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The D-1 Dopamine Receptor

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Central D1 Dopamine Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 235))

Abstract

The entity known today as the D-1 receptor was identified in the late 1960’s. These early studies utilized either the retina or the superior cervical ganglion of the cow (Kebabian and Greengard, 1971; Brown and Makman, 1972). In either of these tissues, dopamine stimulated the production of cyclic AMP. In either of these tissues, dopamine stimulated the production of cyclic AMP. In the case of the superior cervical ganglion, the use of bovine tissue was fortuitous: the bovine ganglion gave a much larger response to dopamine than the homologus structure in rats or rabbits (Cramer et al., 1973; Kalix et al., 1974; Williams et al. 1977). In the case of the retina, the response to dopamine was ubiquitous among common laboratory animals. Dopamine-stimulated accumulation of cAMP provided a convenient biochemical signal for determining the drug-recognition properties of the dopamine receptor. This approach was superior to the behavioral assays then in use to characterize the drug recognition properties of the then unitary dopamine receptor.

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Author information

Authors and Affiliations

  1. Abbott Laboratories, Dept. 47U, Bldg. AP10, Abbott Park, IL, 60064, USA

    John W. Kebabian

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  1. John W. Kebabian
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Editors and Affiliations

  1. New York University Medical Center, New York, New York, USA

    Menek Goldstein

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Fuxe

  3. Schering Corporation, Bloomfield, New Jersey, USA

    Irving Tabachnick

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© 1988 Springer Science+Business Media New York

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Kebabian, J.W. (1988). The D-1 Dopamine Receptor. In: Goldstein, M., Fuxe, K., Tabachnick, I. (eds) Central D1 Dopamine Receptors. Advances in Experimental Medicine and Biology, vol 235. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2723-1_2

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  • DOI: https://doi.org/10.1007/978-1-4899-2723-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2725-5

  • Online ISBN: 978-1-4899-2723-1

  • eBook Packages: Springer Book Archive

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