Abstract
Oral movements in rats, repetitive jaw movements (RJM), can be induced in a dose dependent manner by a specific D1 agonist, SKF 38393, and decreased by D2 receptor stimulation with a specific D2 agonist, LY 141865. Irreversible D1 receptor inactivation by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline severely reduced oral responses induced by SKF 38393, whereas such blockade of D2 receptors greatly augmented the D1 mediated behavior. Further, we found that chronic prolonged D1 receptor blockade following administration of fluphenazine decanoate facilitated repetitive jaw movements.
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References
Burt, D.R., Creese, I, and Snyder, S.H., 1977, Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain, Science 196: 326.
Clow, A., Jenner, P. and Marsden, C.D., 1979, Changes in dopamine-mediated behavior during one year’s neuroleptic administration, Eur. J. Pharmacol. 29: 365.
Costali, B. and Naylor, R.J., 1974, Stereotyped behavior induced by dopaminergic agonists after lesion of the midbrain raphae nuclei, Eur. J. Pharmacol. 29: 206.
Ellison, G., See, R., Levin, E. and Kinney, J., 1987, Tremorous mouth movements in rats administered chronic neuroleptics, Psychopharm. 92: 122.
Farde, L., Halldin, C., Stone-Elander, S., and Sedvall, G., 1987, PET analysis of human dopamine receptor subtypes using 11CSCH 23390 and 11C-raclopride, Psychopharm. 92: 278.
Friedhoff, A.J., Bonnet, K.A. and Rosengarten, H., 1977, Reversal of two manifestations of dopamine receptor supersensitivity by administration of L-dopa, Res. Commun. Chem. Pathol. Pharmacol. 16: 887.
Gianutsos, G., Drawbaugh, R.B., Haynes, M.D. and Lal, H., 1974, Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol, Life Sci. 14: 887.
Hyttel, J., Larsen, J.JH., Christensen, A.V. and Arnt, J., 1985, Receptor binding profile in Dyskinesia-Research and Treatment, Psychopharm. Suppl. 2: 9.
Meller, E. and Friedman, E., 1980, Striatal dopaminergic activity during withdrawal from chronic neuroleptic treatment in rats, in: “Tardive Dyskinesia”, Fann, W.E., Smith, R.C., Davis, J.M. and Domino, E.F., eds., Spectrum Publications, New York.
Meller, E., Bohmaker, K., Goldstein, M. and Friedhoff, A.J., 1985, Inactivation of D1 and D2 dopamne receptors by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinolihe in vivo: Selective protection by neuroleptics, .J. Pharmacol. Exp. Ther. 333: 656.
Molloy, A.G. and Waddington, J.L., 1984, Dopaminergic behavior stereotypically promoted by D1 agonist R-SK&F 38393 and selectively blocked by the D1 antagonist SCH 23390, Psychopharm. 82: 409.
Muller, P. and Seernan, P., 1976, Alterations in dopaminergic sensitivity in chronically pretreated rats, Soc. Neurosci., Abstr. 2: 874.
Muller, P. and Seeman, P., 1977, Brain neurotransmitter receptors after long term haloperidol: Dopamine, acetylcholine, serotonine, — noradrenergic and naloxone receptors, Life Sci. 21: 1751.
Rosengarten, H., Schweitzer, J.W. and Friedhoff, A.J., 1983, Induction of oral dyskinesias in naive rats by D1 stimulation, Life Sci. 33: 2479.
Rosengarten, H., Schweitzer, J.W. and Friedhoff, A.J., 1986, Selective dopamine D2 receptor reduction enhances a D1 mediated oral dyskinesia in rats, Life Sci. 39: 29.
Sahakian, B.J., Robbins, T.W. and Iversen, S.D., 1976, Flupenthixol-induced hyperactivity by chronic dosing in rats, Eur. J. Pharmacol. 37: 169.
Sailer, F.C. and Salama, A., 1986, D1 and D2 dopamine receptor blockade: interactive effects in vitro and in vivo, J. Pharmacol. Exp. Ther. 236: 714.
Stoof, J.C. and Kebabian, J.W., 1981, Opposing roles for the D1 and D2 dopamine receptors in efflux of cyclic AMP from rat neostriatum, Science 294: 366.
Tarsy, D. and Baldessarini, R.J., 1974, Behavioral supersensitivity to apomorphine following chronic treatment with drugs which interfere with synaptic function of catecholamines, Neuropharmacology 13: 927.
Waddington, J.L. and Gamble, S.T., 1980, Neuroleptic treatment for a substantial proportion of adult life: Behavioral sequelae of 9 months haloperidol administration, Eur. J. Pharmacol. 67: 363.
Waddington, J.L., Cross, A.J., Gamble, S.T. and Bourne, R.C., 1983a, Spontaneous orofacial dyskinesia and dopaminergic function in rats after 6 months of neuroleptic treatment, Science 220: 530.
Waddington, J.L., Gross, A.J., Gamble, S.T. and Bourne, R.C., 1983b, Dopamine receptor function and spontaneous orofacial dyskinesia in rats during 6-month neuroleptic treatments, Adv. Biochem. Psychopharmacol. 37: 299.
Weiss, B., Santelli, S. and Tusink, G., 1977, Movement disorders induced in monkeys by chronic haloperidol treatment, Psychopharm. 53: 289.
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Rosengarten, H., Schweitzer, J.W., Egawa, M., Friedhoff, A.J. (1988). Diminished D2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements. In: Goldstein, M., Fuxe, K., Tabachnick, I. (eds) Central D1 Dopamine Receptors. Advances in Experimental Medicine and Biology, vol 235. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2723-1_11
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DOI: https://doi.org/10.1007/978-1-4899-2723-1_11
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