. (1976) Lithium carbonate and hypothyroidism. Med. J. Aust., 1, 266–7.

    PubMed  CAS  Google Scholar 

  173. Spaulding, S.W., Burrow, G.N., Bermudez, F. et al. (1972) The inhibitory effect of lithium on thyroid hormone release in both euthyroid and thyrotoxic patients. J. Clin. Endocrinol. Metab., 35, 905–11.

    Article  PubMed  CAS  Google Scholar 

  174. Kristensen, O., Andersen, H.H. and Pallis-gaard, G. (1976) Lithium carbonate in the treatment of thyrotoxicosis: a controlled trial. Lancet, 1, 603–5.

    Article  PubMed  CAS  Google Scholar 

  175. Turner, J.C. and Brownlie, B.E.W. (1976) Lithium and thyrotoxicosis, Lancet, 2, 904.

    Article  PubMed  CAS  Google Scholar 

  176. Turner, J.G., Brownlie, B.E.W., Rogers, T.G.H. (1976) Lithium as an adjuvant to radioiodine therapy for thyrotoxicosis, Lancet, 1, 614–15.

    Article  PubMed  CAS  Google Scholar 

  177. Hertz, S. and Roberts, A. (1942) Application of radioactive iodine in the therapy of Graves’ disease. J. Clin, Invest., 26, 624.

    Google Scholar 

  178. Hamilton, J.G. and Lawrence, J.H. (1942) Recent clinical developments in the therapeutic application of radiophosphorus and radioiodine. J. Clin. Invest., 26, 624.

    Google Scholar 

  179. Chapman, E.M. (1983), History of the discovery and early use of radioactive iodine. JAMA, 250, 2042–4.

    Article  PubMed  CAS  Google Scholar 

  180. Chapman, E.M. and Evans, R.D. (1946) The treatment of hyperthyroidism with radioactive iodine. JAMA, 131, 86–91.

    Article  CAS  Google Scholar 

  181. Greig, W.R., Smith, J.F.B., Gillespie, F.C. et al. (1969) Iodine-125 for thyrotoxicosis, Lancet, 1, 755–7.

    Article  PubMed  CAS  Google Scholar 

  182. Chapman, E.M. and Maloof, F. (1955) The use of radioactive iodine in the diagnosis and treatment of hyperthyroidism: ten years’ experience. Medicine, 34, 261–321.

    Article  PubMed  CAS  Google Scholar 

  183. Beling, U. and Einhorn, J. (1961) Incidence of hypothyroidism and recurrences following 131I treatment of hyperthyroidism. Acta Radiologica, 56, 275–88.

    Article  PubMed  CAS  Google Scholar 

  184. Green, M. and Wilson, G.M. (1964) Thyrotoxicosis treated by surgery or 131I: with special reference to the development of hypothyroidism. Br. Med. J., 1, 1005–10.

    Article  PubMed  CAS  Google Scholar 

  185. Dunn, J.T. and Chapman, E.M. (1964) Rising incidence of hypothyroidism after radioactive iodine. N. Engl. J. Med., 271, 1037–42.

    Article  PubMed  CAS  Google Scholar 

  186. Nofal M.M., Beierwaltes, W.H. and Patno, M.E. (1966) Treatment of hyperthyroidism with sodium iodide 131I. JAMA, 197, 605–10.

    Article  PubMed  CAS  Google Scholar 

  187. Bronsky, D., Kiamko, R.T. and Waldstein, S.S. (1968) Post-therapeutic myxedema. Arch. Intern. Med., 121, 113–17.

    Article  PubMed  CAS  Google Scholar 

  188. Blahd, W.H. and Hays, M.T. (1972) Graves’ disease in the male. Arch. Intern. Med., 129, 33–40.

    Article  PubMed  CAS  Google Scholar 

  189. Teczan, U.P., Frelick, R.N. and Mecklenburg, R.C. (1967) Low dose therapy for hyperthyroidism. Del Med. J., 39, 142–6.

    Google Scholar 

  190. Zellman, H.E., Matiz, H., Bartels, E.C. et al. (1968) Radioactive iodine in hyperthyroidism Lahey Clin. Foun. Bull, 17, 137–43.

    Google Scholar 

  191. Goolden, A.N.C. and Fraser, T.R. (1969) Treatment of thyrotoxicosis with low doses of radioactive iodine. Br. Med. J., 3, 442–3.

    Article  PubMed  CAS  Google Scholar 

  192. Rapoport, B., Caplan, R. and DeGroot, L.J. (1973) Low-dose sodium iodideI-131 therapy in Graves’ disease. JAMA, 224, 1610–13.

    Article  PubMed  CAS  Google Scholar 

  193. Cevallos, J.L., Hagen, G.A., Maloof, F. et al. (1974) Low-dosage 131I therapy of thyrotoxicosis (diffuse goiters). N. Engl. J. Med., 290, 141–3.

    Article  PubMed  CAS  Google Scholar 

  194. Lowe, D.C., Montgomery, D.A.D., Hadden, D.R. et al. (1971) Hyperthyroidism treated with propranolol and a 2.5 millicurie dose of radioactive iodine, Paper 18, Fourth European Thyroid Association Meeting, Berne, Switzerland.

    Google Scholar 

  195. Von Hofe, S.E., Dorfman, S.G., Carretta, R.F. et al. (1978) The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. J. Nucl. Med., 19, 180–4.

    Google Scholar 

  196. Kendall-Taylor, P., Keir, M.J. and Ross, W.M. (1984) Ablative radioiodine therapy for hyperthyroidism: long term follow up study. Br. Med. J., 289, 361–3.

    Article  CAS  Google Scholar 

  197. Roudebush, C.P., Hoye, K.E. and DeGroot, L.J. (1977) Compensated low-dose 131I therapy of Graves’ disease. Ann. Intern. Med., 87, 441–3.

    Article  PubMed  CAS  Google Scholar 

  198. Scott, G.R., Forfar, J.C. and Toft, A.D. (1984) Graves’ disease and atrial fibrillation: the case for even higher doses of therapeutic iodine-131. Br. Med. J., 289, 399–400.

    Article  CAS  Google Scholar 

  199. Cunnien, A.J., Hay, I.D., Gorman, C.A. et al. (1982) Radio-iodine induced hypothyroidism in Graves’ disease: factors associated with the increasing incidence. J. Nucl. Med., 23, 978–83.

    PubMed  CAS  Google Scholar 

  200. Sridama, V., McCormick, M., Kaplan, E.L. et al. (1984) Long-term follow-up of compensated low-dose 131I therapy for Graves’ disease. N. Engl. J. Med., 311, 426–32.

    Article  PubMed  CAS  Google Scholar 

  201. Smith, R.N. and Wilson, G.M. (1967) Clinical trial of different doses of 131I in the treatment of thyrotoxicosis. Br. Med. J., 1, 129–32.

    Article  PubMed  CAS  Google Scholar 

  202. Holm, I.-E., Lundell, G., Israelsson, A. et al. (1982) Incidence of hypothyroidism occurring long after iodine-131 therapy for hyperthyroidism. J. Nucl. Med., 23, 103–7.

    PubMed  CAS  Google Scholar 

  203. Holm, I.-E. (1982) Changing annual incidence of hypothyroidism after iodine-131 therapy for hyperthyroidism. 1951–75. J. Nucl. Med., 23, 108–12.

    PubMed  CAS  Google Scholar 

  204. Staffurth, J.S. (1987) Hypothyroidism following radioiodine treatment of thyrotoxicosis. J. Roy. Coll, Phys., 21, 55–7.

    CAS  Google Scholar 

  205. Shafer, R.B. and Nuttall, F.Q. (1971) Thyroid crisis induced by radioactive iodine. J. Nucl. Med., 12, 262–4.

    PubMed  CAS  Google Scholar 

  206. Hayek, A. (1978) Thyroid storm following radioiodine for thyrotoxicosis. J. Pediatrics, 93, 978–80.

    Article  CAS  Google Scholar 

  207. McDermott, M.T., Kidd, G.S., Dodson, L.E. Jr. et al. (1983) Radioiodine-induced thyroid storm: case report and literature review. Am. J. Med., 75, 353–9.

    Article  PubMed  CAS  Google Scholar 

  208. Crooks, J., Buchanan, W.W., Wayne, E.J. et al. (1960) Effect of pretreatment with methyl-thiouracil on results of 131I therapy. Br. Med. J., 1, 151–4.

    Article  PubMed  CAS  Google Scholar 

  209. Steinbach, J.J., Donoghue, G.D., Goldman, J.K. (1979) Simultaneous treatment of toxic diffuse goiter withI-131 and antithyroid drugs: a prospective study. J. Nucl. Med., 20, 1263–7.

    PubMed  CAS  Google Scholar 

  210. Cassidy, C.E. and Astwood, E.B. (1959) Evaluation of radioactive iodine (131I) as a treatment for thyrotoxicosis. N. Engl. J. Med., 261, 53–8.

    Article  PubMed  CAS  Google Scholar 

  211. Sheeler, L.B. and Skillern, P.G. (1984) Radioiodine-induced thyroid storm, a point of controversy (letter). Am. J. Med., 76, A69.

    Article  Google Scholar 

  212. Volpe, R., Schatz, D.L., Scott, A. et al. (1960) Radioactive iodine in the treatment of hyperthyroidism. Can. Med. Ass.]., 83, 1407–13.

    CAS  Google Scholar 

  213. Goolden, A.W., Mallard, J.R. and Farran, H.E.A. (1957) Radiation sialitis following radioiodine therapy. Br. J. Radiol., 30, 210–12.

    Article  PubMed  CAS  Google Scholar 

  214. Rigler, R.G. and Scanion, P.W. (1955) Radiation parotitis from radioactive iodine therapy. Mayo Clin. Proc., 30, 149–53.

    CAS  Google Scholar 

  215. Silver, S. (1968) Treatment of hyperthyroidism with 131I, in Radioactive Nuclides in Medicine and Biology, vol 2, 3rd edn, Lea and Febiger, Philadelphia, pp. 144–94.

    Google Scholar 

  216. Snyder, S. (1978) Vocal cord paralysis after radioidine therapy. J. Nucl. Med., 19, 975–6.

    PubMed  CAS  Google Scholar 

  217. Robson, A.M. (1981) Vocal-cord paralysis after treatment of thyrotoxicosis with radioidine. Br. J. Radiol., 54, 632.

    Article  PubMed  CAS  Google Scholar 

  218. Freeman, M., Giuliani, M., Schwartz, E. et al. (1969) Acute thyroiditis, thyroid crisis, and hypocalcemia following radioactive iodine therapy. N.Y. State J. Med., 69, 2036–41.

    PubMed  CAS  Google Scholar 

  219. Gilbert-Dreyfus, Zara M., Gali, P. (1958) Cateracte tétanique après IRA-thérapie. Semaine Hop. Paris, 34, 1301–4.

    PubMed  CAS  Google Scholar 

  220. Townsend, J. (1962) Hypoparathyroidism following radioactive iodine therapy for intractable angina pectoris. Ann. Intern. Med., 55, 662–3.

    Article  Google Scholar 

  221. Committee on the Biological Effects of Ionizing Radiation (1980) The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, National Academy of Sciences, Washington DC.

    Google Scholar 

  222. Saenger, E.L., Thoma, G.E. and Tomkins E.A. (1968) Incidence of leukemia following treatment of hyperthyroidism: preliminary report of the Cooperative Thyrotoxicosis Follow-up Study, JAMA, 205, 147–54.

    Article  Google Scholar 

  223. Pochin, E.E. (1960) Leukaemia following radioactive treatment of thyrotoxicosis. Br. Med. J., 2, 1545–50.

    Article  PubMed  CAS  Google Scholar 

  224. Werner, S.C., Gittleshon, A.M. and Brill, A.B. (1961) Leukemia following radioiodine therapy of hyperthyroidism. JAMA, 177, 646–9.

    Article  PubMed  CAS  Google Scholar 

  225. McCormack, K.R. and Sheline, G.E. (1963) Leukemia after radioiodine therapy for hyperthyroidism. Calif. Med., 98, 267–8.

    Google Scholar 

  226. Boyd, E., Buchanan, W.W. and Lennox, B. (1966) Damage to chromosomes by therapeutic doses of radioiodine. Lancet, 1, 977–8.

    Google Scholar 

  227. Maclntyre, M.N. and Dobyns, B.M. (1962) Anomalies in chromosomes of the circulating leukocytes in man following large doses of radioactive iodine. J. Clin. Endocrinol. Metab., 22, 1171–81.

    Article  Google Scholar 

  228. Nofal, N.M. and Beierwaltes, W.H. (1964) Persistent chromosomal aberrations following radioiodine therapy. J. Nucl. Med., 5, 840–50.

    PubMed  CAS  Google Scholar 

  229. Cantolino, S.J., Schmickel, R.D., Ball, M. et al. (1966) Persistent chromosomal aberrations following radioiodine therapy for thyrotoxicosis. N. Engl. J. Med., 275, 739–45.

    Article  PubMed  CAS  Google Scholar 

  230. Boyd, E., Ferguson-Smith, M.A., McDougall, I.R. et al. (1974) Chromosome breakage in human peripheral lymphocytes after radioactive iodine 125I therapy. Radiation Res., 57, 482–7.

    Article  PubMed  CAS  Google Scholar 

  231. Dobyns, B.M., Sheline, G.E., Workman, J.B. et al. (1974) Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the Cooperative Thyrotoxicosis Therapy Follow-up Study. J. Clin. Endocrinol. Metab., 38, 976–98.

    Article  PubMed  CAS  Google Scholar 

  232. Holm, L-E., Dahlqvist, I., Israelsson, A. et al. (1980) Malignant thyroid tumors after iodine-131 therapy. A retrospective cohort study. N. Engl. J. Med., 303, 188–91.

    Article  PubMed  CAS  Google Scholar 

  233. Holm, L-E. (1984) Malignant disease following iodine-131 therapy in Sweden, in Radiation Carcinogenesis: Epidemiology and Biological Significance, (eds J.D. Boice Jr and J.F. Fraument Jr) Raven Press, New York, pp. 263–71.

    Google Scholar 

  234. McDougall, I.R., Nelsen, T.S. and Kempson, R.L. (1981) Papillary carcinoma of the thyroid seven years after I-131 therapy for Graves’ disease. Clin. Nucl. Med., 6, 368–71.

    Article  PubMed  CAS  Google Scholar 

  235. Tomlison, C., Knowles, K.W. and McDougall, I.R. (1991) Papillary cancer in a patient treated with radioiodine for Graves’ hyperthyroidism: case report and a review of the risk. Clin. Nuc. Med., in press.

    Google Scholar 

  236. Hoffman, D.A., McConahey, W.M., Diamond, E.L. et al. (1982) Mortality in women treated for hyperthyroidism. Am. J. Epidemiol, 115, 243–54.

    PubMed  CAS  Google Scholar 

  237. Hoffman, D.A. (1984) Late effects ofI-131 therapy in the United States, in Radiation Carcinogenesis; Epidemiology and Biological Significance, (eds J.D. Boice Jr and J.F. Fraument Jr), Raven Press, New York, pp. 273–80.

    Google Scholar 

  238. Robertson, J.S. and Gorman, C.A. (1976) Gonadal radiation dose and its genetic significance in radioiodine therapy of hyperthyroidism. J. Nucl. Med., 17, 826–35.

    PubMed  CAS  Google Scholar 

  239. Henneman, G., Krenning, E.P. and Sankara-narayanan, K. (1986) Place of radioactive iodine in the treatment of thyrotoxicosis. Lancet, 1, 1369–72.

    Article  Google Scholar 

  240. Chapman, E.M. (1971) Treatment of hyperthyroidism with radioactive iodine, in Nuclear Medicine, 2nd edn, (ed. W.H. Blahd), McGraw-Hill Book Company, New York, pp. 711–34.

    Google Scholar 

  241. Safa, A.M., Schumaker, O.P. and Rodriguez-Antunez, A. (1975) Long-term follow-up results in children and adolescents treated with radioactive iodine (131I) for hyperthyroidism. N. Engl. J. Med., 292, 167–71.

    Article  PubMed  CAS  Google Scholar 

  242. Gillespie, F.C., Orr, J.S. and Greig, W.R. (1970) Microscopic dose distribution from 125I in the toxic thyroid gland and its relation to therapy. Br. J. Radiol., 43, 40–7.

    Article  PubMed  CAS  Google Scholar 

  243. McDougall, I.R. and Greig, W.R. (1976) 125I therapy in Graves’ disease: long-term results in 355 patients. Ann. Intern. Med., 85, 720–3.

    Article  PubMed  CAS  Google Scholar 

  244. Lewitus, Z., Lubin, E., Rechnic, J. et al. (1971) Treatment of thyrotoxicosis with 125I and 131I. Sem. Nucl. Med., 1, 411–21.

    Article  CAS  Google Scholar 

  245. Weidinger, P., Johnson, P.M. and Werner, S.C. (1974) Five years’ experience with iodine-125 therapy of thyrotoxic Graves’ disease. Lancet, 2, 74–7.

    Article  PubMed  CAS  Google Scholar 

  246. Siemsen, J.K., Wallack, M.S., Martin, R.B. et al. (1974) Early results of 125I therapy of thyrotoxic Graves’ disease. J. Nucl. Med., 15, 257–60.

    PubMed  CAS  Google Scholar 

  247. NRCP Report No. 37 (1970) Precautions in the Management of Patients who have Received Therapeutic Amounts of Radionuclides, October 1, and second reprinting 15 March 1978.

    Google Scholar 

  248. Stoffer, S.S., Hamburger, J.I. (1976) Inadvertent 131I therapy for hyperthyroidism in the first trimester of pregnancy. J. Nucl. Med., 17, 146–9.

    PubMed  CAS  Google Scholar 

  249. Mountford, P.J. and Coakley, A.J. (1989) A review of the secretion of radioactivity in human breast milk: data. quantitative analysis and recommendations. Nucl. Med. Comm., 10, 15–27.

    Article  CAS  Google Scholar 

  250. Halstead, S. (1920) The operative story of goiter; the author’s operation, Johns Hopkins. Hosp. Rep., 19, 71–257.

    Google Scholar 

  251. Mansberger, A.R. (1988) One hundred years of surgical management of hyperthyroidism. Ann. Surg., 207, 724–9.

    Article  PubMed  Google Scholar 

  252. Mayo, C.H. (1905) Goiter: with preliminary report of one hundred and eighty-two operations on the thyroid. Trans South Surg. Gyn. Assoc, 18, 145–66.

    Google Scholar 

  253. Mayo C.H. (1908) A consideration of the mortality in one thousand operations for goiter. Trans South Surg. Gyn. Assoc, 21, 275–87.

    Google Scholar 

  254. Lahey, F.H. (1931) How much tissue should be removed in toxic goiter? Trans South Surg. Assoc, 44, 258–70.

    Google Scholar 

  255. Plummer, H.S. (1923) Results of administering iodine to patients having exophthalmic goiter. JAMA, 80, 1955.

    Google Scholar 

  256. Reeve, T.S. (1988) Surgical treatment for thyrotoxicosis. Br. J. Surg., 75, 833–4.

    Article  PubMed  CAS  Google Scholar 

  257. Green, M. and Wilson, G.M. (1964) Thyrotoxicosis treated by surgery or iodine-131 with special reference to the development of hypothyroidism. Br. Med. J., 1, 1005–10.

    Article  PubMed  CAS  Google Scholar 

  258. Bowers, R.F. (1966) Surgical treatment of hyperthyroidism: follow up of 103 cases. Am. Surgeon, 32, 89–95.

    PubMed  CAS  Google Scholar 

  259. McNeil, A.D. and Thomson, J.A. (1968) Long-term follow up of surgically treated thyrotoxic patients. Br. Med. J., 3, 643–6.

    Article  Google Scholar 

  260. Buchanan, W.W., Koutras, D.A., Crooks, J. et al. (1962) The clinical significance of the complement fixation test in thyrotoxicosis. J. Endocrinol., 24, 115–25.

    Article  PubMed  CAS  Google Scholar 

  261. Irvine, W.J., MacGregor, A.G. and Stuart, A.E. (1962) The prognostic significance of thyroid antibodies in the management of thyrotoxicosis. Lancet., 2, 843–7.

    Article  PubMed  CAS  Google Scholar 

  262. Greene, R. (1950) The significance of lym-phadenoid changes in the thyroid gland. J. Endocrinol., 7, 1–6.

    Article  PubMed  CAS  Google Scholar 

  263. Olsen, W.R., Nishiyama, R.H., Graber, L.W. et al. (1970) Thyroidectomy for hyperthyroidism. Arch. Surg., 101, 175–80.

    Article  PubMed  CAS  Google Scholar 

  264. Hedley, A.J., Flemming, C.J., Chester, M.I. et al. (1970) Surgical treatment of thyrotoxicosis. Br. Med. J., 1, 519–23.

    Article  PubMed  CAS  Google Scholar 

  265. Hedley, A.J., Ross, I.P., Beck, J.S. et al. (1971) Recurrent thyrotoxicosis after subtotal thyroidectomy. Br. Med. J., 4, 258–61.

    Article  PubMed  CAS  Google Scholar 

  266. Lee, T.C., Coffey, R.J., Currier, B.M. et al. (1982) Propranolol and thyroidectomy in the treatment of thyrotoxicosis. Ann. Surg., 195, 766–72.

    Article  PubMed  CAS  Google Scholar 

  267. Bradley, E.L. III, Di Girolamo, M. and Tar-can, Y. (1980) Modified subtotal thyroidectomy in the management of Graves’ disease. Surgery, 87, 623–9.

    PubMed  Google Scholar 

  268. Ozoux, J.P., de Calan L., Portier, G. et al. (1988) Surgical treatment of Graves’ disease. Am. J. Surg., 156, 177–81.

    Article  PubMed  CAS  Google Scholar 

  269. McLarty, D.G., Alexander, W.D., Harden, R. McG. et al. (1969) Results of treatment of thyrotoxicosis after post-operative relapse. Br. Med. J., 3, 200–3.

    Article  PubMed  CAS  Google Scholar 

  270. Gould, E.A., Hirsch, E., Brecher, I. et al. (1965) Complications arising in the course of thyroidectomy. Arch. Surg., 90, 81–5.

    Article  PubMed  CAS  Google Scholar 

  271. Painter, N.S. (1960) The results of surgery in the treatment of toxic goitre: a review of 172 cases. Br. J. Surg., 48, 291–6.

    Article  PubMed  CAS  Google Scholar 

  272. Riddell, V. (1965) The selection of patients for thyroidectomy. Br. J. Surg., 52, 721–7.

    Article  PubMed  CAS  Google Scholar 

  273. Wade, J.H.S. (1965) Three major complications of thyroidectomy. Br. J. Surg., 52, 727–31.

    Article  PubMed  CAS  Google Scholar 

  274. Michie, W., Pegg, C.A.S. and Bewsher, P.D. (1972) Prediction of hypothyroidism after partial thyroidectomy for thyrotoxicosis. Br. Med. J., 1, 13–17.

    Article  PubMed  CAS  Google Scholar 

  275. McDougall, I.R. and Bayer, M.F. (1986) Should a woman taking propylthiouracil breast feed? Clin. Nucl. Med., 11, 249–50.

    Article  PubMed  CAS  Google Scholar 

  276. Michie, W., Hammer-Hodges, D.W., Pegg, C.A.S. et al. (1974) Beta-blockade and partial thyroidectomy for thyrotoxicosis. Lancet, 1, 1009–11.

    Article  PubMed  CAS  Google Scholar 

  277. Toft, A.D., Irvine, W.J., Sinclair, I. et al. (1978) Thyroid function after surgical treatment of thyrotoxicosis: a report of 100 cases treated with propranolol before operation. N. Engl. J. Med., 298, 643–7.

    Article  PubMed  CAS  Google Scholar 

  278. Jamison, M. and Done, H.J. (1979) Postop thyrotoxic crisis in a patient prepared for thyroidectomy with propranolol. Br. J. Clin. Pract., 33, 82–3.

    PubMed  CAS  Google Scholar 

  279. Feek, C.M., Sawers, J.S., Irvine, W.J. et al. (1980) Combination of potassium iodide and propranolol in preparation of patients with Graves’ disease for thyroid surgery. N. Engl. J. Med., 302, 883–5.

    Article  PubMed  CAS  Google Scholar 

  280. Unger, J., Couturier, E., Durez, M. et al. (1981) Failure to reach euthyroidism with potassium iodide and propranolol in preparation of a patient with Graves’ disease for surgery, (letter). J. Endocrinol Invest., 4, 367.

    PubMed  CAS  Google Scholar 

  281. Feek, C.M. and Toft, A.D. (1981) Response to previous reference. J. Endocrinol. Invest., 4, 367–8.

    Google Scholar 

  282. Plummer, H.S. (1913) The clinical and pathological relationships of hyperplastic and non hyperplastic goiter. JAMA, 61, 650–1.

    Article  Google Scholar 

  283. Hamburger, J.I. (1987) The autonomously functioning thyroid nodule: Goetsch’s disease. Endocrine Reviews, 8, 439–47.

    Article  PubMed  CAS  Google Scholar 

  284. Goetsch, E. (1916) Functional significance of mitochondria in toxic thyroid adenomata: preliminary report. Johns Hopkins Hosp. Rep., 27, 129–33.

    Google Scholar 

  285. Goetsch, E. (1918) Newer methods in the diagnosis of thyroid disorders: pathological and clinical. N.Y. State J. Med., 18, 259–67.

    Google Scholar 

  286. Boothby, W. (1921) Adenoma of the thyroid with hyperthyroidism (thyrotoxic adenoma). Endocrinology, 5, 1–20.

    Article  CAS  Google Scholar 

  287. Scott, R.S., Brownlie, B.E.W. and Bremner, J.M. (1978) Toxic autonomous thyroid nodule following neck irradiation. Aust. N.Z.J. Med., 8, 521–2.

    Article  PubMed  CAS  Google Scholar 

  288. Nagai, G.R., Pitts, W.C., Basso, L. et al. (1987) Scintigraphic hot nodules and thyroid cancer. Clin. Nucl. Med., 12, 123–7.

    Article  PubMed  CAS  Google Scholar 

  289. Blum, M., Shenkman, L. and Hollander, C.S. (1975) The autonomous nodule of the thyroid: correlation of patient age, nodule size and functional status. Am. J. Med. Sci., 269, 43–50.

    Article  PubMed  CAS  Google Scholar 

  290. Bransom, C.J., Talbot, C.H., Henry, L. et al. (1979) Solitary toxic adenoma of the thyroid. Br. J. Surg., 66, 590–5.

    Article  Google Scholar 

  291. Burman, K.D., Earll, J.M., Johnson, M.C. et al. (1974) Clinical observations on the solitary autonomous thyroid nodule. Arch. Intern. Med., 134, 915–19.

    Article  PubMed  CAS  Google Scholar 

  292. Goldstein, R. and Hart, I.R. (1983) Follow-up of solitary autonomous thyroid nodules treated with 131I. N. Engl. J. Med., 309, 1473–76.

    Article  PubMed  CAS  Google Scholar 

  293. Hamburger, J.I. (1980) Evolution of toxicity in solitary non toxic autonomously functioning nodules. J. Clin. Endocrinol. Metab., 50, 1089–93.

    Article  PubMed  CAS  Google Scholar 

  294. Psarras, A., Papadopoulos, S.H., Livadas, D. et al. (1972) The single thyroid nodule. Br. J. Surg., 59, 545–8.

    Article  PubMed  CAS  Google Scholar 

  295. Ramsay, I., Marsden, P., Richardson, P.J. et al. (1972) Thyroid ‘hot’ nodules. Postgrad. Med, J., 48, 577–83.

    Article  CAS  Google Scholar 

  296. Blum, M. and Nocero, M.A. (1974) Spontaneous resolution of a euthyroid autonomous nodule of the thyroid. Am. J. Med. Sci., 264, 49–54.

    Article  Google Scholar 

  297. Soin, J.S., Beal, W. and Burdine, J.A. (1974) Disappearance of autonomous thyroid nodule under TSH stimulation. J. Nucl. Med., 15, 1209–11.

    PubMed  CAS  Google Scholar 

  298. Kammer, H. and Loveless, M.D. (1978) Disappearance of a hyperfunctioning thyroid nodule following TSH stimulation. J. Nucl. Med., 19, 1149–50.

    PubMed  CAS  Google Scholar 

  299. McCormack, K.R. and Sheline, G.E. (1967) Long-term studies of solitary autonomous thyroid nodules. J. Nucl. Med., 8, 701–8.

    PubMed  CAS  Google Scholar 

  300. Silverstein, G.E., Burke, G. and Cogan, R. (1967) The natural history of the autonomously hyperfunctioning thyroid nodule. Ann. Intern. Med., 67, 539–48.

    Article  PubMed  CAS  Google Scholar 

  301. Wiener, J.D. and De Vries, A.A.A. (1979) On the natural history of Plummer’s disease. Clin. Nucl. Med., 4, 181–90.

    Article  PubMed  CAS  Google Scholar 

  302. Hamburger, J.I. and Taylor, C.I. (1979) Transient thyrotoxicosis associated with acute hemorrhagic infarction of autonomously functioning thyroid nodule. Ann. Intern, Med., 91, 406–9.

    Article  CAS  Google Scholar 

  303. Abe, K., Konno, M., Sato, T. et al. (1980) Hyperfunctioning thyroid nodules in children. Am. J. Dis. Child, 134, 961–3.

    PubMed  CAS  Google Scholar 

  304. Popma, B.H., Cloutier, M.D. and Hayles, A.B. (1973) Thyroid nodule producing T3 toxicosis in a child. Mayo Clin. Proc., 48, 273–5.

    PubMed  CAS  Google Scholar 

  305. Shambaugh, G.E., Quinn, J.L., Oyasu, R. et al. (1974) Disparate thyroid imaging. Combined studies with pertechnetate Tc-99m and radioactive iodine. JAMA, 228, 866–9.

    Article  PubMed  Google Scholar 

  306. Barth, J.D., Bakker, W.H. and Henneman, G. (1978) Discrepancies between iodine and technetium thyroid scintigraphy. JAMA, 240, 463–4.

    Article  PubMed  CAS  Google Scholar 

  307. Erjavic, M., Mavrin, T., Auersperg, M. et al. (1977) Comparative accumulation of 99mTc and 131I in thyroid nodules: case report. J. Nucl. Med., 18, 346–7.

    Google Scholar 

  308. Sterling, K., Refetoff, S., Selenkow, H.A. (1970) Thyrotoxicosis due to elevated serum triiodothyronine levels. JAMA, 213, 571–5.

    Article  PubMed  CAS  Google Scholar 

  309. Larsen, P.R. (1972) Triiodothyronine, review of recent studies of its physiology and pathophysiology in man. Metabol., 21, 1073–92.

    Article  CAS  Google Scholar 

  310. Means, J.H. (1970) Thyroidology 1950 The Pharos Nov.

    Google Scholar 

  311. Miller, J.M. and Hamburger, J.I. (1965) The thyroid scintigram. 1. The hot nodule. Radiol., 84, 66–73.

    CAS  Google Scholar 

  312. Landgarten, S. and Spencer, R.P. (1973) A study of the natural history of ‘hot’ thyroid nodules. Yale J. Biol. Med., 46, 259–63.

    PubMed  CAS  Google Scholar 

  313. Perlmutter, M. and Slater, S.L. (1956) Which nodular goiter should be removed? N. Engl. J. Med., 255, 65–71.

    Article  PubMed  CAS  Google Scholar 

  314. Livadas, D.P., Kotoulas, O.B., Bouropoulou, V. et al. (1977) The coexistence of thyroid malignancy with autonomous hot nodules of the thyroid. Clin. Nucl. Med., 2, 350–4.

    Article  Google Scholar 

  315. Kendall, L.W. and Condon, R.E. (1969) Prediction of malignancy in solitary thyroid nodules. Lancet, 1, 1071–3.

    Article  PubMed  CAS  Google Scholar 

  316. Becker, F.O., Economou, P.G. and Schwartz, T.B. (1963) The occurrence of carcinoma in ‘hot’ thyroid nodules. Ann. Intern. Med., 58, 877–82.

    Article  PubMed  CAS  Google Scholar 

  317. Sandler, M.P., Fellmeth, B., Salhany, K.E. et al. (1988) Thyroid carcinoma masquerading as a solitary benign hyperfunctioning nodule. Clin. Nucl. Med., 13, 410–15.

    Article  PubMed  CAS  Google Scholar 

  318. Eyre-Brook, I.A. and Talbot, C.H. (1982) The treatment of autonomously functioning thyroid nodules. Br. J. Surg., 69, 577–9.

    Article  PubMed  CAS  Google Scholar 

  319. Skillern, P.G., McCullagh, E.P. and Clamen, M. (1962) Radioiodine in diagnosis and therapy of hyperthyroidism. Arch. Intern. Med., 110, 888–97.

    Article  PubMed  CAS  Google Scholar 

  320. Gorman, C.A. and Robertson, J.S. (1978) Radiation dose in the selection of 131I or surgical treatment for toxic thyroid adenoma. Ann. Intern. Med., 89, 85–90.

    Article  PubMed  CAS  Google Scholar 

  321. Ratcliffe, G.E., Cooke, S., Fogelman, I. et al. (1986) Radioiodine treatment of solitary functioning thyroid nodules. Br. J. Radiol., 59, 385–7.

    Article  PubMed  CAS  Google Scholar 

  322. Ross, D.S., Ridgway, E.C. and Daniels, G.H. (1984) Successful treatment of solitary toxic nodules with relatively low-dose iodine-131, with low prevalence of hypothyroidism. Ann. Intern. Med., 101, 488–90.

    Article  PubMed  CAS  Google Scholar 

  323. Wiener, J.D. (1985) Long-term follow-up after iodine-131 treatment for Plummer’s disease (autonomous goiter). Clin. Nucl. Med., 10, 256–9.

    Article  PubMed  CAS  Google Scholar 

  324. Hamburger, J.I. and Hamburger, S.W. (1985) Diagnosis and management of large toxic multinodular nodules. J. Nucl. Med., 26, 888–92.

    PubMed  CAS  Google Scholar 

  325. Hamburger, J.I. and Meier, D.A. (1971) Cancer following treatment of an autonomously functioning thyroid nodule with sodium iodideI-131. Arch. Surg., 103, 762–4.

    Article  PubMed  CAS  Google Scholar 

  326. Blum, M., Kranjac, T., Park, C.M. et al. (1976) Thyroid storm after cardiac angiography with iodinated contrast medium: occurrence in a patient with a previously euthyroid autonomous nodule of the thyroid. JAMA, 235, 2324

    Article  PubMed  CAS  Google Scholar 

  327. Jensen, M.D., Gharib, H., Naessens, J.M. et al. (1986) Treatment of toxic multinodular goiter (Plummer’s disease): surgery or radioiodine? World]. Surg., 10, 673–80.

    Article  CAS  Google Scholar 

  328. Charkes, N.D. (1972) Graves’ disease with functioning nodules (Marine Lenhart syndrome). J. Nucl. Med., 13, 885–92.

    PubMed  CAS  Google Scholar 

  329. Cooper, D.S. (1988) Thyroid hormone and the skeleton: a bone of contention. JAMA, 259, 3137–41.

    Article  Google Scholar 

  330. Hay, I.D. (1988) Immunometric thyrotropin assays: current roles and future directions. Mayo Clin. Proc., 63, 1230–3.

    Article  PubMed  CAS  Google Scholar 

  331. Ross, D.S. (1988) Subclinical hyperthyroidism: possible danger of overzealous thyroxine replacement therapy. Mayo Clin. Proc., 63, 1223–9.

    Article  PubMed  CAS  Google Scholar 

  332. Fallon, M.D., Perry, H.M. III, Bergfeld, M. et al. (1983) Exogenous hyperthyroidism with osteoporosis. Arch. Intern. Med., 143, 442–4.

    Article  PubMed  CAS  Google Scholar 

  333. Paul, T.L., Kerrigan, J., Kelly, A.M. et al. (1988) Long-term L-thyroxine is associated with decreased hip bone density in premenopausal women. JAMA, 259, 3137–41.

    Article  PubMed  CAS  Google Scholar 

  334. Gorman, C.A., Wahner, H.W. and Tauxe, W.N. (1969) Metabolic malingerers. Patients who deliberately induce or perpetuate a hypermetabolic or hypometabolic state. Am. J. Med., 48, 708–14.

    Article  Google Scholar 

  335. Rose, E., Sanders, T.P., Webb, W.L. et al. (1969) Occult factitial thyrotoxicosis. Thyroxine kinetics and psychological evaluation in three cases. Ann. Intern. Med., 71, 309–15.

    Article  PubMed  CAS  Google Scholar 

  336. Harvey, R.F. (1973) Thyroxine ‘addicts’. Br. Med. J., 2, 35–6.

    Article  PubMed  CAS  Google Scholar 

  337. Mariotti, S., Martino, E., Cupini, C. et al. (1982) Low serum thyroglobulin as a clue to the diagnosis of thyrotoxicosis factitia. N. Engl. J. Med., 307, 410–12.

    Article  PubMed  CAS  Google Scholar 

  338. Kinney, J.S., Hurwitz, E.S., Fishbein, D.B. et al. (1988) Community outbreak of thyrotoxicosis: epidemiology, immunogenetic charac-teristics, and long-term outcome. Am. J. Med., 84, 10–18.

    Article  PubMed  CAS  Google Scholar 

  339. Hedberg, C.W., Fishbein, D.B., Janssen, R.S. et al. (1987) An outbreak of thyrotoxicosis caused by the consumption of bovine thyroid gland in ground beef. N. Engl. J. Med., 316, 993–8.

    Article  PubMed  CAS  Google Scholar 

  340. Shimaoka, K., Van Herle, A.J. and Dindo-gau, A. (1976) Thyrotoxicosis secondary to involvement of the thyroid gland with malignant lymphoma. J. Clin. Endocrinol. Metab., 43, 64–8.

    Article  PubMed  CAS  Google Scholar 

  341. Erikson, M., Ajmani, S.K. and Mallette, L.E. (1977) Hyperthyroidism from thyroid metastasis of pancreatic adenocarcinoma. JAMA, 238, 1276–8.

    Article  Google Scholar 

  342. Rosen, I.B., Strawbridge, H.G., Walfish, P.G. et al. (1978) Malignant pseudothyroidi-tis: a new clinical entity. Am. J. Surg., 136, 445–9.

    Article  PubMed  CAS  Google Scholar 

  343. Tibaldi, J.M., Shapiro, L.E. and Mahadevia, P.S. (1986) Thyroiditis mimicked by metastatic carcinoma to the thyroid. Mayo Clin. Proc., 61, 399–400.

    Article  PubMed  CAS  Google Scholar 

  344. Crapo, L. (1989) personal communication.

    Google Scholar 

  345. Watts, N.B. and Sewell, C.W. (1988) Carcinomatous involvement of thyroid presenting as subacute thyroiditis. Am. J. Med. Sci., 296, 126–8.

    Article  PubMed  CAS  Google Scholar 

  346. Oppenheim, A., Miller, M., Anderson, G.H. et al. (1983) Anaplastic thyroid cancer presenting with hyperthyroidism. Am. J. Med., 75, 702–4.

    Article  PubMed  CAS  Google Scholar 

  347. Kurtz, S.C. and Aber, R.C. (1982) Potassium iodide as a cause of prolonged fever. Arch. Intern. Med., 142, 1543–4.

    Article  PubMed  CAS  Google Scholar 

  348. Rasmussen, H. (1955) Iodide hypersensitivity in the etiology of periarteritis nodosa. J. Allergy Clin. Immunol, 26, 394–407.

    CAS  Google Scholar 

  349. Curd, J.G., Milgrom, H., Stevenson, D.D. et al. (1979) Potassium iodide sensitivity in four patients with hypocomplementemic vasculitis. Ann. Intern. Med., 91, 853–7.

    Article  PubMed  CAS  Google Scholar 

  350. Ingbar, S.H. (1972) Autoregulation of the thyroid: response to iodide excess and depletion. Mayo Clin. Proc., 47, 814–23.

    PubMed  CAS  Google Scholar 

  351. Sternthal, E., Lipworth, L., Stanley, B. et al. (1980) Suppression of thyroid radioiodine uptake by various doses of stable iodine. N. Engl. J. Med., 303, 1083–8.

    Article  PubMed  CAS  Google Scholar 

  352. Braverman, L.E., Ingbar, S.H., Vagenakis, A.G. et al. (1971) Enhanced susceptibility to iodine myxedema in patients with Hashimoto’s disease. J. Clin. Endocrinol. Metab., 32, 515–21.

    Article  PubMed  CAS  Google Scholar 

  353. Braverman, L.E., Woeber, K.A. and Ingbar, S.H. (1969) Induction of myxedema by iodide in patients euthyroid after radioiodine or surgical treatment of hyperthyroidism. N. Engl. J. Med., 281, 816–21.

    Article  PubMed  CAS  Google Scholar 

  354. Vagenakis, A.G., Wang, C., Burger, A. et al. (1972) Iodide-induced thyrotoxicosis in Boston. N. Engl, J. Med., 287, 523–7.

    Article  CAS  Google Scholar 

  355. Wilson, G.M. (1964) Two Scottish doctors and the English bronchocele. Scot. Med. J., 9, 96–102.

    PubMed  CAS  Google Scholar 

  356. Stewart, J.C. and Vidor, G.I. (1976) Thyrotoxicosis induced by iodine contamination of food — a common unrecognised condition. Br. Med. J., 1, 372–5.

    Article  PubMed  CAS  Google Scholar 

  357. Fradkin, J.E. and Wolff, J. (1983) Iodide-induced thyrotoxicosis. Medicine, 62, 1–20.

    Article  PubMed  CAS  Google Scholar 

  358. Martino, E., Aghini-Lombardi, F., Marriotti, S. et al. (1987) Amiodarone: a common source of iodine-induced thyrotoxicosis. Horm. Res., 26, 158–71.

    Article  PubMed  CAS  Google Scholar 

  359. Blum, M., Weinberg, U., Shenkman, L. et al. (1974) Hyperthyroidism after iodinated contrast material. N. Engl. J. Med., 291, 24–5.

    Article  PubMed  CAS  Google Scholar 

  360. Fairhurst, B.J. and Naqvi, N. (1975) Hyperthyroidism after cholecystography. Br. Med. J., 2, 630.

    Article  Google Scholar 

  361. Shetty, S.P., Murthy, G.G., Shreeve, W. et al. (1974) Hyperthyroidism after pyelography. N. Engl. J. Med., 292, 682.

    Google Scholar 

  362. Short, R. (1909) Jodoform and thyroidism. Br. Med. J., 2, 1469.

    Google Scholar 

  363. Miller, H.A., Farley, J.A. and Major, D.A. (1981) Topical iodine and hyperthyroidism. Ann. Intern. Med., 95, 121.

    Article  PubMed  CAS  Google Scholar 

  364. Reith, P.E. and Granner, D.K. (1985) Iodine-induced thyrotoxicosis in a woman with multinodular goiter taking levothyroxine. Arch. Intern. Med., 145, 355–6.

    Article  PubMed  CAS  Google Scholar 

  365. Edmunds, H.T. (1955) Acute thyroiditis from potassium iodide. Br. Med. J., 1, 354.

    Article  Google Scholar 

  366. Melmed, S., Nademanee, K., Reed, A.W. et al. (1981) Hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. J. Clin. Endocrinol. Metab., 53, 997–1001.

    Article  PubMed  CAS  Google Scholar 

  367. Nademanee, K., Singh, B.N., Hendrickson, J.A. et al. (1982) Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy. Circulation, 66, 202–11.

    Article  PubMed  CAS  Google Scholar 

  368. Martino, E., Aghini-Lombardi, F., Lippi, F. et al. (1985) Twenty-four hour radioactive iodine uptake in 35 patients with amiodarone associated thyrotoxicosis. J. Nucl. Med., 26, 1402–7.

    PubMed  CAS  Google Scholar 

  369. Livadas, D.P., Koutras, D.A., Souvatzoglou, A. et al. (1977) The toxic effects of small iodine supplements in patients with autonomous thyroid nodules. Clin. Endocrinol., 7, 121–7.

    Article  CAS  Google Scholar 

  370. Martino, E., Safran, M., Aghini-Lombardi, F. et al. (1984) Environmental iodine intake and thyroid dysfunction during chronic amiodar-one therapy. Ann. Intern. Med., 101, 28–34.

    Article  PubMed  CAS  Google Scholar 

  371. Gammage, M.D. and Franklyn, J.A. (1987) Amiodarone and the thyroid. Quart. J. Med. New Series, 62, 83–6.

    CAS  Google Scholar 

  372. Newnham, H.H., Chosich, N., Topliss, D.J. et al. (1988) Amiodarone-induced hyperthyroidism: assessment of predictive value of biochemical testing and response to combined therapy using propylthiouracil and potassium perchlorate. Aust. N.Z. J. Med., 18, 37–44.

    Article  PubMed  CAS  Google Scholar 

  373. Mechlis, S., Lubin, E., Laor, J. et al. (1988) Amiodarone-induced thyroid gland dysfuc-tion. Am. J. Cardiol, 59, 833–5.

    Article  Google Scholar 

  374. Miaskiewicz, S.L., Amico, J.A., Follansbee, W.P. et al. (1987) Amiodarone-associated thyrotoxicosis masquerading as painful thyroiditis. Ann. Intern. Med., 107, 118–19.

    Article  PubMed  CAS  Google Scholar 

  375. Wimpfheimer, C., Staubli, M., Schadelin, J. et al. (1982) Prednisone in amiodarone-induced thyrotoxicosis. Br. Med. J., 284, 1835–6.

    Article  CAS  Google Scholar 

  376. Woodruff, J.D., Rauh, J.T. and Markley, R.L. (1966) Ovarian struma. Obstet. Gynecol., 27, 194–202.

    PubMed  CAS  Google Scholar 

  377. Janovski, N.A. and Paramanandhan, T.L. (1973) Ovarian Tumors, Vol 4, Major Problems in Obstetrics and Gynecology, WB Saunders Company, Philadelphia, pp. 89–90.

    Google Scholar 

  378. Kempers, R.D., Dockerty, M.B., Hoffman, D.L. et al. (1970) Struma ovarii — ascitic, hyperthyroid and asymptomatic syndromes. Ann. Intern. Med., 72, 883–93.

    Article  PubMed  CAS  Google Scholar 

  379. Pardo-Mindan, F.J. and Vazquez, J.J. (1983) Malignant struma ovarii. Light and electron microscopic study., Cancer, 51, 337–43.

    Article  PubMed  CAS  Google Scholar 

  380. McDougall, I.R., Krasne, D., Hanberry, J.W. et al. (1989) Malignant struma ovarii presenting as paraparesis from a spinal metastasis. J. Nucl. Med., 30, 407–11.

    PubMed  CAS  Google Scholar 

  381. Smith, F.G. (1946) Pathology and physiology of struma ovarii. Arch. Surg., 53, 603–26.

    Article  PubMed  CAS  Google Scholar 

  382. Brown, W.W., Shetty, K.R. and Rosenfeld, P.S. (1973) Hyperthyroidism due to struma ovarii: demonstration by radioiodine scan. Acta Endocrinol., 73, 266–72.

    PubMed  CAS  Google Scholar 

  383. Federman, D.D. (1964) Hyperthyroidism due to functioning metastatic carcinoma of the thyroid. Medicine, 43, 267–74.

    PubMed  CAS  Google Scholar 

  384. Ober, K.P., Cowan, R.J., Sevier, R.E. et al. (1987) Thyrotoxicosis caused by functioning metastatic thyroid carcinoma. A rare and elusive cause of hyperthyroidism with low radioactive iodine uptake. Clin. Nucl Med., 12, 345–8.

    Article  PubMed  CAS  Google Scholar 

  385. Citrin, D.L., Pederson, J., Rose, D.B. et al. (1978) Radiation-induced carcinoma of the thyroid with severe thyrotoxicosis. Wisc. Med. J., 77, 597–9.

    Google Scholar 

  386. Studer, H., Veraguth, P. and Wyss, F. (1961) Thyrotoxicosis due to a solitary hepatic metastasis of thyroid carcinoma. J.Clin. Endocrinol. Metab., 21, 1334–8.

    Article  PubMed  CAS  Google Scholar 

  387. Chapman, C.N., Sziklas, J.J., Spencer, R.P. et al. (1984) Hyperthyroidism with metastatic follicular thyroid carcinoma. J. Nucl. Med., 25, 466–8.

    PubMed  CAS  Google Scholar 

  388. Sung, L.C. and Cavalieri, R.R. (1973) T3 toxicosis due to metastatic thyroid carcinoma. J. Clin. Endocrinol. Metab., 36, 215–17.

    Article  PubMed  CAS  Google Scholar 

  389. Pont, A. Spratt, D. and Shin, J.B. (1982) T3 toxicosis due to nonmetastatic follicular carcinoma of the thyroid. West J. Med., 136, 255–8.

    PubMed  CAS  Google Scholar 

  390. Cerletty, J.M. and Listwan, W.J. (1979) Hyperthyroidism due to functioning metastatic thyroid carcinoma. Precipitation of thyroid storm with therapeutic radioactive iodine. JAMA, 242, 269–70.

    Article  PubMed  CAS  Google Scholar 

  391. Weintraub, B.D., Gershengorn, M.C., Kourides, M.C. et al. (1981) Inappropriate secretion of thyroid-stimulating hormone. Ann. Intern. Med., 95, 339–51.

    Article  Google Scholar 

  392. Brenner-Gati, L. and Gershengorn, M.C. (1985) Thyroid-stimulating hormone-induced hyperthyroidism, in The Pituitary Gland, (ed. H. Imura), Raven Press, New York, pp. 467–500.

    Google Scholar 

  393. Tolis, G., Bird, C., Bertrand, G. et al. (1978) Pituitary hyperthyroidism: case report and review of the literature. Am. J. Med., 64, 177–81.

    Article  PubMed  CAS  Google Scholar 

  394. Smallridge, R.C. and Smith, C.E. (1983) Hyperthyroidism due to thyrotropin-secreting pituitary tumors. Arch. Intern. Med., 143, 503–7.

    Article  PubMed  CAS  Google Scholar 

  395. Kourides, I.A., Ridgway, E.C., Weintraub, B.D. et al. (1977) Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors. J. Clin. Endocrinol. Metab., 45, 534–43.

    Article  PubMed  CAS  Google Scholar 

  396. Kourides, I.A., Pekonen, F. and Weintraub, B.D. (1980) Absence of thyroid-binding immunoglobulins in patients with thyrotropin-mediated hyperthyroidism. J.Clin. Endocrinol. Metab., 51, 271–4.

    Article  Google Scholar 

  397. Yovos, J.G., Falko, J.M., O’Dorisio, T.M. et al. (1981) Thyrotoxicosis and a thyrotropin-secreting pituitary tumor causing unilateral exophthalmos. J. Clin. Endocrinol. Metab., 53, 338–43.

    Article  PubMed  CAS  Google Scholar 

  398. Spanheimer, R.G., Bar, R.S. and Hayford, J.C. (1982) Hyperthyroidism caused by inappropriate thyrotropin hypersecretion: studies in patients with selective pituitary resistance to thyroid hormone. Arch. Intern. Med., 142, 1283–6.

    Article  PubMed  CAS  Google Scholar 

  399. Gharib, H., Carpenter, P.C., Scheithauer, B.W. et al. (1982) The spectrum of inappropriate pituitary thyrotropin secretion associated with hyperthyroidism. Mayo Clin. Proc., 57, 556–63.

    PubMed  CAS  Google Scholar 

  400. Refetoff, S., DeWind, L.T. and DeGroot, L.J. (1967) Familial syndrome combining deaf-mutism, stippled epiphysis, goiter and abnormally high PBI: possible target refractoriness to thyroid hormone. J. Clin. Endocrinol. Metab., 27, 279–94.

    Article  PubMed  CAS  Google Scholar 

  401. Refetoff S., Salazar, A., Smith, T.J. et al. (1983) The consequences of inappropriate treatment because of failure to recognize the syndrome of pituitary and peripheral resistance to thyroid hormone. Metabolism, 32, 822–34.

    Article  PubMed  CAS  Google Scholar 

  402. Hughes, I.A., Ichikawa, K., DeGroot, L.J. et al. (1987) Non-adenoma tous inappropriate TSH hypersecretion and euthyroidism requires no treatment. Clin. Endocrinol., 27, 475–83.

    Article  CAS  Google Scholar 

  403. Tisne, L. et al. (reference in Spanish, interested readers see Higgins, H.P. et al. [403]).

    Google Scholar 

  404. Odell W.D., Bates, R.W., Rivlin, R.S. et al. (1963) Increased thyroid function without clinical hyperthyroidism in patients with choriocarcinoma. J. Clin. Endocrinol. Metab., 23, 658–64.

    Article  PubMed  CAS  Google Scholar 

  405. Hershman, J.M. and Higgins, H.P. (1971) Hydatidiform mole — a cause of clinical hyperthyroidism. N. Engl. J. Med., 284, 573–7.

    Article  PubMed  CAS  Google Scholar 

  406. Higgins H.P., Hershman, J.M., Kenimer, J.G. et al. (1975) The thyrotoxicosis of hydatidiform mole. Ann. Intern. Med., 83, 307–11.

    Article  PubMed  CAS  Google Scholar 

  407. Soutter, W.P., Norman, R. and Green-Thompson, R.W. (1981) The management of choriocarcinoma causing severe thyrotoxicosis. Two case reports. Br. J. Obstet. Gynaecol., 88, 938–43.

    Article  PubMed  CAS  Google Scholar 

  408. Hershman, J.M. (1981) Hyperthyroidism caused by trophoblastic tumors. Thyroid Today, 4 (1), (ed. J. Oppenheimer).

    Google Scholar 

  409. Rajatanavin, R., Chailurkit, L-O., Srisupan-dit, S. et al. (1988) Trophoblastic hyperthyroidism: clinical and biochemical features in five cases. Am. J. Med., 85, 237–241.

    Article  PubMed  CAS  Google Scholar 

  410. Steigbigel, N.H. (1964) Metastatic embryonal carcinoma of the testis asssociated with elevated plasma TSH-like activity and hyperthyroidism. N. Engl, J. Med., 271, 345–9.

    Article  CAS  Google Scholar 

  411. Karp, P.J., Hershman, J.M., Richmond, S. et al. (1973) Thyrotoxicosis from molar thyrotropin. Arch. Intern. Med., 132, 432–6.

    Article  PubMed  CAS  Google Scholar 

  412. Stromberg, P., Ratcliffe, J.G., Trotter, J., et al. (1981) Teratoma of the testis and hyperthyroidism. Scot. Med. J., 26, 346–7.

    PubMed  CAS  Google Scholar 

  413. Safa, A.M., Schumaker, P. and Rodriguez-Antunez, A. (1975) Long-term follow-up results in children and adolescents treated with radioiodine (131I) for hyperthyroidism. N. Engl. J. Med., 292, 167–71.

    Article  PubMed  CAS  Google Scholar 

  414. Hamburger, J.I. (1985) Management of hyperthyroidism in children and adolescents. J. Clin. Endocrinol. Metab., 60, 1019–24.

    Article  PubMed  CAS  Google Scholar 

  415. Barnes, H.V. and Blizzard, R.M. (1977) Antithyroid drug therapy for toxic diffuse goiter (Graves’) disease: thirty years’ experience in children and adolescents. J. Pediatr., 91, 313–20.

    Article  PubMed  CAS  Google Scholar 

  416. Freitas, J.E., Swanson, D.P., Gross, M.D. et al. (1979) Iodine-131: optimal therapy for hyperthyroidism in children and adolescents. J. Nucl Med., 20, 847–50.

    PubMed  CAS  Google Scholar 

  417. Crile, G. Jr and Schumacher, O.P. (1965) Radioactive iodine treatment of Graves’ disease: results of 32 children under 16 years of age. Am. J. Dis. Child, 110, 501–4.

    PubMed  Google Scholar 

  418. Levy, W.J., Schumacher, O.P. and Gupta, M. (1988) Treatment of childhood Graves’ disease. Clev. Clin. J. Med., 55, 373–82.

    Article  CAS  Google Scholar 

  419. Buckingham, B.A., Costin, G., Roe, T.F. et al. (1981) Hyperthyroidism in children: a reevaluation of treatment. Am. J. Dis. Child, 135, 112–17.

    PubMed  CAS  Google Scholar 

  420. Hayles, A.B. and Zimmerman, D. (1986) Graves’ disease in childhood, in The Thyroid, 5th edn, (eds S.H. Ingbar and L.E. Braverman) Lippincott, Philadelphia, pp. 1414–23.

    Google Scholar 

  421. McArthur, R.G. (1978) Hyperthyroidism in childhood. Thyroid Today, 1 (5), (ed. J.H. Oppenheimer).

    Google Scholar 

  422. Marks, P. and Ashraf, H. (1978) Apathetic hyperthyroidism with hypomagnesemia and raised alkaline phosphatase concentration. Br. Med. J., 1, 821–2.

    Article  PubMed  CAS  Google Scholar 

  423. Lahey, F.H. (1931) Non-activated (apathetic) type of hyperthyroidism. N. Engl. J. Med., 204, 747–8.

    Article  Google Scholar 

  424. Lahey, F.H. (1931) Apathetic thyroidism. Ann. Surg., 93, 1021–30.

    Article  Google Scholar 

  425. Tibaldi, J.M., Barzel, U.S., Albin, J. et al. (1986) Thyrotoxicosis in the very old. Am. J. Med., 81, 619–22.

    Article  PubMed  CAS  Google Scholar 

  426. Ronnon-Jensen, V. and Kirkegaard, C. (1973) Hyperthyroidism — a disease of old age. Br. Med. J., 1, 41–3.

    Article  Google Scholar 

  427. Davis, P.J. and Davis, F.B. (1974) Hyperthyroidism in patients over the age of 60 years. Medicine, 53, 161–81.

    Article  PubMed  CAS  Google Scholar 

  428. Bartels, E.C. (1965) Hyperthyroidism in patients over 65. Geriatrics, 20, 459–62.

    PubMed  CAS  Google Scholar 

  429. Thomas, F.B., Mazzaferri, E.L. and Skillman, T.G. (1970) Apathetic thyrotoxicosis: a distinctive clinical and laboratory entity. Ann. Intern. Med., 72, 679–85.

    Article  PubMed  CAS  Google Scholar 

  430. Kawabe, T., Komiya, I., Endo, T. et al. (1979) Hyperthyroidism in the elderly. J. Am. Geriatric. Soc, 27, 152–5.

    CAS  Google Scholar 

  431. Caplan, R.H., Glaser, J.E., Davis, K. et al. (1978) Thyroid function tests in elderly hyperthyroid patients. J. Am. Geriatric Soc., 26, 116–20.

    CAS  Google Scholar 

  432. Burrow, G.N. (1985) The management of thyrotoxicosis in pregnancy. N. Engl. J. Med., 313, 562–5.

    Article  PubMed  CAS  Google Scholar 

  433. Burrow, G.N. (1978) Hyperthyroidism during pregnancy. N. Engl. J. Med., 298, 150–3.

    Article  PubMed  CAS  Google Scholar 

  434. Burrow, G.N. (1982) Thyroid diseases, in Medical Complications During Pregnancy, 2nd edn, (eds G.N. Burrow and T.F. Ferris), W. B. Saunders, London, Philadelphia, Toronto, pp. 187–214.

    Google Scholar 

  435. Ramsay, I. (1983) Drug treatment of thyroid and adrenal disease during pregnancy, in Clinical Pharmacology in Obstetrics, (ed. P. Lewis), Wright PSG, Bristol, London, Boston, pp. 232–50.

    Google Scholar 

  436. Aboul-Khair, S.A., Crooks, J., Turnbull, A.C. et al. (1964) The physiological changes in thyroid function during pregnancy. Clin. Sci., 27, 195–207.

    PubMed  CAS  Google Scholar 

  437. Caplan, R.H. and Wickus, G. (1979) Goiter and plasma inorganic iodide concentration in pregnancy: a reassessment. JAMA, 242, 352–3.

    Article  PubMed  CAS  Google Scholar 

  438. Long, T.J., Felice, M.E. and Hollingsworth, D.R. (1985) Goiter in pregnant teenagers. Am. J. Obstet. Gynecol, 152, 670–4.

    PubMed  CAS  Google Scholar 

  439. Levy, R.P., Newman D.M., Rejali, L.S. et al. (1980) The myth of goiter in pregnancy. Am. J. Obstet. Gynecol, 137, 701–3.

    PubMed  CAS  Google Scholar 

  440. McDougall, I.R. (1989) Maternal-fetal thyroid hormone metabolism and hyperthyroidism, in Endocrine Disorders in Pregnancy, (eds S.A. Brody and K. Ueland), Appleton and Lange, Norwalk Connecticut/San Mateo, California, pp. 151–64.

    Google Scholar 

  441. Hardisy, C.A. and Munro, D.S. (1983) Serum long acting thyroid stimulator protector in pregnancy complicated, by Graves’ disease. Br. Med. J., 286, 554–5.

    Article  Google Scholar 

  442. Momotani N., Ito, K., Hamada, N. et al. (1984) Maternal hyperthyroidism and congenital malformation in the offspring. Clin. Endocrinol., 20, 695–700.

    Article  CAS  Google Scholar 

  443. Montoro, M. and Mestman, J.H. (1981) Graves’ disease and pregnancy. N. Engl. J. Med., 305, 48.

    Article  Google Scholar 

  444. Mujtaba, Q. and Burrow, G.N. (1975) Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole. Obstet. Gynecol, 46, 282–6.

    PubMed  CAS  Google Scholar 

  445. Cheron, R.G., Kaplan, M.M., Larsen, P.R. et al. (1981) Neonatal thyroid function after propylthiouracil therapy for maternal Graves’ disease. N. Engl. J. Med., 304, 525–8.

    Article  PubMed  CAS  Google Scholar 

  446. Rubin, P.C. (1981) Beta-blockers in pregnancy. N. Engl. J. Med., 305, 1323–6.

    Article  PubMed  CAS  Google Scholar 

  447. Galina, M.P., Avnet, N.L. and Einhorn, A. (1962) Iodides during pregnancy: an apparent cause of neonatal death. N. Engl. J. Med., 267, 1124–7.

    Article  PubMed  CAS  Google Scholar 

  448. Howe, P. and Francis, H.H. (1962) Pregnancy and thyrotoxicosis. Br. Med. J., 2, 817–62.

    Article  Google Scholar 

  449. Menon V., McDougall, W.W. and Leatherdale, B.A. (1982) Thyrotoxic crisis following eclampsia and induction of labour. Postgrad. Med. J., 58, 286–7.

    Article  PubMed  CAS  Google Scholar 

  450. Derksen, R.H.W.M., van de Weil, A., Poortman, J. et al. (1984) Plasma-exchange in the treatment of severe thyrotoxicosis in pregnancy. Eur. J. Obstet. Gynec. Reprod. Biol, 18, 139–48.

    Article  CAS  Google Scholar 

  451. Williams, R.H., Kay, G.A. and Jandorf, B.J. (1944) Thiouracil. Its absorbtion, distribution, and excretion. J. Clin. Invest., 23, 613–27.

    Article  PubMed  CAS  Google Scholar 

  452. Kampman, J.P., Johansen, K., Hansen, J.M. et al. (1980) Propylthiouracil in human milk. Revision of a dogma. Lancet, 1, 736–8.

    Article  Google Scholar 

  453. McKenzie, J.M. and Zakarija, M. (1978) Pathogenesis of neonatal Graves’ disease. J. Endocrinol. Invest., 2, 182–9.

    Google Scholar 

  454. Robinson, A.C., O’Connor, M.K., Tempany, E. et al. (1982) Thyroid pertechnetate scan in neonatal hyperthyroidism. Ir. J. Med. Sci., 151, 22–3.

    Article  PubMed  CAS  Google Scholar 

  455. Cove, D.H. and Johnston, P. (1985) Fetal hyperthyroidism: experience of treatment of four siblings. Lancet, 1, 430–2.

    Article  PubMed  CAS  Google Scholar 

  456. Wilson, D.M., Hopper, A.O., McDougall, I.R. et al. (1982) Serum free thyroxine values in term, premature and sick infants. J. Pediatr., 101, 113–17.

    Article  PubMed  CAS  Google Scholar 

  457. Robinson, D.C., Hall, R. and Munro, D.S. (1969) Graves’ disease, an unusual complication: raised intracranial pressure due to premature fusion of skull sutures. Arch. Dis. Child, 44, 252–7.

    Article  PubMed  CAS  Google Scholar 

  458. Riggs, W., Wilroy, R.S. and Etteldorf, J.N. (1971) Neonatal hyperthyroidism with accelerated skeletal maturation craniosynos-tosis and brachydactyly. Radiol., 105, 621–5.

    Google Scholar 

  459. Macklin, J.F., Canary, J.J. and Pittman, C.S. (1974) Thyroid storm and its management. N. Engl. J. Med., 291, 1396–8.

    Article  Google Scholar 

  460. Newmark, S.R., Himathongkam, T. and Shane, J.M. (1974) Hyperthyroid crisis. JAMA, 230, 592–3.

    Article  PubMed  CAS  Google Scholar 

  461. Urbanic, R.C. and Mazzaferri, E.L. (1978) Thyrotoxic crisis and myxedema coma. Heart Lung, 7, 435–47.

    PubMed  CAS  Google Scholar 

  462. Mazzaferri, E.L. and Skillman, T.G. (1969) Thyroid storm: a review of 22 episodes with special emphasis on the use of guanethidine. Arch. Intern. Med., 124, 684–90.

    Article  PubMed  CAS  Google Scholar 

  463. Roizen, M. and Becker, C.E. (1971) Thyroid storm. Calif. Med., 115, 5–9.

    PubMed  CAS  Google Scholar 

  464. Troen, P., Taymor, R.C. and Goldberg, B.I. (1951) Thyroid crisis associated with diabetic coma. N. Engl. J. Med., 244, 394–8.

    Article  PubMed  CAS  Google Scholar 

  465. Hanscom, D.H. and Ryan, R.J. (1957) Thyroid crisis and diabetic ketoacidosis. N. Engl. J. Med., 257, 697–701.

    Article  PubMed  CAS  Google Scholar 

  466. Ingbar, S.H. (1975) When to hospitalize the patient with thyrotoxicosis. Hosp. Pract., Jan, 45–53.

    Google Scholar 

  467. Brooks, M.H. and Waldstein, S.S. (1980) Free thyroxine concentrations in thyroid storm. Ann. Intern. Med., 93, 694–7.

    Article  PubMed  CAS  Google Scholar 

  468. Goldfarb, C.R., Varma, C. and Roginsky, M. (1980) Diagnosis in delirium: prompt confirmation of thyroid storm. Clin. Nucl. Med., 5, 66.

    Article  PubMed  CAS  Google Scholar 

  469. Wu, S-Y., Chopra, I.J., Solomon, D.H. et al. (1978) The effect of repeated doses of ipodate (oragrafin) in hyperthyroidism. J. Clin. Endocrinol. Metab., 47, 1358–62.

    Article  PubMed  CAS  Google Scholar 

  470. Hellman, R., Kelly, K.L. and Mason, W.D. (1977) Propranolol for thyroid storm (letter), N. Engl. J. Med., 297, 671–2.

    PubMed  CAS  Google Scholar 

  471. Ashkar, F.S., Katims, R.B., Smoak, W.M. III, et al. (1970) Thyroid storm treatment with blood exchange and plasmapheresis. JAMA, 214, 1275–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1992 I. Ross McDougall

About this chapter

Cite this chapter

McDougall, I.R. (1992). Hyperthyroidism. In: Thyroid Disease in Clinical Practice. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2881-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-2881-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-19-520936-5

  • Online ISBN: 978-1-4899-2881-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics