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Antituberculous therapy

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Tuberculosis

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Abstract

In 1946, the introduction of streptomycin (the first effective antituberculous agent) had a dramatic effect on patients with pulmonary tuberculosis (TB) and those with the previously uniformly fatal miliary and meningeal forms [1]. Prior to the introduction of this therapy, approximately half of patients with pulmonary TB died. The mortality dropped to 7% with the introduction of specific anti-TB therapy. The combination of streptomycin and para-aminosalicylic acid (PAS) was found to be more efficacious than treatment with either agent alone as well as being able to suppress the emergence of resistance.

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  1. Jeremy D. Gradon
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Larry I. Lutwick

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Gradon, J.D. (1995). Antituberculous therapy. In: Lutwick, L.I. (eds) Tuberculosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2869-6_12

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